JP2018503361A5 - - Google Patents
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- JP2018503361A5 JP2018503361A5 JP2017528166A JP2017528166A JP2018503361A5 JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5 JP 2017528166 A JP2017528166 A JP 2017528166A JP 2017528166 A JP2017528166 A JP 2017528166A JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- group
- binding fragment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094752P | 2014-12-19 | 2014-12-19 | |
| US62/094,752 | 2014-12-19 | ||
| US201562152122P | 2015-04-24 | 2015-04-24 | |
| US62/152,122 | 2015-04-24 | ||
| PCT/US2015/066654 WO2016100807A2 (en) | 2014-12-19 | 2015-12-18 | Human antibodies to influenza hemagglutinin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Division JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503361A JP2018503361A (ja) | 2018-02-08 |
| JP2018503361A5 true JP2018503361A5 (enExample) | 2019-01-31 |
| JP6711828B2 JP6711828B2 (ja) | 2020-06-17 |
Family
ID=55073153
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528166A Active JP6711828B2 (ja) | 2014-12-19 | 2015-12-18 | インフルエンザ赤血球凝集素に対するヒト抗体 |
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10392432B2 (enExample) |
| EP (1) | EP3233908A2 (enExample) |
| JP (2) | JP6711828B2 (enExample) |
| KR (1) | KR102729973B1 (enExample) |
| CN (1) | CN108064240B (enExample) |
| AU (1) | AU2015364415B2 (enExample) |
| BR (1) | BR112017012944A2 (enExample) |
| CA (1) | CA2969749A1 (enExample) |
| CL (2) | CL2017001610A1 (enExample) |
| CO (1) | CO2017006580A2 (enExample) |
| EA (1) | EA036953B1 (enExample) |
| IL (1) | IL252659B (enExample) |
| MX (2) | MX386403B (enExample) |
| MY (1) | MY185320A (enExample) |
| PH (1) | PH12017500949A1 (enExample) |
| SG (2) | SG11201704212SA (enExample) |
| TW (2) | TWI702229B (enExample) |
| UY (1) | UY36458A (enExample) |
| WO (1) | WO2016100807A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| US20170240617A1 (en) | 2016-02-24 | 2017-08-24 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| MX2019003225A (es) | 2016-09-21 | 2019-06-10 | Aptevo Res & Development Llc | Proteínas de unión a cd123 y composiciones y métodos relacionados. |
| WO2018075621A1 (en) * | 2016-10-19 | 2018-04-26 | Vanderbilt University | Human orthopoxvirus antibodies and methods of use therefor |
| TW202311284A (zh) * | 2017-01-03 | 2023-03-16 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| US11434303B2 (en) | 2017-06-28 | 2022-09-06 | Bluefin Biomedicine, Inc. | Anti-LY6H antibodies and antibody drug conjugates |
| AU2018318303A1 (en) * | 2017-08-18 | 2020-04-09 | Gritstone Bio, Inc. | Antigen-binding proteins targeting shared antigens |
| CN111936517B (zh) | 2018-01-26 | 2025-04-18 | 瑞泽恩制药公司 | 抗tmprss2抗体和抗原结合片段 |
| CA3088194A1 (en) * | 2018-01-26 | 2019-08-01 | Regeneron Pharmaceuticals, Inc. | Human antibodies to influenza hemagglutinin |
| WO2019169231A1 (en) | 2018-03-02 | 2019-09-06 | The University Of Chicago | Methods and composition for neutralization of influenza |
| KR20200060969A (ko) | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| KR20210126641A (ko) | 2019-02-12 | 2021-10-20 | 리제너론 파아마슈티컬스, 인크. | 보체 및 표적 항원에 결합하기 위해 이중 특이적 항체를 사용하는 조성물 및 방법 |
| US11230593B2 (en) * | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CN118064502A (zh) | 2019-04-03 | 2024-05-24 | 瑞泽恩制药公司 | 用于将抗体编码序列插入到安全港基因座中的方法和组合物 |
| JP7634231B2 (ja) | 2019-05-31 | 2025-02-21 | ワシントン ユニバーシティ | Ｐａｎ－ノイラミニダーゼ阻害抗体 |
| WO2020251834A1 (en) * | 2019-06-11 | 2020-12-17 | The Rockefeller University | Antibodies and methods for treatment of viral infections |
| WO2021026064A2 (en) * | 2019-08-06 | 2021-02-11 | Regents Of The University Of Minnesota | Compositions and methods for treating serpin b13 disorders |
| PH12022550963A1 (en) * | 2019-10-28 | 2023-09-25 | Regeneron Pharma | Anti-hemagglutinin antibodies and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CA3168496A1 (en) | 2020-01-24 | 2021-07-29 | Regeneron Pharmaceuticals, Inc. | Protein-antiviral compound conjugates |
