JP2018503361A5 - - Google Patents
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- JP2018503361A5 JP2018503361A5 JP2017528166A JP2017528166A JP2018503361A5 JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5 JP 2017528166 A JP2017528166 A JP 2017528166A JP 2017528166 A JP2017528166 A JP 2017528166A JP 2018503361 A5 JP2018503361 A5 JP 2018503361A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- group
- binding fragment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094752P | 2014-12-19 | 2014-12-19 | |
| US62/094,752 | 2014-12-19 | ||
| US201562152122P | 2015-04-24 | 2015-04-24 | |
| US62/152,122 | 2015-04-24 | ||
| PCT/US2015/066654 WO2016100807A2 (en) | 2014-12-19 | 2015-12-18 | Human antibodies to influenza hemagglutinin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Division JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503361A JP2018503361A (ja) | 2018-02-08 |
| JP2018503361A5 true JP2018503361A5 (enExample) | 2019-01-31 |
| JP6711828B2 JP6711828B2 (ja) | 2020-06-17 |
Family
ID=55073153
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528166A Active JP6711828B2 (ja) | 2014-12-19 | 2015-12-18 | インフルエンザ赤血球凝集素に対するヒト抗体 |
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018233091A Withdrawn JP2019055996A (ja) | 2014-12-19 | 2018-12-13 | インフルエンザ赤血球凝集素に対するヒト抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10392432B2 (enExample) |
| EP (1) | EP3233908A2 (enExample) |
| JP (2) | JP6711828B2 (enExample) |
| KR (1) | KR102729973B1 (enExample) |
| CN (1) | CN108064240B (enExample) |
| AU (1) | AU2015364415B2 (enExample) |
| BR (1) | BR112017012944A2 (enExample) |
| CA (1) | CA2969749A1 (enExample) |
| CL (2) | CL2017001610A1 (enExample) |
| CO (1) | CO2017006580A2 (enExample) |
| EA (1) | EA036953B1 (enExample) |
| IL (1) | IL252659B (enExample) |
| MX (2) | MX386403B (enExample) |
| MY (1) | MY185320A (enExample) |
| PH (1) | PH12017500949A1 (enExample) |
| SG (2) | SG10202010170SA (enExample) |
| TW (2) | TWI702229B (enExample) |
| UY (1) | UY36458A (enExample) |
| WO (1) | WO2016100807A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3419663A1 (en) | 2016-02-24 | 2019-01-02 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| US11242400B2 (en) * | 2016-09-21 | 2022-02-08 | Aptevo Research And Development Llc | CD123 binding proteins and related compositions and methods |
| WO2018075621A1 (en) * | 2016-10-19 | 2018-04-26 | Vanderbilt University | Human orthopoxvirus antibodies and methods of use therefor |
| TWI781130B (zh) * | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| WO2019006162A1 (en) | 2017-06-28 | 2019-01-03 | Bluefin Biomedicine, Inc. | ANTI-LY6H ANTIBODIES AND CONJUGATES ANTIBODY-MEDICINE |
| MX2020001879A (es) * | 2017-08-18 | 2020-07-29 | Gritstone Oncology Inc | Proteínas de fijación al antígeno que se dirigen a antígenos compartidos. |
| SMT202100307T1 (it) | 2018-01-26 | 2021-07-12 | Regeneron Pharma | Anticorpi e frammenti di legame di anti-tmprss2 |
| SG11202006379UA (en) * | 2018-01-26 | 2020-07-29 | Regeneron Pharma | Human antibodies to influenza hemagglutinin |
| WO2019169231A1 (en) | 2018-03-02 | 2019-09-06 | The University Of Chicago | Methods and composition for neutralization of influenza |
| KR20200060969A (ko) * | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| US12459991B2 (en) | 2019-02-12 | 2025-11-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for using bispecific antibodies to bind complement and a target antigen |
| CN113924147A (zh) * | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| AU2020256225B9 (en) * | 2019-04-03 | 2025-04-10 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for insertion of antibody coding sequences into a safe harbor locus |
| WO2020243572A2 (en) | 2019-05-31 | 2020-12-03 | Washington University | Pan-neuraminidase inhibiting antibodies |
| US20220298230A1 (en) * | 2019-06-11 | 2022-09-22 | The Rockefeller University | Antibodies and methods for treatment of viral infections |
