JP2020518600A5 - - Google Patents

Info

Publication number

JP2020518600A5

JP2020518600A5 JP2019559836A JP2019559836A JP2020518600A5 JP 2020518600 A5 JP2020518600 A5 JP 2020518600A5 JP 2019559836 A JP2019559836 A JP 2019559836A JP 2019559836 A JP2019559836 A JP 2019559836A JP 2020518600 A5 JP2020518600 A5 JP 2020518600A5

Authority

JP

Japan

Prior art keywords

seq

preparation according

approximately

tigit antibody

preparation

Prior art date

2018-05-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000002360 preparation method Methods 0.000 claims 27
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-Histidine Natural products OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 15
• 238000009472 formulation Methods 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 10
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 9
• FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 8
• 229930195722 L-methionine Natural products 0.000 claims 8
• 229960002885 histidine Drugs 0.000 claims 8
• 229960004452 methionine Drugs 0.000 claims 8
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 8
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 8
• 229920000053 polysorbate 80 Polymers 0.000 claims 8
• 229940068968 polysorbate 80 Drugs 0.000 claims 8
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 7
• 229930006000 Sucrose Natural products 0.000 claims 7
• 239000005720 sucrose Substances 0.000 claims 7
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 6
• 150000001413 amino acids Chemical group 0.000 claims 6
• 238000013368 capillary electrophoresis sodium dodecyl sulfate analysis Methods 0.000 claims 4
• 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 3
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 208000037581 Persistent Infection Diseases 0.000 claims 2
• 239000003963 antioxidant agent Substances 0.000 claims 2
• 230000003078 antioxidant effect Effects 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• 239000002736 nonionic surfactant Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102100035355 Cadherin-related family member 3 Human genes 0.000 claims 1
• 101000737802 Homo sapiens Cadherin-related family member 3 Proteins 0.000 claims 1
• 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 claims 1
• 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 claims 1
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical group OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000011521 glass Substances 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 229960002621 pembrolizumab Drugs 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 238000001542 size-exclusion chromatography Methods 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 125000000185 sucrose group Chemical group 0.000 claims 1