MX358762B - Procesos que utilizan vlps con cápsides resistentes a hidrolasas. - Google Patents

Procesos que utilizan vlps con cápsides resistentes a hidrolasas.

Info

Publication number
MX358762B
MX358762B MX2014007516A MX2014007516A MX358762B MX 358762 B MX358762 B MX 358762B MX 2014007516 A MX2014007516 A MX 2014007516A MX 2014007516 A MX2014007516 A MX 2014007516A MX 358762 B MX358762 B MX 358762B
Authority
MX
Mexico
Prior art keywords
hydrolases
processes
vlps
resistant
capsids
Prior art date
Application number
MX2014007516A
Other languages
English (en)
Other versions
MX2014007516A (es
Inventor
Pedro Humberto Arhancet Juan
P Arhancet Juan
delaney Kimberly
B Hall Kathleen
Summers Neena
Original Assignee
Apse Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apse Llc filed Critical Apse Llc
Publication of MX2014007516A publication Critical patent/MX2014007516A/es
Publication of MX358762B publication Critical patent/MX358762B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/123—Hepatitis delta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/128—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes processing or releasing ribozyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell
    • C12N2330/51—Specially adapted vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18141—Use of virus, viral particle or viral elements as a vector
    • C12N2795/18142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a nuevos procesos y composiciones que utilizan proteínas de cápside virales resistentes a hidrolasas para preparar partículas similares a virus para encerrar y posteriormente aislar y purificar moléculas de carga objetivo de interés, incluyendo ácidos nucleicos tales como siARN y shARN, y péptidos pequeños.
MX2014007516A 2011-12-21 2012-12-21 Procesos que utilizan vlps con cápsides resistentes a hidrolasas. MX358762B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161578706P 2011-12-21 2011-12-21
US201261607900P 2012-03-07 2012-03-07
US201261661688P 2012-06-19 2012-06-19
PCT/US2012/071419 WO2013096866A2 (en) 2011-12-21 2012-12-21 Processes using vlps with capsids resistant to hydrolases

Publications (2)

Publication Number Publication Date
MX2014007516A MX2014007516A (es) 2014-09-22
MX358762B true MX358762B (es) 2018-09-03

Family

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Family Applications (1)

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MX2014007516A MX358762B (es) 2011-12-21 2012-12-21 Procesos que utilizan vlps con cápsides resistentes a hidrolasas.

Country Status (13)

Country Link
US (2) US20130167267A1 (es)
EP (2) EP2798059B1 (es)
JP (3) JP6041896B2 (es)
CN (2) CN104114696B (es)
AR (1) AR089440A1 (es)
AU (2) AU2012358267B2 (es)
BR (1) BR112014012162B1 (es)
CA (1) CA2860310C (es)
HK (1) HK1203082A1 (es)
IL (1) IL232662B (es)
MX (1) MX358762B (es)
SG (1) SG11201402657WA (es)
WO (1) WO2013096866A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130167267A1 (en) 2011-12-21 2013-06-27 Apse, Llc Processes using vlps with capsids resistant to hydrolases
AU2014281061B2 (en) 2013-06-19 2019-07-18 Rnaissance Ag Llc Compositions and methods using capsids resistant to hydrolases
US9932563B2 (en) * 2013-09-11 2018-04-03 Georgia Tech Research Corporation Compositions and methods for inhibiting gene expressions
US20160208221A1 (en) * 2013-09-12 2016-07-21 Apse, Llc Compositions and methods using capsids resistant to hydrolases
EP3356531A4 (en) * 2015-10-01 2019-05-29 Apse Llc METHODS AND COMPOSITIONS COMPRISING APSE NODES
US10688175B2 (en) 2015-10-13 2020-06-23 Daniel C. Carter NSP10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications
US10806150B2 (en) * 2015-12-31 2020-10-20 Apse, Inc. Methods and compositions of insect control
CN109196102B (zh) * 2016-03-15 2022-04-26 阿普斯公司 增加双链rna产生的方法和组合物
CA3037192A1 (en) 2016-11-07 2018-05-11 nanoSUR LLC Post-transcriptionally chemically modified double strand rnas
CN108795961A (zh) * 2018-05-31 2018-11-13 中华人民共和国大榭出入境检验检疫局 肠道病毒pcr质控品装甲rna及制备方法
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
EP4141110A1 (en) 2020-04-24 2023-03-01 Obshchestvo S Ogranichennoy Otvetstvennost'yu "Ingenik" Method for producing particles of bacteriophages of the genus levivirus
CN113045631B (zh) * 2021-03-10 2022-11-08 湖北大学 一种表达病毒样颗粒的质体转化的转基因植物的制备方法及其在抵抗棉铃虫中的应用
EP4166672A1 (en) * 2021-10-15 2023-04-19 NEUWAY Pharma GmbH A novel method for purification of protein- or peptide-based capsules
WO2024006433A1 (en) * 2022-06-30 2024-01-04 Carnegie Mellon University Method for production of virus-like particles for gene delivery

