|
US3896111A
(en)
|
1973-02-20 |
1975-07-22 |
Research Corp |
Ansa macrolides
|
|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4169888A
(en)
|
1977-10-17 |
1979-10-02 |
The Upjohn Company |
Composition of matter and process
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4563304A
(en)
|
1981-02-27 |
1986-01-07 |
Pharmacia Fine Chemicals Ab |
Pyridine compounds modifying proteins, polypeptides or polysaccharides
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4761111A
(en)
|
1981-09-18 |
1988-08-02 |
Brown Andrew M |
Automobile lifting and towing equipment
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4418064A
(en)
|
1982-09-29 |
1983-11-29 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5034223A
(en)
|
1986-10-09 |
1991-07-23 |
Neorx Corporation |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
|
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
|
US5612016A
(en)
|
1988-04-01 |
1997-03-18 |
Immunomedics, Inc. |
Conjugates of antibodies and bifunctional ligands
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0415688B1
(en)
|
1989-08-30 |
1998-12-23 |
Aeci Ltd |
Dosage device and use thereof
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
AU648313B2
(en)
|
1990-04-25 |
1994-04-21 |
Pharmacia & Upjohn Company |
Novel CC-1065 analogs
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
US5998656A
(en)
|
1991-09-23 |
1999-12-07 |
Florida State University |
C10 tricyclic taxanes
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US6080777A
(en)
|
1992-01-31 |
2000-06-27 |
The Trustees Of Columbia University In The City Of New York |
Taxol as a radiation sensitizer
|
|
US5200534A
(en)
|
1992-03-13 |
1993-04-06 |
University Of Florida |
Process for the preparation of taxol and 10-deacetyltaxol
|
|
EP0563475B1
(en)
|
1992-03-25 |
2000-05-31 |
Immunogen Inc |
Cell binding agent conjugates of derivatives of CC-1065
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5703247A
(en)
|
1993-03-11 |
1997-12-30 |
Virginia Tech Intellectual Properties, Inc. |
2-Debenzoyl-2-acyl taxol derivatives and methods for making same
|
|
US5475011A
(en)
|
1993-03-26 |
1995-12-12 |
The Research Foundation Of State University Of New York |
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
|
|
US6740734B1
(en)
|
1994-01-14 |
2004-05-25 |
Biovitrum Ab |
Bacterial receptor structures
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US5763477A
(en)
|
1994-07-22 |
1998-06-09 |
Dr. Reddy's Research Foundation |
Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
|
|
AU5305796A
(en)
|
1995-03-10 |
1996-10-02 |
Hauser Chemical Research, Inc. |
Cephalomannine epoxide, its analogues and a method for preparing the same
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
WO1997011971A1
(en)
|
1995-09-28 |
1997-04-03 |
Alexion Pharmaceuticals, Inc. |
Porcine cell interaction proteins
|
|
US6001358A
(en)
|
1995-11-07 |
1999-12-14 |
Idec Pharmaceuticals Corporation |
Humanized antibodies to human gp39, compositions containing thereof
|
|
DK0923941T3
(da)
|
1996-06-27 |
2006-09-18 |
Chugai Pharmaceutical Co Ltd |
Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
EP1972194A1
(en)
|
1996-12-03 |
2008-09-24 |
Amgen Fremont Inc. |
Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
|
|
JP3876002B2
(ja)
|
1997-04-14 |
2007-01-31 |
ミクロメート・アクチエンゲゼルシャフト |
抗ヒト抗原受容体を産生するための斬新な方法およびそれらの使用
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6962702B2
(en)
|
1998-06-22 |
2005-11-08 |
Immunomedics Inc. |
Production and use of novel peptide-based agents for use with bi-specific antibodies
|
|
US6087362A
(en)
|
1999-03-16 |
2000-07-11 |
Pentech Pharmaceuticals, Inc. |
Apomorphine and sildenafil composition
|
|
US6635677B2
(en)
|
1999-08-13 |
2003-10-21 |
