JP2010512320A5 - - Google Patents
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- JP2010512320A5 JP2010512320A5 JP2009540313A JP2009540313A JP2010512320A5 JP 2010512320 A5 JP2010512320 A5 JP 2010512320A5 JP 2009540313 A JP2009540313 A JP 2009540313A JP 2009540313 A JP2009540313 A JP 2009540313A JP 2010512320 A5 JP2010512320 A5 JP 2010512320A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- monoclonal antibody
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87383406P | 2006-12-08 | 2006-12-08 | |
| US60/873,834 | 2006-12-08 | ||
| PCT/US2007/025080 WO2008073300A2 (en) | 2006-12-08 | 2007-12-06 | Monoclonal antibodies against angptl3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512320A JP2010512320A (ja) | 2010-04-22 |
| JP2010512320A5 true JP2010512320A5 (enExample) | 2011-01-27 |
| JP5484063B2 JP5484063B2 (ja) | 2014-05-07 |
Family
ID=39512267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540313A Expired - Fee Related JP5484063B2 (ja) | 2006-12-08 | 2007-12-06 | Ａｎｇｐｔｌ３に対するモノクローナル抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7935796B2 (enExample) |
| EP (1) | EP2121751B1 (enExample) |
| JP (1) | JP5484063B2 (enExample) |
| KR (1) | KR101503937B1 (enExample) |
| CN (1) | CN101855241B (enExample) |
| AR (1) | AR064205A1 (enExample) |
| AU (1) | AU2007332855B2 (enExample) |
| BR (1) | BRPI0720218A2 (enExample) |
| CA (1) | CA2672049C (enExample) |
| DK (1) | DK2121751T3 (enExample) |
| EA (1) | EA019661B1 (enExample) |
| ES (1) | ES2618830T3 (enExample) |
| HU (1) | HUE033960T2 (enExample) |
| IL (1) | IL199216A (enExample) |
| MX (1) | MX2009006082A (enExample) |
| NO (1) | NO20092215L (enExample) |
| PL (1) | PL2121751T3 (enExample) |
| PT (1) | PT2121751T (enExample) |
| TW (1) | TW200846364A (enExample) |
| WO (1) | WO2008073300A2 (enExample) |
| ZA (1) | ZA200904022B (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2672049C (en) * | 2006-12-08 | 2016-05-10 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
| US8802646B2 (en) | 2008-10-08 | 2014-08-12 | Trustees Of Dartmouth College | Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease |
| US9388413B2 (en) | 2008-10-08 | 2016-07-12 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US9149492B2 (en) | 2008-10-08 | 2015-10-06 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease |
| WO2010042292A1 (en) * | 2008-10-08 | 2010-04-15 | Trustees Of Dartmouth College | Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease |
| US9388414B2 (en) | 2008-10-08 | 2016-07-12 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| CN101852805B (zh) * | 2009-03-31 | 2015-04-01 | 浙江大学 | Angptl3作为卵巢癌的诊断标记物的用途 |
| AU2015200969A1 (en) * | 2010-01-08 | 2015-03-19 | Ionis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| CN106146591B (zh) | 2010-01-08 | 2020-07-31 | Ionis制药公司 | 血管生成素样3表达的调节 |
| US9150656B2 (en) | 2010-03-04 | 2015-10-06 | Macrogenics, Inc. | Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| WO2012109282A2 (en) * | 2011-02-07 | 2012-08-16 | Agamin Pharmaceuticals, Llc | Methods and systems for treating or preventing pregnancy-related hypertensive disorders |
| US8852592B2 (en) | 2011-05-10 | 2014-10-07 | Biocare Medical, Llc | Systems and methods for anti-PAX8 antibodies |
| AR087329A1 (es) * | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| AU2012272970A1 (en) | 2011-06-21 | 2014-02-06 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof |
| NZ780183A (en) | 2011-06-23 | 2024-12-20 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| CA2848201C (en) | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| SG11201408538PA (en) | 2012-07-13 | 2015-02-27 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| NZ704771A (en) | 2012-08-13 | 2018-02-23 | Regeneron Pharma | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
| US9429577B2 (en) | 2012-09-27 | 2016-08-30 | Biocare Medical, Llc | Anti-uroplakin II antibodies systems and methods |
