IN2015DN01448A - - Google Patents
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- IN2015DN01448A IN2015DN01448A IN1448DEN2015A IN2015DN01448A IN 2015DN01448 A IN2015DN01448 A IN 2015DN01448A IN 1448DEN2015 A IN1448DEN2015 A IN 1448DEN2015A IN 2015DN01448 A IN2015DN01448 A IN 2015DN01448A
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- Prior art keywords
- rsv
- infection
- subject
- nucleotide sequence
- sequence encoding
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A61K39/12—Viral antigens
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- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/065—Poxviridae, e.g. avipoxvirus
- C07K14/07—Vaccinia virus; Variola virus
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C07K2319/00—Fusion polypeptide
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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- C12N2710/00011—Details
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- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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- C12N2710/00011—Details
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- C12N2710/00011—Details
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- Health & Medical Sciences (AREA)
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Abstract
Provided herein are recombinant modified vaccinia virus Ankara (MVA) strains as improved vaccines against infection with Respiratory Syncytial Virus (RSV virus) and to related products methods and uses. Specifically provided herein are genetically engineered recombinant MVA vectors comprising at least one nucleotide sequence encoding an antigenic determinant of an RSV membrane glycoprotein and at least one nucleotide sequence encoding an antigenic determinant of an RSV nucleocapsid protein. Also provided herein are products methods and uses thereof e.g. suitable to affect an immune response in a subject or suitable to diagnose an RSV infection as well as to determine whether a subject is at risk of recurrent RSV infection.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261678367P | 2012-08-01 | 2012-08-01 | |
EP12005594 | 2012-08-01 | ||
PCT/EP2013/055483 WO2014019718A1 (en) | 2012-08-01 | 2013-03-15 | Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine |
Publications (1)
Publication Number | Publication Date |
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IN2015DN01448A true IN2015DN01448A (en) | 2015-07-03 |
Family
ID=46614287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1448DEN2015 IN2015DN01448A (en) | 2012-08-01 | 2013-03-15 |
Country Status (19)
Country | Link |
---|---|
US (6) | US9480738B2 (en) |
EP (2) | EP3656396A1 (en) |
JP (2) | JP6523955B2 (en) |
KR (3) | KR102435054B1 (en) |
CN (2) | CN109266622B (en) |
AU (1) | AU2013298915B2 (en) |
BR (1) | BR112015002131B1 (en) |
CA (2) | CA3158572A1 (en) |
CY (1) | CY1122717T1 (en) |
EA (2) | EA031453B1 (en) |
HK (1) | HK1205459A1 (en) |
IL (1) | IL236744B (en) |
IN (1) | IN2015DN01448A (en) |
MX (3) | MX362511B (en) |
MY (1) | MY171498A (en) |
NZ (1) | NZ704005A (en) |
SG (1) | SG11201500696VA (en) |
SI (1) | SI2879702T1 (en) |
WO (1) | WO2014019718A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2879702T3 (en) * | 2012-08-01 | 2020-02-24 | Bavarian Nordic As | RECOMBINANT MODIFIED VACCINIAVIRUS ANKARA (VAT) -VACCINE AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV) |
CA2905569C (en) * | 2013-03-15 | 2023-07-25 | Bavarian Nordic A/S | Single high dose of modified vaccinia virus ankara induces a protective immune response in neonates and infants |
WO2015189425A1 (en) | 2014-06-13 | 2015-12-17 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
EA038402B9 (en) | 2015-06-12 | 2021-09-22 | Глаксосмитклайн Байолоджикалс Са | Adenovirus polynucleotides and polypeptides |
FR3042121A1 (en) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | ANTI-TUMOR COMPOSITION |
MX2019011869A (en) | 2017-04-04 | 2020-01-09 | Univ Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use. |
AU2018269319A1 (en) | 2017-05-15 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
EP3624845A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
BR112020012361A2 (en) | 2017-12-20 | 2020-11-24 | Glaxosmithkline Biologicals S.A. | epstein-barr virus antigen constructs |
WO2019169120A1 (en) | 2018-02-28 | 2019-09-06 | University Of Washington | Self-asssembling nanostructure vaccines |
JP7437385B2 (en) | 2018-09-06 | 2024-02-22 | バヴァリアン・ノルディック・アクティーゼルスカブ | Poxvirus composition with improved storage |
US20220195016A1 (en) * | 2019-04-18 | 2022-06-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Biological and synthetic molecules inhibiting respiratory syncytial virus infection |
JP2022544414A (en) * | 2019-08-13 | 2022-10-18 | アルティミューン インコーポレーティッド | Efficacy of Therapeutic Agents and Routes of Their Administration |
EP4117722A1 (en) | 2020-03-12 | 2023-01-18 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
CA3230406A1 (en) | 2021-09-03 | 2023-03-09 | Jurgen Hausmann | Utilization of micro-rna for downregulation of cytotoxic transgene expression by modified vaccinia virus ankara (mva) |
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US5639853A (en) | 1987-09-29 | 1997-06-17 | Praxis Biologics, Inc. | Respiratory syncytial virus vaccines |
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IE912586A1 (en) | 1990-07-24 | 1992-01-29 | Uab Research Foundation | Bovine respiratory syncytial virus vaccines |
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