JP2018503361A5 - - Google Patents
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- JP2018503361A5 JP2018503361A5 JP2017528166A JP2017528166A JP2018503361A5 JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5 JP 2017528166 A JP2017528166 A JP 2017528166A JP 2017528166 A JP2017528166 A JP 2017528166A JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- group
- binding fragment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094752P | 2014-12-19 | 2014-12-19 | |
| US62/094,752 | 2014-12-19 | ||
| US201562152122P | 2015-04-24 | 2015-04-24 | |
| US62/152,122 | 2015-04-24 | ||
| PCT/US2015/066654 WO2016100807A2 (en) | 2014-12-19 | 2015-12-18 | Human antibodies to influenza hemagglutinin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Division JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503361A JP2018503361A (ja) | 2018-02-08 |
| JP2018503361A5 true JP2018503361A5 (enExample) | 2019-01-31 |
| JP6711828B2 JP6711828B2 (ja) | 2020-06-17 |
Family
ID=55073153
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528166A Active JP6711828B2 (ja) | 2014-12-19 | 2015-12-18 | インフルエンザ赤血球凝集素に対するヒト抗体 |
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10392432B2 (enExample) |
| EP (1) | EP3233908A2 (enExample) |
| JP (2) | JP6711828B2 (enExample) |
| KR (1) | KR102729973B1 (enExample) |
| CN (1) | CN108064240B (enExample) |
| AU (1) | AU2015364415B2 (enExample) |
| BR (1) | BR112017012944A2 (enExample) |
| CA (1) | CA2969749A1 (enExample) |
| CL (2) | CL2017001610A1 (enExample) |
| CO (1) | CO2017006580A2 (enExample) |
| EA (1) | EA036953B1 (enExample) |
| IL (1) | IL252659B (enExample) |
| MX (2) | MX386403B (enExample) |
| MY (1) | MY185320A (enExample) |
| PH (1) | PH12017500949A1 (enExample) |
| SG (2) | SG11201704212SA (enExample) |
| TW (2) | TWI702229B (enExample) |
| UY (1) | UY36458A (enExample) |
| WO (1) | WO2016100807A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3419663A1 (en) | 2016-02-24 | 2019-01-02 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| AU2017331256B2 (en) | 2016-09-21 | 2024-11-07 | Aptevo Research And Development Llc | CD123 binding proteins and related compositions and methods |
| US11667697B2 (en) | 2016-10-19 | 2023-06-06 | Vanderbilt University | Human orthopoxvirus antibodies and methods of use therefor |
| TWI781130B (zh) * | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| US11434303B2 (en) | 2017-06-28 | 2022-09-06 | Bluefin Biomedicine, Inc. | Anti-LY6H antibodies and antibody drug conjugates |
| AU2018318303A1 (en) * | 2017-08-18 | 2020-04-09 | Gritstone Bio, Inc. | Antigen-binding proteins targeting shared antigens |
| SG11202006379UA (en) * | 2018-01-26 | 2020-07-29 | Regeneron Pharma | Human antibodies to influenza hemagglutinin |
| BR112020015112A2 (pt) * | 2018-01-26 | 2021-04-06 | Regeneron Pharmaceuticals, Inc. | Anticorpos anti-tmprss2 e fragmentos que ligam antígenos |
| EP3758749A4 (en) * | 2018-03-02 | 2022-07-06 | The University of Chicago | METHOD AND COMPOSITION FOR NEUTRALIZING INFLUENZA |
| KR20200060969A (ko) * | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| MA54945A (fr) | 2019-02-12 | 2021-12-22 | Regeneron Pharma | Compositions et procédés d'utilisation d'anticorps bispécifiques pour lier un complément et un antigène cible |
| CA3132521A1 (en) * | 2019-03-25 | 2020-10-01 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| JP7524214B2 (ja) * | 2019-04-03 | 2024-07-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体コード配列をセーフハーバー遺伝子座に挿入するための方法および組成物 |
| WO2020243572A2 (en) | 2019-05-31 | 2020-12-03 | Washington University | Pan-neuraminidase inhibiting antibodies |
