JP2014515036A5 - - Google Patents
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- Publication number
- JP2014515036A5 JP2014515036A5 JP2014510798A JP2014510798A JP2014515036A5 JP 2014515036 A5 JP2014515036 A5 JP 2014515036A5 JP 2014510798 A JP2014510798 A JP 2014510798A JP 2014510798 A JP2014510798 A JP 2014510798A JP 2014515036 A5 JP2014515036 A5 JP 2014515036A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- maytansinoid immunoconjugate
- maytansinoid
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 39
- 229940127121 immunoconjugate Drugs 0.000 claims 35
- 208000024891 symptom Diseases 0.000 claims 16
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 11
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 7
- 239000005022 packaging material Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000036210 malignancy Effects 0.000 claims 5
- 230000002411 adverse Effects 0.000 claims 4
- 231100000419 toxicity Toxicity 0.000 claims 4
- 230000001988 toxicity Effects 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- JSHOVKSMJRQOGY-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCSSC1=CC=CC=N1 JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 206010061137 Ocular toxicity Diseases 0.000 claims 1
- 206010044245 Toxic optic neuropathy Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 231100000327 ocular toxicity Toxicity 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11290232.5 | 2011-05-17 | ||
| EP11290232A EP2524929A1 (en) | 2011-05-17 | 2011-05-17 | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| PCT/EP2012/059141 WO2012156455A1 (en) | 2011-05-17 | 2012-05-16 | Use of anti-cd19 maytansinoid immunoconjugate antibody for the treatment of b-cell malignancies symptoms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016226407A Division JP6181273B2 (ja) | 2011-05-17 | 2016-11-22 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515036A JP2014515036A (ja) | 2014-06-26 |
| JP2014515036A5 true JP2014515036A5 (enExample) | 2014-08-07 |
| JP6050328B2 JP6050328B2 (ja) | 2016-12-21 |
Family
ID=46085972
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510798A Expired - Fee Related JP6050328B2 (ja) | 2011-05-17 | 2012-05-16 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
| JP2016226407A Expired - Fee Related JP6181273B2 (ja) | 2011-05-17 | 2016-11-22 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
| JP2017138852A Pending JP2018021020A (ja) | 2011-05-17 | 2017-07-18 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
| JP2019087962A Pending JP2019142961A (ja) | 2011-05-17 | 2019-05-08 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016226407A Expired - Fee Related JP6181273B2 (ja) | 2011-05-17 | 2016-11-22 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
| JP2017138852A Pending JP2018021020A (ja) | 2011-05-17 | 2017-07-18 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
| JP2019087962A Pending JP2019142961A (ja) | 2011-05-17 | 2019-05-08 | Ｂ細胞悪性腫瘍の症状の治療のための抗ｃｄ１９メイタンシンノイドイムノコンジュゲート抗体の使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9555126B2 (enExample) |
| EP (2) | EP2524929A1 (enExample) |
| JP (4) | JP6050328B2 (enExample) |
| KR (1) | KR20140043388A (enExample) |
| CN (2) | CN107007840A (enExample) |
| AR (1) | AR086412A1 (enExample) |
| AU (3) | AU2012258254B2 (enExample) |
| BR (1) | BR112013029330A8 (enExample) |
| CA (1) | CA2835738A1 (enExample) |
| CL (1) | CL2013003272A1 (enExample) |
| CO (1) | CO6821893A2 (enExample) |
| CR (1) | CR20130593A (enExample) |
| DO (1) | DOP2013000260A (enExample) |
| EA (1) | EA028574B1 (enExample) |
| EC (1) | ECSP13013084A (enExample) |
| GT (1) | GT201300276A (enExample) |
| IL (3) | IL229380B (enExample) |
| MA (1) | MA35180B1 (enExample) |
| MX (1) | MX347019B (enExample) |
| MY (1) | MY163736A (enExample) |
