JP2020518598A5 - - Google Patents
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- Publication number
- JP2020518598A5 JP2020518598A5 JP2019559826A JP2019559826A JP2020518598A5 JP 2020518598 A5 JP2020518598 A5 JP 2020518598A5 JP 2019559826 A JP2019559826 A JP 2019559826A JP 2019559826 A JP2019559826 A JP 2019559826A JP 2020518598 A5 JP2020518598 A5 JP 2020518598A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- formulation
- antigen
- antibody
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023085581A JP7653465B2 (ja) | 2017-05-02 | 2023-05-24 | 単独およびプログラム死受容体１（ｐｄ－１）抗体と組み合わされた抗ｃｔｌａ４抗体の安定な製剤、ならびにその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762500268P | 2017-05-02 | 2017-05-02 | |
| US62/500,268 | 2017-05-02 | ||
| PCT/US2018/030420 WO2018204343A1 (en) | 2017-05-02 | 2018-05-01 | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085581A Division JP7653465B2 (ja) | 2017-05-02 | 2023-05-24 | 単独およびプログラム死受容体１（ｐｄ－１）抗体と組み合わされた抗ｃｔｌａ４抗体の安定な製剤、ならびにその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020518598A JP2020518598A (ja) | 2020-06-25 |
| JP2020518598A5 true JP2020518598A5 (enExample) | 2021-04-30 |
Family
ID=64016829
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019559826A Ceased JP2020518598A (ja) | 2017-05-02 | 2018-05-01 | 単独およびプログラム死受容体１（ｐｄ−１）抗体と組み合わされた抗ｃｔｌａ４抗体の安定な製剤、ならびにその使用方法 |
| JP2023085581A Active JP7653465B2 (ja) | 2017-05-02 | 2023-05-24 | 単独およびプログラム死受容体１（ｐｄ－１）抗体と組み合わされた抗ｃｔｌａ４抗体の安定な製剤、ならびにその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085581A Active JP7653465B2 (ja) | 2017-05-02 | 2023-05-24 | 単独およびプログラム死受容体１（ｐｄ－１）抗体と組み合わされた抗ｃｔｌａ４抗体の安定な製剤、ならびにその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20200262922A1 (enExample) |
| EP (1) | EP3618866A4 (enExample) |
| JP (2) | JP2020518598A (enExample) |
| KR (1) | KR102624564B1 (enExample) |
| CN (1) | CN110678199B (enExample) |
| AU (1) | AU2018263837B2 (enExample) |
| BR (1) | BR112019022695A2 (enExample) |
| CA (1) | CA3060695A1 (enExample) |
| CL (1) | CL2019003143A1 (enExample) |
| CO (1) | CO2019012143A2 (enExample) |
| EA (1) | EA201992526A1 (enExample) |
| MA (1) | MA50501A (enExample) |
| MX (1) | MX2019013034A (enExample) |
| SG (1) | SG11201910134SA (enExample) |
| TN (1) | TN2019000294A1 (enExample) |
| UA (1) | UA129862C2 (enExample) |
| WO (1) | WO2018204343A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2170959E (pt) | 2007-06-18 | 2014-01-07 | Merck Sharp & Dohme | Anticorpos para o receptor humano de morte programada pd-1 |
| PT3199552T (pt) | 2012-11-20 | 2020-03-25 | Sanofi Sa | Anticorpos anti-ceacam5 e suas utilizações |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| IL307242B1 (en) | 2016-12-07 | 2026-07-01 | Agenus Inc | Anti-CTLA-4 antibodies and methods of using them |
| CA3060695A1 (en) * | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| SG11201909941QA (en) * | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| JOP20190260A1 (ar) * | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN119792515A (zh) * | 2018-02-13 | 2025-04-11 | 默沙东有限责任公司 | 用抗pd-1抗体和抗ctla-4抗体治疗癌症的方法 |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体および抗ｐｄ－１抗体の共－製剤 |
| US20210380694A1 (en) * | 2018-11-07 | 2021-12-09 | Merck Sharp & Dohme Corp. | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| US12188063B2 (en) * | 2019-02-08 | 2025-01-07 | Institute Of Science Tokyo | Enzymatic mutant suitable for homogeneous immunoassay method |
| MA55316A (fr) * | 2019-03-13 | 2022-01-19 | Merck Sharp & Dohme | Polythérapies anticancéreuses comprenant des agents de blocage de ctla-4 et pd-1 |
| CN112203642B (zh) | 2019-03-25 | 2025-03-07 | 阿特根公司 | 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物 |
| SG11202111602YA (en) * | 2019-04-23 | 2021-11-29 | Sanofi Sa | Anti-cd38 antibodies and formulations |
| CA3154726A1 (en) * | 2019-09-23 | 2021-04-01 | Merck Sharp & Dohme Corp. | Methods and compositions comprising an anti-ctla4 monoclonal antibody with reduced host cell proteins and increased polysorbate-80 stability |
| TW202615652A (zh) | 2020-01-23 | 2026-04-16 | 南韓商阿特根公司 | 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物 |
| JP2023515675A (ja) * | 2020-03-05 | 2023-04-13 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｐｄ－１アンタゴニスト、ｃｔｌａ４アンタゴニストおよびレンバチニブまたはその薬学的に許容される塩の組合せを用いる癌を治療する方法 |
| JP2023525898A (ja) * | 2020-05-19 | 2023-06-19 | エフ． ホフマン－ラ ロシュ アーゲー | 非経口タンパク質溶液における可視粒子の形成を防止するためのキレート剤の使用 |
| CA3185091A1 (en) * | 2020-07-08 | 2022-01-13 | Yuan Cheng | Stabilized formulations containing anti-ctla-4 antibodies |
