CL2017001610A1 - Anticuerpos humanos para hemagglutinina de influenza - Google Patents

Anticuerpos humanos para hemagglutinina de influenza

Info

Publication number
CL2017001610A1
CL2017001610A1 CL2017001610A CL2017001610A CL2017001610A1 CL 2017001610 A1 CL2017001610 A1 CL 2017001610A1 CL 2017001610 A CL2017001610 A CL 2017001610A CL 2017001610 A CL2017001610 A CL 2017001610A CL 2017001610 A1 CL2017001610 A1 CL 2017001610A1
Authority
CL
Chile
Prior art keywords
human antibodies
influenza hemagglutinin
bind
antibodies
influenza
Prior art date
Application number
CL2017001610A
Other languages
English (en)
Inventor
Lisa A Purcell
Jonathan Viau
William Olson
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of CL2017001610A1 publication Critical patent/CL2017001610A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

<p>La presente invención provee anticuerpos monoclonales, o frgmentos que unen antígenos, que se unen a la proteína hemaglutinina de influenza (HA). También se protegen composiciones farmacéuticas que comprende el anticuerpo y el uso de ellas. Los anticuerpos son utilies para inhibir o neutralizar la actividad del virus influenza.</p>
CL2017001610A 2014-12-19 2017-06-19 Anticuerpos humanos para hemagglutinina de influenza CL2017001610A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462094752P 2014-12-19 2014-12-19
US201562152122P 2015-04-24 2015-04-24

Publications (1)

Publication Number Publication Date
CL2017001610A1 true CL2017001610A1 (es) 2018-03-09

Family

ID=55073153

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2017001610A CL2017001610A1 (es) 2014-12-19 2017-06-19 Anticuerpos humanos para hemagglutinina de influenza
CL2019002196A CL2019002196A1 (es) 2014-12-19 2019-08-05 Anticuerpos humanos neutralizantes que se unen a hemaglutinina de influenza a. (divisional solicitud 201701610)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2019002196A CL2019002196A1 (es) 2014-12-19 2019-08-05 Anticuerpos humanos neutralizantes que se unen a hemaglutinina de influenza a. (divisional solicitud 201701610)

Country Status (19)

Country Link
US (3) US10392432B2 (es)
EP (1) EP3233908A2 (es)
JP (2) JP6711828B2 (es)
KR (1) KR20170098888A (es)
CN (1) CN108064240B (es)
AU (1) AU2015364415B2 (es)
BR (1) BR112017012944A2 (es)
CA (1) CA2969749A1 (es)
CL (2) CL2017001610A1 (es)
CO (1) CO2017006580A2 (es)
EA (1) EA036953B1 (es)
IL (1) IL252659B (es)
MX (2) MX2017008186A (es)
MY (1) MY185320A (es)
PH (1) PH12017500949A1 (es)
SG (2) SG11201704212SA (es)
TW (2) TWI702229B (es)
UY (1) UY36458A (es)
WO (1) WO2016100807A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
CN109952112A (zh) 2016-09-21 2019-06-28 阿帕特夫研究和发展有限公司 Cd123结合蛋白和相关的组合物和方法
WO2018075621A1 (en) * 2016-10-19 2018-04-26 Vanderbilt University Human orthopoxvirus antibodies and methods of use therefor
TWI781130B (zh) * 2017-01-03 2022-10-21 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體
WO2019006162A1 (en) * 2017-06-28 2019-01-03 Bluefin Biomedicine, Inc. ANTI-LY6H ANTIBODIES AND CONJUGATES ANTIBODY-MEDICINE
US20210147550A1 (en) * 2017-08-18 2021-05-20 Joshua Michael Francis Antigen-binding proteins targeting shared antigens
HUE054403T2 (hu) * 2018-01-26 2021-09-28 Regeneron Pharma TMPRSS2 elleni antitestek és antigénkötõ fragmentumok
JP7372925B2 (ja) * 2018-01-26 2023-11-01 リジェネロン・ファーマシューティカルズ・インコーポレイテッド インフルエンザヘマグルチニンに対するヒト抗体
US11702464B2 (en) 2018-03-02 2023-07-18 The University Of Chicago Methods and composition for neutralization of influenza
KR20200060969A (ko) * 2018-11-23 2020-06-02 (주)셀트리온 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법
CA3127696A1 (en) 2019-02-12 2020-08-20 Regeneron Pharmaceuticals, Inc. Compositions and methods for using bispecific antibodies to bind complement and a target antigen
AU2020248404A1 (en) * 2019-03-25 2021-09-30 Visterra, Inc. Compositions and methods for treating and preventing influenza
CA3133361A1 (en) 2019-04-03 2020-10-08 Regeneron Pharmaceuticals, Inc. Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
EP4010021A4 (en) * 2019-08-06 2023-08-30 Regents of the University of Minnesota COMPOSITIONS AND METHODS FOR TREATMENT OF SERPINB13 DISEASES
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
CA3168496A1 (en) 2020-01-24 2021-07-29 Regeneron Pharmaceuticals, Inc. Protein-antiviral compound conjugates
JP2023513124A (ja) 2020-02-10 2023-03-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｔｍｐｒｓｓ２抗体および抗原結合断片
US20230122364A1 (en) * 2020-03-27 2023-04-20 Vanderbilt University HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
CN117050175A (zh) * 2020-04-17 2023-11-14 珠海泰诺麦博制药股份有限公司 抗人神经生长因子的抗体
US20230391856A1 (en) * 2020-10-23 2023-12-07 Icahn School Of Medicine At Mount Sinai Sars-cov-2 antibodies and uses thereof
KR102604669B1 (ko) * 2021-03-30 2023-11-21 충남대학교산학협력단 조류인플루엔자 바이러스의 ha 단백질에 특이적인 단클론항체, 및 이의 용도
CA3220081A1 (en) 2021-07-28 2023-02-02 Thomas Nittoli Protein-antiviral compound conjugates
AU2022340645A1 (en) * 2021-09-02 2024-02-29 Memorial Hospital For Cancer And Allied Diseases Anti-cd33 antibodies and uses thereof
WO2023122647A2 (en) * 2021-12-22 2023-06-29 The University Of Chicago Methods for detecting or treating influenza infections
WO2023137443A1 (en) 2022-01-14 2023-07-20 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof
CN115993452B (zh) * 2023-03-23 2023-06-16 深圳市卫光生物制品股份有限公司 一种流感病毒疫苗血凝素含量测定方法及试剂盒