| CA3163164A1 (en) | 2020-02-10 | 2021-08-19 | Alina Baum | Anti-tmprss2 antibodies and antigen-binding fragments |
| PL4045533T3 (pl) | 2020-03-26 | 2024-04-15 | Vanderbilt University | Ludzkie przeciwciała monoklonalne przeciwko ciężkiemu ostremu zespołowi oddechowemu wywołanemu koronawirusem 2 (sars-cov-2) |
| WO2021195485A1 (en) * | 2020-03-27 | 2021-09-30 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| CN117050175B (zh) * | 2020-04-17 | 2024-07-16 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| IL297700A (en) | 2020-04-27 | 2022-12-01 | Twist Bioscience Corp | Variant nucleic acid libraries for coronavirus |
| WO2022087393A1 (en) * | 2020-10-23 | 2022-04-28 | Icahn School Of Medicine At Mount Sinai | Sars-cov-2 antibodies and uses thereof |
| IL302938A (en) * | 2020-11-23 | 2023-07-01 | Vir Biotechnology Inc | Antibodies against influenza A viruses |
| KR102604669B1 (ko) * | 2021-03-30 | 2023-11-21 | 충남대학교산학협력단 | 조류인플루엔자 바이러스의 ha 단백질에 특이적인 단클론항체, 및 이의 용도 |
| CN117813119A (zh) | 2021-07-28 | 2024-04-02 | 里珍纳龙药品有限公司 | 蛋白质-抗病毒化合物偶联物 |
| JP2024533162A (ja) * | 2021-09-02 | 2024-09-12 | メモリアル スローン ケタリング キャンサー センター | 抗ｃｄ３３抗体及びその使用 |
| WO2023122647A2 (en) * | 2021-12-22 | 2023-06-29 | The University Of Chicago | Methods for detecting or treating influenza infections |
| WO2023137443A1 (en) | 2022-01-14 | 2023-07-20 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
| JP2025540064A (ja) | 2022-11-30 | 2025-12-11 | レゲネロン ファーマシューティカルス，インコーポレーテッド | Ｔｌｒ７アゴニスト及びその抗体薬物コンジュゲート |
| CN115993452B (zh) * | 2023-03-23 | 2023-06-16 | 深圳市卫光生物制品股份有限公司 | 一种流感病毒疫苗血凝素含量测定方法及试剂盒 |
| WO2025077869A1 (en) * | 2023-10-13 | 2025-04-17 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-ny-eso-1 antibodies and uses thereof |
| WO2025117727A1 (en) | 2023-11-29 | 2025-06-05 | Regeneron Pharmaceuticals, Inc. | Analogs of quinoxaline/quinoline cytotoxins, linker- payloads, protein-drug conjugates, and uses thereof |
| WO2025160340A2 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| TW202540428A (zh) | 2024-01-26 | 2025-10-16 | 美商雷傑納榮製藥公司 | 使用漿細胞耗乏劑及／或ｂ細胞耗乏劑遏制宿主抗ａａｖ抗體反應且實現ａａｖ轉導及重複給藥的方法及組成物 |
| WO2025166216A1 (en) * | 2024-02-02 | 2025-08-07 | The Board Of Regents Of The University Of Texas System | Trop2-targeting antibodies and uses thereof |
| WO2025184137A1 (en) * | 2024-02-27 | 2025-09-04 | Adimab, Llc | Influenza antibodies and methods of use thereof |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
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| US5589174A (en) | 1992-09-17 | 1996-12-31 | Takara Shuzo Co., Ltd. | Anti-human influenza virus antibody |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| JP5848861B2 (ja) | 2004-04-20 | 2016-01-27 | ジェンマブ エー／エスＧｅｎｍａｂ Ａ／Ｓ | Ｃｄ２０に対するヒトモノクローナル抗体 |
| US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| US8192927B2 (en) | 2006-09-07 | 2012-06-05 | Crucell Holland B.V. | Human bind molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| WO2008110937A2 (en) | 2007-03-13 | 2008-09-18 | Humabs Llc | Antibodies against h5n1 strains of influenza a virus |
| EP2155787A4 (en) | 2007-05-11 | 2010-06-16 | Temasek Life Sciences Lab Ltd | SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP |
| EP2174957B1 (en) | 2007-06-15 | 2016-03-16 | Xiamen University | Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof |
| JP5490696B2 (ja) | 2007-09-13 | 2014-05-14 | テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド | インフルエンザウイルスｈ５亜型またはｎ１亜型からのヘマグルチニンおよびノイラミニダーゼに特異的なモノクローナル抗体ならびにそれらの使用 |
| WO2009035412A1 (en) | 2007-09-13 | 2009-03-19 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof |
| FR2921928B1 (fr) | 2007-10-08 | 2011-03-04 | Sanofi Pasteur | Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal |
| CN101970483A (zh) | 2007-12-06 | 2011-02-09 | 达纳-法伯癌症研究公司 | 抗流感病毒抗体及其使用方法 |
| EP2250197B1 (en) | 2008-02-05 | 2016-05-11 | Temasek Life Sciences Laboratory Limited | Binding protein and epitope-blocking elisa for the universal detection of h5-subtype influenza viruses |