| US20220298230A1 (en) * | 2019-06-11 | 2022-09-22 | The Rockefeller University | Antibodies and methods for treatment of viral infections |
| US12441811B2 (en) | 2019-08-06 | 2025-10-14 | Regents Of The University Of Minnesota | Compositions and methods for treating serpin B13 disorders |
| MY207220A (en) * | 2019-10-28 | 2025-02-06 | Regeneron Pharma | Anti-hemagglutinin antibodies and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| BR112022014278A2 (pt) | 2020-01-24 | 2022-09-20 | Regeneron Pharma | Conjugados de composto proteico-antiviral |
| EP4103619A1 (en) | 2020-02-10 | 2022-12-21 | Regeneron Pharmaceuticals, Inc. | Anti-tmprss2 antibodies and antigen-binding fragments |
| MX2022011892A (es) | 2020-03-26 | 2022-10-18 | Univ Vanderbilt | Anticuerpos monoclonales humanos dirigidos contra el coronavirus 2 del sindrome respiratorio agudo grave (sars-cov-2). |
| WO2021195485A1 (en) * | 2020-03-27 | 2021-09-30 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| CN113527483B (zh) * | 2020-04-17 | 2023-09-22 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| WO2021222316A2 (en) | 2020-04-27 | 2021-11-04 | Twist Bioscience Corporation | Variant nucleic acid libraries for coronavirus |
| US20230391856A1 (en) * | 2020-10-23 | 2023-12-07 | Icahn School Of Medicine At Mount Sinai | Sars-cov-2 antibodies and uses thereof |
| TWI901812B (zh) * | 2020-11-23 | 2025-10-21 | 美商維爾生物科技股份有限公司 | 針對a型流感病毒的抗體 |
| KR102604669B1 (ko) * | 2021-03-30 | 2023-11-21 | 충남대학교산학협력단 | 조류인플루엔자 바이러스의 ha 단백질에 특이적인 단클론항체, 및 이의 용도 |
| KR20240038928A (ko) | 2021-07-28 | 2024-03-26 | 리제너론 파마슈티칼스 인코포레이티드 | 단백질-항바이러스 화합물 접합체 |
| AU2022340645A1 (en) * | 2021-09-02 | 2024-02-29 | Memorial Hospital For Cancer And Allied Diseases | Anti-cd33 antibodies and uses thereof |
| US20250059260A1 (en) * | 2021-12-22 | 2025-02-20 | The University Of Chicago | Methods for detecting or treating influenza infections |
| CA3242639A1 (en) | 2022-01-14 | 2023-07-20 | Regeneron Pharmaceuticals, Inc. | Verrucarin A derivatives and their antibody-drug conjugates |
| CN120659785A (zh) | 2022-11-30 | 2025-09-16 | 里珍纳龙药品有限公司 | Tlr7激动剂及其抗体-药物缀合物 |
| CN115993452B (zh) * | 2023-03-23 | 2023-06-16 | 深圳市卫光生物制品股份有限公司 | 一种流感病毒疫苗血凝素含量测定方法及试剂盒 |
| WO2025077869A1 (en) * | 2023-10-13 | 2025-04-17 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-ny-eso-1 antibodies and uses thereof |
| WO2025117727A1 (en) | 2023-11-29 | 2025-06-05 | Regeneron Pharmaceuticals, Inc. | Analogs of quinoxaline/quinoline cytotoxins, linker- payloads, protein-drug conjugates, and uses thereof |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| US20250242018A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| WO2025166216A1 (en) * | 2024-02-02 | 2025-08-07 | The Board Of Regents Of The University Of Texas System | Trop2-targeting antibodies and uses thereof |
| WO2025184137A1 (en) * | 2024-02-27 | 2025-09-04 | Adimab, Llc | Influenza antibodies and methods of use thereof |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| WO2025255258A2 (en) * | 2024-06-05 | 2025-12-11 | Vaxart, Inc. | Antibodies targeting gii genotypes of human norovirus |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589174A (en) | 1992-09-17 | 1996-12-31 | Takara Shuzo Co., Ltd. | Anti-human influenza virus antibody |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| WO2005103081A2 (en) | 2004-04-20 | 2005-11-03 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| NZ587107A (en) | 2006-06-02 | 2012-05-25 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| EP2059532B1 (en) | 2006-09-07 | 2012-12-26 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| JP5346820B2 (ja) | 2007-03-13 | 2013-11-20 | エイチユーエムエイビーエス・リミテッド・ライアビリティ・カンパニー | Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体 |
