GB201515094D0 - Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto - Google Patents

Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

Info

Publication number
GB201515094D0
GB201515094D0 GBGB1515094.9A GB201515094A GB201515094D0 GB 201515094 D0 GB201515094 D0 GB 201515094D0 GB 201515094 A GB201515094 A GB 201515094A GB 201515094 D0 GB201515094 D0 GB 201515094D0
Authority
GB
United Kingdom
Prior art keywords
sialyl
glycolipids
glycoproteins
lewis
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1515094.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nottingham
Original Assignee
University of Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Nottingham filed Critical University of Nottingham
Priority to GBGB1515094.9A priority Critical patent/GB201515094D0/en
Publication of GB201515094D0 publication Critical patent/GB201515094D0/en
Priority to US15/754,882 priority patent/US10835618B2/en
Priority to EP16760541.9A priority patent/EP3341412B1/en
Priority to PCT/GB2016/052647 priority patent/WO2017033020A1/en
Priority to PT167605419T priority patent/PT3341412T/pt
Priority to CA2996436A priority patent/CA2996436A1/en
Priority to ES16760541T priority patent/ES2788159T3/es
Priority to CN201680056234.5A priority patent/CN108137695B/zh
Priority to KR1020187008554A priority patent/KR102713512B1/ko
Priority to BR112018003779-6A priority patent/BR112018003779B1/pt
Priority to JP2018510883A priority patent/JP6928602B2/ja
Priority to DK16760541.9T priority patent/DK3341412T3/da
Priority to ZA2018/01994A priority patent/ZA201801994B/en
Ceased legal-status Critical Current

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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GBGB1515094.9A 2015-08-25 2015-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto Ceased GB201515094D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GBGB1515094.9A GB201515094D0 (en) 2015-08-25 2015-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
DK16760541.9T DK3341412T3 (da) 2015-08-25 2016-08-25 Sialyl-di-lewis a som udtrykt på glycoproteins, men ikke glycolipider som funktionelt cancermål og antistoffer dertil
ES16760541T ES2788159T3 (es) 2015-08-25 2016-08-25 Sialil-di-Lewisa tal como se expresa en las glucoproteínas pero no en los glucolípidos como diana funcional del cáncer y sus anticuerpos
EP16760541.9A EP3341412B1 (en) 2015-08-25 2016-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
PCT/GB2016/052647 WO2017033020A1 (en) 2015-08-25 2016-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
PT167605419T PT3341412T (pt) 2015-08-25 2016-08-25 Sialil-di-lewis a conforme expresso em glicoproteínas, mas não glicolípidos como alvo de cancro funcional e anticorpos para o mesmo
CA2996436A CA2996436A1 (en) 2015-08-25 2016-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
US15/754,882 US10835618B2 (en) 2015-08-25 2016-08-25 Sialyl-di-Lewisa as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
CN201680056234.5A CN108137695B (zh) 2015-08-25 2016-08-25 作为功能性癌症靶标的、不在糖脂而在糖蛋白上表达的唾液酸化二路易斯a及其抗体
KR1020187008554A KR102713512B1 (ko) 2015-08-25 2016-08-25 기능성 암 표적 및 이에 대한 항체로서 당지질이 아닌 당단백질 상에 발현되는 시알릴-다이-루이스a
BR112018003779-6A BR112018003779B1 (pt) 2015-08-25 2016-08-25 Sialil-di-lewis a conforme expresso em glicoproteínas, mas não glicolipídios, como um alvo de câncer funcional e anticorpos para o mesmo
JP2018510883A JP6928602B2 (ja) 2015-08-25 2016-08-25 機能的な癌標的として、糖脂質ではなく糖タンパク質上で発現させたシアリル−ジ−ルイスａ及びそれに対する抗体
ZA2018/01994A ZA201801994B (en) 2015-08-25 2018-03-26 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

Applications Claiming Priority (1)

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GBGB1515094.9A GB201515094D0 (en) 2015-08-25 2015-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

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CN (1) CN108137695B (enExample)
CA (1) CA2996436A1 (enExample)
DK (1) DK3341412T3 (enExample)
ES (1) ES2788159T3 (enExample)
GB (1) GB201515094D0 (enExample)
PT (1) PT3341412T (enExample)
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Publication number Priority date Publication date Assignee Title
US9475874B2 (en) * 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa
JP7672340B2 (ja) * 2018-10-19 2025-05-07 メモリアル スローン ケタリング キャンサー センター シアリルルイスａを標的とするキメラ抗原受容体およびその使用
GB201910900D0 (en) 2019-07-31 2019-09-11 Scancell Ltd Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
GB201910899D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Binding members
US20250064966A1 (en) * 2022-01-06 2025-02-27 PTM Therapeutics, Inc. Methods of treating solid tumors and compositions thereof

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AT413486B (de) * 2002-07-03 2006-03-15 Igeneon Krebs Immuntherapie Verwendung eines antikörpers gerichtet gegen lewis-antigene
US9475874B2 (en) 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa
GB201319374D0 (en) 2013-11-01 2013-12-18 Univ Nottingham Glycans as functional cancer targets abd antibodies thereto

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DK3341412T3 (da) 2020-05-18
ZA201801994B (en) 2019-01-30
PT3341412T (pt) 2020-05-21
US10835618B2 (en) 2020-11-17
JP6928602B2 (ja) 2021-09-01
US20180236095A1 (en) 2018-08-23
WO2017033020A1 (en) 2017-03-02
EP3341412B1 (en) 2020-03-25
KR102713512B1 (ko) 2024-10-04
CA2996436A1 (en) 2017-03-02
EP3341412A1 (en) 2018-07-04
CN108137695A (zh) 2018-06-08
CN108137695B (zh) 2022-03-29
ES2788159T3 (es) 2020-10-20
BR112018003779A2 (pt) 2018-09-25
JP2018529328A (ja) 2018-10-11
KR20180100541A (ko) 2018-09-11

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