JP2011501671A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011501671A5 JP2011501671A5 JP2010530058A JP2010530058A JP2011501671A5 JP 2011501671 A5 JP2011501671 A5 JP 2011501671A5 JP 2010530058 A JP2010530058 A JP 2010530058A JP 2010530058 A JP2010530058 A JP 2010530058A JP 2011501671 A5 JP2011501671 A5 JP 2011501671A5
- Authority
- JP
- Japan
- Prior art keywords
- bispecific antibody
- seq
- antibody fragment
- amino acid
- chain region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 24
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07291259.5 | 2007-10-15 | ||
| EP07291259A EP2050764A1 (en) | 2007-10-15 | 2007-10-15 | Novel polyvalent bispecific antibody format and uses thereof |
| US3712808P | 2008-03-17 | 2008-03-17 | |
| US61/037,128 | 2008-03-17 | ||
| PCT/US2008/079787 WO2009052081A2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151695A Division JP6126653B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151694A Division JP6126652B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151693A Division JP6280526B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501671A JP2011501671A (ja) | 2011-01-13 |
| JP2011501671A5 true JP2011501671A5 (enExample) | 2011-11-24 |
| JP5858616B2 JP5858616B2 (ja) | 2016-02-10 |
Family
ID=39313041
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530058A Active JP5858616B2 (ja) | 2007-10-15 | 2008-10-14 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151694A Active JP6126652B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151695A Active JP6126653B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151693A Active JP6280526B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2018006055A Pending JP2018078907A (ja) | 2007-10-15 | 2018-01-18 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151694A Active JP6126652B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151695A Active JP6126653B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2015151693A Active JP6280526B2 (ja) | 2007-10-15 | 2015-07-31 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
| JP2018006055A Pending JP2018078907A (ja) | 2007-10-15 | 2018-01-18 | Ｉｌ−４および／またはｉｌ−１３に結合する抗体およびそれらの使用 |
Country Status (43)
Families Citing this family (196)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| CA2700714C (en) | 2007-09-26 | 2018-09-11 | Ucb Pharma S.A. | Dual specificity antibody fusions |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP2615115A3 (en) * | 2007-11-30 | 2014-01-08 | Glaxo Group Limited | Antigen-binding constructs |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20110144311A1 (en) * | 2008-08-14 | 2011-06-16 | Rebecca Chmielowski | Methods for purifying antibodies using protein a affinity chromatography |
| CN102164965B (zh) | 2008-09-26 | 2016-03-30 | Ucb医药有限公司 | 生物产品 |
| SI2417156T1 (sl) | 2009-04-07 | 2015-06-30 | Roche Glycart Ag | Trivalentna, bispecifiäśna protitelesa |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| ES2667258T3 (es) * | 2009-09-10 | 2018-05-10 | Ucb Biopharma Sprl | Anticuerpos multivalentes |
| MX2012003396A (es) | 2009-09-16 | 2012-04-10 | Genentech Inc | Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos. |
| GB201000467D0 (en) * | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| FR2958936A1 (fr) | 2010-04-14 | 2011-10-21 | Sanofi Aventis | Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs |
| WO2012009544A2 (en) * | 2010-07-14 | 2012-01-19 | Amgen Inc. | Domain insertion immunoglobulin |
| CA2807282A1 (en) * | 2010-08-02 | 2012-02-09 | Regeneron Pharamaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| TW201206473A (en) | 2010-08-03 | 2012-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| JP5753903B2 (ja) | 2010-08-24 | 2015-07-22 | ロシュ グリクアート アーゲー | 活性化可能な二重特異性抗体 |
| CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| BR112013020338A2 (pt) | 2011-02-28 | 2016-10-18 | Hoffmann La Roche | proteína de ligação de antígeno monovalente, composição farmacêutica, uso da proteína de ligação de antígeno monovalente, método para o tratamento de um paciente com necessidade de terapia, método para a preparação de uma proteína de ligação de antígeno monovalente, ácido nucleico, vetor e célula hospedeira |
| CN102675460B (zh) * | 2011-02-28 | 2015-08-19 | 珠海市丽珠单抗生物技术有限公司 | 抗肿瘤坏死因子α的人源化抗体 |
| AR085911A1 (es) | 2011-03-16 | 2013-11-06 | Sanofi Sa | Dosis terapeutica segura de una proteina similar a un anticuerpo con region v dual |
| TWI671315B (zh) | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| PH12018501305B1 (en) * | 2011-03-28 | 2022-11-04 | Sanofi Sa | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN107903325B (zh) * | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| UY34105A (es) * | 2011-06-03 | 2012-07-31 | Lg Life Sciences Ltd | Formulación líquida estable de etanercept |
| FI3865581T3 (fi) | 2011-08-05 | 2024-11-02 | Regeneron Pharma | Humanisoituja universaaleja kevytketjun hiiriä |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| CA2856255C (en) | 2011-11-23 | 2021-06-22 | Bioven 3 Limited | Recombinant proteins and their therapeutic uses |