| EP2155787A4 (en) | 2007-05-11 | 2010-06-16 | Temasek Life Sciences Lab Ltd | SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP |
| EP2716656B1 (en) | 2007-06-15 | 2016-10-12 | Xiamen University | Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof |
| JP5490696B2 (ja) | 2007-09-13 | 2014-05-14 | テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド | インフルエンザウイルスｈ５亜型またはｎ１亜型からのヘマグルチニンおよびノイラミニダーゼに特異的なモノクローナル抗体ならびにそれらの使用 |
| WO2009035412A1 (en) | 2007-09-13 | 2009-03-19 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof |
| FR2921928B1 (fr) | 2007-10-08 | 2011-03-04 | Sanofi Pasteur | Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal |
| BRPI0819971A2 (pt) | 2007-12-06 | 2017-06-27 | Burnham Institute For Medical Res | anticorpos contra vírus influenza e métodos de seu uso |
| JP5490725B2 (ja) | 2008-02-05 | 2014-05-14 | テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド | Ｈ５亜型インフルエンザウイルスの普遍的な検出のための結合タンパク質およびエピトープブロッキングｅｌｉｓａ |
| US8669046B2 (en) | 2008-03-12 | 2014-03-11 | Xuguang (Sean) Li | Reagents and methods for detecting influenza virus proteins |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| EP2274334A2 (en) | 2008-03-28 | 2011-01-19 | Sea Lane Biotechnologies,llc. | Neutralizing molecules to viral antigens |
| EP2284260A4 (en) | 2008-03-28 | 2011-08-10 | Univ Hokkaido Nat Univ Corp | MONOCLONAL ANTIBODY TO HEMAGGLUTININE OF INFLUENZA A VIRUS SUBTYPE H5 |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| CA2733218A1 (en) | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| US20120128684A1 (en) | 2008-08-25 | 2012-05-24 | Burnham Institute For Medical Research | Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use |
| US8540995B2 (en) | 2008-12-24 | 2013-09-24 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof |
| US8975378B2 (en) | 2008-12-25 | 2015-03-10 | Osaka University | Human anti-human influenza virus antibody |
| CA2760553A1 (en) | 2009-04-30 | 2010-11-04 | Jr. James E. Crowe | Monoclonal antibodies to influenza h1n1 virus and uses thereof |
| MX2011011331A (es) | 2009-05-11 | 2011-11-18 | Crucell Holland Bv | Moleculas de union humanas capaces de neutralizar el virus de la influenza h3n2 y usos de las mismas. |
| JP2012526839A (ja) | 2009-05-13 | 2012-11-01 | シー レーン バイオテクノロジーズ， エルエルシー | インフルエンザウイルスに対する中和分子 |
| WO2010138564A1 (en) | 2009-05-26 | 2010-12-02 | Mount Sinai School Of Medicine Of New York University | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| LT2975051T (lt) | 2009-06-26 | 2021-07-12 | Regeneron Pharmaceuticals, Inc. | Lengvai išskiriami bispecifiniai antikūnai su natyvios formos imunoglobulinu |
| WO2011019932A2 (en) | 2009-08-14 | 2011-02-17 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| EP2483307A1 (en) | 2009-09-29 | 2012-08-08 | Fraunhofer USA, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| CA2849668A1 (en) | 2010-03-08 | 2011-09-15 | Celltrion, Inc. | Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses |
| HRP20170490T1 (hr) | 2010-03-26 | 2017-06-02 | Pomona Ricerca S.R.L. | Imunoglobulini pune dužine igg izotipa sposobni za prepoznavanje heterosubtipnog epitopa neutralizacije na području stabljike hemaglutinina i njihova uporaba kao lijek protiv gripe |
| KR101849738B1 (ko) | 2010-06-17 | 2018-04-17 | 트렐리스 바이오싸이언스 인코포레이티드 | 수동 인플루엔자 면역에 유용한 항체 |