| JP7849358B2 (ja) * | 2020-11-10 | 2026-04-21 | サノフイ | Ｃｅａｃａｍ５抗体－薬物コンジュゲート製剤 |
| AU2022212007A1 (en) | 2021-01-29 | 2023-09-07 | Merck Sharp & Dohme Llc | Compositions of programmed death receptor 1 (pd-1) antibodies and methods of obtaining the compositions thereof |
| CN118489006A (zh) * | 2021-12-24 | 2024-08-13 | 株式会社三养社 | 糖基转移酶变体和使用其制备甜菊糖苷的方法 |
| WO2023163968A1 (en) * | 2022-02-24 | 2023-08-31 | Merck Sharp & Dohme Llc | Stable formulations of a multivalent vhh based cytotoxic t lymphocyte associated antigen 4 (ctla4) binder binding to human ctla4 and methods of use thereof |
| CA3250812A1 (en) * | 2022-04-29 | 2023-11-02 | Merck Sharp & Dohme Llc | Stable formulations of anti-ILT4 antibodies or antigen-binding fragments thereof in combination with anti-PD-1 antibodies and their methods of use |
| WO2024025986A1 (en) * | 2022-07-28 | 2024-02-01 | Merck Sharp & Dohme Llc | Pharmaceutical compositions of programmed death receptor 1 (pd-1) antibodies and ph20 variants or fragments thereof |
| CN119894932A (zh) * | 2022-07-28 | 2025-04-25 | 默沙东有限责任公司 | 程序性死亡受体1（PD-1）抗体和rHuPH20或其变体或片段的药物组合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| WO2000032634A1 (en) | 1998-12-01 | 2000-06-08 | Protein Design Labs, Inc. | Humanized antibodies to gamma-interferon |
| EP1820516B1 (en) | 1999-02-22 | 2013-07-24 | University of Connecticut | Novel albumin-free factor VIII formulations |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| US20070134247A9 (en) | 2002-04-12 | 2007-06-14 | Ramot At Tel Aviv University Ltd. | Prevention of brain inflammation as a result of induced autoimmune response |
| US7410483B2 (en) | 2003-05-23 | 2008-08-12 | Novare Surgical Systems, Inc. | Hand-actuated device for remote manipulation of a grasping tool |
| WO2005120571A2 (en) | 2004-06-07 | 2005-12-22 | Ramot At Tel Aviv University Ltd. | Method of passive immunization against disease or disorder characterized by amyloid aggregation with diminished risk of neuroinflammation |
| EP1865986B1 (en) * | 2005-03-08 | 2016-02-17 | Pfizer Products Inc. | Anti-ctla-4 antibody compositions |
| EP3530736A3 (en) * | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| WO2007113648A2 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| PT2170959E (pt) | 2007-06-18 | 2014-01-07 | Merck Sharp & Dohme | Anticorpos para o receptor humano de morte programada pd-1 |
| MX2011013722A (es) * | 2009-06-18 | 2012-05-08 | Wyeth Llc | Formulaciones liofilizadas para inmunofarmaceuticos modulares pequeños. |
| CA2769473A1 (en) * | 2009-07-31 | 2011-02-03 | N.V. Organon | Fully human antibodies to btla |
| ES2699965T3 (es) | 2011-03-10 | 2019-02-13 | Provectus Pharmatech Inc | Una combinación de rosa de bengala y anticuerpo anti-CTLA4 para su uso en el tratamiento del cáncer |
| CN105296433B (zh) * | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
| HRP20201334T1 (hr) * | 2015-04-17 | 2020-11-27 | Bristol-Myers Squibb Company | Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba |
| US9995753B2 (en) * | 2015-09-25 | 2018-06-12 | Merck Sharp & Dohme Corp. | Anti-pembrolizumab antibodies |
| CA3060695A1 (en) * | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
-
2018
- 2018-05-01 CA CA3060695A patent/CA3060695A1/en active Pending
- 2018-05-01 MX MX2019013034A patent/MX2019013034A/es unknown
- 2018-05-01 SG SG11201910134S patent/SG11201910134SA/en unknown
- 2018-05-01 UA UAA201911521A patent/UA129862C2/uk unknown
- 2018-05-01 BR BR112019022695-8A patent/BR112019022695A2/pt unknown
- 2018-05-01 EP EP18793916.0A patent/EP3618866A4/en active Pending
- 2018-05-01 KR KR1020197035373A patent/KR102624564B1/ko active Active
- 2018-05-01 JP JP2019559826A patent/JP2020518598A/ja not_active Ceased
- 2018-05-01 US US16/609,671 patent/US20200262922A1/en not_active Abandoned
- 2018-05-01 CN CN201880029175.1A patent/CN110678199B/zh active Active
- 2018-05-01 AU AU2018263837A patent/AU2018263837B2/en active Active
- 2018-05-01 WO PCT/US2018/030420 patent/WO2018204343A1/en not_active Ceased
- 2018-05-01 TN TNP/2019/000294A patent/TN2019000294A1/en unknown
- 2018-05-01 MA MA050501A patent/MA50501A/fr unknown
- 2018-05-01 EA EA201992526A patent/EA201992526A1/ru unknown
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2019
- 2019-10-30 CO CONC2019/0012143A patent/CO2019012143A2/es unknown
- 2019-10-30 CL CL2019003143A patent/CL2019003143A1/es unknown
-
2023
- 2023-05-24 JP JP2023085581A patent/JP7653465B2/ja active Active
-
2024
- 2024-09-11 US US18/882,177 patent/US20250074985A1/en active Pending