| GB201219487D0 (en) * | 2012-10-30 | 2012-12-12 | Cancer Rec Tech Ltd | Anti-S100A4 antibody molecules and their uses |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| EP2962113B1 (en) | 2013-02-28 | 2019-04-03 | Biocare Medical, LLC | Anti-p40 antibodies systems and methods |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| US9301971B2 (en) * | 2013-03-08 | 2016-04-05 | Novartis Ag | Peptides and compositions for treatment of joint damage |
| KR102482890B1 (ko) | 2013-05-01 | 2022-12-30 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법 |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| DK3052522T3 (da) | 2013-10-03 | 2020-02-24 | Biocare Medical Llc | Anti-sox 10 antistofsystemer og -fremgangsmåder |
| BR112016013514B1 (pt) | 2013-12-13 | 2022-04-19 | Stora Enso Oyj (Fi) | Papelão de múltiplas camadas |
| MX383753B (es) * | 2013-12-24 | 2025-03-14 | Ionis Pharmaceuticals Inc | Modulación de la expresión similar a la angiopoyetina tipo 3. |
| SI3137605T1 (sl) | 2014-05-01 | 2021-02-26 | Ionis Pharmaceuticals, Inc. | Sestavki in metode za modulacijo ekspresije angiopoetin 3-podobnega |
| US10100308B2 (en) | 2014-05-29 | 2018-10-16 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US9527922B2 (en) * | 2014-12-31 | 2016-12-27 | Development Center For Biotechnology | Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy |
| EP3283631A1 (en) | 2015-04-13 | 2018-02-21 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| CA2999341A1 (en) | 2015-11-06 | 2017-05-11 | Ionis Pharmaceuticals, Inc. | Modulating apolipoprotein (a) expression |
| KR102860143B1 (ko) * | 2016-02-17 | 2025-09-16 | 리제너론 파아마슈티컬스, 인크. | Angptl3의 억제제를 투여함으로써 죽상 동맥경화증을 치료하거나 예방하기 위한 방법 |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| MY198114A (en) | 2016-04-15 | 2023-08-04 | Macrogenics Inc | Novel b7-h3-binding molecules, antibody drug conjugates thereof and methods of use thereof |
| MA44764B1 (fr) * | 2016-04-28 | 2025-09-30 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement de patients présentant une hypercholestérolémie familiale |
| US11124562B2 (en) | 2016-10-28 | 2021-09-21 | Washington University | Anti-ApoE antibodies |
| CN107085112B (zh) * | 2017-05-10 | 2019-03-19 | 武汉圣润生物科技有限公司 | 一种用于检测白血病的试剂盒 |
| WO2019195561A2 (en) * | 2018-04-06 | 2019-10-10 | BioLegend, Inc. | Anti-tetraspanin 33 agents and compositions and methods for making and using the same |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US20210308273A1 (en) | 2018-08-02 | 2021-10-07 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
| TWI747098B (zh) * | 2018-12-21 | 2021-11-21 | 美商美國禮來大藥廠 | 抗angptl3/8複合物抗體及其使用方法 |
| US20200369760A1 (en) | 2019-05-24 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-angptl3 antibodies |
| CN112062844B (zh) * | 2019-06-10 | 2022-07-19 | 山东博安生物技术股份有限公司 | 抗angptl3抗体及其用途 |
| WO2021001804A1 (en) * | 2019-07-04 | 2021-01-07 | Cadila Healthcare Limited | Angptl3 based vaccine for the treatment of liver disease |
| WO2021041300A2 (en) * | 2019-08-23 | 2021-03-04 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| CN110938144B (zh) * | 2019-11-27 | 2022-07-26 | 复旦大学附属儿科医院 | 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途 |
| BR112022014306A2 (pt) * | 2020-01-22 | 2022-09-20 | Jiangsu Hengrui Medicine Co | Anticorpo anti-angptl3 e uso do mesmo |
| US20240002479A1 (en) * | 2020-11-23 | 2024-01-04 | The Regents Of The University Of Michigan | Single-chain antibody against flavivirus ns1 protein |
| WO2022187435A1 (en) | 2021-03-04 | 2022-09-09 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| WO2022187353A1 (en) * | 2021-03-05 | 2022-09-09 | Anji Pharmaceuticals Inc. | Methods and compositions for treating sepsis |
| JPWO2022244845A1 (enExample) * | 2021-05-19 | 2022-11-24 | ||
| CN118355035A (zh) * | 2021-07-09 | 2024-07-16 | 达因疗法公司 | 肌肉靶向复合物及其用于治疗肌养蛋白病的用途 |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| EP4366784A1 (en) | 2021-07-09 | 2024-05-15 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating dystrophinopathies |