| WO2013103783A1 (en) * | 2012-01-04 | 2013-07-11 | Sanofi Us | Murine il-13 antibodies |
| CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
| EP3725892A1 (en) * | 2012-03-27 | 2020-10-21 | F. Hoffmann-La Roche AG | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| EP2867254B1 (en) | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| KR20150023889A (ko) | 2012-06-27 | 2015-03-05 | 에프. 호프만-라 로슈 아게 | 2 개 이상의 상이한 결합 단위를 함유하는 맞춤-제작된 고도로 선별적이고 다중-특이적인 표적화 단위의 선별 및 제조 방법 및 이의 용도 |
| JP6306588B2 (ja) | 2012-08-21 | 2018-04-04 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| PL2895513T3 (pl) | 2012-09-12 | 2018-11-30 | Genzyme Corporation | FC zawierające polipeptydy o zmienionej glikozylacji i zmniejszonej funkcji efektorowej |
| UY35110A (es) | 2012-11-01 | 2014-05-30 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
| SG11201503324WA (en) | 2012-11-01 | 2015-05-28 | Abbvie Inc | Stable dual variable domain immunoglobulin protein formulations |
| UA120247C2 (uk) | 2012-11-20 | 2019-11-11 | Санофі | Антитіло до ceacam5 і його застосування |
| ES2871816T3 (es) | 2012-12-27 | 2021-11-02 | Sanofi Sa | Anticuerpos anti-LAMP1 y conjugados anticuerpo-fármaco, y usos de los mismos |
| IL275376B2 (en) | 2013-03-11 | 2024-01-01 | Genzyme Corp | Hyperglycosylated binding polypeptides |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| WO2014144573A2 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Multimerization technologies |
| EP2970484B2 (en) * | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimeric bispecific antibodies |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| EP2981286A4 (en) * | 2013-04-05 | 2016-08-24 | Hoffmann La Roche | ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF |
| TWI679019B (zh) * | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物 |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| KR20160044060A (ko) | 2013-10-11 | 2016-04-22 | 에프. 호프만-라 로슈 아게 | 다중특이적 도메인 교환된 통상의 가변 경쇄 항체 |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| CA2927099A1 (en) | 2013-10-31 | 2015-05-07 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
| EP3065769A4 (en) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Procoagulant fusion compound |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN105849124B (zh) | 2013-12-20 | 2022-04-12 | 豪夫迈·罗氏有限公司 | 双重特异性抗体 |
| EP2893939A1 (en) | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
| US20150225479A1 (en) * | 2014-02-12 | 2015-08-13 | Sanofi | Anti-IL-4/Anti-IL-13 Bispecific Antibody/Polyglutamate Formulations |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| MX2016010729A (es) * | 2014-02-21 | 2016-10-26 | Genentech Inc | Anticuerpos biespecificos anti-il-13 / il-17 y sus usos. |
| EP4640239A2 (en) * | 2014-03-19 | 2025-10-29 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| SG11201607015VA (en) | 2014-03-21 | 2016-09-29 | Regeneron Pharma | V<sb>L</sb> ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| TW201628647A (zh) | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗－ｉｌ４－ｉｌ１３雙特異性抗體 |
| ME03665B (me) | 2014-07-11 | 2020-10-20 | Genmab As | Antitela koja vezuju axl |
| JP7095990B2 (ja) | 2014-09-18 | 2022-07-05 | シーダーズ－サイナイ メディカル センター | 線維症を治療するための組成物及び方法 |
| CA3205824A1 (en) | 2014-10-09 | 2016-04-14 | Genzyme Corporation | Glycoengineered antibody drug conjugates |
| JP6861630B2 (ja) | 2014-11-14 | 2021-04-21 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| US10927185B2 (en) | 2014-11-21 | 2021-02-23 | Astellas Pharma Inc. | Bispecific antibody format |
| WO2016087416A1 (en) | 2014-12-03 | 2016-06-09 | F. Hoffmann-La Roche Ag | Multispecific antibodies |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| CA2974453A1 (en) | 2015-01-23 | 2016-07-28 | Sanofi | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| EP3067062A1 (en) | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
| CA2977285A1 (en) * | 2015-03-16 | 2016-09-22 | F. Hoffmann-La Roche Ag | Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases |
| WO2016149678A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| ME03772B (me) | 2015-07-10 | 2021-04-20 | Genmab As | Konjugati antitijela specifičnog za axl i lijeka za liječenje kancera |
| KR20180053674A (ko) | 2015-10-02 | 2018-05-23 | 에프. 호프만-라 로슈 아게 | 공자극 tnf 수용체에 특이적인 이중특이성 항체 |
| ES2894304T3 (es) | 2015-10-25 | 2022-02-14 | Sanofi Sa | Proteínas de unión triespecíficas y/o trivalentes para la prevención o tratamiento de infección por VIH |
| AR106543A1 (es) | 2015-11-02 | 2018-01-24 | Netris Pharma | Terapia de combinación de agente neutralizante de ntn1 con fármacos que inhiben el control epigenético |
| WO2017117384A1 (en) | 2015-12-31 | 2017-07-06 | Development Center For Biotechnology | Anti-vegfr antibody and uses thereof |
| AU2017206074B2 (en) * | 2016-01-08 | 2023-09-07 | Altrubio Inc. | Tetravalent anti-PSGL-1 antibodies and uses thereof |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| TWI788286B (zh) | 2016-04-13 | 2023-01-01 | 法商賽諾菲公司 | 三特異性和/或三價結合蛋白 |
| EP4257193A3 (en) | 2016-04-13 | 2024-01-24 | Sanofi | Trispecific and/or trivalent binding proteins |