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589174A (en) 1992-09-17 1996-12-31 Takara Shuzo Co., Ltd. Anti-human influenza virus antibody
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
WO2005103081A2 (en) 2004-04-20 2005-11-03 Genmab A/S Human monoclonal antibodies against cd20
US8257740B1 (en) 2011-08-15 2012-09-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
PL2041177T3 (pl) 2006-06-02 2012-09-28 Regeneron Pharma Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6
AU2007293662B2 (en) 2006-09-07 2012-10-04 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
EP2125886A2 (en) 2007-03-13 2009-12-02 Humabs LLC Antibodies against h5n1 strains of influenza a virus
WO2008140415A1 (en) 2007-05-11 2008-11-20 Temasek Life Sciences Laboratory Limited H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance
EP2716656B1 (en) 2007-06-15 2016-10-12 Xiamen University Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof
JP5490695B2 (ja) 2007-09-13 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド インフルエンザウイルスｈ５亜型からのヘマグルチニンに特異的なモノクローナル抗体およびそれらの使用
EP2201039B1 (en) 2007-09-13 2015-07-15 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof
FR2921928B1 (fr) 2007-10-08 2011-03-04 Sanofi Pasteur Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal
AU2008338691B2 (en) 2007-12-06 2015-01-22 Burnham Institute For Medical Research Antibodies against influenza virus and methods of use thereof
JP5490725B2 (ja) 2008-02-05 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド Ｈ５亜型インフルエンザウイルスの普遍的な検出のための結合タンパク質およびエピトープブロッキングｅｌｉｓａ
WO2009111865A1 (en) 2008-03-12 2009-09-17 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Health Reagents and methods for detecting influenza virus proteins
ITTO20080204A1 (it) 2008-03-17 2009-09-18 Pomona Biotechnologies Llc Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a
AU2009228058A1 (en) 2008-03-28 2009-10-01 Sea Lane Biotechnologies, Llc Neutralizing molecules to viral antigens
JP5586064B2 (ja) 2008-03-28 2014-09-10 国立大学法人北海道大学 抗ｈ５亜型ａ型インフルエンザウイルスヘマグルチニンモノクローナル抗体
ITTO20080398A1 (it) 2008-05-27 2009-11-28 Pomona Biotechnologies Llc Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1
KR101732056B1 (ko) 2008-07-25 2017-05-02 인스티튜트 포 리서치 인 바이오메드슨 중화 항-인플루엔자 ａ 바이러스 항체 및 이의 용도
US8871207B2 (en) 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
WO2010027818A2 (en) 2008-08-25 2010-03-11 Dana-Farber Cancer Institute, Inc. Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use
SG172333A1 (en) 2008-12-24 2011-07-28 Temasek Life Sciences Lab Ltd Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza a viruses and uses thereof
CN102264896B (zh) 2008-12-25 2014-02-26 国立大学法人大阪大学 抗人流感病毒人型抗体
WO2010127252A2 (en) 2009-04-30 2010-11-04 Vanderbilt University Monoclonal antibodies to influenza h1n1 virus and uses thereof
CN102448986B (zh) 2009-05-11 2015-11-25 克鲁塞尔荷兰公司 能中和流感病毒h3n2的人结合分子及其应用
AU2010249046A1 (en) 2009-05-13 2011-12-01 Sea Lane Biotechnologies, Llc Neutralizing molecules to influenza viruses
