JP2013544078A5 - - Google Patents
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- JP2013544078A5 JP2013544078A5 JP2013534142A JP2013534142A JP2013544078A5 JP 2013544078 A5 JP2013544078 A5 JP 2013544078A5 JP 2013534142 A JP2013534142 A JP 2013534142A JP 2013534142 A JP2013534142 A JP 2013534142A JP 2013544078 A5 JP2013544078 A5 JP 2013544078A5
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- JP
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- Prior art keywords
- antibody
- sequence
- seq
- administration
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 29
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 10
- 230000001404 mediated effect Effects 0.000 claims description 8
- 239000004475 Arginine Substances 0.000 claims description 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- 206010046851 Uveitis Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical group 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 208000009137 Behcet syndrome Diseases 0.000 claims description 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 3
- 206010013774 Dry eye Diseases 0.000 claims description 3
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims description 3
- 206010038910 Retinitis Diseases 0.000 claims description 3
- 206010039705 Scleritis Diseases 0.000 claims description 3
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 3
- 206010023332 keratitis Diseases 0.000 claims description 3
- 208000002780 macular degeneration Diseases 0.000 claims description 3
- 201000011588 macular keratitis Diseases 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 102000057041 human TNF Human genes 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40579810P | 2010-10-22 | 2010-10-22 | |
| US61/405,798 | 2010-10-22 | ||
| US201161484749P | 2011-05-11 | 2011-05-11 | |
| US61/484,749 | 2011-05-11 | ||
| PCT/CH2011/000256 WO2012051734A1 (en) | 2010-10-22 | 2011-10-24 | Stable and soluble antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151924A Division JP2015193664A (ja) | 2010-10-22 | 2015-07-31 | 安定で可溶性の抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544078A JP2013544078A (ja) | 2013-12-12 |
| JP2013544078A5 true JP2013544078A5 (enExample) | 2014-06-05 |
| JP6245985B2 JP6245985B2 (ja) | 2017-12-13 |
Family
ID=44897558
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013534142A Active JP6245985B2 (ja) | 2010-10-22 | 2011-10-24 | 安定で可溶性の抗体 |
| JP2015151924A Withdrawn JP2015193664A (ja) | 2010-10-22 | 2015-07-31 | 安定で可溶性の抗体 |
| JP2017142892A Active JP7148228B2 (ja) | 2010-10-22 | 2017-07-24 | 安定で可溶性の抗体 |
| JP2018227992A Pending JP2019054814A (ja) | 2010-10-22 | 2018-12-05 | 安定で可溶性の抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151924A Withdrawn JP2015193664A (ja) | 2010-10-22 | 2015-07-31 | 安定で可溶性の抗体 |
| JP2017142892A Active JP7148228B2 (ja) | 2010-10-22 | 2017-07-24 | 安定で可溶性の抗体 |
| JP2018227992A Pending JP2019054814A (ja) | 2010-10-22 | 2018-12-05 | 安定で可溶性の抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8545849B2 (enExample) |
| EP (2) | EP2630159B1 (enExample) |
| JP (4) | JP6245985B2 (enExample) |
| KR (4) | KR20160083970A (enExample) |
| CN (2) | CN108359012B (enExample) |
| AR (1) | AR083495A1 (enExample) |
| AU (1) | AU2011318179B2 (enExample) |
| BR (1) | BR112013010949B1 (enExample) |
| CA (1) | CA2814766C (enExample) |
| CL (2) | CL2013001089A1 (enExample) |
| CO (1) | CO6741152A2 (enExample) |
| CY (1) | CY1119941T1 (enExample) |
| MX (2) | MX2013004295A (enExample) |
| PH (1) | PH12013500675B1 (enExample) |
| PL (1) | PL2630159T3 (enExample) |
| RU (2) | RU2015119440A (enExample) |
| TW (3) | TWI652068B (enExample) |
| UA (1) | UA111340C2 (enExample) |
| UY (1) | UY33679A (enExample) |
| WO (1) | WO2012051734A1 (enExample) |
| ZA (1) | ZA201302537B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2307458T3 (pl) * | 2008-06-25 | 2018-08-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała |
| UY33679A (es) * | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| AU2012325232B2 (en) * | 2011-10-20 | 2017-08-31 | Esbatech - A Novartis Company Llc | Stable multiple antigen-binding antibody |
| EP2809344B1 (en) | 2012-02-02 | 2016-08-24 | ESBATech - a Novartis Company LLC | Antibody-containing sustained-release formulation for ocular administration |
| CN104582717B (zh) | 2012-07-19 | 2018-03-13 | 雷德伍德生物科技股份有限公司 | 对cd22有特异性的抗体及其使用方法 |
| KR20150095684A (ko) | 2012-12-18 | 2015-08-21 | 노파르티스 아게 | 히알루로난에 결합하는 펩티드 태그를 이용하는 조성물 및 방법 |
| US20170327553A1 (en) | 2014-06-25 | 2017-11-16 | Novartis Ag | Compositions and methods for long acting proteins |
| US20170290876A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Compositions and methods for long acting proteins |
| ES2964713T3 (es) | 2014-10-23 | 2024-04-09 | Amgen Inc | Reducción de la viscosidad de formulaciones farmacéuticas |
| CA3001131A1 (en) | 2015-11-02 | 2017-05-11 | Five Prime Therapeutics, Inc. | Cd80 extracellular domain polypeptides and their use in cancer treatment |
| WO2017083306A1 (en) | 2015-11-09 | 2017-05-18 | R.P. Scherer Technologies, Llc | Anti-cd22 antibody-maytansine conjugates and methods of use thereof |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| JP7583515B2 (ja) * | 2016-06-20 | 2024-11-14 | ノバルティス アーゲー | ＴＮＦα拮抗薬を使用したドライアイ疾患の治療方法 |
| IL307684B2 (en) | 2016-09-29 | 2025-04-01 | Amgen Inc | Low viscosity antigen binding proteins and methods for preparing them |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| US12649792B2 (en) | 2019-05-06 | 2026-06-09 | Brown University | Bispecific antibodies against CHI3L1 and PD1 with enhanced T cell-mediated cytotoxic effects on tumor cells |
| CN114401988A (zh) * | 2019-07-09 | 2022-04-26 | 国家生物技术研究所公司 | 具有降低的免疫原性的抗体 |
| CN112786101B (zh) * | 2019-11-07 | 2024-11-12 | 中国农业大学 | 热稳定性抗体的制备方法 |
| EP4061849A4 (en) * | 2019-11-21 | 2024-05-29 | Brown University | BISPECIFIC ANTIBODIES AGAINST CHI3L1 AND CTLA4 WITH IMPROVED CYTOTOXIC EFFECTS ON TUMOR CELLS |
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| AU2012328921B2 (en) | 2011-10-24 | 2017-05-11 | Abbvie Inc. | Immunobinders directed against TNF |
| UY34410A (es) | 2011-10-24 | 2013-05-31 | Abbvie Inc | Inmunoligantes biespecificos dirigidos contra tnf |
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