JP2012509881A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012509881A5 JP2012509881A5 JP2011537557A JP2011537557A JP2012509881A5 JP 2012509881 A5 JP2012509881 A5 JP 2012509881A5 JP 2011537557 A JP2011537557 A JP 2011537557A JP 2011537557 A JP2011537557 A JP 2011537557A JP 2012509881 A5 JP2012509881 A5 JP 2012509881A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- binding fragment
- monoclonal antibody
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 239000012634 fragment Substances 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 1
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 108010076504 Protein Sorting Signals Proteins 0.000 description 5
- 108091035707 Consensus sequence Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical group 0.000 description 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 102000009203 Sema domains Human genes 0.000 description 1
- 108050000099 Sema domains Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11682508P | 2008-11-21 | 2008-11-21 | |
| US61/116,825 | 2008-11-21 | ||
| US21990309P | 2009-06-24 | 2009-06-24 | |
| US61/219,903 | 2009-06-24 | ||
| PCT/US2009/064881 WO2010059654A1 (en) | 2008-11-21 | 2009-11-18 | c-MET ANTIBODIES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509881A JP2012509881A (ja) | 2012-04-26 |
| JP2012509881A5 true JP2012509881A5 (enExample) | 2013-01-17 |
| JP5688027B2 JP5688027B2 (ja) | 2015-03-25 |
Family
ID=41435259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537557A Active JP5688027B2 (ja) | 2008-11-21 | 2009-11-18 | ｃ−Ｍｅｔ抗体 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8217148B2 (enExample) |
| EP (2) | EP2963058B1 (enExample) |
| JP (1) | JP5688027B2 (enExample) |
| KR (1) | KR101334450B1 (enExample) |
| CN (1) | CN102216333B (enExample) |
| AR (1) | AR074360A1 (enExample) |
| AU (1) | AU2009316742B2 (enExample) |
| BR (1) | BRPI0922800A2 (enExample) |
| CA (1) | CA2743508C (enExample) |
| CY (1) | CY1116886T1 (enExample) |
| DK (1) | DK2358755T3 (enExample) |
| EA (1) | EA020398B1 (enExample) |
| ES (2) | ES2549760T3 (enExample) |
| HR (1) | HRP20151019T1 (enExample) |
| HU (1) | HUE026058T2 (enExample) |
| IL (1) | IL212633A (enExample) |
| JO (1) | JO3097B1 (enExample) |
| MX (1) | MX2011005400A (enExample) |
| NZ (1) | NZ592215A (enExample) |
| PA (1) | PA8849001A1 (enExample) |
| PL (1) | PL2358755T3 (enExample) |
| PT (1) | PT2358755E (enExample) |
| SI (1) | SI2358755T1 (enExample) |
| TR (1) | TR201802841T4 (enExample) |
| TW (1) | TWI477284B (enExample) |
| WO (1) | WO2010059654A1 (enExample) |
| ZA (1) | ZA201103586B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8849001A1 (es) | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
| KR101814571B1 (ko) | 2010-03-10 | 2018-01-04 | 젠맵 에이/에스 | Ｃ―ｍｅｔ에 대한 모노클로날 항체 |
| US9169329B2 (en) * | 2010-06-01 | 2015-10-27 | Ludwig Institute For Cancer Research | Antibodies directed to the receptor tyrosine kinase c-Met |
| JP2013537966A (ja) | 2010-08-31 | 2013-10-07 | ジェネンテック， インコーポレイテッド | バイオマーカー及び治療の方法 |
| CA2809677A1 (en) | 2010-09-03 | 2012-03-08 | Academia Sinica | Anti-c-met antibody and methods of use thereof |
| WO2012059561A1 (en) | 2010-11-03 | 2012-05-10 | Argen-X-Bv | Anti c-met antibodies |
| CN102276726B (zh) * | 2011-03-16 | 2014-02-19 | 常州新泉生物医药科技有限公司 | 肝细胞生长因子受体活性基团的融合蛋白 |
