CN108137695B - 作为功能性癌症靶标的、不在糖脂而在糖蛋白上表达的唾液酸化二路易斯a及其抗体 - Google Patents
作为功能性癌症靶标的、不在糖脂而在糖蛋白上表达的唾液酸化二路易斯a及其抗体 Download PDFInfo
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- CN108137695B CN108137695B CN201680056234.5A CN201680056234A CN108137695B CN 108137695 B CN108137695 B CN 108137695B CN 201680056234 A CN201680056234 A CN 201680056234A CN 108137695 B CN108137695 B CN 108137695B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1515094.9 | 2015-08-25 | ||
| GBGB1515094.9A GB201515094D0 (en) | 2015-08-25 | 2015-08-25 | Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto |
| PCT/GB2016/052647 WO2017033020A1 (en) | 2015-08-25 | 2016-08-25 | Sialyl-di-lewis a as expressed on glycoproteins but not glycolipids as a functional cancer target and antibodies thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108137695A CN108137695A (zh) | 2018-06-08 |
| CN108137695B true CN108137695B (zh) | 2022-03-29 |
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| PT (1) | PT3341412T (enExample) |
| WO (1) | WO2017033020A1 (enExample) |
| ZA (1) | ZA201801994B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2922478C (en) * | 2013-08-26 | 2020-09-29 | MabVax Therapeutics, Inc. | Nucleic acids encoding human antibodies to sialyl-lewisa |
| JP7672340B2 (ja) * | 2018-10-19 | 2025-05-07 | メモリアル スローン ケタリング キャンサー センター | シアリルルイスaを標的とするキメラ抗原受容体およびその使用 |
| GB201910899D0 (en) * | 2019-07-31 | 2019-09-11 | Scancell Ltd | Binding members |
| GB201910900D0 (en) | 2019-07-31 | 2019-09-11 | Scancell Ltd | Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof |
| AU2023204801A1 (en) * | 2022-01-06 | 2024-07-11 | PTM Therapeutics, Inc. | Methods of treating solid tumors and compositions thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015053871A3 (en) * | 2013-08-26 | 2015-06-11 | MabVax Therapeutics, Inc. | NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa |
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| AT413486B (de) * | 2002-07-03 | 2006-03-15 | Igeneon Krebs Immuntherapie | Verwendung eines antikörpers gerichtet gegen lewis-antigene |
| GB201319374D0 (en) | 2013-11-01 | 2013-12-18 | Univ Nottingham | Glycans as functional cancer targets abd antibodies thereto |
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2015
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2016
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- 2016-08-25 CA CA2996436A patent/CA2996436A1/en active Pending
- 2016-08-25 US US15/754,882 patent/US10835618B2/en active Active
- 2016-08-25 WO PCT/GB2016/052647 patent/WO2017033020A1/en not_active Ceased
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015053871A3 (en) * | 2013-08-26 | 2015-06-11 | MabVax Therapeutics, Inc. | NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa |
Non-Patent Citations (5)
| Title |
|---|
| Cancer vaccines and carbohydrate epitopes;molinaro等;《vaccine》;20111108;第29卷(第48期);第8802-8826页 * |
| Characterisation of anti-glycan;noble;《the university of nottingham》;20110101;第153-154页、表5.5 * |
| Loss of Disialyl Lewisa, the Ligand for Lymphocyte Inhibitory Receptor Sialic Acid-;Miyazaki等;《cancer research》;20040701;第64卷(第13期);摘要 * |
| noble.Characterisation of anti-glycan.《the university of nottingham》.2011,第1-263页. * |
| Synthesis of Disialyl Lewis a (Lea) Structure in Colon Cancer Cell;Tsuchida等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20030613;第278卷(第25期);第22787页左栏第2段和右栏第1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2996436A1 (en) | 2017-03-02 |
| EP3341412B1 (en) | 2020-03-25 |
| JP2018529328A (ja) | 2018-10-11 |
| BR112018003779A2 (pt) | 2018-09-25 |
| JP6928602B2 (ja) | 2021-09-01 |
| CN108137695A (zh) | 2018-06-08 |
| KR102713512B1 (ko) | 2024-10-04 |
| DK3341412T3 (da) | 2020-05-18 |
| KR20180100541A (ko) | 2018-09-11 |
| ES2788159T3 (es) | 2020-10-20 |
| PT3341412T (pt) | 2020-05-21 |
| ZA201801994B (en) | 2019-01-30 |
| EP3341412A1 (en) | 2018-07-04 |
| US10835618B2 (en) | 2020-11-17 |
| WO2017033020A1 (en) | 2017-03-02 |
| GB201515094D0 (en) | 2015-10-07 |
| US20180236095A1 (en) | 2018-08-23 |
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