JP2010043089A5 - - Google Patents
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- JP2010043089A5 JP2010043089A5 JP2009211917A JP2009211917A JP2010043089A5 JP 2010043089 A5 JP2010043089 A5 JP 2010043089A5 JP 2009211917 A JP2009211917 A JP 2009211917A JP 2009211917 A JP2009211917 A JP 2009211917A JP 2010043089 A5 JP2010043089 A5 JP 2010043089A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hngf
- human
- agent
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 15
- 102000015336 Nerve Growth Factor Human genes 0.000 claims description 15
- 101150111783 NTRK1 gene Proteins 0.000 claims description 12
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 7
- 208000004454 Hyperalgesia Diseases 0.000 claims description 6
- 208000035154 Hyperesthesia Diseases 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 15
- 208000027866 inflammatory disease Diseases 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 208000002193 Pain Diseases 0.000 claims 10
- 206010003246 arthritis Diseases 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 8
- 201000004681 Psoriasis Diseases 0.000 claims 7
- 208000006673 asthma Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
- 206010025135 lupus erythematosus Diseases 0.000 claims 5
- 201000006417 multiple sclerosis Diseases 0.000 claims 5
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 206010012442 Dermatitis contact Diseases 0.000 claims 4
- 208000007514 Herpes zoster Diseases 0.000 claims 4
- 101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 claims 4
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 4
- 101000801232 Homo sapiens Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 4
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 4
- 208000010668 atopic eczema Diseases 0.000 claims 4
- 206010009887 colitis Diseases 0.000 claims 4
- 208000010247 contact dermatitis Diseases 0.000 claims 4
- 201000003146 cystitis Diseases 0.000 claims 4
- 102000052073 human NGFR Human genes 0.000 claims 4
- 210000000987 immune system Anatomy 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 2
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 102000046917 human NGF Human genes 0.000 claims 2
- 102000057041 human TNF Human genes 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 108091008604 NGF receptors Proteins 0.000 claims 1
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229940125644 antibody drug Drugs 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 102100036220 PC4 and SFRS1-interacting protein Human genes 0.000 description 5
- 230000003993 interaction Effects 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29439201P | 2001-05-30 | 2001-05-30 | |
| US60/294,392 | 2001-05-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592967A Division JP4567944B2 (ja) | 2001-05-30 | 2002-05-09 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013025893A Division JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010043089A JP2010043089A (ja) | 2010-02-25 |
| JP2010043089A5 true JP2010043089A5 (enExample) | 2012-10-25 |
| JP5761902B2 JP5761902B2 (ja) | 2015-08-12 |
Family
ID=23133215
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592967A Expired - Lifetime JP4567944B2 (ja) | 2001-05-30 | 2002-05-09 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2009211917A Expired - Lifetime JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592967A Expired - Lifetime JP4567944B2 (ja) | 2001-05-30 | 2002-05-09 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US7727527B2 (enExample) |
| EP (2) | EP1401498B1 (enExample) |
| JP (5) | JP4567944B2 (enExample) |
| KR (3) | KR101004353B1 (enExample) |
| CN (2) | CN1684708A (enExample) |
| AT (1) | ATE522229T1 (enExample) |
| AU (7) | AU2002308722B2 (enExample) |
| BR (1) | BR0210231A (enExample) |
| CA (2) | CA2448956C (enExample) |
| CY (1) | CY1112425T1 (enExample) |
| DK (1) | DK1401498T3 (enExample) |
| ES (1) | ES2371748T3 (enExample) |
| IL (2) | IL158921A0 (enExample) |
| MX (1) | MXPA03010911A (enExample) |
| NZ (2) | NZ529612A (enExample) |
| PT (1) | PT1401498E (enExample) |
| WO (1) | WO2002096458A1 (enExample) |
| ZA (1) | ZA200308999B (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1684708A (zh) * | 2001-05-30 | 2005-10-19 | 基因技术股份有限公司 | 抗ngf抗体用于治疗各种疾病 |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| AU2003285864C1 (en) | 2002-10-08 | 2010-07-01 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering a nerve growth factor antagonist and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| AU2011201157C1 (en) * | 2002-12-24 | 2017-09-07 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| SI2270048T1 (sl) * | 2002-12-24 | 2016-01-29 | Rinat Neuroscience Corp. | Protitelesa proti NGF-ju in postopki uporabe le-teh |
| PL379983A1 (pl) * | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
| KR100894191B1 (ko) | 2003-07-15 | 2009-04-22 | 암젠 인코포레이티드 | 선택적인 ｎｇｆ 경로 저해제로서의 인체 항-ｎｇｆ 중화 항체 및 이 항체를 포함하는 약학적 조성물 |
