JP2011507932A5 - - Google Patents
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- JP2011507932A5 JP2011507932A5 JP2010540129A JP2010540129A JP2011507932A5 JP 2011507932 A5 JP2011507932 A5 JP 2011507932A5 JP 2010540129 A JP2010540129 A JP 2010540129A JP 2010540129 A JP2010540129 A JP 2010540129A JP 2011507932 A5 JP2011507932 A5 JP 2011507932A5
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- JP
- Japan
- Prior art keywords
- cells
- immune complex
- tumor
- amino acid
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 22
- 210000004881 tumor cell Anatomy 0.000 claims 22
- 238000000034 method Methods 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000012636 effector Substances 0.000 claims 11
- 230000004614 tumor growth Effects 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 7
- 238000004113 cell culture Methods 0.000 claims 7
- 229940127089 cytotoxic agent Drugs 0.000 claims 7
- 239000002254 cytotoxic agent Substances 0.000 claims 7
- 231100000599 cytotoxic agent Toxicity 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 208000034578 Multiple myelomas Diseases 0.000 claims 5
- 230000005764 inhibitory process Effects 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 3
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 3
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 3
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
- 229960001467 bortezomib Drugs 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 3
- 229960004316 cisplatin Drugs 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- 229960000684 cytarabine Drugs 0.000 claims 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 3
- 229960003957 dexamethasone Drugs 0.000 claims 3
- 229960004679 doxorubicin Drugs 0.000 claims 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 3
- 229960005420 etoposide Drugs 0.000 claims 3
- 230000012010 growth Effects 0.000 claims 3
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 3
- 229960004942 lenalidomide Drugs 0.000 claims 3
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 3
- 229960001924 melphalan Drugs 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 3
- 229960004618 prednisone Drugs 0.000 claims 3
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 3
- 229960003452 romidepsin Drugs 0.000 claims 3
- OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 claims 3
- 108010091666 romidepsin Proteins 0.000 claims 3
- 229960003787 sorafenib Drugs 0.000 claims 3
- 229960003433 thalidomide Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 3
- 229960004528 vincristine Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 201000010175 gallbladder cancer Diseases 0.000 claims 2
- 201000007487 gallbladder carcinoma Diseases 0.000 claims 2
- 238000011081 inoculation Methods 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 201000010174 renal carcinoma Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010066476 Haematological malignancy Diseases 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- -1 antibodies Proteins 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000008901 benefit Effects 0.000 claims 1
- 230000025084 cell cycle arrest Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 239000000367 immunologic factor Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000007480 spreading Effects 0.000 claims 1
- 238000003892 spreading Methods 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1662007P | 2007-12-26 | 2007-12-26 | |
| US61/016,620 | 2007-12-26 | ||
| US8759008P | 2008-08-08 | 2008-08-08 | |
| US8746608P | 2008-08-08 | 2008-08-08 | |
| US61/087,590 | 2008-08-08 | ||
| US61/087,466 | 2008-08-08 | ||
| PCT/EP2008/068267 WO2009080830A1 (en) | 2007-12-26 | 2008-12-23 | Immunoconjugates targeting cd138 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507932A JP2011507932A (ja) | 2011-03-10 |