| NI (1) | NI201300119A (enExample) |
| PE (1) | PE20141018A1 (enExample) |
| PH (2) | PH12013502305A1 (enExample) |
| SG (2) | SG194894A1 (enExample) |
| TN (1) | TN2013000468A1 (enExample) |
| TW (3) | TW201834687A (enExample) |
| UA (1) | UA114401C2 (enExample) |
| UY (1) | UY34077A (enExample) |
| WO (1) | WO2012156455A1 (enExample) |
| ZA (1) | ZA201309400B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2524929A1 (en) * | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| EP2777714A1 (en) * | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| CA2921975C (en) | 2013-08-30 | 2024-02-13 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| CN105837689B (zh) * | 2015-01-13 | 2020-06-19 | 博生吉安科细胞技术有限公司 | 抗cd19单克隆抗体及其制备方法 |
| WO2016180941A1 (en) * | 2015-05-13 | 2016-11-17 | Sanofi | Liquid compositions for anti-cd19 antibody-drug conjugates |
| CN107660151B (zh) | 2015-05-26 | 2022-03-11 | 莫佛塞斯公司 | 抗-cd19抗体和布鲁顿酪氨酸激酶抑制剂的组合及其用途 |
| IL257345B2 (en) | 2015-08-21 | 2023-03-01 | Morphosys Ag | Combinations and their uses |
| US10172875B2 (en) | 2015-09-17 | 2019-01-08 | Immunogen, Inc. | Therapeutic combinations comprising anti-FOLR1 immunoconjugates |
| PT3380525T (pt) | 2015-11-25 | 2024-02-05 | Immunogen Inc | Formulações farmacêuticas e métodos que as utilizam |
| MD3916392T2 (ro) | 2016-05-30 | 2024-10-31 | Incyte Corp | Metode de predicție a beneficiului terapeutic al terapiei anti-CD19 la pacienți |
| CN109415440B (zh) | 2016-06-27 | 2022-12-06 | 莫佛塞斯公司 | 抗-cd19抗体制剂 |
| RU2756405C2 (ru) | 2016-10-28 | 2021-09-30 | МорфоСис АГ | Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| WO2018193105A1 (en) * | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy |
| BR112019026564A2 (pt) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd19 |
| JP7295098B2 (ja) * | 2017-09-21 | 2023-06-20 | ウーシー バイオロジクス アイルランド リミテッド | 新規抗ｃｄ１９抗体 |
| IL273424B2 (en) | 2017-09-22 | 2024-09-01 | Wuxi Biologics Ireland Ltd | Novel bispecific cd3/cd19 polypeptide complexes |
| KR20200108843A (ko) | 2018-01-12 | 2020-09-21 | 이뮤노젠 아이엔씨 | 항체 약물 접합, 정제, 및 제제화 방법 |
| RS64961B1 (sr) | 2019-04-26 | 2024-01-31 | Immunogen Inc | Derivati kamptotecina |
| US20220242952A1 (en) | 2019-05-03 | 2022-08-04 | Morphosys Ag | Anti-cd19 therapy in patients having a limited number of nk cells |
| JP2023501209A (ja) | 2019-10-31 | 2023-01-18 | モルフォシス・アーゲー | 白血病またはリンパ腫の治療のためのレナリドミドと組み合わせた抗ｃｄ１９療法 |
| IL292213A (en) | 2019-10-31 | 2022-06-01 | Morphosys Ag | Combination anti-tumor therapy including anti-cd19 antibody and gamma delta t cells |
| CN114599392A (zh) * | 2019-10-31 | 2022-06-07 | 四十七公司 | 基于抗cd47和抗cd20的血癌治疗 |
| CN110845617B (zh) * | 2019-12-05 | 2021-07-09 | 常州费洛斯药业科技有限公司 | 针对cd19的全人源抗体或抗体片段、嵌合抗原受体及应用 |
| KR20230030636A (ko) | 2020-06-22 | 2023-03-06 | 모르포시스 아게 | 항-CD19 항체, 및 SIRPα-CD47 선천성 면역 체크포인트를 차단하는 폴리펩티드를 포함하는 항-종양 조합 요법 |
| KR20230104152A (ko) | 2020-10-06 | 2023-07-07 | 젠코어 인코포레이티드 | 전신 홍반성 루푸스(sle)를 포함하는 자가면역 질환을 치료하기 위한 바이오마커, 방법 및 조성물 |
| KR20230131464A (ko) | 2020-12-04 | 2023-09-13 | 모르포시스 아게 | 항-cd19 병용 요법 |
| WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
| JP2025528837A (ja) | 2022-08-17 | 2025-09-02 | インサイト・コーポレイション | 抗ｃｄ１９抗体及びｅｚｈ２モジュレーターを含む治療 |
| WO2025087382A1 (zh) * | 2023-10-26 | 2025-05-01 | 上海先博生物科技有限公司 | 靶向cd19的嵌合抗原受体的治疗用途 |
| WO2025157132A1 (en) | 2024-01-23 | 2025-07-31 | Wuxi Biologics (Shanghai) Co., Ltd. | Multispecific antibodies targeting cd3, cd19 and cd20 and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| EP3524611B1 (en) * | 2003-05-20 | 2020-12-30 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| ES2383710T3 (es) * | 2006-09-08 | 2012-06-25 | Medimmune, Llc | Anticuerpos anti-CD19 humanizados y su uso en el tratamiento de tumores, trasplantes y enfermedades autoinmunes |
