BR112018075651A2 - anticorpos anti-cd98 e conjugados anticorpo fármaco - Google Patents
anticorpos anti-cd98 e conjugados anticorpo fármacoInfo
- Publication number
- BR112018075651A2 BR112018075651A2 BR112018075651-2A BR112018075651A BR112018075651A2 BR 112018075651 A2 BR112018075651 A2 BR 112018075651A2 BR 112018075651 A BR112018075651 A BR 112018075651A BR 112018075651 A2 BR112018075651 A2 BR 112018075651A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- antibody conjugates
- drug antibody
- cafs
- drug
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 1
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
a invenção se relaciona com anticorpos anti-cd98 e conjugados anticorpo fármaco (cafs), incluindo composições e métodos de uso dos referidos anticorpos e cafs.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662347521P | 2016-06-08 | 2016-06-08 | |
US62/347,521 | 2016-06-08 | ||
PCT/US2017/036650 WO2017214462A2 (en) | 2016-06-08 | 2017-06-08 | Anti-cd98 antibodies and antibody drug conjugates |
Publications (1)
Publication Number | Publication Date |
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BR112018075651A2 true BR112018075651A2 (pt) | 2019-04-09 |
Family
ID=59227907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018075651-2A BR112018075651A2 (pt) | 2016-06-08 | 2017-06-08 | anticorpos anti-cd98 e conjugados anticorpo fármaco |
Country Status (9)
Country | Link |
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US (2) | US20200121803A1 (pt) |
EP (1) | EP3468596A2 (pt) |
JP (1) | JP2019524649A (pt) |
CN (2) | CN116173232A (pt) |
AU (1) | AU2017277920A1 (pt) |
BR (1) | BR112018075651A2 (pt) |
CA (1) | CA3027047A1 (pt) |
MX (1) | MX2018015268A (pt) |
WO (1) | WO2017214462A2 (pt) |
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WO2017214335A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
JP2019522643A (ja) * | 2016-06-08 | 2019-08-15 | アッヴィ・インコーポレイテッド | 抗cd98抗体及び抗体薬物コンジュゲート |
BR112018075630A2 (pt) * | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de fármaco de anticorpo |
EP3709021A4 (en) * | 2017-11-07 | 2021-07-21 | J-Pharma Co., Ltd. | METHOD FOR PREDICTING THE EFFECTIVENESS OF ANTI-PD-1 ANTIBODY OR ANTI-PD-L1 ANTIBODY THERAPY, METHOD OF EVALUATING THE LEVEL OF CANCER AND METHOD OF IMPROVING THE EFFECTIVENESS OF ANTI-BODY THERAPY ANTI-PD-1 OR ANTI-PD-L1 ANTIBODY |
RU2020129184A (ru) | 2018-02-07 | 2022-03-09 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для доставки терапевтического белка |
JP7458997B2 (ja) | 2018-05-29 | 2024-04-01 | ブリストル-マイヤーズ スクイブ カンパニー | プロドラッグおよび複合体に使用する修飾自己切断部分ならびにその使用方法および製造方法 |
CN112321714B (zh) * | 2019-01-08 | 2022-06-28 | 上海霖科生物科技有限公司 | 与间皮素结合的单克隆抗体及其核酸分子 |
AU2020279230A1 (en) | 2019-05-20 | 2021-12-02 | Les Laboratoires Servier | Mcl-1 inhibitor antibody-drug conjugates and methods of use |
UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
WO2024036961A1 (zh) * | 2022-08-19 | 2024-02-22 | 北京三秀生物医药科技有限公司 | 一种抗衰老相关疾病的前药及其使用方法 |
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2017
- 2017-06-08 CN CN202211671777.1A patent/CN116173232A/zh active Pending
- 2017-06-08 CA CA3027047A patent/CA3027047A1/en active Pending
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EP3468596A2 (en) | 2019-04-17 |
MX2018015268A (es) | 2019-08-12 |
CN116173232A (zh) | 2023-05-30 |
CN109562170B (zh) | 2023-01-13 |
WO2017214462A2 (en) | 2017-12-14 |
US20230135723A1 (en) | 2023-05-04 |
CN109562170A (zh) | 2019-04-02 |
CA3027047A1 (en) | 2017-12-14 |
JP2019524649A (ja) | 2019-09-05 |
WO2017214462A3 (en) | 2018-01-18 |
US20200121803A1 (en) | 2020-04-23 |
WO2017214462A4 (en) | 2018-04-05 |
AU2017277920A1 (en) | 2019-01-03 |
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