MX358680B - Usos de inmunoconjugados dirigidos a cd138. - Google Patents
Usos de inmunoconjugados dirigidos a cd138.Info
- Publication number
- MX358680B MX358680B MX2014006770A MX2014006770A MX358680B MX 358680 B MX358680 B MX 358680B MX 2014006770 A MX2014006770 A MX 2014006770A MX 2014006770 A MX2014006770 A MX 2014006770A MX 358680 B MX358680 B MX 358680B
- Authority
- MX
- Mexico
- Prior art keywords
- dose
- immunoconjugate
- administered
- amtd
- single dose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente invención se refiere a un método para tratar una enfermedad asociada con hacer blanco de células que expresan CD138, que comprende: administrar a un sujeto, en particular a un sujeto humano que lo requiere, un inmunoconjugado que comprende al menos un anticuerpo dirigido de ingeniería que hace blanco en células que expresan CD138, y al menos una molécula efectora, en donde el anticuerpo que hace blanco de ingeniería se enlaza funcionalmente a la molécula efectora para formar el inmunoconjugado, en donde de preferencia al menos una parte del anticuerpo dirigido de ingeniería confiere propiedades de isotipo IgG4, en donde el inmunoconjugado se adininistra en un régimen de múltiples dosis que comprende al menos dos dosis, en donde la dosis agregada administrada dentro de un ciclo de tratamiento activo es una dosis tolerable máxima agregada (AMTD) o una fracción de AMTD y en donde AMTD y/o la fracción excede la dosis que resulta en una toxicidad limitante de dosis (DLT) cuando el inmunoconjugado se administra como una sola dosis, incluyendo como parte de un régimen de dosis sencillas múltiples y/o excede la dosis máxima tolerable (MTD) cuando el inmunoconjugado se administra como una sola dosis, incluyendo como parte de un régimen de dosis sencillas múltiples dentro del ciclo de tratamiento activo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161568640P | 2011-12-08 | 2011-12-08 | |
US201261722367P | 2012-11-05 | 2012-11-05 | |
PCT/EP2012/074867 WO2013083817A1 (en) | 2011-12-08 | 2012-12-07 | Uses of immunoconjugates targeting cd138 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014006770A MX2014006770A (es) | 2014-10-17 |
MX358680B true MX358680B (es) | 2018-08-31 |
Family
ID=47326154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006770A MX358680B (es) | 2011-12-08 | 2012-12-07 | Usos de inmunoconjugados dirigidos a cd138. |
Country Status (15)
Country | Link |
---|---|
US (2) | US10117932B2 (es) |
EP (1) | EP2788030B1 (es) |
JP (1) | JP6218746B2 (es) |
KR (1) | KR20140100571A (es) |
CN (1) | CN104302324A (es) |
AU (1) | AU2012372140B9 (es) |
BR (1) | BR112014013694A2 (es) |
CA (1) | CA2858133A1 (es) |
ES (1) | ES2684950T3 (es) |
HK (1) | HK1203053A1 (es) |
IL (1) | IL232991A0 (es) |
MX (1) | MX358680B (es) |
RU (1) | RU2632108C2 (es) |
SG (1) | SG11201402887SA (es) |
WO (1) | WO2013083817A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI541022B (zh) * | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體-3(fgfr3)之化合物及治療方法 |
WO2015179801A1 (en) | 2014-05-23 | 2015-11-26 | University Of Florida Research Foundation, Inc. | Car based immunotherapy |
US10647778B2 (en) * | 2015-02-09 | 2020-05-12 | University Of Florida Research Foundation, Incorporated | Bi-specific chimeric antigen receptor and uses thereof |
EP3259352A4 (en) | 2015-02-19 | 2018-12-05 | University of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
TW201711702A (zh) * | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體3(fgfr3)之化合物的療法 |
WO2017190096A1 (en) | 2016-04-29 | 2017-11-02 | University Of Florida Research Foundation Incorporated | Chimeric antigen receptors and uses thereof |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
