CO6210831A2 - Nuevas proteinas h5 moleculas de acido nucleico y vectores que las codifican y su uso medicinal - Google Patents

Nuevas proteinas h5 moleculas de acido nucleico y vectores que las codifican y su uso medicinal

Info

Publication number
CO6210831A2
CO6210831A2 CO09042413A CO09042413A CO6210831A2 CO 6210831 A2 CO6210831 A2 CO 6210831A2 CO 09042413 A CO09042413 A CO 09042413A CO 09042413 A CO09042413 A CO 09042413A CO 6210831 A2 CO6210831 A2 CO 6210831A2
Authority
CO
Colombia
Prior art keywords
protein
amino acid
new
nucleic acid
acid molecules
Prior art date
Application number
CO09042413A
Other languages
English (en)
Inventor
Eric Vaughn
Juergen Daemmgen
Paulino Carlos Gonzalez-Hernandez
Original Assignee
Boehringer Ingelheim Vetmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed Inc filed Critical Boehringer Ingelheim Vetmed Inc
Publication of CO6210831A2 publication Critical patent/CO6210831A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1.- Proteína H5 del virus de la gripe, en la que la proteína H5 tiene el aminoácido 223N y la modificación 328K+, donde la numeración de las posiciones de aminoácido de la proteína H5 se refiere a la posición de aminoácido como se da a modo de ejemplo en la secuencia SEQ ID NO:1 y donde la modificación 328K+ significa que se ha insertado una segunda lisina (K+) en la posición del aminoácido 328 de la proteína H5. 2.- La proteína H5 según la reivindicación 1, en la que dicha proteína H5 tiene el aminoácido 94N. 3.- La proteína H5 según la reivindicación 1 ó 2, en la que dicha proteína H5 tiene el aminoácido 120N. 4.- La proteína H5 según una cualquiera de las reivindicaciones 1 a 3, en la que dicha proteína H5 tiene el aminoácido 155N. 5.- La proteína H5 según una cualquiera de las reivindicaciones 1 a 4, en la que dicha proteína H5 tiene uno o más de los siguientes agrupamientos de aminoácidos elegidos entre el grupo que consiste en: a. aa 93-95: GNF b. aa 123-125: SDH c. aa 128-130: SSG d. aa 138-140: GSS e. aa 226- 228: MDF f. aa 270-272: EVE g. aa 309-311: NKL.
CO09042413A 2006-10-27 2009-04-27 Nuevas proteinas h5 moleculas de acido nucleico y vectores que las codifican y su uso medicinal CO6210831A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86314206P 2006-10-27 2006-10-27
US11/923,326 US8202967B2 (en) 2006-10-27 2007-10-24 H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use

Publications (1)

Publication Number Publication Date
CO6210831A2 true CO6210831A2 (es) 2010-10-20

Family

ID=39325469

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09042413A CO6210831A2 (es) 2006-10-27 2009-04-27 Nuevas proteinas h5 moleculas de acido nucleico y vectores que las codifican y su uso medicinal

Country Status (18)

Country Link
US (3) US8202967B2 (es)
EP (1) EP2086576B8 (es)
JP (2) JP5442442B2 (es)
KR (2) KR101520307B1 (es)
AU (1) AU2007308869B2 (es)
BR (1) BRPI0718183B8 (es)
CA (1) CA2664914C (es)
CO (1) CO6210831A2 (es)
DK (1) DK2086576T3 (es)
ES (1) ES2391123T3 (es)
MX (1) MX2009004243A (es)
MY (1) MY150226A (es)
PL (1) PL2086576T3 (es)
PT (1) PT2086576E (es)
RU (1) RU2479589C2 (es)
SG (1) SG176419A1 (es)
SI (1) SI2086576T1 (es)
WO (1) WO2008052173A2 (es)

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JOP20190088A1 (ar) 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها
KR20210088655A (ko) * 2018-11-06 2021-07-14 베링거잉겔하임베트메디카게엠베하 조류 인플루엔자 바이러스 h5 서브타입에 대한 면역원성 조성물
CN117229370A (zh) * 2022-06-08 2023-12-15 中科南京生命健康高等研究院 H5n6禽流感广谱性疫苗的开发及其应用

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Also Published As

Publication number Publication date
EP2086576B1 (en) 2012-07-18
RU2009119597A (ru) 2010-12-10
WO2008052173A2 (en) 2008-05-02
CA2664914C (en) 2016-11-22
BRPI0718183B8 (pt) 2022-05-24
US20080193471A1 (en) 2008-08-14
KR20150041200A (ko) 2015-04-15
US9375469B2 (en) 2016-06-28
DK2086576T3 (da) 2012-10-15
RU2479589C2 (ru) 2013-04-20
EP2086576A4 (en) 2011-01-19
US20120231027A1 (en) 2012-09-13
WO2008052173A9 (en) 2012-03-22
SI2086576T1 (sl) 2012-11-30
AU2007308869A1 (en) 2008-05-02
EP2086576B8 (en) 2015-02-18
JP5442442B2 (ja) 2014-03-12
MY150226A (en) 2013-12-31
AU2007308869B2 (en) 2013-10-24
SG176419A1 (en) 2011-12-29
BRPI0718183B1 (pt) 2020-03-17
US8592558B2 (en) 2013-11-26
WO2008052173A8 (en) 2011-02-03
US20140050755A1 (en) 2014-02-20
US8202967B2 (en) 2012-06-19
JP2014012008A (ja) 2014-01-23
KR20090078362A (ko) 2009-07-17
EP2086576A2 (en) 2009-08-12
PT2086576E (pt) 2012-10-11
MX2009004243A (es) 2009-05-14
BRPI0718183A2 (pt) 2013-11-05
WO2008052173A3 (en) 2008-11-13
CA2664914A1 (en) 2008-05-02
ES2391123T3 (es) 2012-11-21
JP2010508030A (ja) 2010-03-18
KR101520307B1 (ko) 2015-05-29
PL2086576T3 (pl) 2012-12-31

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