JP2011518125A5 - - Google Patents

Info

Publication number

JP2011518125A5

JP2011518125A5 JP2011501904A JP2011501904A JP2011518125A5 JP 2011518125 A5 JP2011518125 A5 JP 2011518125A5 JP 2011501904 A JP2011501904 A JP 2011501904A JP 2011501904 A JP2011501904 A JP 2011501904A JP 2011518125 A5 JP2011518125 A5 JP 2011518125A5

Authority

JP

Japan

Prior art keywords

seq

fab fragment

heavy chain

light chain

monoclonal antibody

Prior art date

2009-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 38
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 38
• 102000051325 Glucagon Human genes 0.000 claims 2
• 108060003199 Glucagon Proteins 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
• 229960004666 glucagon Drugs 0.000 claims 2
• 102220479740 Cell division cycle protein 123 homolog_S11I_mutation Human genes 0.000 claims 1
• 102220502941 Geranylgeranyl transferase type-2 subunit alpha_D10E_mutation Human genes 0.000 claims 1
• 102220502946 Geranylgeranyl transferase type-2 subunit alpha_D10N_mutation Human genes 0.000 claims 1
• 108010063919 Glucagon Receptors Proteins 0.000 claims 1
• 102100040890 Glucagon receptor Human genes 0.000 claims 1
• 101001040075 Homo sapiens Glucagon receptor Proteins 0.000 claims 1
• 101001040082 Mus musculus Glucagon receptor Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 101001040081 Rattus norvegicus Glucagon receptor Proteins 0.000 claims 1
• 150000001413 amino acids Chemical group 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 102220083031 rs746990000 Human genes 0.000 claims 1
• 102220322685 rs777811020 Human genes 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1