| WO2021026064A2 (en) * | 2019-08-06 | 2021-02-11 | Regents Of The University Of Minnesota | Compositions and methods for treating serpin b13 disorders |
| BR112022007923A2 (pt) * | 2019-10-28 | 2022-07-26 | Regeneron Pharma | Anticorpo recombinante isolado ou fragmento de ligação ao antígeno deste, composição farmacêutica, molécula de polinucleotídeo, vetor, célula, e, método para prevenir, tratar ou melhorar pelo menos um sintoma da infecção por influenza |
| IL294989A (en) * | 2020-01-24 | 2022-09-01 | Regeneron Pharma | Conjugated protein-antiviral compounds |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| JP7772702B2 (ja) | 2020-02-10 | 2025-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
| DK4045533T5 (da) | 2020-03-26 | 2024-07-29 | Univ Vanderbilt | Humane monoklonale antistoffer mod svær akut respiratorisk syndrom-coronavirus 2 (sars-cov-2) |
| US20230122364A1 (en) * | 2020-03-27 | 2023-04-20 | Vanderbilt University | HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2) |
| CN113527483B (zh) * | 2020-04-17 | 2023-09-22 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| EP4142739A2 (en) | 2020-04-27 | 2023-03-08 | Twist Bioscience Corporation | Variant nucleic acid libraries for coronavirus |
| US20230391856A1 (en) * | 2020-10-23 | 2023-12-07 | Icahn School Of Medicine At Mount Sinai | Sars-cov-2 antibodies and uses thereof |
| KR20230135569A (ko) * | 2020-11-23 | 2023-09-25 | 비르 바이오테크놀로지, 인코포레이티드 | 인플루엔자 a 바이러스에 대한 항체 |
| KR102604669B1 (ko) * | 2021-03-30 | 2023-11-21 | 충남대학교산학협력단 | 조류인플루엔자 바이러스의 ha 단백질에 특이적인 단클론항체, 및 이의 용도 |
| CA3220081A1 (en) | 2021-07-28 | 2023-02-02 | Thomas Nittoli | Protein-antiviral compound conjugates |
| CN118234750A (zh) * | 2021-09-02 | 2024-06-21 | 纪念斯隆-凯特琳癌症中心 | 抗cd33抗体和其用途 |
| WO2023122647A2 (en) * | 2021-12-22 | 2023-06-29 | The University Of Chicago | Methods for detecting or treating influenza infections |
| AU2023208050A1 (en) | 2022-01-14 | 2024-07-04 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
| EP4626553A2 (en) | 2022-11-30 | 2025-10-08 | Regeneron Pharmaceuticals, Inc. | Tlr7 agonists and antibody-drug-conjugates thereof |
| CN115993452B (zh) * | 2023-03-23 | 2023-06-16 | 深圳市卫光生物制品股份有限公司 | 一种流感病毒疫苗血凝素含量测定方法及试剂盒 |
| WO2025077869A1 (en) * | 2023-10-13 | 2025-04-17 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-ny-eso-1 antibodies and uses thereof |
| WO2025117727A1 (en) | 2023-11-29 | 2025-06-05 | Regeneron Pharmaceuticals, Inc. | Analogs of quinoxaline/quinoline cytotoxins, linker- payloads, protein-drug conjugates, and uses thereof |
| US20250242018A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| TW202540428A (zh) | 2024-01-26 | 2025-10-16 | 美商雷傑納榮製藥公司 | 使用漿細胞耗乏劑及／或ｂ細胞耗乏劑遏制宿主抗ａａｖ抗體反應且實現ａａｖ轉導及重複給藥的方法及組成物 |
| WO2025166216A1 (en) * | 2024-02-02 | 2025-08-07 | The Board Of Regents Of The University Of Texas System | Trop2-targeting antibodies and uses thereof |
| WO2025184137A1 (en) * | 2024-02-27 | 2025-09-04 | Adimab, Llc | Influenza antibodies and methods of use thereof |
| US20250276092A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| WO2025255258A2 (en) * | 2024-06-05 | 2025-12-11 | Vaxart, Inc. | Antibodies targeting gii genotypes of human norovirus |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5589174A (en) | 1992-09-17 | 1996-12-31 | Takara Shuzo Co., Ltd. | Anti-human influenza virus antibody |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| RS52176B (sr) | 2006-06-02 | 2012-08-31 | Regeneron Pharmaceuticals Inc. | Antitela visokog afiniteta prema humanom il-6 receptoru |
| CA2663388C (en) | 2006-09-07 | 2017-01-17 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| CN102046654A (zh) | 2007-03-13 | 2011-05-04 | 胡马斯有限公司 | 针对甲型流感病毒h5n1株系的抗体 |
| CA2687147C (en) | 2007-05-11 | 2016-08-23 | Temasek Life Sciences Laboratory Limited | H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance |
| CN101607995B (zh) | 2007-06-15 | 2013-05-01 | 厦门大学 | 特异性结合h5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 |
| AU2008297594B2 (en) | 2007-09-13 | 2013-06-20 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof |
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| AU2008349862B2 (en) | 2008-02-05 | 2014-02-06 | Temasek Life Sciences Laboratory Limited | Binding protein and epitope-blocking ELISA for the universal detection of H5-subtype influenza viruses |
| US8669046B2 (en) | 2008-03-12 | 2014-03-11 | Xuguang (Sean) Li | Reagents and methods for detecting influenza virus proteins |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| WO2009121004A2 (en) | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
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| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ES2662519T3 (es) * | 2008-07-25 | 2018-04-06 | Institute For Research In Biomedicine | Anticuerpos neutralizantes contra el virus de la gripe A y usos de estos |
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| US8894997B2 (en) | 2009-04-30 | 2014-11-25 | Vanderbilt University | Monoclonal antibodies to influenza H1N1 virus uses thereof |
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| CN102482345A (zh) | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| KR101747103B1 (ko) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
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| WO2013169377A1 (en) | 2012-05-10 | 2013-11-14 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US20140086927A1 (en) | 2012-09-25 | 2014-03-27 | Fujita Health University | Novel epitope and mechanism of antigen-antibody interaction in an influenza virus |
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| KR20140118682A (ko) | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| JP6535675B2 (ja) | 2013-10-02 | 2019-06-26 | メディミューン，エルエルシー | 抗ａ型インフルエンザ抗体の中和及びその使用 |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| SMT202100307T1 (it) * | 2018-01-26 | 2021-07-12 | Regeneron Pharma | Anticorpi e frammenti di legame di anti-tmprss2 |
-
2015
- 2015-12-17 TW TW108142869A patent/TWI702229B/zh not_active IP Right Cessation
- 2015-12-17 TW TW104142578A patent/TWI701258B/zh not_active IP Right Cessation
- 2015-12-18 AU AU2015364415A patent/AU2015364415B2/en active Active
- 2015-12-18 US US14/974,361 patent/US10392432B2/en active Active
- 2015-12-18 CA CA2969749A patent/CA2969749A1/en active Pending
- 2015-12-18 MX MX2017008186A patent/MX386403B/es unknown
- 2015-12-18 BR BR112017012944-2A patent/BR112017012944A2/pt not_active IP Right Cessation
- 2015-12-18 JP JP2017528166A patent/JP6711828B2/ja active Active
- 2015-12-18 MY MYPI2017701896A patent/MY185320A/en unknown
- 2015-12-18 WO PCT/US2015/066654 patent/WO2016100807A2/en not_active Ceased
- 2015-12-18 SG SG10202010170SA patent/SG10202010170SA/en unknown
- 2015-12-18 UY UY0001036458A patent/UY36458A/es not_active Application Discontinuation
- 2015-12-18 SG SG11201704212SA patent/SG11201704212SA/en unknown
- 2015-12-18 CN CN201580076671.9A patent/CN108064240B/zh active Active
- 2015-12-18 EP EP15820981.7A patent/EP3233908A2/en active Pending
- 2015-12-18 KR KR1020177020050A patent/KR102729973B1/ko active Active
- 2015-12-18 EA EA201791086A patent/EA036953B1/ru unknown
-
2017
- 2017-05-24 PH PH12017500949A patent/PH12017500949A1/en unknown
- 2017-06-04 IL IL252659A patent/IL252659B/en active IP Right Grant
- 2017-06-19 MX MX2021007679A patent/MX2021007679A/es unknown
- 2017-06-19 CL CL2017001610A patent/CL2017001610A1/es unknown
- 2017-06-29 CO CONC2017/0006580A patent/CO2017006580A2/es unknown
-
2018
- 2018-12-13 JP JP2018233091A patent/JP2019055996A/ja not_active Withdrawn
-
2019
- 2019-07-25 US US16/522,603 patent/US10689436B2/en active Active
- 2019-08-05 CL CL2019002196A patent/CL2019002196A1/es unknown
-
2020
- 2020-05-08 US US16/870,669 patent/US11453714B2/en active Active
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