| KR102460040B1 (ko) | 2016-04-27 | 2022-11-01 | 애브비 인코포레이티드 | 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법 |
| TW201808336A (zh) | 2016-05-11 | 2018-03-16 | 賽諾菲公司 | 用抗ｍｕｃ１類美登素免疫綴合物抗體治療腫瘤的治療方案 |
| MX2018015853A (es) | 2016-07-14 | 2019-08-21 | Genmab As | Anticuerpos multiespecificos frente a los grupos de diferenciacion 40 y 137 (cd40 y cd137). |
| TWI790206B (zh) | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
| CN109641949B (zh) | 2016-08-26 | 2023-09-15 | 赛诺菲 | 促进选择性轻链配对的多特异性抗体 |
| TWI778985B (zh) | 2016-10-20 | 2022-10-01 | 法商賽諾菲公司 | 抗chikv抗體及其用途 |
| KR20190070977A (ko) | 2016-11-01 | 2019-06-21 | 젠맵 비. 브이 | 폴리펩티드 변이체 및 그의 용도 |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| KR102679324B1 (ko) | 2017-01-05 | 2024-06-28 | 네트리 파르마 | 네트린-1 간섭 약물과 면역 관문 억제제 약물의 조합 치료 |
| EP4659808A2 (en) | 2017-02-17 | 2025-12-10 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| CA3053774A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| KR101961871B1 (ko) * | 2017-02-20 | 2019-07-17 | 주식회사 와이바이오로직스 | 신규 다중특이적 결합 단백질 |
| WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
| JP2020522543A (ja) | 2017-06-07 | 2020-07-30 | ゲンマブ ビー．ブイ． | 変異ＩｇＧ六量体に基づく治療用抗体 |
| KR20200015921A (ko) * | 2017-07-03 | 2020-02-13 | 재단법인 생물기술개발중심 | 항-vegfr 항체 및 이의 사용 |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| US10849960B2 (en) | 2017-09-08 | 2020-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer |
| US11186649B2 (en) | 2017-10-10 | 2021-11-30 | Sanofi | Anti-CD38 antibodies and methods of use |
| CN109705217B (zh) * | 2017-10-25 | 2020-09-11 | 北京智仁美博生物科技有限公司 | 抗il-13抗体及其用途 |
| EP4344706A3 (en) | 2017-10-30 | 2024-05-22 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| JP7394767B2 (ja) | 2018-01-12 | 2023-12-08 | ジェンザイム・コーポレーション | ポリペプチドの定量化方法 |
| EP3743440A1 (en) | 2018-01-24 | 2020-12-02 | Genmab B.V. | Polypeptide variants and uses thereof |
| IL318916A (en) | 2018-01-26 | 2025-04-01 | Genzyme Corp | FC variants with improved binding to FCRN and extended half-life |
| WO2019170677A1 (en) * | 2018-03-05 | 2019-09-12 | Etablissement Francais Du Sang | Recombinant single chain immunoglobulins |
| SG11202008718UA (en) * | 2018-03-09 | 2020-10-29 | Brigham & Womens Hospital Inc | Combination therapy for cardiovascular diseases |
| AU2019264217A1 (en) | 2018-05-03 | 2020-12-17 | Genmab B.V. | Antibody variant combinations and uses thereof |
| EP3574915A1 (en) | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
| US12275797B2 (en) | 2018-06-22 | 2025-04-15 | Genmab Holding B.V. | Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof |
| MY205398A (en) | 2018-07-13 | 2024-10-19 | Genmab As | Variants of cd38 antibody and uses thereof |
| JP7534281B2 (ja) | 2018-07-13 | 2024-08-14 | ジェンマブ エー／エス | Ｃｄ３８抗体を使用したトロゴサイトーシスを介した治療 |
| US12460000B2 (en) | 2018-09-07 | 2025-11-04 | Itabmed (Hk) Limited | Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof |
| BR112021006055A2 (pt) | 2018-10-04 | 2021-07-20 | Genmab Holding B.V. | composição farmacêutica, uso da composição farmacêutica, e, métodos para induzir a morte celular ou para inibir o crescimento e/ou proliferação de uma célula tumoral e para tratar um indivíduo. |
| JP7462621B2 (ja) | 2018-10-09 | 2024-04-05 | サノフイ | 三重特異性抗ｃｄ３８、抗ｃｄ２８、および抗ｃｄ３結合タンパク質ならびにウイルス感染を処置するための使用方法 |
| WO2020096381A1 (ko) * | 2018-11-09 | 2020-05-14 | 아주대학교 산학협력단 | 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도 |
| WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| JP7737143B2 (ja) | 2018-12-21 | 2025-09-10 | エイム・イムノテック・インコーポレイテッド | がん治療のための組成物および方法 |
| CN110746507B (zh) * | 2018-12-25 | 2020-06-26 | 江苏荃信生物医药有限公司 | 抗人白介素4受体α单克隆抗体及其应用 |
| WO2020180727A1 (en) | 2019-03-06 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| WO2020191346A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| MA55529A (fr) | 2019-04-03 | 2022-02-09 | Genzyme Corp | Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| KR20220012894A (ko) | 2019-05-24 | 2022-02-04 | 사노피 | 전신 경화증의 치료 방법 |
| EP3753954A1 (en) | 2019-06-21 | 2020-12-23 | Université de Franche-Comté | Anti-cd123 antibodies, anti-cd123 chimeric antigen receptors and anti-cd123 chimeric antigen receptors t cells |
| CN115175932B (zh) | 2019-07-16 | 2025-10-31 | 赛诺菲 | 用于治疗阿尔茨海默病的中和抗β淀粉样蛋白抗体 |
| EP3999114A1 (en) | 2019-07-16 | 2022-05-25 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| TW202120539A (zh) | 2019-07-25 | 2021-06-01 | 美商健臻公司 | 以FcRn拮抗劑治療抗體媒介之病症的方法 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| GB201919062D0 (en) * | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
| WO2021144020A1 (en) | 2020-01-15 | 2021-07-22 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| US20230047809A1 (en) | 2020-01-31 | 2023-02-16 | Sanofi | Pulmonary delivery of antibodies |
| AR121462A1 (es) | 2020-02-28 | 2022-06-08 | Genzyme Corp | Polipéptidos de unión modificados para conjugación optimizada con drogas |
| US20230085883A1 (en) | 2020-03-03 | 2023-03-23 | Active Biotech Ab | Tasquinimod or a pharmaceutically acceptable salt thereof for use in combination therapy |