CN111183157A (zh) | 2017-10-02 | 2020-05-19 | 威特拉公司 | Cd138抗体分子及其用途 |
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US20060045877A1 (en) | 2004-08-30 | 2006-03-02 | Goldmakher Viktor S | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
EA037929B1 (ru) | 2005-03-23 | 2021-06-08 | Генмаб А/С | Антитела к cd38 человека и их применение |
BRPI0608175A2 (pt) | 2005-04-15 | 2009-11-10 | Immunogen Inc | método de eliminação de população de células heterogêneas ou mistas em tumores, assim como compostos maitansinóides |
JP2009518025A (ja) | 2005-12-06 | 2009-05-07 | ドマンティス リミテッド | 細胞表面標的に対して結合特異性を有する二重特異性リガンドおよびその使用方法 |
AU2007245164A1 (en) | 2006-03-28 | 2007-11-08 | Biogen Idec Ma Inc. | Anti-IGF-IR antibodies and uses thereof |
WO2007144046A2 (de) | 2006-05-03 | 2007-12-21 | Elke Pogge Von Strandmann | Mittel zur behandlung von malignen erkrankungen |
SI2242772T1 (sl) * | 2007-12-26 | 2015-03-31 | Biotest Ag | Imunokonjugati, ki ciljajo v CD138, in njihova uporaba |
WO2009080829A1 (en) | 2007-12-26 | 2009-07-02 | Biotest Ag | Agents targeting cd138 and uses thereof |
AR069979A1 (es) | 2007-12-26 | 2010-03-03 | Biotest Ag | Metodo para disminuir los efectos secundarios citotoxicos y mejorar la eficacia de los inmunoconjugados |
CN101945892B (zh) | 2007-12-26 | 2017-11-24 | 生物测试股份公司 | 用于改进对表达cd138的肿瘤细胞的靶向的方法和试剂 |
EP2300052A4 (en) | 2008-06-16 | 2012-11-14 | Immunogen Inc | NEW SYNERGISTIC EFFECTS |
JP2012526079A (ja) * | 2009-05-06 | 2012-10-25 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体の使用 |
-
2012
- 2012-12-07 SG SG11201402887SA patent/SG11201402887SA/en unknown
- 2012-12-07 RU RU2014127298A patent/RU2632108C2/ru not_active IP Right Cessation
- 2012-12-07 AU AU2012372140A patent/AU2012372140B9/en not_active Ceased
- 2012-12-07 KR KR1020147018841A patent/KR20140100571A/ko not_active Application Discontinuation
- 2012-12-07 BR BR112014013694A patent/BR112014013694A2/pt not_active Application Discontinuation
- 2012-12-07 ES ES12798723.8T patent/ES2684950T3/es active Active
- 2012-12-07 WO PCT/EP2012/074867 patent/WO2013083817A1/en active Application Filing
- 2012-12-07 MX MX2014006770A patent/MX358680B/es active IP Right Grant
- 2012-12-07 JP JP2014545298A patent/JP6218746B2/ja not_active Expired - Fee Related
- 2012-12-07 CN CN201280069240.6A patent/CN104302324A/zh active Pending
- 2012-12-07 CA CA2858133A patent/CA2858133A1/en not_active Abandoned
- 2012-12-07 US US13/708,014 patent/US10117932B2/en not_active Expired - Fee Related
- 2012-12-07 EP EP12798723.8A patent/EP2788030B1/en not_active Not-in-force
-
2014
- 2014-06-05 IL IL232991A patent/IL232991A0/en unknown
-
2015
- 2015-04-13 HK HK15103595.6A patent/HK1203053A1/xx not_active IP Right Cessation
-
2018
- 2018-09-24 US US16/139,379 patent/US20190117770A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2684950T3 (es) | 2018-10-05 |
AU2012372140A1 (en) | 2013-09-26 |
EP2788030B1 (en) | 2018-06-20 |
US10117932B2 (en) | 2018-11-06 |
JP6218746B2 (ja) | 2017-10-25 |
US20140010828A1 (en) | 2014-01-09 |
JP2015500822A (ja) | 2015-01-08 |
AU2012372140B2 (en) | 2015-09-17 |
NZ626680A (en) | 2016-05-27 |
CN104302324A (zh) | 2015-01-21 |
HK1203053A1 (en) | 2015-10-16 |
BR112014013694A2 (pt) | 2017-06-13 |
WO2013083817A1 (en) | 2013-06-13 |
CA2858133A1 (en) | 2013-06-13 |
KR20140100571A (ko) | 2014-08-14 |
IL232991A0 (en) | 2014-07-31 |
AU2012372140B9 (en) | 2015-10-15 |
RU2014127298A (ru) | 2016-01-27 |
RU2632108C2 (ru) | 2017-10-02 |
EP2788030A1 (en) | 2014-10-15 |
SG11201402887SA (en) | 2014-07-30 |
US20190117770A1 (en) | 2019-04-25 |
MX2014006770A (es) | 2014-10-17 |
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