| JP2011507932A5 true JP2011507932A5 (enExample) | 2012-02-16 |
| JP5817034B2 JP5817034B2 (ja) | 2015-11-18 |
Family
ID=40577735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540129A Expired - Fee Related JP5817034B2 (ja) | 2007-12-26 | 2008-12-23 | Ｃｄ１３８を標的とする免疫複合体及びその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9387261B2 (enExample) |
| EP (1) | EP2242772B1 (enExample) |
| JP (1) | JP5817034B2 (enExample) |
| KR (2) | KR20100097753A (enExample) |
| CN (1) | CN101965366B (enExample) |
| AR (1) | AR069980A1 (enExample) |
| AU (1) | AU2008339911B2 (enExample) |
| BR (1) | BRPI0821449A2 (enExample) |
| CA (1) | CA2710471C (enExample) |
| DK (1) | DK2242772T3 (enExample) |
| ES (1) | ES2526433T3 (enExample) |
| HR (1) | HRP20150143T1 (enExample) |
| HU (1) | HUE024291T2 (enExample) |
| IL (1) | IL206553A (enExample) |
| MX (1) | MX2010007102A (enExample) |
| PL (1) | PL2242772T3 (enExample) |
| PT (1) | PT2242772E (enExample) |
| RU (1) | RU2547939C2 (enExample) |
| SI (1) | SI2242772T1 (enExample) |
| TW (1) | TWI501778B (enExample) |
| WO (1) | WO2009080830A1 (enExample) |
| ZA (1) | ZA201004324B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045877A1 (en) * | 2004-08-30 | 2006-03-02 | Goldmakher Viktor S | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
| RU2547939C2 (ru) | 2007-12-26 | 2015-04-10 | Биотест Аг | Иммуноконъюгаты, направленные на cd138, и их применение |
| BRPI0821417A2 (pt) * | 2007-12-26 | 2015-06-16 | Biotest Ag | Método para diminuir a adesão de células de estroma a células tumorais que expressam cd138 em células tumorais de um indivíduo em necessidade do mesmo |
| WO2010128087A2 (en) * | 2009-05-06 | 2010-11-11 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| RU2013115747A (ru) * | 2010-09-09 | 2014-10-20 | ТРИФОЙЛИУМ АпС | Введение антиангиогенных агентов в дыхательные пути |
| US20130066055A1 (en) | 2011-04-21 | 2013-03-14 | Bayer Intellectual Property Gmbh | New binder-drug conjugates (adcs) and use thereof |
| US8846042B2 (en) | 2011-05-16 | 2014-09-30 | Fabion Pharmaceuticals, Inc. | Multi-specific FAB fusion proteins and methods of use |
| US10117932B2 (en) | 2011-12-08 | 2018-11-06 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| CA2885340C (en) | 2012-10-12 | 2016-11-08 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| ITFI20120257A1 (it) * | 2012-11-26 | 2014-05-27 | Maria Barbara Carnemolla | Anticorpo ricombinante umano e suo uso per l¿identificazione di syndecano-1 (cd-138) per scopi diagnostici e terapeutici. |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| NZ712035A (en) | 2013-03-13 | 2019-06-28 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| US10370450B2 (en) * | 2013-11-20 | 2019-08-06 | National University Corporation Hokkaido University | Anti-DR6 antibodies and methods of immune regulation |
| AU2014372833B2 (en) | 2013-12-23 | 2019-08-22 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) |
| DK3160513T3 (da) | 2014-06-30 | 2020-04-06 | Glykos Finland Oy | Saccharidderivat af en toksisk payload og antistofkonjugater deraf |
| US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CN108025084B (zh) | 2015-06-22 | 2024-08-09 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
| RU2611685C2 (ru) * | 2015-07-20 | 2017-02-28 | Илья Владимирович Духовлинов | Гуманизированное моноклональное антитело, специфичное к синдекану-1 |
| US10172875B2 (en) | 2015-09-17 | 2019-01-08 | Immunogen, Inc. | Therapeutic combinations comprising anti-FOLR1 immunoconjugates |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
| SG10202008909VA (en) | 2016-03-24 | 2020-10-29 | Bayer Pharma AG | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| US20200023072A1 (en) | 2016-10-11 | 2020-01-23 | Medimmune Limited | Antibody-drug conjugates with immune-mediated therapy agents |
| CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| WO2018114578A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| JP2021501566A (ja) | 2017-10-02 | 2021-01-21 | ビステラ， インコーポレイテッド | Ｃｄ１３８に対する抗体分子およびその使用 |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| DK3720883T5 (da) * | 2017-12-05 | 2024-08-26 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | T-celler omfattende kimære anti-cd38- og anti-cd138-antigenreceptorer og anvendelser deraf |
| CN112899350B (zh) * | 2018-05-14 | 2023-01-24 | 北京艾克伦医疗科技有限公司 | 核酸检测方法和试剂盒 |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| WO2020071365A1 (en) * | 2018-10-02 | 2020-04-09 | Mitsubishi Tanabe Pharma Corporation | Bi-specific binding agents targeting syndecan-1 and fibroblast growth factor receptor |
| EP3917528A4 (en) * | 2019-01-28 | 2022-12-28 | University of Rhode Island Board of Trustees | Phlip® targeted delivery of potent cytotoxic compounds |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2020257289A2 (en) | 2019-06-17 | 2020-12-24 | Visterra, Inc. | Humanized antibody molecules to cd138 and uses thereof |
| CN111455341B (zh) * | 2020-06-18 | 2020-09-08 | 上海陛通半导体能源科技股份有限公司 | 基于磁耦合旋转的物理气相沉积设备 |
| WO2022079211A1 (en) | 2020-10-16 | 2022-04-21 | Adc Therapeutics Sa | Glycoconjugates |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| KR20230049463A (ko) | 2021-10-06 | 2023-04-13 | 주식회사 이뮤노로지컬디자이닝랩 | Cd138을 인식하는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
| KR20230058232A (ko) | 2021-10-22 | 2023-05-03 | 주식회사 이뮤노로지컬디자이닝랩 | Cd138에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| KR20240095442A (ko) | 2021-11-03 | 2024-06-25 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 항체의 특이적 접합 |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| TW202502388A (zh) | 2023-03-02 | 2025-01-16 | 日商大鵬藥品工業股份有限公司 | 包含抗cd138抗體之抗體藥物複合體 |
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| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
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-
2008
- 2008-12-23 RU RU2010130977/10A patent/RU2547939C2/ru not_active IP Right Cessation
- 2008-12-23 EP EP08865838.0A patent/EP2242772B1/en not_active Not-in-force
- 2008-12-23 AR ARP080105723A patent/AR069980A1/es not_active Application Discontinuation
- 2008-12-23 BR BRPI0821449-2A patent/BRPI0821449A2/pt not_active Application Discontinuation
- 2008-12-23 AU AU2008339911A patent/AU2008339911B2/en not_active Ceased
- 2008-12-23 CA CA2710471A patent/CA2710471C/en not_active Expired - Fee Related
- 2008-12-23 WO PCT/EP2008/068267 patent/WO2009080830A1/en not_active Ceased
- 2008-12-23 MX MX2010007102A patent/MX2010007102A/es active IP Right Grant
- 2008-12-23 ES ES08865838.0T patent/ES2526433T3/es active Active
- 2008-12-23 KR KR1020107016665A patent/KR20100097753A/ko not_active Withdrawn
- 2008-12-23 CN CN200880126959.2A patent/CN101965366B/zh not_active Expired - Fee Related
- 2008-12-23 US US12/342,407 patent/US9387261B2/en not_active Expired - Fee Related
- 2008-12-23 JP JP2010540129A patent/JP5817034B2/ja not_active Expired - Fee Related
- 2008-12-23 PT PT88658380T patent/PT2242772E/pt unknown
- 2008-12-23 SI SI200831380T patent/SI2242772T1/sl unknown
- 2008-12-23 HR HRP20150143AT patent/HRP20150143T1/hr unknown
- 2008-12-23 HU HUE08865838A patent/HUE024291T2/en unknown
- 2008-12-23 DK DK08865838.0T patent/DK2242772T3/en active
- 2008-12-23 PL PL08865838T patent/PL2242772T3/pl unknown
- 2008-12-23 KR KR1020167005226A patent/KR101654822B1/ko not_active Expired - Fee Related
- 2008-12-24 TW TW097150433A patent/TWI501778B/zh not_active IP Right Cessation
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2016
- 2016-06-18 US US15/186,435 patent/US20170081418A1/en not_active Abandoned
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