Case Western Reserve University |
Methoxyamine combinations in the treatment of cancer
|
|
JP4776843B2
(ja)
|
1999-10-01 |
2011-09-21 |
イムノゲン インコーポレーティッド |
免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
|
|
HK1049997B
(en)
|
1999-11-24 |
2007-02-23 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
US7229960B2
(en)
|
2000-11-03 |
2007-06-12 |
University Of Vermont And State Agricultural College |
Methods and compositions for inhibiting GRB7
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
EP1423510A4
(en)
|
2001-08-03 |
2005-06-01 |
Glycart Biotechnology Ag |
ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY
|
|
US20030109682A1
(en)
|
2001-09-07 |
2003-06-12 |
Daniel Santi |
Maytansines and maytansine conjugates
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
US6534660B1
(en)
|
2002-04-05 |
2003-03-18 |
Immunogen, Inc. |
CC-1065 analog synthesis
|
|
US20050271653A1
(en)
|
2002-04-23 |
2005-12-08 |
Meir Strahilevitz |
Methods and devices for targeting a site in a mammal and for removing species from a mammal
|
|
BR122019027966B8
(pt)
|
2002-05-02 |
2021-07-27 |
Wyeth Corp |
conjugado monomérico de derivado de caliqueamicina/anti-corpo anti-cd22 e uso dos mesmos
|
|
US6596757B1
(en)
|
2002-05-14 |
2003-07-22 |
Immunogen Inc. |
Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
|
|
US7390898B2
(en)
|
2002-08-02 |
2008-06-24 |
Immunogen Inc. |
Cytotoxic agents containing novel potent taxanes and their therapeutic use
|
|
EP1542723B1
(en)
|
2002-08-16 |
2011-02-23 |
ImmunoGen, Inc. |
Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
|
|
US20040126379A1
(en)
|
2002-08-21 |
2004-07-01 |
Boehringer Ingelheim International Gmbh |
Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
|
|
KR101498588B1
(ko)
|
2003-01-22 |
2015-03-05 |
로슈 글리카트 아게 |
융합 구성체와 Ｆｃ 수용체 결합 친화도 및 이펙터 기능이 증가된 항체를 생성하기 위한 이의 용도
|
|
US7449303B2
(en)
|
2003-05-02 |
2008-11-11 |
Health Research, Inc. |
Use of JAG2 expression in diagnosis of plasma cell disorders
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
EA014640B1
(ru)
|
2003-07-21 |
2010-12-30 |
Иммьюноджен, Инк. |
Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения
|
|
NZ551180A
(en)
|
2004-06-01 |
2009-10-30 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
AU2004224925C1
(en)
|
2004-08-30 |
2011-07-21 |
Biotest Ag |
Immunoconjugates targeting syndecan-1 expressing cells and use thereof
|
|
EP2551282A3
(en)
|
2005-03-23 |
2013-02-13 |
Genmab A/S |
Antibodies against CD38 for treatment of multiple myeloma
|
|
EA200702239A1
(ru)
|
2005-04-15 |
2008-10-30 |
Иммьюноджен, Инк. |
Уничтожение гетерогенной или смешанной клеточной популяции в опухолях
|
|
US20100021473A1
(en)
|
2005-12-06 |
2010-01-28 |
Domantis Limited |
Bispecific Ligands With Binding Specificity to Cell Surface Targets and Methods of Use Therefor
|
|
JP2009532027A
(ja)
|
2006-03-28 |
2009-09-10 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
抗ｉｇｆ−１ｒ抗体およびその使用
|
|
US20100291105A1
(en)
|
2006-05-03 |
2010-11-18 |
Elke Pogge Von Strandmann |
Agent for the treatment of malignant diseases
|
|
PL2242772T3
(pl)
*
|
2007-12-26 |
2015-05-29 |
Biotest Ag |
Immunokonjugaty nakierowane na CD138 i ich zastosowanie
|
|
US9446146B2
(en)
|
2007-12-26 |
2016-09-20 |
Biotest Ag |
Methods and agents for improving targeting of CD138 expressing tumor cells
|
|
US9011864B2
(en)
|
2007-12-26 |
2015-04-21 |
Biotest Ag |
Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
|
|
ES2475201T3
(es)
*
|
2007-12-26 |
2014-07-10 |
Biotest Ag |
Agentes dirigidos contra CD138 y usos de los mismos
|
|
KR20110028450A
(ko)
|
2008-06-16 |
2011-03-18 |
이뮤노젠 아이엔씨 |
새로운 상승 효과
|
|
CA2761120A1
(en)
|
2009-05-06 |
2010-11-11 |
Biotest Ag |
Uses of immunoconjugates targeting cd138
|