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS501B1 (es) 1970-05-19 1975-01-06
US5443969A (en) 1992-10-29 1995-08-22 Rutgers University RNA packaging system
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
CA2274584A1 (en) * 1996-12-03 1998-06-11 Medical University Of South Carolina Tissue specific and target rna-specific ribozymes as antimicrobial therapeutics against microbial pathogens
GB9925459D0 (en) 1999-10-27 1999-12-29 Plant Bioscience Ltd Gene silencing
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
JP4790984B2 (ja) * 2001-09-06 2011-10-12 アルファヴァックス，インコーポレイテッド アルファウイルスレプリコンベクター系
AU2002339224B2 (en) 2001-09-14 2008-10-09 Kuros Us Llc Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
US6932971B2 (en) * 2002-07-18 2005-08-23 Cytos Biotechnology Ag Hapten-carrier conjugates and uses thereof
WO2005001039A2 (en) * 2003-05-29 2005-01-06 Creighton University Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof
WO2005021751A1 (en) * 2003-09-01 2005-03-10 Patrick Arbuthnot A self-processing rna expression cassette
EP1512742A1 (en) * 2003-09-08 2005-03-09 Margarete Odenthal Conditional modification of sirnas expression
EP3388521A1 (en) 2004-02-27 2018-10-17 Dow AgroSciences LLC High efficiency peptide production in plant cells
US20080171361A1 (en) 2007-01-11 2008-07-17 The Board Of Regents For Oklahoma State University CAP-Independent Translational Enhancer for Protein Synthesis in Wheat Germ Extract and Transgenic Cereals
CN101784655A (zh) * 2007-04-27 2010-07-21 菲尼克斯股份有限公司 可溶性重组二十面体病毒样颗粒的改良生成和体内装配
EP2085479A1 (en) * 2008-01-31 2009-08-05 Institut Pasteur Reverse genetics of negative-strand rna viruses in yeast
WO2009120883A2 (en) * 2008-03-26 2009-10-01 Life Technologies Corporation Virus-like particle mediated cellular delivery
US8324149B2 (en) * 2008-11-18 2012-12-04 The Board Of Trustees Of The Leland Stanford Junior University Encapsidation of heterologous entities into virus-like particles
US8906863B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector
US8906862B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Multiple antigen delivery system using hepatitis E virus-like particle
EP2443241A1 (en) 2009-06-15 2012-04-25 Plant Bioscience Limited Production of viral capsids
AU2010300033B2 (en) * 2009-09-22 2015-01-22 Medicago Inc. Method of preparing plant-derived VLPS
ES2809679T3 (es) 2010-03-08 2021-03-05 Monsanto Technology Llc Moléculas polinucleotídicas para la regulación génica en plantas
US20130245102A1 (en) 2010-10-12 2013-09-19 Research Foundation Of The City University Of New York Novel dna templates for small rna production in mammalian cells
US20130224828A1 (en) * 2010-11-01 2013-08-29 Qapsule Technologies, Inc. RNA-Directed Packaging of Enzymes Within Protein Particles
US20130167267A1 (en) 2011-12-21 2013-06-27 Apse, Llc Processes using vlps with capsids resistant to hydrolases
CN102533831B (zh) * 2012-02-16 2013-09-11 郑州大学 一种包含自剪切位点的组织特异性双基因沉默RNAi表达载体
AU2014281061B2 (en) * 2013-06-19 2019-07-18 Rnaissance Ag Llc Compositions and methods using capsids resistant to hydrolases
US20160208221A1 (en) * 2013-09-12 2016-07-21 Apse, Llc Compositions and methods using capsids resistant to hydrolases

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US20130167267A1 (en) 2013-06-27
CA2860310C (en) 2023-03-21
HK1203082A1 (en) 2015-10-16
AU2012358267A1 (en) 2014-06-05
JP6332879B2 (ja) 2018-05-30
IL232662B (en) 2019-05-30
WO2013096866A3 (en) 2013-10-03
EP4019636A1 (en) 2022-06-29
BR112014012162A2 (pt) 2019-08-13
EP2798059A4 (en) 2015-07-29
CN107164376B (zh) 2021-03-30
AR089440A1 (es) 2014-08-20
US9181531B2 (en) 2015-11-10
CN107164376A (zh) 2017-09-15
CA2860310A1 (en) 2013-06-27
JP2018038437A (ja) 2018-03-15
BR112014012162B1 (pt) 2021-09-08
JP6041896B2 (ja) 2016-12-14
US20140302593A1 (en) 2014-10-09
JP2015500662A (ja) 2015-01-08
MX2014007516A (es) 2014-09-22
IL232662A0 (en) 2014-07-31
AU2017261590A1 (en) 2017-12-07
EP2798059B1 (en) 2021-09-29
EP2798059A2 (en) 2014-11-05
CN104114696B (zh) 2017-05-03
CN104114696A (zh) 2014-10-22
WO2013096866A2 (en) 2013-06-27
AU2012358267B2 (en) 2017-10-26
SG11201402657WA (en) 2014-09-26
AU2017261590B2 (en) 2019-12-12
JP2017035109A (ja) 2017-02-16

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