| US20140301989A1 (en) * | 2011-06-17 | 2014-10-09 | Brian Johnstone | Methods for increasing the potency and efficacy of stem cells |
| KR20140064971A (ko) | 2011-09-19 | 2014-05-28 | 제넨테크, 인크. | c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료 |
| EP2758430A4 (en) * | 2011-09-20 | 2015-06-03 | Lilly Co Eli | ANTI-C-MET ANTIBODY |
| KR20130036993A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체 |
| KR101865223B1 (ko) * | 2011-10-05 | 2018-06-08 | 삼성전자주식회사 | 항 ｃ-Ｍｅｔ 인간화 항체 및 그의 용도 |
| KR20130037153A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | 항 ｃ-Ｍｅｔ 항체 및 그의 용도 |
| WO2013064700A2 (en) | 2011-11-03 | 2013-05-10 | Argen-X B.V. | Chimeric polypeptides and methods of use |
| CN104066748A (zh) | 2011-11-21 | 2014-09-24 | 霍夫曼-拉罗奇有限公司 | 抗c-met抗体的纯化 |
| EP2785741A1 (en) | 2011-12-02 | 2014-10-08 | Cancer Research Technology Limited | Antibodies against hgf - receptor and uses |
| CN104334581B (zh) * | 2012-05-09 | 2018-02-02 | 伊莱利利公司 | 抗‑c‑Met抗体 |
| CA2877573A1 (en) * | 2012-06-21 | 2013-12-27 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind c-met |
| EP2708556B1 (en) * | 2012-09-12 | 2018-11-07 | Samsung Electronics Co., Ltd | Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases |
| DK2839860T3 (da) | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| WO2014128235A1 (en) | 2013-02-22 | 2014-08-28 | F. Hoffmann-La Roche Ag | Methods of treating cancer and preventing drug resistance |
| ES2687439T3 (es) | 2013-03-13 | 2018-10-25 | Medimmune Limited | Pirrolobenzodiazepinas y conjugados de las mismas |
| KR102049990B1 (ko) * | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| KR102042174B1 (ko) * | 2013-03-29 | 2019-11-08 | 삼성전자주식회사 | 인간화 및 친화도 성숙된 항 ｃ-Ｍｅｔ 항체 및 그의 용도 |
| WO2014178791A1 (en) * | 2013-04-30 | 2014-11-06 | Agency For Science, Technology And Research | Mab 2 anti-met antibody |
| EP3033434A2 (en) * | 2013-08-14 | 2016-06-22 | Qiagen Mansfield, Inc. | Compositions and methods for multimodal analysis of cmet nucleic acids |
| EP3057608B1 (en) * | 2013-10-14 | 2025-12-10 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type iii domain binding molecules |
| US9717715B2 (en) | 2013-11-15 | 2017-08-01 | Samsung Electronics Co., Ltd. | Method of combination therapy using an anti-C-Met antibody |
| TW201609805A (zh) * | 2013-12-23 | 2016-03-16 | 美國禮來大藥廠 | 結合ｅｇｆｒ及ｍｅｔ之多功能抗體 |
| TW201622744A (zh) | 2014-03-04 | 2016-07-01 | 美國禮來大藥廠 | 癌症之組合療法 |
| CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
| KR20170005016A (ko) | 2014-05-23 | 2017-01-11 | 제넨테크, 인크. | MiT 바이오마커 및 그의 사용 방법 |
| CN106687141A (zh) | 2014-09-10 | 2017-05-17 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其缀合物 |
| CN107001471B (zh) * | 2014-09-16 | 2022-01-18 | 西福根有限公司 | 抗met抗体和组合物 |
| US10398774B2 (en) | 2014-12-09 | 2019-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against AXL |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| KR20170136536A (ko) | 2015-03-16 | 2017-12-11 | 셀덱스 쎄라퓨틱스, 인크. | 항-met 항체 및 그 사용 방법 |
| WO2017019454A2 (en) * | 2015-07-28 | 2017-02-02 | Musc Foundation For Research Development | Identification of novel anti-fibrotic peptide in c-terminal region of the met receptor tyrosine kinase |
| CN108350078A (zh) | 2015-11-03 | 2018-07-31 | 默克专利股份公司 | 用于提高肿瘤选择性和抑制的双特异性抗体及其用途 |