| TW202146463A (zh) | 2020-03-05 | 2021-12-16 | 法商賽諾菲公司 | 蛋白酶加工的分子 |
| KR20220154757A (ko) | 2020-03-18 | 2022-11-22 | 젠맵 에이/에스 | B7h4에 결합하는 항체 |
| TW202206109A (zh) | 2020-04-24 | 2022-02-16 | 法商賽諾菲公司 | 含有抗ｃｅａｃａｍ５抗體接合物與ｆｏｌｆｉｒｉ之抗腫瘤組合 |
| AU2021260823A1 (en) | 2020-04-24 | 2023-01-05 | Sanofi | Antitumor combinations containing anti-CEACAM5 antibody conjugates and FOLFOX |
| KR20230005258A (ko) | 2020-04-24 | 2023-01-09 | 사노피 | 항-ceacam5 항체 접합체 및 트리플루리딘 및 티피라실을 함유하는 항종양 병용물 |
| BR112022020477A2 (pt) | 2020-04-24 | 2022-11-29 | Sanofi Sa | Combinações antitumor contendo conjugados de anticorpo anti-ceacam5 e cetuximabe |
| CN111690066B (zh) * | 2020-06-22 | 2022-07-22 | 南京融捷康生物科技有限公司 | 抗IL-4Rα的单域抗体以及应用和药物 |
| WO2021263075A1 (en) * | 2020-06-26 | 2021-12-30 | St. Jude Children's Research Hospital, Inc. | Methods of generating an activation inducible expression system in immune cells |
| WO2022018294A1 (en) | 2020-07-23 | 2022-01-27 | Genmab B.V. | A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma |
| CN116472060A (zh) | 2020-09-02 | 2023-07-21 | 健玛保 | 抗体疗法 |
| KR20230062600A (ko) | 2020-09-04 | 2023-05-09 | 메르크 파텐트 게엠베하 | 항-ceacam5 항체 및 접합체 및 이의 용도 |
| PE20231953A1 (es) * | 2020-12-07 | 2023-12-06 | UCB Biopharma SRL | Anticuerpos multiespecificos y combinaciones de anticuerpos |
| WO2022184805A1 (en) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein |
| KR20240004949A (ko) | 2021-05-07 | 2024-01-11 | 젠맵 에이/에스 | B7h4 및 cd3에 결합하는 이중특이적 항체를 포함하는 제약 조성물 |
| US12297273B2 (en) | 2021-05-27 | 2025-05-13 | Sanofi | Fc variant with enhanced affinity to Fc receptors and improved thermal stability |
| JP2024526259A (ja) | 2021-07-02 | 2024-07-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗ｐｒｏｔａｃ抗体および複合体 |
| JPWO2023008404A1 (enExample) * | 2021-07-26 | 2023-02-02 | ||
| CA3229324A1 (en) * | 2021-08-20 | 2023-02-23 | Beatrice DROUET | Mrna vaccines comprising il-4 and/or il-13 rna and uses thereof |
| MX2024005484A (es) | 2021-11-05 | 2024-07-19 | Sanofi Sa | Combinaciones antineoplásicas que contienen conjugados de anticuerpo-fármaco anti-ceacam5 y anticuerpos anti-vegfr-2. |
| WO2023130010A1 (en) | 2021-12-30 | 2023-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for attenuating atopic march by administering an il-4/il-13 antagonist |
| WO2023166420A1 (en) * | 2022-03-03 | 2023-09-07 | Pfizer Inc. | Multispecific antibodies and uses thereof |
| EP4489861A1 (en) | 2022-03-09 | 2025-01-15 | Merck Patent GmbH | Methods and tools for conjugation to antibodies |
| EP4245772A1 (en) | 2022-03-18 | 2023-09-20 | Netris Pharma | Anti-netrin-1 antibody to treat liver inflammation |
| EP4249509A1 (en) | 2022-03-22 | 2023-09-27 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
| AU2023274452A1 (en) | 2022-05-27 | 2025-01-16 | Innate Pharma | Natural killer (nk) cell engagers binding to nkp46 and bcma variants with fc-engineering |
| CU20250005A7 (es) | 2022-06-17 | 2025-11-05 | Apogee Biologics Inc | Anticuerpos que se unen a interleuquina 13 |
| AR130869A1 (es) | 2022-10-25 | 2025-01-29 | Ablynx Nv | Polipéptidos de variantes de fc diseñados por glicoingeniería con función efectora aumentada |
| EP4642482A1 (en) | 2022-12-27 | 2025-11-05 | Merck Patent GmbH | Vhh anti-protac antibodies and complexes |
| EP4413995A1 (en) | 2023-02-07 | 2024-08-14 | Université de Franche-Comté | Anti-cd123 chimeric antigen receptors t cells for use in the treatement of autoimmune diseases |
| CN120858111A (zh) | 2023-02-27 | 2025-10-28 | 奈特里斯药物公司 | 用于治疗子宫内膜异位症和相关疼痛的抗轴突导向因子-1单克隆抗体 |
| AU2024228735A1 (en) | 2023-03-01 | 2025-10-16 | Sanofi | Use of anti-ceacam5 immunoconjugates for treating neuroendocrine cancers expressing ceacam5 |
| EP4427763A1 (en) | 2023-03-06 | 2024-09-11 | Sanofi | Antitumor combinations containing anti-ceacam5 antibody-drug conjugates, anti-vegfr-2 antibodies and anti-pd1/pd-l1 antibodies |
| EP4434586A1 (en) | 2023-03-23 | 2024-09-25 | Xenothera | Combination of antibodies, or antigen-binding fragments thereof, for the treatment of cancer and composition thereof |
| WO2024194455A1 (en) | 2023-03-23 | 2024-09-26 | Sanofi | CEACAM5 mRNA ASSAY FOR PATIENT SELECTION IN CANCER THERAPY |
| US12410258B2 (en) | 2023-05-12 | 2025-09-09 | Ganmab A/S | Antibodies capable of binding to OX40, variants thereof and uses thereof |
| WO2024238614A2 (en) * | 2023-05-15 | 2024-11-21 | Sthria Sciences Limited Liability Company | A method of treating autoimmune disease |
| TW202513094A (zh) | 2023-06-05 | 2025-04-01 | 法商賽諾菲公司 | 含有抗ceacam5抗體藥物接合物、抗pd1/pd-l1抗體及抗ctla4抗體之抗腫瘤組合 |
| WO2025049347A1 (en) * | 2023-08-25 | 2025-03-06 | Triveni Bio, Inc. | Klk5/7 + il-4 targeting antibodies and uses thereof |
| WO2025049348A1 (en) * | 2023-08-25 | 2025-03-06 | Triveni Bio, Inc. | Klk5/7 + il-13 targeting antibodies and uses thereof |
| WO2025049346A1 (en) * | 2023-08-25 | 2025-03-06 | Triveni Bio, Inc. | Klk5/7 + th2 targeting antibodies and uses thereof |
| TW202525846A (zh) | 2023-08-25 | 2025-07-01 | 美商普羅特歐拉吉克適美國公司 | 抗ｉｌ—１３多特異性抗體構築體及其用途 |
| JP2025036273A (ja) * | 2023-08-30 | 2025-03-14 | ファイザー・インク | 多重特異性抗体およびその使用 |
