TH124155B - Protein 85 of the peripheral membrane of Burkholderia pseudomallei. - Google Patents
Protein 85 of the peripheral membrane of Burkholderia pseudomallei.Info
- Publication number
- TH124155B TH124155B TH1001000573A TH1001000573A TH124155B TH 124155 B TH124155 B TH 124155B TH 1001000573 A TH1001000573 A TH 1001000573A TH 1001000573 A TH1001000573 A TH 1001000573A TH 124155 B TH124155 B TH 124155B
- Authority
- TH
- Thailand
- Prior art keywords
- peripheral membrane
- protein
- pseudomallei
- omp85
- recombinant
- Prior art date
Links
- 241001136175 Burkholderia pseudomallei Species 0.000 title claims abstract 6
- 108090000623 proteins and genes Proteins 0.000 title claims 5
- 102000004169 proteins and genes Human genes 0.000 title claims 5
- 239000012528 membrane Substances 0.000 title claims 4
- 230000002093 peripheral Effects 0.000 title claims 3
- 101700048310 AMA2 Proteins 0.000 claims abstract 5
- 230000002265 prevention Effects 0.000 claims abstract 2
- 206010069748 Burkholderia pseudomallei infection Diseases 0.000 claims 1
- 108091005686 peripheral membrane proteins Proteins 0.000 abstract 3
- 102000007312 Recombinant Proteins Human genes 0.000 abstract 1
- 108010033725 Recombinant Proteins Proteins 0.000 abstract 1
- 201000009910 diseases by infectious agent Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001681 protective Effects 0.000 abstract 1
- 229960005486 vaccines Drugs 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับวัคซีนยูนิตย่อยชนิดใหม่ สำหรับการป้องกันภาวะติดเชื้อ (เมลิ ออยโดลิส) ซึ่งพัฒนาไปตามโปรตีนของเมมเบรนรอบนอกของ Burkholderia pseudomallei โปรตีนของเมมเบรนรอบนอกเป็นโปรตีน 85 ของเมมเบรนรอบนอก (Omp85) ของ B. pseudomallei ที่สามารถให้การตอบสนองต่อภูมิคุ้มกันป้องที่ต้านการติดเชื้อ B. pseudomallei ยีนที่แปลรหัสสำหรับ Omp85 จากจีโนม B. pseudomallei จะถูกโคลนเข้าไปในเวคเตอร์ที่มีการ แสดงออกสำหรับการผลิตรีคอมบิแนนท์โปรตีนในเวลาต่อมา The invention involved a new subunit vaccine. For the prevention of sepsis (melioidolis), developed along the peripheral membrane proteins of Burkholderia pseudomallei, the peripheral membrane proteins are 85 of the peripheral membrane proteins (Omp85 ) Of B. pseudomallei capable of providing a protective immune response against B. pseudomallei infection. The gene coded for Omp85 from the B. pseudomallei genome is cloned into the active vector. Expressed for the subsequent production of recombinant proteins.
Claims (3)
Publications (1)
Publication Number | Publication Date |
---|---|
TH124155B true TH124155B (en) | 2013-05-31 |
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