AU2010254136B2 (en) 2009-05-26 2016-09-29 Mount Sinai School Of Medicine Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof
MX342623B (es) 2009-06-26 2016-10-06 Regeneron Pharma Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original.
US8974788B2 (en) 2009-08-14 2015-03-10 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of influenza
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
AU2011213585B2 (en) 2010-02-08 2014-02-06 Regeneron Pharmaceuticals, Inc. Common light chain mouse
EP2860190A3 (en) 2010-03-08 2015-07-15 Celltrion, Inc. Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
EA029198B1 (ru) 2010-03-26 2018-02-28 Помона Ричерка С.Р.Л. Полноразмерные иммуноглобулины изотипа igg, способные к распознаванию нейтрализующего эпитопа в области стебля гемагглютинина различных подтипов и их использование в качестве лекарственного средства против гриппа
RU2635999C2 (ru) 2010-06-17 2017-11-17 ТРЕЛЛИС БАЙОСАЙЕНС, ЭлЭлСи Антитела, подходящие для пассивной иммунизации против гриппа
US8900590B2 (en) 2010-08-12 2014-12-02 Theraclone Sciences, Inc. Anti-hemagglutinin antibody compositions and methods of use thereof
EP2609113B1 (en) 2010-08-23 2017-03-22 Temasek Life Sciences Laboratory Limited Monoclonal antibody specific to major neutralizing epitope of influenza h5 hemagglutinin
US9534042B2 (en) 2010-09-03 2017-01-03 Fujita Health University Influenza virus-neutralizing antibody and screening method therefor
WO2012045001A2 (en) 2010-09-30 2012-04-05 Vanderbilt University Influenza virus antibodies and immunogens and uses therefor
US8900585B2 (en) 2010-10-20 2014-12-02 New York Blood Center, Inc. Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
KR20140012098A (ko) 2011-02-14 2014-01-29 테라클론 사이언시스, 아이엔씨. 인플루엔자의 치료 및 진단을 위한 조성물 및 방법
IN2014CN00953A (es) 2011-07-14 2015-04-10 Crucell Holland Bv
EP2734545B1 (en) 2011-07-18 2019-03-27 Institute for Research in Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
AU2012346669B2 (en) 2011-12-02 2017-08-31 Kling Biotherapeutics B.V. Influenza A virus specific antibodies
NZ628382A (en) 2012-03-08 2017-03-31 Janssen Vaccines & Prevention Bv Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof
KR102122618B1 (ko) 2012-05-10 2020-06-29 메사츄세츠 인스티튜트 어브 테크놀로지 인플루엔자 중화를 위한 작용제
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
US20140086927A1 (en) 2012-09-25 2014-03-27 Fujita Health University Novel epitope and mechanism of antigen-antibody interaction in an influenza virus
TWI657095B (zh) 2012-11-13 2019-04-21 美商建南德克公司 抗血球凝集素抗體及使用方法
KR20140118682A (ko) 2013-03-29 2014-10-08 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
LT3052192T (lt) 2013-10-02 2020-12-10 Medimmune, Llc Neutralizuojantys antikūnai prieš gripą a ir jų naudojimas
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
HUE054403T2 (hu) * 2018-01-26 2021-09-28 Regeneron Pharma TMPRSS2 elleni antitestek és antigénkötõ fragmentumok

