ZA201801994B - Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto - Google Patents

Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

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Publication number
ZA201801994B
ZA201801994B ZA2018/01994A ZA201801994A ZA201801994B ZA 201801994 B ZA201801994 B ZA 201801994B ZA 2018/01994 A ZA2018/01994 A ZA 2018/01994A ZA 201801994 A ZA201801994 A ZA 201801994A ZA 201801994 B ZA201801994 B ZA 201801994B
Authority
ZA
South Africa
Prior art keywords
sialyl
glycolipids
glycoproteins
lewis
antibodies
Prior art date
Application number
ZA2018/01994A
Other languages
English (en)
Inventor
Lindy Gillian Durrant
Mireille Vankemmelbeke
Silvana Tivadar
Tina Parsons
Richard Mcintosh
Original Assignee
Univ Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nottingham filed Critical Univ Nottingham
Publication of ZA201801994B publication Critical patent/ZA201801994B/en

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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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ZA2018/01994A 2015-08-25 2018-03-26 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto ZA201801994B (en)

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GBGB1515094.9A GB201515094D0 (en) 2015-08-25 2015-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto
PCT/GB2016/052647 WO2017033020A1 (en) 2015-08-25 2016-08-25 Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto

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PT3041507T (pt) * 2013-08-26 2021-07-26 Biontech Res And Development Inc Ácidos nucleicos que codificam anticorpos humanos para sialil-lewis
EP3867279A4 (en) * 2018-10-19 2022-07-13 Memorial Sloan Kettering Cancer Center AN AGAINST SIALYL-LEWIS A CHIMERIC ANTIGEN RECEPTOR AND ITS USES
GB201910900D0 (en) 2019-07-31 2019-09-11 Scancell Ltd Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
GB201910899D0 (en) * 2019-07-31 2019-09-11 Scancell Ltd Binding members
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PT3041507T (pt) * 2013-08-26 2021-07-26 Biontech Res And Development Inc Ácidos nucleicos que codificam anticorpos humanos para sialil-lewis
GB201319374D0 (en) 2013-11-01 2013-12-18 Univ Nottingham Glycans as functional cancer targets abd antibodies thereto

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KR20180100541A (ko) 2018-09-11
WO2017033020A1 (en) 2017-03-02
JP2018529328A (ja) 2018-10-11
CA2996436A1 (en) 2017-03-02
BR112018003779A2 (pt) 2018-09-25
EP3341412B1 (en) 2020-03-25
PT3341412T (pt) 2020-05-21
DK3341412T3 (da) 2020-05-18
US20180236095A1 (en) 2018-08-23
EP3341412A1 (en) 2018-07-04
JP6928602B2 (ja) 2021-09-01
US10835618B2 (en) 2020-11-17
ES2788159T3 (es) 2020-10-20

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