| WO2025073856A1 (en) | 2023-10-04 | 2025-04-10 | Xenothera | Combination of antibodies, or antigen-binding fragments thereof, for the treatment of cancers |
| TW202535925A (zh) | 2023-10-25 | 2025-09-16 | 比利時商艾伯霖克斯公司 | 具有增強的Ｆｃ受體結合之Ｆｃ結構域變體 |
| WO2025166146A1 (en) * | 2024-02-02 | 2025-08-07 | Triveni Bio, Inc. | Klk5/7 + ox40 targeting antibodies and uses thereof |
| WO2025166138A1 (en) * | 2024-02-02 | 2025-08-07 | Triveni Bio, Inc. | Klk5/7 + tslp targeting antibodies and uses thereof |
| WO2025242845A1 (en) | 2024-05-22 | 2025-11-27 | Merck Patent Gmbh | Colorectal cancer treatment |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) * | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
| AU631545B2 (en) | 1988-04-15 | 1992-12-03 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| JP3105898B2 (ja) | 1988-04-16 | 2000-11-06 | セルテック リミテッド | 組換えｄｎａタンパクの製造方法 |
| WO1989012624A2 (en) | 1988-06-14 | 1989-12-28 | Cetus Corporation | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ZA902949B (en) | 1989-05-05 | 1992-02-26 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
| CA2018228C (en) | 1989-06-05 | 1996-02-27 | Nancy L. Parenteau | Cell culture systems and media |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| CA2078689C (en) | 1990-03-20 | 2003-02-11 | Sherie L. Morrison | Chimeric antibodies with receptor binding ligands in place of their constant region |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| JP2938569B2 (ja) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| DK0574395T3 (da) | 1990-11-09 | 2002-10-07 | Stephen D Gillies | Cytokin-immunkonjugater |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| WO1993011236A1 (en) | 1991-12-02 | 1993-06-10 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2686901A1 (fr) | 1992-01-31 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant. |
| EP1997894B1 (en) | 1992-02-06 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Biosynthetic binding protein for cancer marker |
| DE69231123T2 (de) | 1992-03-25 | 2001-02-15 | Immunogen Inc | Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065 |
| AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| WO1993025788A1 (en) | 1992-06-09 | 1993-12-23 | Hoppe Ag | Latch and lockset system |
| CA2141602A1 (en) | 1992-08-26 | 1994-03-03 | Philip Leder | Use of the cytokine ip-10 as an anti-tumor agent |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| AP583A (en) | 1993-09-07 | 1997-04-14 | Smithkline Beecham Corp | Recombination IL4 antibodies useful in treatment of IL4 mediated disorders. |
| US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
| RU2162711C2 (ru) * | 1993-09-07 | 2001-02-10 | Смитклайн Бичам Корпорейшн | Рекомбинантные il4-антитела, используемые для лечения нарушений, связанных с действием il4 |
| WO1995009917A1 (en) * | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| US5597710A (en) | 1994-03-10 | 1997-01-28 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| WO1997014719A1 (en) * | 1995-10-16 | 1997-04-24 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
| US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| AU5711196A (en) | 1996-03-14 | 1997-10-01 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
| AU728657B2 (en) | 1996-03-18 | 2001-01-18 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| KR100497017B1 (ko) | 1996-03-22 | 2005-11-29 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 고사유도분자ii |
| NZ331688A (en) | 1996-03-28 | 2000-02-28 | Univ Johns Hopkins | Soluble divalent and multivalent heterodimeric analogs of proteins |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
| ES2301183T3 (es) | 1996-12-03 | 2008-06-16 | Amgen Fremont Inc. | Anticuerpo completamente humano que se une al receptor del egfr. |
| GB9625899D0 (en) * | 1996-12-13 | 1997-01-29 | Glaxo Group Ltd | Substances and their uses |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| CN100387621C (zh) | 1997-04-14 | 2008-05-14 | 麦可麦脱股份公司 | 抗人抗原受体的新的生产方法及其用途 |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| CA2309541C (en) | 1997-11-03 | 2011-01-11 | Human Genome Sciences, Inc. | Vegi, an inhibitor of angiogenesis and tumor growth |
| ATE255420T1 (de) | 1998-09-25 | 2003-12-15 | Horst Lindhofer | Verwendung von tumorzellen zeitversetzt in kombination mit intakten antikörpern zur immunisierung |
| EP2319870A3 (en) * | 1999-03-25 | 2011-10-26 | Abbott GmbH & Co. KG | Human antibodies that bind human IL-12 and methods for producing |
| PT2857516T (pt) * | 2000-04-11 | 2017-08-28 | Genentech Inc | Anticorpos multivalentes e utilizações dos mesmos |
| AU2001261024A1 (en) | 2000-04-12 | 2001-10-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| EP1299419A2 (en) * | 2000-05-24 | 2003-04-09 | Imclone Systems, Inc. | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| CA2417185A1 (en) * | 2000-07-25 | 2002-01-31 | Shui-On Leung | Multivalent target binding protein |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| RU2295537C2 (ru) * | 2000-10-20 | 2007-03-20 | Тугаи Сейяку Кабусики Кайся | Модифицированное агонистическое антитело |
