ES2682981T3 - Proteínas de hemaglutinina del virus de la gripe y método de uso de las mismas - Google Patents
Proteínas de hemaglutinina del virus de la gripe y método de uso de las mismas Download PDFInfo
- Publication number
- ES2682981T3 ES2682981T3 ES14799913T ES14799913T ES2682981T3 ES 2682981 T3 ES2682981 T3 ES 2682981T3 ES 14799913 T ES14799913 T ES 14799913T ES 14799913 T ES14799913 T ES 14799913T ES 2682981 T3 ES2682981 T3 ES 2682981T3
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- amino acid
- hemagglutinin
- virus proteins
- flu virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16071—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
Abstract
Un polipéptido, proteína o complejo de proteínas de hemaglutinina (HA) del virus de la gripe, que comprende un dominio de tallo de la HA que comprende una secuencia de aminoácidos que tiene una identidad de secuencia de al menos 65% con los restos de aminoácidos 229 a 519 de la SEQ ID NO: 1, en donde la secuencia de aminoácidos comprende una mutación puntual a tirosina en una o más de las posiciones de aminoácidos 403, 406, 429, 432, 433 y 435, o un resto de aminoácido que corresponde a las mismas por alineamiento con la SEQ ID NO: 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361861989P | 2013-08-03 | 2013-08-03 | |
PCT/US2014/049509 WO2015020913A2 (en) | 2013-08-03 | 2014-08-02 | Influenza hemagglutinin proteins and methods of thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2682981T3 true ES2682981T3 (es) | 2018-09-24 |
Family
ID=51905385
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14799913T Active ES2682981T3 (es) | 2013-08-03 | 2014-08-02 | Proteínas de hemaglutinina del virus de la gripe y método de uso de las mismas |
ES18156060T Active ES2832733T3 (es) | 2013-08-03 | 2014-08-02 | Métodos de preparación y uso de complejos de hemaglutinina del virus de la gripe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES18156060T Active ES2832733T3 (es) | 2013-08-03 | 2014-08-02 | Métodos de preparación y uso de complejos de hemaglutinina del virus de la gripe |
Country Status (6)
Country | Link |
---|---|
US (4) | US9393297B2 (es) |
EP (3) | EP3395826B1 (es) |
JP (2) | JP6704849B2 (es) |
CA (1) | CA2920016A1 (es) |
ES (2) | ES2682981T3 (es) |
WO (1) | WO2015020913A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3024483B1 (en) | 2013-07-25 | 2020-01-15 | Calder Biosciences Inc. | Conformationally stabilized rsv pre-fusion f proteins |
EP3395826B1 (en) * | 2013-08-03 | 2020-10-14 | Calder Biosciences Inc. | Methods of making and using influenza virus hemagglutinin complexes |
CA3000313A1 (en) * | 2015-10-08 | 2017-04-13 | The Governors Of The University Of Alberta | Hepatitis c virus e1/e2 heterodimers and methods of producing same |
CA3012703A1 (en) | 2016-02-03 | 2017-08-10 | Cg Discovery, Inc. | Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites |
US11596683B2 (en) * | 2016-07-12 | 2023-03-07 | Duke University | Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same |
WO2018213097A1 (en) * | 2017-05-15 | 2018-11-22 | University Of Rochester | Broadly neutralizing anti-influenza monoclonal antibody and uses thereof |
JP2020532953A (ja) | 2017-08-07 | 2020-11-19 | カルダー・バイオサイエンシズ・インコーポレイテッド | コンフォメーションが安定化されたrsv融合前fタンパク質 |
JP7317047B2 (ja) * | 2018-01-23 | 2023-07-28 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | インフルエンザウイルスワクチン及びその使用 |
US11623004B2 (en) | 2018-03-16 | 2023-04-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions and methods for vaccination against respiratory syncytial virus infection |
US20210395333A1 (en) * | 2018-06-07 | 2021-12-23 | Palleon Pharmaceuticals Inc. | Multimeric proteins for detecting a carbohydrate and/or treating a siglec-mediated disorder |
