EA033242B1 - Усовершенствованные нуклеиновые кислоты и белки вируса человеческой папилломы, вакцины и композиции на их основе и способы индукции иммунного ответа против впч с их применением - Google Patents

Усовершенствованные нуклеиновые кислоты и белки вируса человеческой папилломы, вакцины и композиции на их основе и способы индукции иммунного ответа против впч с их применением

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Publication number
EA033242B1
EA033242B1 EA201490758A EA201490758A EA033242B1 EA 033242 B1 EA033242 B1 EA 033242B1 EA 201490758 A EA201490758 A EA 201490758A EA 201490758 A EA201490758 A EA 201490758A EA 033242 B1 EA033242 B1 EA 033242B1
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Eurasian Patent Office
Prior art keywords
hpv
vaccines
inducing
methods
immune response
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EA201490758A
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English (en)
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EA201490758A1 (ru
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Дэвид Б. Уэйнер
Цзянь Янь
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201490758A1 publication Critical patent/EA201490758A1/ru
Publication of EA033242B1 publication Critical patent/EA033242B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Предложены усовершенствованные молекулы нуклеиновых кислот, кодирующие иммуногенные белки против ВПЧ, которые включают консенсусные E6 и E7 ВПЧ 6, ВПЧ 11, ВПЧ 33 и ВПЧ 58. Кроме того, предложены фармацевтические составы против ВПЧ, рекомбинантные вакцины и живые ослабленные вакцины, содержащие указанные молекулы нуклеиновых кислот, а также способы индукции иммунного ответа у индивидуума против ВПЧ, включающие введение индивидууму указанных фармацевтических составов, рекомбинантных вакцин или живых ослабленных вакцин.
EA201490758A 2011-10-12 2011-10-12 Усовершенствованные нуклеиновые кислоты и белки вируса человеческой папилломы, вакцины и композиции на их основе и способы индукции иммунного ответа против впч с их применением EA033242B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/055932 WO2013055326A2 (en) 2011-10-12 2011-10-12 Vaccines for human papilloma virus and methods for using the same

Publications (2)

Publication Number Publication Date
EA201490758A1 EA201490758A1 (ru) 2014-09-30
EA033242B1 true EA033242B1 (ru) 2019-09-30

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EA201490758A EA033242B1 (ru) 2011-10-12 2011-10-12 Усовершенствованные нуклеиновые кислоты и белки вируса человеческой папилломы, вакцины и композиции на их основе и способы индукции иммунного ответа против впч с их применением

Country Status (10)

Country Link
EP (2) EP2750703B1 (ru)
KR (4) KR102373828B1 (ru)
CN (3) CN107723299B (ru)
AU (2) AU2011378812B2 (ru)
CA (2) CA2848658C (ru)
EA (1) EA033242B1 (ru)
HK (1) HK1198940A1 (ru)
MX (1) MX360449B (ru)
WO (1) WO2013055326A2 (ru)
ZA (1) ZA201402553B (ru)

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JP6517779B2 (ja) * 2013-03-12 2019-05-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒトパピローマウイルスの改良型ワクチンおよびその使用方法
WO2021081480A2 (en) * 2019-10-24 2021-04-29 Inovio Pharmaceuticals, Inc. Improved vaccines for recurrent respiratory papillomatosis and methods for using the same
CN111647067B (zh) * 2020-07-02 2021-06-04 北京广未生物科技有限公司 AP-2alpha抗体联合用药用于制备治疗宫颈癌的药物中的用途

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Also Published As

Publication number Publication date
AU2017265076A1 (en) 2017-12-14
CN103889450A (zh) 2014-06-25
CN107723299A (zh) 2018-02-23
AU2017265076B2 (en) 2019-12-05
CA2848658A1 (en) 2013-04-18
EP2750703B1 (en) 2018-07-04
EP2750703A4 (en) 2015-09-09
ZA201402553B (en) 2015-12-23
KR20140076613A (ko) 2014-06-20
CN107723299B (zh) 2022-02-01
CA3161127A1 (en) 2013-04-18
KR20220035279A (ko) 2022-03-21
AU2011378812A1 (en) 2014-04-10
MX2014004537A (es) 2014-08-01
KR20210019133A (ko) 2021-02-19
WO2013055326A3 (en) 2014-04-10
CN114277038A (zh) 2022-04-05
WO2013055326A2 (en) 2013-04-18
KR102216962B1 (ko) 2021-02-18
MX360449B (es) 2018-11-01
EP3443982A1 (en) 2019-02-20
AU2011378812B2 (en) 2017-08-24
EP2750703A2 (en) 2014-07-09
HK1198940A1 (en) 2015-06-19
KR102373828B1 (ko) 2022-03-14
CN103889450B (zh) 2017-11-21
EA201490758A1 (ru) 2014-09-30
CA2848658C (en) 2022-08-02
KR20190056450A (ko) 2019-05-24

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