| US20040023338A1 (en) | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-4 mutein proteins, antibodies, compositions, methods and uses |
| EP1578912A4 (en) | 2001-10-26 | 2007-12-26 | Centocor Inc | IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES |
| US6811780B2 (en) | 2002-05-01 | 2004-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of using cytokine antagonists to treat HIV infection and AIDS |
| US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
| CA2522819A1 (en) | 2003-04-22 | 2004-11-04 | Immunomedics, Inc. | Polyvalent protein complex |
| GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| WO2005047331A2 (en) * | 2003-11-07 | 2005-05-26 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| DK3718564T3 (da) * | 2003-12-23 | 2023-11-06 | Genentech Inc | Nye anti-IL-13-antistoffer og anvendelser |
| US7652146B2 (en) | 2004-02-06 | 2010-01-26 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors |
| EP1729795B1 (en) | 2004-02-09 | 2016-02-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP2026071B1 (en) | 2004-02-19 | 2013-07-31 | Yale University | Identification of cancer protein biomarkers using proteomic techniques |
| ATE395358T1 (de) | 2004-02-27 | 2008-05-15 | Regeneron Pharma | Il-4/il-13-spezifische polypetide und deren therapeutische verwendung |
| GB0411186D0 (en) * | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| US8101726B2 (en) * | 2004-05-25 | 2012-01-24 | Tactic Pharma, Llc | Ligands binding the complex of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) that inhibit downstream uPAR interactions: identification and use in diagnosis or therapy |
| AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| GB0414799D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Immunoglobulins |
| WO2006042333A2 (en) | 2004-10-12 | 2006-04-20 | Xencor, Inc. | Prediction and assessment of immunogenicity |
| TW200902555A (en) * | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| WO2006117910A1 (ja) * | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
| GB0514319D0 (en) * | 2005-07-13 | 2006-06-14 | Secr Defence | Antibodies for anthrax |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2007036745A2 (en) | 2005-09-30 | 2007-04-05 | Medimmune Limited | Interleukin-13 antibody composition |
| EP1957530A2 (en) * | 2005-10-21 | 2008-08-20 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| GB0600488D0 (en) * | 2006-01-11 | 2006-02-22 | Glaxo Group Ltd | Immunoglobulins |
| BRPI0710572A2 (pt) * | 2006-01-24 | 2013-01-08 | Domantis Ltd | ligante, uso do ligante, mÉtodos para o tratamento de uma doenÇa alÉrgica, de asma e de cÂncer, para a inibiÇço de uma resposta imune do tipo th2, e administraÇço de tratamento anti-il-4 e tratamento anti-il-13, composiÇço farmacÊutica, dispositivo de dispensaÇço de droga, Ácido nucleico isolado ou recombinante, vetor, cÉlula hospedeira, mÉtodos para a produÇço de um ligante e de inibiÇço da proliferaÇço de cÉlulas |
| WO2007107349A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treament of cancer |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| AR085911A1 (es) * | 2011-03-16 | 2013-11-06 | Sanofi Sa | Dosis terapeutica segura de una proteina similar a un anticuerpo con region v dual |
| TWI679019B (zh) * | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物 |
| TW201628647A (zh) * | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗－ｉｌ４－ｉｌ１３雙特異性抗體 |
-
2007
- 2007-10-15 EP EP07291259A patent/EP2050764A1/en not_active Ceased
-
2008
- 2008-10-13 PE PE2008001760A patent/PE20091382A1/es active IP Right Grant
- 2008-10-14 PT PT88399589T patent/PT2205640E/pt unknown
- 2008-10-14 NZ NZ709353A patent/NZ709353A/en unknown
- 2008-10-14 LT LTEP12006790.5T patent/LT2573121T/lt unknown
- 2008-10-14 NO NO12006790A patent/NO2573121T3/no unknown
- 2008-10-14 RS RS20171174A patent/RS56553B1/sr unknown
- 2008-10-14 ES ES12006791.3T patent/ES2679281T3/es active Active
- 2008-10-14 EP EP08839958.9A patent/EP2205640B1/en active Active
- 2008-10-14 JP JP2010530058A patent/JP5858616B2/ja active Active
- 2008-10-14 NZ NZ601342A patent/NZ601342A/en unknown
- 2008-10-14 PL PL12006789T patent/PL2574629T3/pl unknown
- 2008-10-14 MY MYPI2010001251A patent/MY171214A/en unknown
- 2008-10-14 KR KR1020107008006A patent/KR101681909B1/ko active Active
- 2008-10-14 TR TR2018/02225T patent/TR201802225T4/tr unknown
- 2008-10-14 LT LTEP12006789.7T patent/LT2574629T/lt unknown
- 2008-10-14 RU RU2013120318/10A patent/RU2580049C2/ru active
- 2008-10-14 DK DK12006790.5T patent/DK2573121T3/en active
- 2008-10-14 MX MX2012002053A patent/MX354150B/es unknown
- 2008-10-14 LT LTEP12006791.3T patent/LT2574630T/lt unknown
- 2008-10-14 NO NO12006789A patent/NO2574629T3/no unknown
- 2008-10-14 PL PL12006791T patent/PL2574630T3/pl unknown
- 2008-10-14 CA CA3015470A patent/CA3015470C/en active Active
- 2008-10-14 UA UAA201005855A patent/UA104130C2/uk unknown
- 2008-10-14 SI SI200831890T patent/SI2573121T1/en unknown
- 2008-10-14 CL CL2008003037A patent/CL2008003037A1/es unknown
- 2008-10-14 AU AU2008312655A patent/AU2008312655B2/en active Active
- 2008-10-14 HU HUE12006791A patent/HUE038444T2/hu unknown