Also Published As

Publication number Publication date
TWI701258B (zh) 2020-08-11
TW202026310A (zh) 2020-07-16
WO2016100807A3 (en) 2016-08-04
IL252659B (en) 2021-06-30
KR20170098888A (ko) 2017-08-30
BR112017012944A2 (pt) 2018-05-15
EA036953B1 (ru) 2021-01-19
TW201632548A (zh) 2016-09-16
US20200017576A1 (en) 2020-01-16
SG10202010170SA (en) 2020-11-27
CO2017006580A2 (es) 2017-09-29
AU2015364415B2 (en) 2021-09-02
PH12017500949A1 (en) 2017-10-02
UY36458A (es) 2016-07-29
WO2016100807A2 (en) 2016-06-23
MX2017008186A (es) 2018-02-09
MY185320A (en) 2021-05-04
SG11201704212SA (en) 2017-06-29
CN108064240A (zh) 2018-05-22
JP2018503361A (ja) 2018-02-08
TWI702229B (zh) 2020-08-21
MX2021007679A (es) 2021-08-05
US20200377575A1 (en) 2020-12-03
CN108064240B (zh) 2022-01-04
US20160176953A1 (en) 2016-06-23
US10392432B2 (en) 2019-08-27
CL2019002196A1 (es) 2019-12-13
US10689436B2 (en) 2020-06-23
CA2969749A1 (en) 2016-06-23
EP3233908A2 (en) 2017-10-25
US11453714B2 (en) 2022-09-27
JP6711828B2 (ja) 2020-06-17
JP2019055996A (ja) 2019-04-11
EA201791086A1 (ru) 2018-01-31
AU2015364415A1 (en) 2017-06-15
IL252659A0 (en) 2017-07-31

Similar Documents

Publication Publication Date Title
CL2017001610A1 (es) Anticuerpos humanos para hemagglutinina de influenza
CO2018010458A2 (es) Composiciones y anticuerpos anti-tim-3
ECSP18005520A (es) Anticuerpos de factor xi y métodos de uso
EA201891339A1 (ru) Водный фармацевтический препарат, который содержит антитело к pd-l1 авелумаб
BR112018012164A2 (pt) anticorpos neutralizantes do vírus da imunodeficiência humana
CL2016001723A1 (es) Molécula de anticuerpo que se une al receptor de muerte programada 1 (pd-1) y usos.
BR112017006178A2 (pt) região fc, anticorpos, formulação farmacêutica e usos dos anticorpos
CL2018002874A1 (es) Anticuerpos de hemaglutinina contra el virus de la influenza b y métodos de uso (divisional de solicitud n° 2413-2016).
EA201790569A1 (ru) Антитела и иммуноконъюгаты против cll-1
CL2017003240A1 (es) Anticuerpos anti-rnf43 novedosos y métodos para su uso
BR112016022658A2 (pt) anticorpos anti-ox40 e métodos de uso
BR112016018891A2 (pt) anticorpos anti-dll3 e conjugados de fármacos para uso em melanoma
BR112016025819A2 (pt) vetores de vírus adeno-associados para o tratamento de doenças de depósito lisossômico
CY1124521T1 (el) Σκευασματα αντισωματος anti-cd19
CL2017002596A1 (es) Neutralización del virus chikungunya mediada por anticuerpos
BR112018075651A2 (pt) anticorpos anti-cd98 e conjugados anticorpo fármaco
CU20170012A7 (es) Anticuerpos anti proteína similar a angiopoyetina 4
BR112017008952A2 (pt) métodos e composições para vírus recombinantes da dengue para desenvolvimento de vacina e diagnóstico
UY36261A (es) Anticuerpos anti proteína similar a angiopoyetina-4 (angptl4) y métodos de uso
UY36217A (es) Compuestos piridona sustituídos, composiciones farmacéuticas y métodos de uso.
BR112016015078A2 (pt) método para prevenir ou tratar infecção por vírus influenza a h7n9, uso do anticorpo e composição farmacêutica
CL2019003557A1 (es) Anticuerpos anti-trkb.
BR112016029935A2 (pt) ?anticorpos anti-brdu, complexo, formulação farmacêutica e uso de anticorpo?
BR112018010596A2 (pt) anticorpos para cgrp e usos dos mesmos
BR112019001233A2 (pt) formulação farmacêutica e uso da mesma