| EP1648509B8 (en) * | 2003-07-15 | 2012-10-24 | Amgen Inc. | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| PT1732949E (pt) * | 2004-04-07 | 2010-03-23 | Univ Minnesota | Métodos de tratamento da dor associada ao cancro ósseo através da administração de um antagonista do factor de crescimento nervoso |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| RU2406728C2 (ru) * | 2005-01-24 | 2010-12-20 | Медиммун Лимитэд | Партнеры специфического связывания с ngf |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| EP1857146A1 (en) * | 2006-05-16 | 2007-11-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Treatment of respiratory disorders |
| US20090075378A1 (en) | 2007-02-20 | 2009-03-19 | Anaptysbio, Inc. | Somatic hypermutation systems |
| ES2517872T3 (es) * | 2007-08-10 | 2014-11-04 | Regeneron Pharmaceuticals, Inc. | Anticuerpos humanos de alta afinidad para el factor de crecimiento nervioso humano |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| KR101499278B1 (ko) * | 2007-12-17 | 2015-03-06 | 화이자 리미티드 | 간질성 방광염의 치료 |
| WO2009134776A2 (en) | 2008-04-29 | 2009-11-05 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| RU2010153580A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двумя вариабельными доменами и их применение |
| NZ589436A (en) | 2008-06-03 | 2012-12-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
| CN102224153B (zh) | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1，2-b]哒嗪化合物 |
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| TW201119673A (en) * | 2009-09-01 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| JP2013507928A (ja) * | 2009-10-15 | 2013-03-07 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリンおよびその使用 |
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| UY33280A (es) | 2010-03-17 | 2011-10-31 | Abbott Res Bv | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) |
| HUE044025T2 (hu) | 2010-05-20 | 2019-09-30 | Array Biopharma Inc | Makrociklusos vegyületek mint TRK-kináz inhibitorok |
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| EP2606067B1 (en) | 2010-08-19 | 2018-02-21 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
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| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
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| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| ITRM20110024A1 (it) * | 2011-01-24 | 2012-07-25 | Consiglio Nazionale Ricerche | Uso di antagonisti del recettore p75ntr e/o di agonisti del recettore trka per il trattamento delle malattie infiammatorie croniche. |
| US8986952B2 (en) | 2011-08-11 | 2015-03-24 | Astellas Pharma Inc. | Anti-human NGF antibody |
| US8926978B2 (en) | 2011-10-25 | 2015-01-06 | Anaptysbio, Inc. | Antibodies directed against nerve growth factor (NGF) |
| BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
| WO2013184871A1 (en) * | 2012-06-06 | 2013-12-12 | Zoetis Llc | Caninized anti-ngf antibodies and methods thereof |
| BR112015009961B1 (pt) | 2012-11-01 | 2020-10-20 | Abbvie Inc. | proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende |
| US9127055B2 (en) | 2013-02-08 | 2015-09-08 | Astellas Pharma Inc. | Method of treating pain with anti-human NGF antibody |
| WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
| EP3099713B1 (en) | 2014-02-02 | 2020-01-15 | MedImmune Limited | Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain |
| PT3699181T (pt) | 2014-11-16 | 2023-04-05 | Array Biopharma Inc | Forma cristalina de hidrogenossulfato de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| JP2018534296A (ja) | 2015-10-26 | 2018-11-22 | ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． | Ｔｒｋ阻害薬耐性がんにおける点変異およびそれに関連する方法 |
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| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
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| JP2021517461A (ja) | 2018-03-12 | 2021-07-26 | ゾエティス・サービシーズ・エルエルシー | 抗ｎｇｆ抗体およびその方法 |
| CN108743568B (zh) * | 2018-06-05 | 2021-09-07 | 桂林医学院附属医院 | 用于降低气道高反应性的抗ngf抗体缓释微球及制备方法 |
| CN116003590A (zh) * | 2020-08-06 | 2023-04-25 | 熙源安健医药（上海）有限公司 | 抗ngf抗体及其抗原结合片段、其制备方法和应用 |
| CA3195380A1 (en) | 2020-09-28 | 2022-03-31 | Medimmune Limited | Compounds and methods for treating pain |
| CA3198362A1 (en) | 2020-10-07 | 2022-04-14 | Zoetis Services Llc | Anti-ngf antibodies and methods of use thereof |
| US20250340626A1 (en) | 2021-12-16 | 2025-11-06 | Intervet Inc. | Caninized antibodies to human ngf |
| EP4514998A1 (en) | 2022-04-27 | 2025-03-05 | Regeneron Pharmaceuticals, Inc. | Treatment of arthropathy based upon stratification of osteoarthritis polygenic risk score |
| AU2024238259A1 (en) | 2023-03-17 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Proteomic risk score for osteoarthritis (oa) |
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2002
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- 2002-05-09 EP EP10010557A patent/EP2340849A1/en not_active Ceased
- 2002-05-09 KR KR1020107027004A patent/KR20100132559A/ko not_active Withdrawn
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2003
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2007
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