- 2008-10-14 ES ES12006789.7T patent/ES2660152T3/es active Active
- 2008-10-14 EP EP19214415.2A patent/EP3686220A1/en active Pending
- 2008-10-14 SG SG2012076568A patent/SG185303A1/en unknown
- 2008-10-14 EP EP12006795A patent/EP2573117A1/en not_active Withdrawn
- 2008-10-14 PL PL12006790T patent/PL2573121T3/pl unknown
- 2008-10-14 KR KR1020167033258A patent/KR101823859B1/ko active Active
- 2008-10-14 PT PT120067913T patent/PT2574630T/pt unknown
- 2008-10-14 MX MX2010003290A patent/MX2010003290A/es active IP Right Grant
- 2008-10-14 EP EP12006792A patent/EP2573115A1/en not_active Ceased
- 2008-10-14 CA CA3071750A patent/CA3071750C/en active Active
- 2008-10-14 RS RS20180381A patent/RS57060B1/sr unknown
- 2008-10-14 DK DK12006791.3T patent/DK2574630T3/en active
- 2008-10-14 WO PCT/US2008/079787 patent/WO2009052081A2/en not_active Ceased
- 2008-10-14 KR KR1020147024155A patent/KR101682373B1/ko active Active
- 2008-10-14 PT PT120067905T patent/PT2573121T/pt unknown
- 2008-10-14 EP EP12006790.5A patent/EP2573121B1/en active Active
- 2008-10-14 EP EP12006797.0A patent/EP2573119B1/en active Active
- 2008-10-14 PT PT120067897T patent/PT2574629T/pt unknown
- 2008-10-14 HU HUE12006790A patent/HUE037205T2/hu unknown
- 2008-10-14 KR KR1020197005667A patent/KR20190022928A/ko not_active Ceased
- 2008-10-14 PT PT120067970T patent/PT2573119T/pt unknown
- 2008-10-14 RU RU2010119521/10A patent/RU2488595C2/ru active
- 2008-10-14 CN CN201710131539.4A patent/CN106986938B/zh active Active
- 2008-10-14 SI SI200831976T patent/SI2574630T1/en unknown
- 2008-10-14 CN CN200880111668.6A patent/CN101827863B/zh active Active
- 2008-10-14 DK DK12006797.0T patent/DK2573119T3/en active
- 2008-10-14 US US12/682,864 patent/US8388965B2/en active Active
- 2008-10-14 RS RS20140077A patent/RS53175B/sr unknown
- 2008-10-14 EP EP12006794A patent/EP2573116A1/en not_active Ceased
- 2008-10-14 ES ES12006797.0T patent/ES2664476T3/es active Active
- 2008-10-14 RS RS20180809A patent/RS57396B1/sr unknown
- 2008-10-14 CA CA2702473A patent/CA2702473C/en active Active
- 2008-10-14 EP EP12006789.7A patent/EP2574629B1/en active Active
- 2008-10-14 HU HUE12006797A patent/HUE038556T2/hu unknown
- 2008-10-14 DK DK12006789.7T patent/DK2574629T3/en active
- 2008-10-14 LT LTEP12006797.0T patent/LT2573119T/lt unknown
- 2008-10-14 SI SI200831156T patent/SI2205640T1/sl unknown
- 2008-10-14 MX MX2012010172A patent/MX363901B/es unknown
- 2008-10-14 BR BRPI0818677A patent/BRPI0818677B8/pt active IP Right Grant
- 2008-10-14 AR ARP080104471A patent/AR068861A1/es active IP Right Grant
- 2008-10-14 ES ES08839958.9T patent/ES2447915T3/es active Active
- 2008-10-14 TR TR2018/10005T patent/TR201810005T4/tr unknown
- 2008-10-14 NZ NZ584658A patent/NZ584658A/xx unknown
- 2008-10-14 SG SG10201602770UA patent/SG10201602770UA/en unknown
- 2008-10-14 MX MX2012010171A patent/MX363634B/es unknown
- 2008-10-14 EP EP12006796A patent/EP2573118A1/en not_active Withdrawn
- 2008-10-14 ES ES12006790.5T patent/ES2647872T3/es active Active
- 2008-10-14 SG SG10201913836SA patent/SG10201913836SA/en unknown
- 2008-10-14 DK DK08839958.9T patent/DK2205640T3/en active
- 2008-10-14 CN CN202110668094.XA patent/CN113480647B/zh active Active
- 2008-10-14 EP EP12006793A patent/EP2574626A1/en not_active Withdrawn
- 2008-10-14 PL PL12006797T patent/PL2573119T3/pl unknown
- 2008-10-14 SG SG10201913838RA patent/SG10201913838RA/en unknown
- 2008-10-14 MX MX2012002055A patent/MX363638B/es unknown
- 2008-10-14 SI SI200831924T patent/SI2574629T1/en unknown
- 2008-10-14 UA UAA201310544A patent/UA118949C2/uk unknown
- 2008-10-14 SI SI200831938T patent/SI2573119T1/en unknown
- 2008-10-14 HR HRP20140150AT patent/HRP20140150T1/hr unknown
- 2008-10-14 RS RS20180201A patent/RS56914B1/sr unknown
- 2008-10-14 KR KR1020187002319A patent/KR101954596B1/ko active Active
- 2008-10-14 PL PL08839958T patent/PL2205640T3/pl unknown
- 2008-10-14 EP EP12006791.3A patent/EP2574630B1/en active Active
- 2008-10-14 HU HUE12006789A patent/HUE036530T2/hu unknown
- 2008-10-15 PA PA20088799001A patent/PA8799001A1/es unknown
- 2008-10-15 TW TW097139453A patent/TWI619508B/zh active
- 2008-10-15 UY UY31394A patent/UY31394A1/es not_active Application Discontinuation
- 2008-10-15 TW TW104112967A patent/TWI616206B/zh active
- 2008-10-15 TW TW104112966A patent/TWI616205B/zh active
- 2008-10-15 TW TW106136056A patent/TW201825117A/zh unknown
-
2010
- 2010-03-22 TN TNP2010000126A patent/TN2010000126A1/fr unknown
- 2010-03-23 NI NI2010000403A patent/NI201000403A/es unknown
- 2010-03-23 NI NI2010000402A patent/NI201000402A/es unknown
- 2010-03-23 NI NI2010000401A patent/NI201000401A/es unknown
- 2010-03-23 NI NI2010000405A patent/NI201000405A/es unknown
- 2010-03-23 NI NI201000040A patent/NI201000040A/es unknown
- 2010-03-23 NI NI2010000404A patent/NI201000404A/es unknown
- 2010-03-23 NI NI2010000406A patent/NI201000406A/es unknown
- 2010-03-24 ZA ZA2010/02069A patent/ZA201002069B/en unknown
- 2010-03-24 GT GT201000067A patent/GT201000067A/es unknown
- 2010-03-25 MX MX2012002056A patent/MX354666B/es unknown
