EA201891945A3 - VACCINE OF THE RECOMBINANT MODIFIED ANPARA OSPOVACZINA VIRUS (MVA) RESPIRATORY-SYNCYTIAL VIRUS (RSV) - Google Patents

VACCINE OF THE RECOMBINANT MODIFIED ANPARA OSPOVACZINA VIRUS (MVA) RESPIRATORY-SYNCYTIAL VIRUS (RSV)

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Publication number
EA201891945A3
EA201891945A3 EA201891945A EA201891945A EA201891945A3 EA 201891945 A3 EA201891945 A3 EA 201891945A3 EA 201891945 A EA201891945 A EA 201891945A EA 201891945 A EA201891945 A EA 201891945A EA 201891945 A3 EA201891945 A3 EA 201891945A3
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Eurasian Patent Office
Prior art keywords
rsv
virus
mva
respiratory
ospovaczina
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EA201891945A
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Russian (ru)
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EA201891945A2 (en
Inventor
Цедрик Кеминай
Робин Штайгервальд
Пол Чаплин
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Бавариан Нордик А/С
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Publication of EA201891945A2 publication Critical patent/EA201891945A2/en
Publication of EA201891945A3 publication Critical patent/EA201891945A3/en

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Abstract

В данной заявке предусмотрены штаммы рекомбинантного модифицированного вируса осповакцины Анкара (MVA) в качестве улучшенной вакцины против инфекции респираторно-синцитиального вируса (вирус RSV) и связанных с ним продуктов, способов и применений. В частности, настоящее изобретение относится к генно-инженерному рекомбинантному вектору MVA, содержащему по меньшей мере одну нуклеотидную последовательность, кодирующую антигенную детерминанту мембранного гликопротеина RSV, и по меньшей мере одну нуклеотидную последовательность, кодирующую антигенную детерминанту нуклеокапсидного белка RSV. Изобретение также относится к продуктам, способам и их применениям, например, пригодным для воздействия на иммунный ответ у субъекта или пригодным для диагностики инфекции RSV, а также определения того, имеется ли опасность рецидива инфекции RSV у субъекта.This application provides strains of the recombinant modified Ankara Vaccinia virus (MVA) as an improved vaccine against infection of the respiratory syncytial virus (RSV virus) and related products, methods and applications. In particular, the present invention relates to a genetically engineered recombinant vector MVA, containing at least one nucleotide sequence encoding an antigenic determinant of the membrane glycoprotein RSV, and at least one nucleotide sequence encoding an antigenic determinant of the RSV nucleocapsid protein. The invention also relates to products, methods and their applications, for example, suitable for influencing the immune response in a subject or suitable for diagnosing RSV infection, as well as determining whether there is a danger of a relapse of RSV infection in a subject.

EA201891945A 2012-08-01 2013-03-15 VACCINE OF THE RECOMBINANT MODIFIED ANPARA OSPOVACZINA VIRUS (MVA) RESPIRATORY-SYNCYTIAL VIRUS (RSV) EA201891945A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261678367P 2012-08-01 2012-08-01
EP12005594 2012-08-01

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EA201891945A2 EA201891945A2 (en) 2019-01-31
EA201891945A3 true EA201891945A3 (en) 2019-05-31

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EA201590304A EA031453B1 (en) 2012-08-01 2013-03-15 Recombinant modified vaccinia virus ankara (mva) and use thereof
EA201891945A EA201891945A3 (en) 2012-08-01 2013-03-15 VACCINE OF THE RECOMBINANT MODIFIED ANPARA OSPOVACZINA VIRUS (MVA) RESPIRATORY-SYNCYTIAL VIRUS (RSV)

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US (6) US9480738B2 (en)
EP (2) EP2879702B9 (en)
JP (2) JP6523955B2 (en)
KR (3) KR102264852B1 (en)
CN (2) CN104540520B (en)
AU (1) AU2013298915B2 (en)
BR (1) BR112015002131B1 (en)
CA (2) CA3158572A1 (en)
CY (1) CY1122717T1 (en)
EA (2) EA031453B1 (en)
HK (1) HK1205459A1 (en)
IL (1) IL236744B (en)
IN (1) IN2015DN01448A (en)
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NZ (1) NZ704005A (en)
SG (1) SG11201500696VA (en)
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WO (1) WO2014019718A1 (en)

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PT2879702T (en) * 2012-08-01 2020-02-04 Bavarian Nordic As Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine
SG10201707340XA (en) * 2013-03-15 2017-10-30 Bavarian Nordic As Single high dose of mva induces a protective immune response in neonates and infants
EP3154576A1 (en) 2014-06-13 2017-04-19 GlaxoSmithKline Biologicals S.A. Immunogenic combinations
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
EP3307313A1 (en) 2015-06-12 2018-04-18 GlaxoSmithKline Biologicals SA Adenovirus polynucleotides and polypeptides
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