JP2018529328A5 - - Google Patents

Info

Publication number

JP2018529328A5

JP2018529328A5 JP2018510883A JP2018510883A JP2018529328A5 JP 2018529328 A5 JP2018529328 A5 JP 2018529328A5 JP 2018510883 A JP2018510883 A JP 2018510883A JP 2018510883 A JP2018510883 A JP 2018510883A JP 2018529328 A5 JP2018529328 A5 JP 2018529328A5

Authority

JP

Japan

Prior art keywords

binding member

binding

sialyl

lewis

member according

Prior art date

2016-08-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000027455 binding Effects 0.000 claims 42
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000000611 antibody drug conjugate Substances 0.000 claims 2
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 150000004676 glycans Chemical group 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 238000000746 purification Methods 0.000 claims 2
• 125000005630 sialyl group Chemical group 0.000 claims 2
• 125000006850 spacer group Chemical group 0.000 claims 2
• HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical group O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 229930186217 Glycolipid Natural products 0.000 claims 1
• 102000003886 Glycoproteins Human genes 0.000 claims 1
• 108090000288 Glycoproteins Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• DUKURNFHYQXCJG-JEOLMMCMSA-N alpha-L-Fucp-(1->4)-[beta-D-Galp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)[C@H](O[C@@H]2[C@H]([C@H](O[C@@H]3[C@H](OC(O)[C@H](O)[C@H]3O)CO)O[C@H](CO)[C@@H]2O)O)O[C@@H]1CO DUKURNFHYQXCJG-JEOLMMCMSA-N 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 239000000562 conjugate Substances 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1