- 2010-03-25 CR CR11337A patent/CR11337A/es unknown
- 2010-04-11 IL IL205005A patent/IL205005A/en active IP Right Grant
- 2010-04-14 HN HN2010000710A patent/HN2010000710A/es unknown
- 2010-04-14 DO DO2010000109A patent/DOP2010000109A/es unknown
- 2010-05-10 MA MA32823A patent/MA31838B1/fr unknown
-
2012
- 2012-11-15 CL CL2012003196A patent/CL2012003196A1/es unknown
-
2013
- 2013-02-04 US US13/758,858 patent/US20130209469A1/en not_active Abandoned
- 2013-03-11 US US13/794,370 patent/US20130236463A1/en not_active Abandoned
- 2013-03-11 US US13/794,320 patent/US20130236460A1/en not_active Abandoned
- 2013-03-11 US US13/794,341 patent/US20130236461A1/en not_active Abandoned
- 2013-03-11 US US13/794,354 patent/US20130236462A1/en not_active Abandoned
- 2013-03-11 US US13/794,295 patent/US9738728B2/en active Active
- 2013-03-11 US US13/794,384 patent/US20130251718A1/en not_active Abandoned
- 2013-03-11 US US13/794,394 patent/US20130259866A1/en not_active Abandoned
- 2013-03-11 US US13/794,310 patent/US20130251717A1/en not_active Abandoned
- 2013-03-15 US US13/831,866 patent/US20140023649A1/en not_active Abandoned
- 2013-03-15 US US13/831,884 patent/US20130243778A1/en not_active Abandoned
- 2013-03-15 US US13/831,856 patent/US20130243776A1/en not_active Abandoned
- 2013-03-15 US US13/831,862 patent/US9732162B2/en active Active
- 2013-04-04 AU AU2013202389A patent/AU2013202389B9/en active Active
- 2013-04-10 AU AU2013203339A patent/AU2013203339B9/en active Active
- 2013-04-10 AU AU2013203324A patent/AU2013203324C1/en active Active
- 2013-04-10 AU AU2013203328A patent/AU2013203328B9/en active Active
- 2013-05-21 PH PH12013501033A patent/PH12013501033B1/en unknown
- 2013-05-21 PH PH12013501032A patent/PH12013501032B1/en unknown
- 2013-07-12 CL CL2013002039A patent/CL2013002039A1/es unknown
- 2013-07-12 CL CL2013002040A patent/CL2013002040A1/es unknown
- 2013-12-12 DO DO2013000302A patent/DOP2013000302A/es unknown
- 2013-12-12 DO DO2013000301A patent/DOP2013000301A/es unknown
-
2014
- 2014-02-20 CY CY20141100136T patent/CY1114987T1/el unknown
-
2015
- 2015-02-26 CR CR20150103A patent/CR20150103A/es unknown
- 2015-02-26 CR CR20150101A patent/CR20150101A/es unknown
- 2015-02-26 CR CR20150102A patent/CR20150102A/es unknown
- 2015-07-31 JP JP2015151694A patent/JP6126652B2/ja active Active
- 2015-07-31 JP JP2015151695A patent/JP6126653B2/ja active Active
- 2015-07-31 JP JP2015151693A patent/JP6280526B2/ja active Active
- 2015-09-29 RU RU2015141418A patent/RU2721236C2/ru active
- 2015-09-29 RU RU2015141428A patent/RU2705551C2/ru active
- 2015-12-10 CR CR20150654A patent/CR20150654A/es unknown
-
2016
- 2016-11-29 IL IL249289A patent/IL249289A0/en unknown
-
2017
- 2017-07-10 US US15/645,765 patent/US10759871B2/en active Active
- 2017-11-16 HR HRP20171765TT patent/HRP20171765T1/hr unknown
- 2017-11-22 CY CY20171101220T patent/CY1119875T1/el unknown
-
2018
- 2018-01-18 JP JP2018006055A patent/JP2018078907A/ja active Pending
- 2018-02-21 HR HRP20180320TT patent/HRP20180320T1/hr unknown
- 2018-02-22 CY CY20181100211T patent/CY1120033T1/el unknown
- 2018-03-27 HR HRP20180517TT patent/HRP20180517T1/hr unknown
- 2018-03-30 CY CY20181100360T patent/CY1120108T1/el unknown
- 2018-07-10 HR HRP20181085TT patent/HRP20181085T1/hr unknown
- 2018-07-17 CY CY181100741T patent/CY1120887T1/el unknown
- 2018-10-18 AR ARP180103042A patent/AR122833A2/es unknown
- 2018-10-18 AR ARP180103043A patent/AR122834A2/es unknown
-
2020
- 2020-07-28 US US16/941,272 patent/US11453727B2/en active Active
-
2022
- 2022-08-10 US US17/818,927 patent/US20230235088A1/en not_active Abandoned
-
2024
- 2024-12-12 US US18/978,951 patent/US20250313651A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011501671A5 (enExample) | ||
| RU2010119521A (ru) | Антитела, связывающие il-4 и/или il-13, и их применение | |
| JP2008538564A5 (enExample) | ||
| JP2024075713A5 (enExample) | ||
| WO2008050329A3 (en) | Novel sirnas and methods of use thereof | |
| JP2010500371A5 (enExample) | ||
| SI3064511T1 (en) | THE MEDICINE USE OF HUMAN HIGHLIGHTS FOR HUMAN RECEPTOR IL-4 | |
| JP2017529838A5 (enExample) | ||
| JP2017530722A5 (enExample) | ||
| JP2010502207A5 (enExample) | ||
| JP2013544078A5 (enExample) | ||
| IL180364A (en) | Use of antibodies specifically related to amyloid-beta peptide in the manufacture of drugs for the treatment of diseases characterized by amyloid-beta deficiency, pharmaceutical compositions including them and methods for their preparation and methods for use thereof | |
| RU2013123266A (ru) | Стабильные и растворимые антитела | |
| JP2010528601A5 (enExample) | ||
| JP2011528901A5 (enExample) | ||
| JP2014074046A5 (enExample) | ||
| FI3978522T3 (fi) | Humaaneja vasta-aineita Fel d1:lle ja niiden käyttömenetelmiä | |
| JP2017523786A5 (enExample) | ||
| JP2013519364A5 (enExample) | ||
| JP2014502955A5 (enExample) | ||
| JP2010526028A5 (enExample) | ||
| RU2009148886A (ru) | Рсв-специфичные связывающие молекулы и средства для их получения | |
| JP2013537418A5 (enExample) | ||
| JP2009521909A5 (enExample) | ||
| RU2571204C3 (ru) | Специфические связывающие агенты против в7-н1 |