| CN106810611A (zh) * | 2015-11-30 | 2017-06-09 | 中国科学院深圳先进技术研究院 | 抗cMet和CD3特异性双靶向抗体及其制备方法和应用、含该双靶向抗体表达盒的微环DNA及应用 |
| EP3411067B1 (en) | 2016-02-05 | 2021-10-20 | Helixmith Co., Ltd | Anti-c-met antibodies and uses thereof |
| GB2551372A (en) * | 2016-06-16 | 2017-12-20 | Bombardier Primove Gmbh | A secondary unit, a system for inductive power transfer and a method for operating a secondary unit and a system for inductive power transfer |
| WO2017223180A2 (en) | 2016-06-21 | 2017-12-28 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type iii domain binding molecules |
| CN107573416A (zh) * | 2016-06-30 | 2018-01-12 | 中国科学院深圳先进技术研究院 | 抗igf1r和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用 |
| CN107556386A (zh) * | 2016-06-30 | 2018-01-09 | 中国科学院深圳先进技术研究院 | 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用 |
| CN107556387A (zh) * | 2016-06-30 | 2018-01-09 | 中国科学院深圳先进技术研究院 | 抗gpc3和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用 |
| CN107556388A (zh) * | 2016-06-30 | 2018-01-09 | 中国科学院深圳先进技术研究院 | 抗CD44v6和CD3特异性双靶向抗体、含该双靶向抗体表达盒的微环DNA及应用 |
| EP3492105A4 (en) * | 2016-07-26 | 2020-02-26 | Nihon University | THERAPEUTIC AGENT FOR PERIODONTITIS. |
| US10439449B2 (en) | 2016-08-10 | 2019-10-08 | Microsoft Technology Licensing, Llc | Coupling device modules for inductive data transmission |
| TWI770065B (zh) * | 2016-09-29 | 2022-07-11 | 日商田邊三菱製藥股份有限公司 | Ｃｍｅｔ單株結合劑、其藥物複合體及其用途 |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| BR112019007369A2 (pt) | 2016-10-11 | 2019-07-16 | Agenus Inc | anticorpos anti-lag-3 e métodos de uso dos mesmos |
| ES2866348T3 (es) | 2016-11-16 | 2021-10-19 | Lilly Co Eli | Terapia de combinación para el cáncer con mutación o mutaciones de omisión del exón 14 o fenotipo de omisión del exón 14 |
| TWI782930B (zh) * | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| PL3544634T3 (pl) * | 2016-11-23 | 2021-09-27 | Eli Lilly And Company | Koniugaty przeciwciało MET-lek |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| RU2759952C2 (ru) | 2016-12-14 | 2021-11-19 | Янссен Байотек, Инк. | Cd8a-связывающие домены типа iii фибронектина |
| TW201825515A (zh) * | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Ｍｅｔ抗體以及其免疫結合物及用途 |
| CN106986932A (zh) * | 2017-04-06 | 2017-07-28 | 海口市人民医院 | 一种c‑Met表位肽及其应用 |
| AU2018278730B2 (en) * | 2017-05-30 | 2021-02-04 | Chong Kun Dang Pharmaceutical Corp. | A novel anti-c-Met antibody and use thereof |
| CN109771642B (zh) | 2017-11-13 | 2022-09-20 | 同济大学苏州研究院 | c-MET激动型抗体及其用途 |
| GB201803892D0 (en) | 2018-03-12 | 2018-04-25 | Ultrahuman Six Ltd | C-met binding agents |
| EP3796942A1 (en) | 2018-05-23 | 2021-03-31 | ADC Therapeutics SA | Molecular adjuvant |
| WO2021055350A1 (en) | 2019-09-16 | 2021-03-25 | Regeneron Pharmaceuticals, Inc. | Radiolabeled met binding proteins for immuno-pet imaging |
| US12491255B2 (en) | 2019-10-14 | 2025-12-09 | Aro Biotherapeutics Company | EPCAM binding fibronectin type III domains |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
| WO2022079211A1 (en) | 2020-10-16 | 2022-04-21 | Adc Therapeutics Sa | Glycoconjugates |
| EP4494660A3 (en) * | 2021-02-03 | 2025-04-16 | Mythic Therapeutics, Inc. | Anti-met antibodies and uses thereof |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CA3214718A1 (en) | 2021-04-08 | 2022-10-13 | Marion Blomenrohr | Anti-c-met antibodies and antibody-drug conjugates |