| WO2012021786A2 (en) | 2010-08-12 | 2012-02-16 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
| EP2609113B1 (en) | 2010-08-23 | 2017-03-22 | Temasek Life Sciences Laboratory Limited | Monoclonal antibody specific to major neutralizing epitope of influenza h5 hemagglutinin |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| WO2012045001A2 (en) | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
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| EP2675478A4 (en) | 2011-02-14 | 2015-06-10 | Theraclone Sciences Inc | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF GRIP |
| IN2014CN00953A (enExample) | 2011-07-14 | 2015-04-10 | Crucell Holland Bv | |
| EP3418300B1 (en) * | 2011-07-18 | 2020-10-28 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| JP6325451B2 (ja) | 2011-12-02 | 2018-05-16 | アイム・セラピューティクス・べー・フェー | Ａ型インフルエンザに特異的な抗体 |
| EP2822968B1 (en) | 2012-03-08 | 2018-01-10 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| CA2871160C (en) | 2012-05-10 | 2023-03-14 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
| US20140086927A1 (en) | 2012-09-25 | 2014-03-27 | Fujita Health University | Novel epitope and mechanism of antigen-antibody interaction in an influenza virus |
| JP6386465B2 (ja) | 2012-11-13 | 2018-09-05 | ジェネンテック， インコーポレイテッド | 抗ヘマグルチニン抗体及び使用方法 |
| KR20140118682A (ko) | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| PT3052192T (pt) | 2013-10-02 | 2020-09-24 | Medimmune Llc | Anticorpos neutralizantes anti-influenza a e suas utilizações |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| BR112020015112A2 (pt) * | 2018-01-26 | 2021-04-06 | Regeneron Pharmaceuticals, Inc. | Anticorpos anti-tmprss2 e fragmentos que ligam antígenos |
-
2015
- 2015-12-17 TW TW108142869A patent/TWI702229B/zh not_active IP Right Cessation
- 2015-12-17 TW TW104142578A patent/TWI701258B/zh not_active IP Right Cessation
- 2015-12-18 SG SG11201704212SA patent/SG11201704212SA/en unknown
- 2015-12-18 AU AU2015364415A patent/AU2015364415B2/en active Active
- 2015-12-18 US US14/974,361 patent/US10392432B2/en active Active
- 2015-12-18 MY MYPI2017701896A patent/MY185320A/en unknown
- 2015-12-18 KR KR1020177020050A patent/KR102729973B1/ko active Active
- 2015-12-18 BR BR112017012944-2A patent/BR112017012944A2/pt not_active IP Right Cessation
- 2015-12-18 MX MX2017008186A patent/MX386403B/es unknown
- 2015-12-18 JP JP2017528166A patent/JP6711828B2/ja active Active
- 2015-12-18 CA CA2969749A patent/CA2969749A1/en active Pending
- 2015-12-18 SG SG10202010170SA patent/SG10202010170SA/en unknown
- 2015-12-18 WO PCT/US2015/066654 patent/WO2016100807A2/en not_active Ceased
- 2015-12-18 EA EA201791086A patent/EA036953B1/ru unknown
- 2015-12-18 UY UY0001036458A patent/UY36458A/es not_active Application Discontinuation
- 2015-12-18 CN CN201580076671.9A patent/CN108064240B/zh active Active
- 2015-12-18 EP EP15820981.7A patent/EP3233908A2/en active Pending
-
2017
- 2017-05-24 PH PH12017500949A patent/PH12017500949A1/en unknown
- 2017-06-04 IL IL252659A patent/IL252659B/en active IP Right Grant
- 2017-06-19 MX MX2021007679A patent/MX2021007679A/es unknown
- 2017-06-19 CL CL2017001610A patent/CL2017001610A1/es unknown
- 2017-06-29 CO CONC2017/0006580A patent/CO2017006580A2/es unknown
-
2018
- 2018-12-13 JP JP2018233091A patent/JP2019055996A/ja not_active Withdrawn
-
2019
- 2019-07-25 US US16/522,603 patent/US10689436B2/en active Active
- 2019-08-05 CL CL2019002196A patent/CL2019002196A1/es unknown
-
2020
- 2020-05-08 US US16/870,669 patent/US11453714B2/en active Active
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