| EP2265646B1 (en) | 2008-03-12 | 2016-01-27 | Her Majesty, The Queen in Right of Canada, as Represented by The Minister of Health | Reagents and methods for detecting influenza virus proteins |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| WO2009121004A2 (en) | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
| CN101990575B (zh) | 2008-03-28 | 2015-06-17 | 国立大学法人北海道大学 | 抗h5亚型a型流感病毒血凝素单克隆抗体 |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
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| CA2760553A1 (en) | 2009-04-30 | 2010-11-04 | Jr. James E. Crowe | Monoclonal antibodies to influenza h1n1 virus and uses thereof |
| AU2010247530B2 (en) | 2009-05-11 | 2016-10-13 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof |
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| EP2435475B1 (en) | 2009-05-26 | 2018-10-17 | Icahn School of Medicine at Mount Sinai | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| KR102010827B1 (ko) | 2009-06-26 | 2019-08-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
| EP2464383A4 (en) | 2009-08-14 | 2013-02-13 | Theraclone Sciences Inc | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF GRIP |
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| CN103180341B (zh) | 2010-08-23 | 2015-04-22 | 淡马锡生命科学研究院有限公司 | 特异于流感h5血凝素主要中和表位的单克隆抗体 |
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| LT3418300T (lt) * | 2011-07-18 | 2021-01-11 | Institute For Research In Biomedicine | Neutralizuojantys antikūnai prieš gripo virusą a ir jų panaudojimas |
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| CN108640989B (zh) | 2012-03-08 | 2021-12-14 | 扬森疫苗与预防公司 | 可结合并中和b型流感病毒的人类结合分子及其用途 |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| EP2846833A4 (en) | 2012-05-10 | 2016-01-06 | Massachusetts Inst Technology | MEANS FOR INFLUENZOEUTRALIZATION |
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| CN104968367B (zh) * | 2012-11-13 | 2018-04-13 | 弗·哈夫曼-拉罗切有限公司 | 抗血凝素抗体和使用方法 |
| KR20140118682A (ko) | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| LT3052192T (lt) | 2013-10-02 | 2020-12-10 | Medimmune, Llc | Neutralizuojantys antikūnai prieš gripą a ir jų naudojimas |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| CN111936517B (zh) * | 2018-01-26 | 2025-04-18 | 瑞泽恩制药公司 | 抗tmprss2抗体和抗原结合片段 |
-
2015
- 2015-12-17 TW TW108142869A patent/TWI702229B/zh not_active IP Right Cessation
- 2015-12-17 TW TW104142578A patent/TWI701258B/zh not_active IP Right Cessation
- 2015-12-18 MY MYPI2017701896A patent/MY185320A/en unknown
- 2015-12-18 KR KR1020177020050A patent/KR102729973B1/ko active Active
- 2015-12-18 CA CA2969749A patent/CA2969749A1/en active Pending
- 2015-12-18 BR BR112017012944-2A patent/BR112017012944A2/pt not_active IP Right Cessation
- 2015-12-18 US US14/974,361 patent/US10392432B2/en active Active
- 2015-12-18 EA EA201791086A patent/EA036953B1/ru unknown
- 2015-12-18 AU AU2015364415A patent/AU2015364415B2/en active Active
- 2015-12-18 JP JP2017528166A patent/JP6711828B2/ja active Active
- 2015-12-18 MX MX2017008186A patent/MX386403B/es unknown
- 2015-12-18 CN CN201580076671.9A patent/CN108064240B/zh active Active
- 2015-12-18 WO PCT/US2015/066654 patent/WO2016100807A2/en not_active Ceased
- 2015-12-18 UY UY0001036458A patent/UY36458A/es not_active Application Discontinuation
- 2015-12-18 SG SG11201704212SA patent/SG11201704212SA/en unknown
- 2015-12-18 SG SG10202010170SA patent/SG10202010170SA/en unknown
- 2015-12-18 EP EP15820981.7A patent/EP3233908A2/en active Pending
-
2017
- 2017-05-24 PH PH12017500949A patent/PH12017500949A1/en unknown
- 2017-06-04 IL IL252659A patent/IL252659B/en active IP Right Grant
- 2017-06-19 MX MX2021007679A patent/MX2021007679A/es unknown
- 2017-06-19 CL CL2017001610A patent/CL2017001610A1/es unknown
- 2017-06-29 CO CONC2017/0006580A patent/CO2017006580A2/es unknown
-
2018
- 2018-12-13 JP JP2018233091A patent/JP2019055996A/ja not_active Withdrawn
-
2019
- 2019-07-25 US US16/522,603 patent/US10689436B2/en active Active
- 2019-08-05 CL CL2019002196A patent/CL2019002196A1/es unknown
-
2020
- 2020-05-08 US US16/870,669 patent/US11453714B2/en active Active
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