| CA3214552A1 (en) | 2021-04-14 | 2022-10-20 | Russell C. Addis | Cd71 binding fibronectin type iii domains |
| CA3215367A1 (en) | 2021-04-14 | 2022-10-20 | Swapnil Kulkarni | Fn3 domain-sirna conjugates and uses thereof |
| CN113788895B (zh) * | 2021-10-14 | 2023-09-15 | 陕西健吉跃生物科技有限公司 | 一种兔多克隆抗体及其制备方法和应用 |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 抗体の特異的共役 |
| AU2024277829A1 (en) | 2023-05-19 | 2025-12-04 | Les Laboratoires Servier | Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof |
| WO2025025434A1 (zh) * | 2023-08-02 | 2025-02-06 | 百泰生物药业有限公司 | EGFR/c-Met双特异性抗体及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2102595C (en) | 1991-05-10 | 2003-01-14 | Paolo Comoglio | Truncated forms of the hepatocyte growth factor (hgf) receptor |
| US6214344B1 (en) | 1995-06-02 | 2001-04-10 | Genetech, Inc. | Hepatocyte growth factor receptor antagonists and uses thereof |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| MXPA01010891A (es) | 1999-04-28 | 2002-11-07 | Univ Texas | Composiciones y metodos para el tratamiento contra el cancer mediante la inhibicion selectiva del factor de crecimiento endotelial vascular (vegf). |
| EP1592713A2 (en) * | 2003-02-13 | 2005-11-09 | Pharmacia Corporation | Antibodies to c-met for the treatment of cancers |
| US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| ITMI20031127A1 (it) | 2003-06-05 | 2004-12-06 | Uni Degli Studi Del Piemont E Orientale Am | Anticorpi anti-hgf-r e loro uso |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| KR100556660B1 (ko) * | 2003-11-11 | 2006-03-10 | 국립암센터 | Ｈｇｆ의 중화가능 에피토프 및 이에 결합하는 중화 항체 |
| CA2548282A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
| EP2275448A3 (en) | 2003-12-19 | 2013-02-06 | Genentech, Inc. | Monovalent antibody fragments useful as therapeutics |
| US7476724B2 (en) | 2004-08-05 | 2009-01-13 | Genentech, Inc. | Humanized anti-cmet antibodies |
| EP1868648B1 (en) | 2005-03-25 | 2015-04-15 | Genentech, Inc. | Methods and compositions for modulating hyperstabilized c-met |
| ES2368864T3 (es) | 2006-02-06 | 2011-11-23 | Metheresis Translational Research Sa | Anticuerpos monoclonales anti-met, sus fragmentos y vectores para el tratamiento de tumores y productos correspondientes. |
| KR20080090522A (ko) * | 2006-02-22 | 2008-10-08 | 일라이 릴리 앤드 캄파니 | 인간화된 항-그렐린 항체 |
| BRPI0709917A2 (pt) | 2006-03-30 | 2011-07-05 | Novartis Ag | composições e métodos de uso para anticorpos de c-met |
| KR100829972B1 (ko) | 2006-07-14 | 2008-05-16 | 재단법인서울대학교산학협력재단 | 항-ｈｇｆ/ｓｆ 인간화 항체 및 이의 제조방법 |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| US8501404B2 (en) * | 2007-02-08 | 2013-08-06 | The Regents Of The University Of California | Gnaq mutations in melanoma |
| EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| PA8849001A1 (es) | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
-
2009
- 2009-11-13 PA PA20098849001A patent/PA8849001A1/es unknown
- 2009-11-15 JO JOP/2009/0424A patent/JO3097B1/ar active
- 2009-11-16 AR ARP090104438A patent/AR074360A1/es unknown
- 2009-11-17 TW TW098139025A patent/TWI477284B/zh not_active IP Right Cessation
- 2009-11-18 ES ES09752708.9T patent/ES2549760T3/es active Active