| IL271761B (en) * | 2009-02-05 | 2022-09-01 | Immunogen Inc | (12as)-8-methoxy-9-benzyloxy-11,12,12a,13-tetrahydro-6h-indolo[2,1-c][1,4]benzodiazepin-6-one, 4-benzyloxy-5-methoxy-2-nitrobenzoic acid and processes for preparing the same |
| WO2010128087A2 (en) * | 2009-05-06 | 2010-11-11 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| WO2011050180A1 (en) * | 2009-10-21 | 2011-04-28 | Immunogen, Inc. | Novel dosing regimen and method of treatment |
| EP2524929A1 (en) * | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| EP2550975A1 (en) * | 2011-07-29 | 2013-01-30 | Sanofi | Combination therapy for the treatment of CD19+ B-cell malignancies symptoms comprising an anti-CD19 maytansinoid immunoconjugate and rituximab |
-
2011
- 2011-05-17 EP EP11290232A patent/EP2524929A1/en not_active Ceased
-
2012
- 2012-05-16 US US14/117,806 patent/US9555126B2/en not_active Expired - Fee Related
- 2012-05-16 AU AU2012258254A patent/AU2012258254B2/en not_active Ceased
- 2012-05-16 EA EA201391714A patent/EA028574B1/ru not_active IP Right Cessation
- 2012-05-16 EP EP12721529.1A patent/EP2710034A1/en not_active Withdrawn
- 2012-05-16 MY MYPI2013004057A patent/MY163736A/en unknown
- 2012-05-16 MX MX2013013455A patent/MX347019B/es active IP Right Grant
- 2012-05-16 PE PE2013002503A patent/PE20141018A1/es not_active Application Discontinuation
- 2012-05-16 BR BR112013029330A patent/BR112013029330A8/pt not_active IP Right Cessation
- 2012-05-16 SG SG2013083407A patent/SG194894A1/en unknown
- 2012-05-16 JP JP2014510798A patent/JP6050328B2/ja not_active Expired - Fee Related
- 2012-05-16 CN CN201611022631.9A patent/CN107007840A/zh active Pending
- 2012-05-16 PH PH1/2013/502305A patent/PH12013502305A1/en unknown
- 2012-05-16 KR KR1020137033076A patent/KR20140043388A/ko not_active Abandoned
- 2012-05-16 SG SG10201609729VA patent/SG10201609729VA/en unknown
- 2012-05-16 AR ARP120101724A patent/AR086412A1/es unknown
- 2012-05-16 WO PCT/EP2012/059141 patent/WO2012156455A1/en not_active Ceased
- 2012-05-16 UA UAA201314732A patent/UA114401C2/uk unknown
- 2012-05-16 CA CA2835738A patent/CA2835738A1/en not_active Abandoned
- 2012-05-16 CN CN201280023918.7A patent/CN103547596A/zh active Pending
- 2012-05-17 TW TW107102069A patent/TW201834687A/zh unknown
- 2012-05-17 UY UY0001034077A patent/UY34077A/es not_active Application Discontinuation
- 2012-05-17 TW TW105134320A patent/TW201726167A/zh unknown
- 2012-05-17 TW TW101117628A patent/TWI601537B/zh not_active IP Right Cessation
-
2013
- 2013-11-11 IL IL229380A patent/IL229380B/en active IP Right Grant
- 2013-11-12 GT GT201300276A patent/GT201300276A/es unknown
- 2013-11-12 DO DO2013000260A patent/DOP2013000260A/es unknown
- 2013-11-12 TN TNP2013000468A patent/TN2013000468A1/fr unknown
- 2013-11-12 NI NI201300119A patent/NI201300119A/es unknown
- 2013-11-13 CR CR20130593A patent/CR20130593A/es unknown
- 2013-11-14 CL CL2013003272A patent/CL2013003272A1/es unknown
- 2013-12-12 ZA ZA2013/09400A patent/ZA201309400B/en unknown
- 2013-12-12 MA MA36558A patent/MA35180B1/fr unknown
- 2013-12-16 EC ECSP13013084 patent/ECSP13013084A/es unknown
- 2013-12-16 CO CO13293559A patent/CO6821893A2/es unknown
-
2016
- 2016-07-21 AU AU2016206317A patent/AU2016206317A1/en not_active Abandoned
- 2016-11-22 JP JP2016226407A patent/JP6181273B2/ja not_active Expired - Fee Related
- 2016-12-16 US US15/381,266 patent/US20170196988A1/en not_active Abandoned
-
2017
- 2017-07-18 JP JP2017138852A patent/JP2018021020A/ja active Pending
- 2017-07-28 PH PH12017501368A patent/PH12017501368A1/en unknown
-
2018
- 2018-02-12 IL IL257475A patent/IL257475A/en unknown
- 2018-03-01 AU AU2018201504A patent/AU2018201504A1/en not_active Abandoned
- 2018-12-16 IL IL263728A patent/IL263728A/en unknown
-
2019
- 2019-05-08 JP JP2019087962A patent/JP2019142961A/ja active Pending
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