HRP20201334T1 - Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba - Google Patents
Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba Download PDFInfo
- Publication number
- HRP20201334T1 HRP20201334T1 HRP20201334TT HRP20201334T HRP20201334T1 HR P20201334 T1 HRP20201334 T1 HR P20201334T1 HR P20201334T T HRP20201334T T HR P20201334TT HR P20201334 T HRP20201334 T HR P20201334T HR P20201334 T1 HRP20201334 T1 HR P20201334T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- composition
- disease
- lymphoma
- ipilimumab
- Prior art date
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- 229960005386 ipilimumab Drugs 0.000 claims 3
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Claims (9)
1. Farmaceutska kompozicija koja sadrži nivolumab prema ipilimumabu u odnosu 1:3, koja sadrži 4.62 mg/ml ipilimumaba, 1.54 mg/ml nivolumaba, 18.46 mM Tris hidroklorida (HCl), 1.54 mM natrij citrat dihidrata, 96.15 mM NaCl, 1.15% m/v manitola, 93.85 µM pentetične kiseline (dietilen-triamin-pentaoctene kiseline), i 0.012 % m/v PS80.
2. Farmaceutska kompozicija iz patentnog zahtjeva 1, koja obuhvaća pH od 6.0.
3. Oprema koji sadrži kompoziciju iz patentnog zahtjeva 1 ili 2.
4. Metoda pravljenja kompozicije iz patentnog zahtjeva 1 ili 2, koja obuhvaća miješanje nivolumaba i ipilimumaba da se dobije željeni odnos.
5. Kompozicija iz patentnog zahtjeva 1 ili 2 za primjenu u modulaciji imunog odgovora kod pacijenta koji ima potrebu za istom.
6. Kompozicija iz patentnog zahtjeva 1 ili 2 za primjenu u liječenju bolesti ili stanja kod pacijenta.
7. Kompozicija za primjenu iz patentnog zahtjeva 6, gdje bolest ili stanje je infektivna bolest.
8. Kompozicija za primjenu iz patentnog zahtjeva 6, gdje bolest je rak.
9. Kompozicija za primjenu iz patentnog zahtjeva 8, gdje rak je melanomski rak, renalni rak, rak prostate, rak dojke, rak debelog crijeva, rak pluća, rak kostiju, rak pankreasa, rak kože, rak glave ili vrata, kutani ili intraokularni maligni melanom, rak materice, rak jajnika, rektalni rak, rak analne regije, rak trbuha, rak testisa, rak materice, karcinom jajovoda, karcinom endometrija, rak grlića materice, rak vagine, rak vulve, Hodgkinova bolest, Nehodgkinov limfom, rak jednjaka, rak tankog crijeva, rak endokrinog sistema, rak tiroidne žlijezde, rak paratiroidne žlijezde, rak nadbubrežne žlijezde, sarkom mekog tkiva, rak uretre, rak penisa, kronične ili akutne leukemije uključujući akutnu mijeloidnu leukemiju, kroničnu mijeloidnu leukemiju, akutnu limfoblastičnu leukemiju, kroničnu limfocitnu leukemiju, solidni tumori u djetinjstvu, limfocitni limfom, rak mokraćnog mjehura, rak bubrega ili uretera, rak bubrežne karlice, neoplazma centralnog živčanog sustava (CNS), primarni limfom CNS-a, angiogeneza tumora, tumor kičmenog stupa, gliom moždanog stabla, adenom hipofize, Kaposijev sarkom, epidermoidni rak, rak skvamoznih stanica, T-stanični limfom, karcinomi inducirani okolinom uključujući one inducirane azbestom, i bilo koje njihove kombinacije.
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US201662303855P | 2016-03-04 | 2016-03-04 | |
EP16718835.8A EP3283107B1 (en) | 2015-04-17 | 2016-04-15 | Compositions comprising a combination of ipilimumab and nivolumab |
PCT/US2016/027913 WO2016168716A1 (en) | 2015-04-17 | 2016-04-15 | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
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HRP20201334TT HRP20201334T1 (hr) | 2015-04-17 | 2020-08-25 | Kompozicije koje sadrže kombinaciju ipilimumaba i nivolumaba |
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EP (2) | EP3738610A1 (hr) |
JP (3) | JP6949718B2 (hr) |
KR (1) | KR20170138477A (hr) |
CN (2) | CN113577264A (hr) |
AU (2) | AU2016249395B2 (hr) |
BR (1) | BR112017021688A2 (hr) |
CA (1) | CA2982839A1 (hr) |
CL (1) | CL2017002636A1 (hr) |
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