BR112014017242A8 - vlps contendo hpv l2 imunogênico e composições e métodos relacionados - Google Patents
vlps contendo hpv l2 imunogênico e composições e métodos relacionadosInfo
- Publication number
- BR112014017242A8 BR112014017242A8 BR112014017242A BR112014017242A BR112014017242A8 BR 112014017242 A8 BR112014017242 A8 BR 112014017242A8 BR 112014017242 A BR112014017242 A BR 112014017242A BR 112014017242 A BR112014017242 A BR 112014017242A BR 112014017242 A8 BR112014017242 A8 BR 112014017242A8
- Authority
- BR
- Brazil
- Prior art keywords
- related compositions
- immunogenic
- hpv
- vlps
- hpv12
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18141—Use of virus, viral particle or viral elements as a vector
- C12N2795/18142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18141—Use of virus, viral particle or viral elements as a vector
- C12N2795/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
resumo patente de invenção: "vlps contendo hpv l2 imunogênico e composições e métodos relacionados". em um aspecto, a presente invenção refere-se às partículas semelhantes a vírus contendo hpv l2 imunogênicas (vlps). as composições relacionadas (por exemplo, vacinas), constructos de ácido nucleico, e os métodos terapêuticos são também fornecidos. em certos aspectos, as vlp são compostas por meio de um polipeptídeo de revestimento dos bacteriófagos pp7 ou ms2, em que a proteína de revestimento é modificada por meio da inserção de antígenos de peptídeos derivados de hpv l2, e em que o peptídeo hpv l2 é apresentado na vlp e pp7 ou encapsida ms2 mrna. especificamente, as vlps da presente invenção exibem os peptídeos l2 na região n-terminal da proteína de revestimento do bacteriófago. surpreendentemente, estas vlps exibindo l2 induzem mais amplamente as respostas de anticorpos neutralizantes do que quando o mesmo peptídeo é apresentado no loop ab de modo que a resposta imunogênica é aumentada por meio de um fator de pelo menos 10. vlps imunogênicas e composições relacionadas da presente invenção induzem a altas respostas de anticorpos de título contra hpv l2 e protegem contra o desafio com hpv in vivo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261585839P | 2012-01-12 | 2012-01-12 | |
| PCT/US2013/020960 WO2013106525A1 (en) | 2012-01-12 | 2013-01-10 | Immunogenic hpv l2-containing vlps and related compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014017242A2 BR112014017242A2 (pt) | 2017-06-13 |
| BR112014017242A8 true BR112014017242A8 (pt) | 2017-07-04 |
Family
ID=48781889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014017242A BR112014017242A8 (pt) | 2012-01-12 | 2013-01-10 | vlps contendo hpv l2 imunogênico e composições e métodos relacionados |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2802349B1 (pt) |
| JP (1) | JP6185932B2 (pt) |
| CN (1) | CN104159606A (pt) |
| AU (1) | AU2013207962B2 (pt) |
| BR (1) | BR112014017242A8 (pt) |
| CA (1) | CA2861021A1 (pt) |
| HK (1) | HK1203837A1 (pt) |
| WO (1) | WO2013106525A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9549976B1 (en) | 2012-11-16 | 2017-01-24 | Stc.Unm | Affinity selection of Nipah and Hendra virus-related vaccine candidates from a complex random peptide library displayed on bacteriophage virus-like particles |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015038708A1 (en) | 2013-09-12 | 2015-03-19 | Stc.Unm | Malaria vaccine |
| WO2015051214A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US10821167B2 (en) | 2016-02-02 | 2020-11-03 | Unm Rainforest Innovations | VLP-based vaccines for targeting Staphylococcus aureus secreted virulence factors |
| JP6916209B2 (ja) * | 2016-05-13 | 2021-08-11 | フラッシュ セラピューティクス | 特に免疫応答に関与する細胞への、ｒｎａの転移のためのウイルス粒子 |
| AU2018270111B2 (en) | 2017-05-18 | 2022-07-14 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
| WO2019063841A1 (en) * | 2017-09-29 | 2019-04-04 | Deutsches Krebsforschungszentrum | VACCINE AGAINST SKIN PAPILLOMAVIRUS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9113809D0 (en) * | 1991-06-26 | 1991-08-14 | Cancer Res Campaign Tech | Papillomavirus l2 protein |
| GB9420146D0 (en) * | 1994-10-06 | 1994-11-23 | Cancer Res Campaign Tech | Papillomavirus vaccine |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US20090028886A1 (en) * | 2004-08-04 | 2009-01-29 | Cytos Biotechnology Ag | Carrier conjugates of gnrh-peptides |
| WO2011100234A2 (en) * | 2010-02-09 | 2011-08-18 | Stc.Unm | Immunogenic hpv l2-containing vlps and related compositions, constructs, and therapeutic methods |
-
2013
- 2013-01-10 BR BR112014017242A patent/BR112014017242A8/pt not_active IP Right Cessation
- 2013-01-10 EP EP13736349.5A patent/EP2802349B1/en active Active
- 2013-01-10 JP JP2014552287A patent/JP6185932B2/ja not_active Expired - Fee Related
- 2013-01-10 CA CA2861021A patent/CA2861021A1/en not_active Abandoned
- 2013-01-10 WO PCT/US2013/020960 patent/WO2013106525A1/en active Application Filing
- 2013-01-10 AU AU2013207962A patent/AU2013207962B2/en not_active Ceased
- 2013-01-10 CN CN201380012267.6A patent/CN104159606A/zh active Pending
-
2015
- 2015-05-14 HK HK15104584.7A patent/HK1203837A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013207962B2 (en) | 2017-07-20 |
| AU2013207962A1 (en) | 2014-08-07 |
| BR112014017242A2 (pt) | 2017-06-13 |
| EP2802349A4 (en) | 2015-08-26 |
| EP2802349A1 (en) | 2014-11-19 |
| CA2861021A1 (en) | 2013-07-18 |
| JP6185932B2 (ja) | 2017-08-23 |
| CN104159606A (zh) | 2014-11-19 |
| JP2015504897A (ja) | 2015-02-16 |
| WO2013106525A1 (en) | 2013-07-18 |
| EP2802349B1 (en) | 2017-12-06 |
| HK1203837A1 (en) | 2015-11-06 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2612 DE 26-01-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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