US11642407B2 (en) * | 2020-02-28 | 2023-05-09 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
US20230310575A1 (en) * | 2020-09-02 | 2023-10-05 | St. Jude Children's Research Hospital, Inc. | Hemagglutinin Modifications for Improved Influenza Vaccine Production |
CN114703207B (zh) * | 2022-04-07 | 2023-05-23 | 华南农业大学 | 重组质粒的制备方法和重组病毒 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6337070B1 (en) | 1993-04-29 | 2002-01-08 | Takara Shuzo Co., Ltd. | Polypeptides for use in generating anti-human influenza virus antibodies |
US5589174A (en) | 1992-09-17 | 1996-12-31 | Takara Shuzo Co., Ltd. | Anti-human influenza virus antibody |
ES2367475T3 (es) * | 1999-10-15 | 2011-11-03 | Avatar Medical, L.L.C. | Proteínas estabilizadas. |
US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
JP5009614B2 (ja) | 2003-07-03 | 2012-08-22 | アバター バイオテクノロジーズ,インク. | 免疫原性を低減した分子の取得方法 |
US20070042001A1 (en) * | 2005-08-16 | 2007-02-22 | Hawaii Biotech, Inc. | Influenza recombinant subunit vaccine |
EP3524619A1 (en) * | 2007-12-06 | 2019-08-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
WO2011066221A1 (en) | 2009-11-24 | 2011-06-03 | International Aids Vaccine Initiative | Immunogen prioritization for vaccine design |
WO2011146120A2 (en) | 2010-05-18 | 2011-11-24 | Marshall Christopher P | Assay for identifying antigens that activate b cell receptors comprising neutralizing antibodies |
US20130289246A1 (en) | 2010-09-30 | 2013-10-31 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
SG11201402633UA (en) * | 2011-11-28 | 2014-09-26 | Crucell Holland Bv | Influenza virus vaccines and uses thereof |
US20130302366A1 (en) | 2012-05-09 | 2013-11-14 | Christopher Marshall | Conformationally Specific Viral Immunogens |
EP3024483B1 (en) | 2013-07-25 | 2020-01-15 | Calder Biosciences Inc. | Conformationally stabilized rsv pre-fusion f proteins |
EP3395826B1 (en) * | 2013-08-03 | 2020-10-14 | Calder Biosciences Inc. | Methods of making and using influenza virus hemagglutinin complexes |
-
2014
- 2014-08-02 EP EP18156060.8A patent/EP3395826B1/en active Active
- 2014-08-02 US US14/450,236 patent/US9393297B2/en active Active
- 2014-08-02 ES ES14799913T patent/ES2682981T3/es active Active
- 2014-08-02 JP JP2016533349A patent/JP6704849B2/ja active Active
- 2014-08-02 WO PCT/US2014/049509 patent/WO2015020913A2/en active Application Filing
- 2014-08-02 CA CA2920016A patent/CA2920016A1/en active Pending
- 2014-08-02 ES ES18156060T patent/ES2832733T3/es active Active
- 2014-08-02 EP EP20196948.2A patent/EP3805254A1/en active Pending
- 2014-08-02 EP EP14799913.0A patent/EP3027640B1/en active Active
-
2016
- 2016-06-15 US US15/182,958 patent/US20170072045A1/en not_active Abandoned
-
2017
- 2017-12-22 US US15/852,208 patent/US11129887B2/en active Active
-
2020
- 2020-05-13 JP JP2020084547A patent/JP7298046B2/ja active Active
-
2021
- 2021-09-27 US US17/485,705 patent/US20220288189A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3395826B1 (en) | 2020-10-14 |
JP2016530881A (ja) | 2016-10-06 |
JP7298046B2 (ja) | 2023-06-27 |
ES2832733T3 (es) | 2021-06-11 |
US20220288189A1 (en) | 2022-09-15 |
WO2015020913A3 (en) | 2015-04-09 |
EP3805254A1 (en) | 2021-04-14 |
EP3027640A2 (en) | 2016-06-08 |
WO2015020913A2 (en) | 2015-02-12 |
EP3395826A1 (en) | 2018-10-31 |
US20180243403A1 (en) | 2018-08-30 |
US9393297B2 (en) | 2016-07-19 |
US20150056233A1 (en) | 2015-02-26 |
JP2020156487A (ja) | 2020-10-01 |
EP3027640B1 (en) | 2018-03-07 |
US11129887B2 (en) | 2021-09-28 |
CA2920016A1 (en) | 2015-02-12 |
JP6704849B2 (ja) | 2020-06-03 |
US20170072045A1 (en) | 2017-03-16 |
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