| JP2024525613A (ja) * | 2021-07-09 | 2024-07-12 | ダイン セラピューティクス，インコーポレーテッド | 筋標的化複合体およびジストロフィノパチーを処置するためのその使用 |
| JP2024529377A (ja) * | 2021-07-21 | 2024-08-06 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 抗ａｎｇｐｔｌ３抗体又はその抗原結合断片の医薬組成物及びその使用 |
| CN116284377A (zh) * | 2021-12-21 | 2023-06-23 | 复旦大学 | 抗人血管生成素3纳米抗体及其应用 |
| IL316249A (en) | 2022-05-02 | 2024-12-01 | Novo Nordisk As | Novel anti-angptl3 antibodies suitable for high concentration compositions and subcutaneous administration |
| CN117447595B (zh) * | 2022-07-26 | 2024-06-28 | 北京东方百泰生物科技股份有限公司 | 一种抗Siglec-15单克隆抗体 |
| CN116199779B (zh) * | 2022-12-08 | 2023-08-11 | 北京东方百泰生物科技股份有限公司 | 一种抗lilrb4单克隆抗体、其抗原结合片段及其应用 |
| WO2024130165A1 (en) | 2022-12-16 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Angptl3 inhibitors for triglyceride reduction in multifactorial chylomicronemia syndrome |
| CN119192369A (zh) * | 2023-06-25 | 2024-12-27 | 百奥泰生物制药股份有限公司 | 抗angptl3抗体及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2199935T3 (es) | 1991-03-15 | 2004-03-01 | Amgen Inc. | Pegilacion de polipeptidos. |
| DE69233204T2 (de) | 1991-12-13 | 2004-07-15 | Xoma Corp., Berkeley | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5912000A (en) | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW313568B (enExample) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
| DE69738539T2 (de) | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| US20030100051A1 (en) * | 1998-05-12 | 2003-05-29 | Ruben Steven M. | 97 human secreted proteins |
| US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| US6030831A (en) * | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| AU4643699A (en) * | 1998-06-24 | 2000-01-10 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| MXPA02005758A (es) | 1999-12-09 | 2002-09-18 | Sankyo Co | Metodo para evaluar un remedio o agente preventivo para hiperlipidemia. |
| EP1403367A4 (en) | 2001-06-08 | 2005-08-17 | Sankyo Co | A MEDICAMENT TEST METHOD FOR TREATING OR PREVENTING DISEASES SUCH AS HYPERLIPEMIA |
| ES2429034T3 (es) * | 2001-11-16 | 2013-11-12 | Genentech, Inc. | Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas |
| MX2007008256A (es) | 2005-01-07 | 2007-12-06 | Lexicon Pharmaceuticals Inc | Anticuerpos monoclonales contra proteina 4 similar a angiopoyetina (angptl4). |
| CA2672049C (en) * | 2006-12-08 | 2016-05-10 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
-
2007
- 2007-12-06 CA CA2672049A patent/CA2672049C/en active Active
- 2007-12-06 AU AU2007332855A patent/AU2007332855B2/en not_active Ceased
- 2007-12-06 PL PL07862629T patent/PL2121751T3/pl unknown
- 2007-12-06 DK DK07862629.8T patent/DK2121751T3/en active
- 2007-12-06 WO PCT/US2007/025080 patent/WO2008073300A2/en not_active Ceased
- 2007-12-06 PT PT78626298T patent/PT2121751T/pt unknown
- 2007-12-06 EA EA200970556A patent/EA019661B1/ru not_active IP Right Cessation
- 2007-12-06 KR KR1020097013595A patent/KR101503937B1/ko not_active Expired - Fee Related
- 2007-12-06 CN CN2007800511058A patent/CN101855241B/zh not_active Expired - Fee Related
- 2007-12-06 HU HUE07862629A patent/HUE033960T2/en unknown
- 2007-12-06 JP JP2009540313A patent/JP5484063B2/ja not_active Expired - Fee Related
- 2007-12-06 US US12/001,012 patent/US7935796B2/en active Active
- 2007-12-06 MX MX2009006082A patent/MX2009006082A/es active IP Right Grant
- 2007-12-06 BR BRPI0720218-0A2A patent/BRPI0720218A2/pt not_active Application Discontinuation
- 2007-12-06 ES ES07862629.8T patent/ES2618830T3/es active Active
- 2007-12-06 ZA ZA200904022A patent/ZA200904022B/xx unknown
- 2007-12-06 EP EP07862629.8A patent/EP2121751B1/en active Active
- 2007-12-07 AR ARP070105505A patent/AR064205A1/es active IP Right Grant
- 2007-12-07 TW TW096146844A patent/TW200846364A/zh unknown
-
2009
- 2009-06-07 IL IL199216A patent/IL199216A/en active IP Right Grant
- 2009-06-09 NO NO20092215A patent/NO20092215L/no not_active Application Discontinuation
-
2011
- 2011-03-28 US US13/073,617 patent/US8742075B2/en active Active
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