MX358680B - Usos de inmunoconjugados dirigidos a cd138. - Google Patents

Usos de inmunoconjugados dirigidos a cd138.

Info

Publication number
MX358680B
MX358680B MX2014006770A MX2014006770A MX358680B MX 358680 B MX358680 B MX 358680B MX 2014006770 A MX2014006770 A MX 2014006770A MX 2014006770 A MX2014006770 A MX 2014006770A MX 358680 B MX358680 B MX 358680B
Authority
MX
Mexico
Prior art keywords
dose
immunoconjugate
administered
amtd
single dose
Prior art date
Application number
MX2014006770A
Other languages
English (en)
Other versions
MX2014006770A (es
Inventor
Schulz Gregor
Osterroth Frank
Haeder Thomas
Bruecher Christoph
Niemann Gabriele
Engling Andre
Uherek Christoph
Daelken Benjamin
Wartenberg-Demand Andrea
Zuber Chantal
Gutscher Marcus
Bernoester Katrin
Koenig Martin
Original Assignee
Biotest Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Ag filed Critical Biotest Ag
Publication of MX2014006770A publication Critical patent/MX2014006770A/es
Publication of MX358680B publication Critical patent/MX358680B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un método para tratar una enfermedad asociada con hacer blanco de células que expresan CD138, que comprende: administrar a un sujeto, en particular a un sujeto humano que lo requiere, un inmunoconjugado que comprende al menos un anticuerpo dirigido de ingeniería que hace blanco en células que expresan CD138, y al menos una molécula efectora, en donde el anticuerpo que hace blanco de ingeniería se enlaza funcionalmente a la molécula efectora para formar el inmunoconjugado, en donde de preferencia al menos una parte del anticuerpo dirigido de ingeniería confiere propiedades de isotipo IgG4, en donde el inmunoconjugado se adininistra en un régimen de múltiples dosis que comprende al menos dos dosis, en donde la dosis agregada administrada dentro de un ciclo de tratamiento activo es una dosis tolerable máxima agregada (AMTD) o una fracción de AMTD y en donde AMTD y/o la fracción excede la dosis que resulta en una toxicidad limitante de dosis (DLT) cuando el inmunoconjugado se administra como una sola dosis, incluyendo como parte de un régimen de dosis sencillas múltiples y/o excede la dosis máxima tolerable (MTD) cuando el inmunoconjugado se administra como una sola dosis, incluyendo como parte de un régimen de dosis sencillas múltiples dentro del ciclo de tratamiento activo.
MX2014006770A 2011-12-08 2012-12-07 Usos de inmunoconjugados dirigidos a cd138. MX358680B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568640P 2011-12-08 2011-12-08
US201261722367P 2012-11-05 2012-11-05
PCT/EP2012/074867 WO2013083817A1 (en) 2011-12-08 2012-12-07 Uses of immunoconjugates targeting cd138

Publications (2)

Publication Number Publication Date
MX2014006770A MX2014006770A (es) 2014-10-17
MX358680B true MX358680B (es) 2018-08-31

Family

ID=47326154

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006770A MX358680B (es) 2011-12-08 2012-12-07 Usos de inmunoconjugados dirigidos a cd138.

Country Status (14)

Country Link
US (2) US10117932B2 (es)
EP (1) EP2788030B1 (es)
JP (1) JP6218746B2 (es)
KR (1) KR20140100571A (es)
CN (1) CN104302324A (es)
AU (1) AU2012372140B9 (es)
BR (1) BR112014013694A2 (es)
CA (1) CA2858133A1 (es)
ES (1) ES2684950T3 (es)
IL (1) IL232991A0 (es)
MX (1) MX358680B (es)
RU (1) RU2632108C2 (es)
SG (1) SG11201402887SA (es)
WO (1) WO2013083817A1 (es)

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US10647778B2 (en) * 2015-02-09 2020-05-12 University Of Florida Research Foundation, Incorporated Bi-specific chimeric antigen receptor and uses thereof
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TW201711702A (zh) * 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
WO2017190096A1 (en) 2016-04-29 2017-11-02 University Of Florida Research Foundation Incorporated Chimeric antigen receptors and uses thereof
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
MY205689A (en) 2017-10-02 2024-11-06 Visterra Inc Antibody molecules to cd138 and uses thereof
CA3107423A1 (en) * 2018-10-02 2020-04-09 Mitsubishi Tanabe Pharma Corporation Bi-specific binding agents targeting syndecan-1 and fibroblast growth factor receptor
WO2020257289A2 (en) 2019-06-17 2020-12-24 Visterra, Inc. Humanized antibody molecules to cd138 and uses thereof
WO2024181570A1 (ja) * 2023-03-02 2024-09-06 大鵬薬品工業株式会社 抗ｃｄ１３８抗体を含む抗体薬物複合体
WO2025106118A2 (en) * 2023-05-23 2025-05-22 Board Of Regents, The University Of Texas System Cd138/syndecan1 antibodies and methods of use thereof

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SG11201402887SA (en) 2014-07-30
HK1203053A1 (en) 2015-10-16
AU2012372140B9 (en) 2015-10-15
CN104302324A (zh) 2015-01-21
ES2684950T3 (es) 2018-10-05
US20140010828A1 (en) 2014-01-09
AU2012372140A1 (en) 2013-09-26
IL232991A0 (en) 2014-07-31
RU2014127298A (ru) 2016-01-27
RU2632108C2 (ru) 2017-10-02
WO2013083817A1 (en) 2013-06-13
JP6218746B2 (ja) 2017-10-25
BR112014013694A2 (pt) 2017-06-13
US20190117770A1 (en) 2019-04-25
KR20140100571A (ko) 2014-08-14
EP2788030B1 (en) 2018-06-20
NZ626680A (en) 2016-05-27
EP2788030A1 (en) 2014-10-15
AU2012372140B2 (en) 2015-09-17
JP2015500822A (ja) 2015-01-08
CA2858133A1 (en) 2013-06-13
US10117932B2 (en) 2018-11-06

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