- 2009-11-18 BR BRPI0922800A patent/BRPI0922800A2/pt not_active IP Right Cessation
- 2009-11-18 KR KR1020117011522A patent/KR101334450B1/ko not_active Expired - Fee Related
- 2009-11-18 HR HRP20151019TT patent/HRP20151019T1/hr unknown
- 2009-11-18 CA CA2743508A patent/CA2743508C/en not_active Expired - Fee Related
- 2009-11-18 TR TR2018/02841T patent/TR201802841T4/tr unknown
- 2009-11-18 DK DK09752708.9T patent/DK2358755T3/en active
- 2009-11-18 CN CN200980146173.1A patent/CN102216333B/zh active Active
- 2009-11-18 MX MX2011005400A patent/MX2011005400A/es active IP Right Grant
- 2009-11-18 EP EP15175051.0A patent/EP2963058B1/en active Active
- 2009-11-18 ES ES15175051.0T patent/ES2663825T3/es active Active
- 2009-11-18 EP EP09752708.9A patent/EP2358755B1/en active Active
- 2009-11-18 AU AU2009316742A patent/AU2009316742B2/en not_active Ceased
- 2009-11-18 WO PCT/US2009/064881 patent/WO2010059654A1/en not_active Ceased
- 2009-11-18 PT PT97527089T patent/PT2358755E/pt unknown
- 2009-11-18 JP JP2011537557A patent/JP5688027B2/ja active Active
- 2009-11-18 EA EA201170716A patent/EA020398B1/ru not_active IP Right Cessation
- 2009-11-18 US US12/620,617 patent/US8217148B2/en active Active
- 2009-11-18 HU HUE09752708A patent/HUE026058T2/en unknown
- 2009-11-18 PL PL09752708T patent/PL2358755T3/pl unknown
- 2009-11-18 SI SI200931262T patent/SI2358755T1/sl unknown
- 2009-11-18 NZ NZ592215A patent/NZ592215A/xx not_active IP Right Cessation
-
2011
- 2011-05-02 IL IL212633A patent/IL212633A/en not_active IP Right Cessation
- 2011-05-16 ZA ZA2011/03586A patent/ZA201103586B/en unknown
-
2012
- 2012-06-25 US US13/531,858 patent/US8398974B2/en active Active
-
2015
- 2015-10-02 CY CY20151100880T patent/CY1116886T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012509881A5 (enExample) | ||
| HRP20151019T1 (hr) | PROTUTIJELA PROTIV c-MET | |
| JP2022031635A5 (enExample) | ||
| TWI758558B (zh) | Cd96抗體、其抗原結合片段及醫藥用途 | |
| JP2012532851A5 (enExample) | ||
| RU2012112829A (ru) | Анти-gitr-антитела | |
| JP2009532336A5 (enExample) | ||
| RU2018119165A (ru) | Антитело против лиганда 1 запрограммированной гибели клеток (pd-l1), его антигенсвязывающий фрагмент и их медицинское применение | |
| RU2018145852A (ru) | Антитело против lag-3, его антигенсвязывающий фрагмент и их фармацевтическое применение | |
| JP2020500538A5 (enExample) | ||
| CN109843927A (zh) | 抗b7-h3抗体、其抗原结合片段及其医药用途 | |
| HRP20130922T1 (hr) | U potpunosti humana protutijela protiv humanog 4-1bb (cd137) | |
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2018527919A5 (enExample) | ||
| JP2010516229A5 (enExample) | ||
| JP2010526028A5 (enExample) | ||
| JP2011526785A5 (enExample) | ||
| JP2017534253A5 (enExample) | ||
| HRP20160151T1 (hr) | PROTUTIJELA PROTIV N3pGlu-AMILOIDNOG BETA PEPTIDA I NJIHOVA UPOTREBA | |
| IL205257A (en) | Isolated monoclonal antibody associated with the epitope of a respiratory syncytial virus strain a2 virus and various aspects related to this antibody | |
| JP2014524902A5 (enExample) | ||
| RU2014146503A (ru) | Белки, связывающие антиген - лиганд cd30 человека | |
| RU2020127196A (ru) | Антитело против 4-1bb, его антигенсвязывающий фрагмент и его медицинское применение | |
| RU2016138744A (ru) | Антитела, фармацевтические композиции и их применения | |
| JP2019205480A5 (enExample) |