JP2009533367A5 - - Google Patents

Info

Publication number

JP2009533367A5

JP2009533367A5 JP2009504628A JP2009504628A JP2009533367A5 JP 2009533367 A5 JP2009533367 A5 JP 2009533367A5 JP 2009504628 A JP2009504628 A JP 2009504628A JP 2009504628 A JP2009504628 A JP 2009504628A JP 2009533367 A5 JP2009533367 A5 JP 2009533367A5

Authority

JP

Japan

Prior art keywords

antibody

antibody according

amount

less

acc2795

Prior art date

2007-04-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 238000000034 method Methods 0.000 claims 4
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• SUHQNCLNRUAGOO-UHFFFAOYSA-N N-glycoloyl-neuraminic acid Natural products OCC(O)C(O)C(O)C(NC(=O)CO)C(O)CC(=O)C(O)=O SUHQNCLNRUAGOO-UHFFFAOYSA-N 0.000 claims 2
• FDJKUWYYUZCUJX-UHFFFAOYSA-N N-glycolyl-beta-neuraminic acid Natural products OCC(O)C(O)C1OC(O)(C(O)=O)CC(O)C1NC(=O)CO FDJKUWYYUZCUJX-UHFFFAOYSA-N 0.000 claims 2
• FDJKUWYYUZCUJX-KVNVFURPSA-N N-glycolylneuraminic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-KVNVFURPSA-N 0.000 claims 2
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
• 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 1
• 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
• 230000000259 anti-tumor effect Effects 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 229920001184 polypeptide Polymers 0.000 description 1
• 108090000765 processed proteins & peptides Proteins 0.000 description 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 1