JP5442442B2 - 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 - Google Patents

新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 Download PDF

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Publication number
JP5442442B2
JP5442442B2 JP2009534896A JP2009534896A JP5442442B2 JP 5442442 B2 JP5442442 B2 JP 5442442B2 JP 2009534896 A JP2009534896 A JP 2009534896A JP 2009534896 A JP2009534896 A JP 2009534896A JP 5442442 B2 JP5442442 B2 JP 5442442B2
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Prior art keywords
protein
hemagglutinin
vaccine
nucleic acid
amino acid
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JP2009534896A
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Japanese (ja)
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JP2010508030A5 (enExample
JP2010508030A (ja
Inventor
エリック エム ヴォーン
エルナンデス パウリノ カルロス ゴンザレス
ユールゲン デムゲン
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Boehringer Ingelheim Animal Health USA Inc
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Boehringer Ingelheim Animal Health USA Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009534896A 2006-10-27 2007-10-26 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 Active JP5442442B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86314206P 2006-10-27 2006-10-27
US60/863,142 2006-10-27
US11/923,326 US8202967B2 (en) 2006-10-27 2007-10-24 H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
US11/923,326 2007-10-24
PCT/US2007/082699 WO2008052173A2 (en) 2006-10-27 2007-10-26 Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013165132A Division JP2014012008A (ja) 2006-10-27 2013-08-08 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用

Publications (3)

Publication Number Publication Date
JP2010508030A JP2010508030A (ja) 2010-03-18
JP2010508030A5 JP2010508030A5 (enExample) 2010-12-16
JP5442442B2 true JP5442442B2 (ja) 2014-03-12

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JP2009534896A Active JP5442442B2 (ja) 2006-10-27 2007-10-26 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用
JP2013165132A Withdrawn JP2014012008A (ja) 2006-10-27 2013-08-08 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用

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JP2013165132A Withdrawn JP2014012008A (ja) 2006-10-27 2013-08-08 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用

Country Status (18)

Country Link
US (3) US8202967B2 (enExample)
EP (1) EP2086576B8 (enExample)
JP (2) JP5442442B2 (enExample)
KR (2) KR101520307B1 (enExample)
AU (1) AU2007308869B2 (enExample)
BR (1) BRPI0718183B8 (enExample)
CA (1) CA2664914C (enExample)
CO (1) CO6210831A2 (enExample)
DK (1) DK2086576T3 (enExample)
ES (1) ES2391123T3 (enExample)
MX (1) MX2009004243A (enExample)
MY (1) MY150226A (enExample)
PL (1) PL2086576T3 (enExample)
PT (1) PT2086576E (enExample)
RU (1) RU2479589C2 (enExample)
SG (1) SG176419A1 (enExample)
SI (1) SI2086576T1 (enExample)
WO (1) WO2008052173A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014012008A (ja) * 2006-10-27 2014-01-23 Boehringer Ingelheim Vetmedica Inc 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用

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AR088028A1 (es) * 2011-08-15 2014-05-07 Boehringer Ingelheim Vetmed Proteinas h5, de h5n1 para un uso medicinal
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
EP2958586B1 (en) * 2013-02-21 2018-09-05 Boehringer Ingelheim Vetmedica GmbH H5 proteins of h5n1 influenza virus for use as a medicament
JP2015015931A (ja) * 2013-07-12 2015-01-29 株式会社Ｕｍｎファーマ ウイルス様粒子を含む培養物の製造方法
JOP20190088A1 (ar) 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها
CN113260378B (zh) 2018-11-06 2024-06-07 勃林格殷格翰动物保健有限公司 针对禽流感病毒h5亚型的免疫原性组合物
CN117229370B (zh) * 2022-06-08 2024-11-01 中科南京生命健康高等研究院 H5n6禽流感广谱性疫苗的开发及其应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014012008A (ja) * 2006-10-27 2014-01-23 Boehringer Ingelheim Vetmedica Inc 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用

Also Published As

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SI2086576T1 (sl) 2012-11-30
WO2008052173A2 (en) 2008-05-02
CA2664914C (en) 2016-11-22
US8202967B2 (en) 2012-06-19
US20120231027A1 (en) 2012-09-13
AU2007308869A1 (en) 2008-05-02
RU2479589C2 (ru) 2013-04-20
WO2008052173A9 (en) 2012-03-22
CO6210831A2 (es) 2010-10-20
PT2086576E (pt) 2012-10-11
US8592558B2 (en) 2013-11-26
RU2009119597A (ru) 2010-12-10
WO2008052173A8 (en) 2011-02-03
MY150226A (en) 2013-12-31
BRPI0718183A2 (pt) 2013-11-05
US20140050755A1 (en) 2014-02-20
DK2086576T3 (da) 2012-10-15
JP2010508030A (ja) 2010-03-18
SG176419A1 (en) 2011-12-29
US20080193471A1 (en) 2008-08-14
ES2391123T3 (es) 2012-11-21
US9375469B2 (en) 2016-06-28
BRPI0718183B1 (pt) 2020-03-17
KR101520307B1 (ko) 2015-05-29
MX2009004243A (es) 2009-05-14
CA2664914A1 (en) 2008-05-02
EP2086576A2 (en) 2009-08-12
KR20090078362A (ko) 2009-07-17
BRPI0718183B8 (pt) 2022-05-24
JP2014012008A (ja) 2014-01-23
PL2086576T3 (pl) 2012-12-31
AU2007308869B2 (en) 2013-10-24
EP2086576B1 (en) 2012-07-18
WO2008052173A3 (en) 2008-11-13
EP2086576B8 (en) 2015-02-18
KR20150041200A (ko) 2015-04-15
EP2086576A4 (en) 2011-01-19

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