DK3341412T3 - Sialyl-di-lewis a som udtrykt på glycoproteins, men ikke glycolipider som funktionelt cancermål og antistoffer dertil - Google Patents

Sialyl-di-lewis a som udtrykt på glycoproteins, men ikke glycolipider som funktionelt cancermål og antistoffer dertil Download PDF

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Publication number
DK3341412T3
DK3341412T3 DK16760541.9T DK16760541T DK3341412T3 DK 3341412 T3 DK3341412 T3 DK 3341412T3 DK 16760541 T DK16760541 T DK 16760541T DK 3341412 T3 DK3341412 T3 DK 3341412T3
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sialyl
glycolipids
glycoproteins
lewis
antibodies
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DK16760541.9T
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Danish (da)
English (en)
Inventor
Silvana Tivadar
Tina Parsons
Richard Mcintosh
Lindy Gillian Durrant
Mireille Vankemmelbeke
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Scancell Ltd
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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DK16760541.9T 2015-08-25 2016-08-25 Sialyl-di-lewis a som udtrykt på glycoproteins, men ikke glycolipider som funktionelt cancermål og antistoffer dertil DK3341412T3 (da)

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GBGB1515094.9A GB201515094D0 (en) 2015-08-25 2015-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
PCT/GB2016/052647 WO2017033020A1 (en) 2015-08-25 2016-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

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US9475874B2 (en) * 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa
JP7672340B2 (ja) * 2018-10-19 2025-05-07 メモリアル スローン ケタリング キャンサー センター シアリルルイスａを標的とするキメラ抗原受容体およびその使用
GB201910899D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Binding members
GB201910900D0 (en) 2019-07-31 2019-09-11 Scancell Ltd Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
US20250064966A1 (en) * 2022-01-06 2025-02-27 PTM Therapeutics, Inc. Methods of treating solid tumors and compositions thereof

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AT413486B (de) * 2002-07-03 2006-03-15 Igeneon Krebs Immuntherapie Verwendung eines antikörpers gerichtet gegen lewis-antigene
US9475874B2 (en) * 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa
GB201319374D0 (en) 2013-11-01 2013-12-18 Univ Nottingham Glycans as functional cancer targets abd antibodies thereto

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CN108137695A (zh) 2018-06-08
EP3341412A1 (en) 2018-07-04
CN108137695B (zh) 2022-03-29
PT3341412T (pt) 2020-05-21
ES2788159T3 (es) 2020-10-20
CA2996436A1 (en) 2017-03-02
JP2018529328A (ja) 2018-10-11
KR102713512B1 (ko) 2024-10-04
US10835618B2 (en) 2020-11-17
WO2017033020A1 (en) 2017-03-02
KR20180100541A (ko) 2018-09-11
EP3341412B1 (en) 2020-03-25
JP6928602B2 (ja) 2021-09-01
ZA201801994B (en) 2019-01-30
US20180236095A1 (en) 2018-08-23
BR112018003779A2 (pt) 2018-09-25
GB201515094D0 (en) 2015-10-07

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