ES2684950T3 - Usos de inmunoconjugados dirigidos a CD138 - Google Patents
Usos de inmunoconjugados dirigidos a CD138 Download PDFInfo
- Publication number
- ES2684950T3 ES2684950T3 ES12798723.8T ES12798723T ES2684950T3 ES 2684950 T3 ES2684950 T3 ES 2684950T3 ES 12798723 T ES12798723 T ES 12798723T ES 2684950 T3 ES2684950 T3 ES 2684950T3
- Authority
- ES
- Spain
- Prior art keywords
- dose
- carcinoma
- immunoconjugate
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 9
- 125000000539 amino acid group Chemical group 0.000 abstract 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 3
- 231100000371 dose-limiting toxicity Toxicity 0.000 abstract 3
- 239000012636 effector Substances 0.000 abstract 3
- 201000009030 Carcinoma Diseases 0.000 abstract 2
- 206010009944 Colon cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 206010014733 Endometrial cancer Diseases 0.000 abstract 1
- 206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 208000006265 Renal cell carcinoma Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 201000009365 Thymic carcinoma Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 201000010989 colorectal carcinoma Diseases 0.000 abstract 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 abstract 1
- 206010041823 squamous cell carcinoma Diseases 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
- 208000012991 uterine carcinoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568640P | 2011-12-08 | 2011-12-08 | |
| US201161568640P | 2011-12-08 | ||
| US201261722367P | 2012-11-05 | 2012-11-05 | |
| US201261722367P | 2012-11-05 | ||
| PCT/EP2012/074867 WO2013083817A1 (en) | 2011-12-08 | 2012-12-07 | Uses of immunoconjugates targeting cd138 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2684950T3 true ES2684950T3 (es) | 2018-10-05 |
Family
ID=47326154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12798723.8T Active ES2684950T3 (es) | 2011-12-08 | 2012-12-07 | Usos de inmunoconjugados dirigidos a CD138 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10117932B2 (enExample) |
| EP (1) | EP2788030B1 (enExample) |
| JP (1) | JP6218746B2 (enExample) |
| KR (1) | KR20140100571A (enExample) |
| CN (1) | CN104302324A (enExample) |
| AU (1) | AU2012372140B9 (enExample) |
| BR (1) | BR112014013694A2 (enExample) |
| CA (1) | CA2858133A1 (enExample) |
| ES (1) | ES2684950T3 (enExample) |
| IL (1) | IL232991A0 (enExample) |
| MX (1) | MX358680B (enExample) |
| RU (1) | RU2632108C2 (enExample) |
| SG (1) | SG11201402887SA (enExample) |
| WO (1) | WO2013083817A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541022B (zh) * | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| CN106535925A (zh) | 2014-05-23 | 2017-03-22 | 佛罗里达大学研究基金会有限公司 | 基于car的免疫治疗 |
| EP3256492A4 (en) * | 2015-02-09 | 2018-07-11 | University of Florida Research Foundation, Inc. | Bi-specific chimeric antigen receptor and uses thereof |
| EP3259352A4 (en) | 2015-02-19 | 2018-12-05 | University of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| TW201711702A (zh) * | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| US11634498B2 (en) | 2016-04-29 | 2023-04-25 | University Of Florida Research Foundation, Incorporated | Chimeric antigen receptors and uses thereof |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| AU2018345637A1 (en) | 2017-10-02 | 2020-03-05 | Visterra, Inc. | Antibody molecules to CD138 and uses thereof |
| AU2019353367A1 (en) * | 2018-10-02 | 2021-02-18 | Mitsubishi Tanabe Pharma Corporation | Bi-specific binding agents targeting syndecan-1 and fibroblast growth factor receptor |
| TW202112822A (zh) | 2019-06-17 | 2021-04-01 | 美商威特拉公司 | 針對cd138之人類化抗體分子及其用途 |
| JPWO2024181570A1 (enExample) * | 2023-03-02 | 2024-09-06 | ||
| WO2025106118A2 (en) * | 2023-05-23 | 2025-05-22 | Board Of Regents, The University Of Texas System | Cd138/syndecan1 antibodies and methods of use thereof |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4169888A (en) | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
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-
2012
- 2012-12-07 KR KR1020147018841A patent/KR20140100571A/ko not_active Ceased
- 2012-12-07 RU RU2014127298A patent/RU2632108C2/ru not_active IP Right Cessation
- 2012-12-07 WO PCT/EP2012/074867 patent/WO2013083817A1/en not_active Ceased
- 2012-12-07 ES ES12798723.8T patent/ES2684950T3/es active Active
- 2012-12-07 SG SG11201402887SA patent/SG11201402887SA/en unknown
- 2012-12-07 CA CA2858133A patent/CA2858133A1/en not_active Abandoned
- 2012-12-07 CN CN201280069240.6A patent/CN104302324A/zh active Pending
- 2012-12-07 US US13/708,014 patent/US10117932B2/en not_active Expired - Fee Related
- 2012-12-07 EP EP12798723.8A patent/EP2788030B1/en not_active Not-in-force
- 2012-12-07 AU AU2012372140A patent/AU2012372140B9/en not_active Ceased
- 2012-12-07 BR BR112014013694A patent/BR112014013694A2/pt not_active Application Discontinuation
- 2012-12-07 MX MX2014006770A patent/MX358680B/es active IP Right Grant
- 2012-12-07 JP JP2014545298A patent/JP6218746B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-05 IL IL232991A patent/IL232991A0/en unknown
-
2018
- 2018-09-24 US US16/139,379 patent/US20190117770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140100571A (ko) | 2014-08-14 |
| AU2012372140B9 (en) | 2015-10-15 |
| EP2788030B1 (en) | 2018-06-20 |
| CA2858133A1 (en) | 2013-06-13 |
| AU2012372140B2 (en) | 2015-09-17 |
| JP6218746B2 (ja) | 2017-10-25 |
| SG11201402887SA (en) | 2014-07-30 |
| US20190117770A1 (en) | 2019-04-25 |
| BR112014013694A2 (pt) | 2017-06-13 |
| RU2632108C2 (ru) | 2017-10-02 |
| CN104302324A (zh) | 2015-01-21 |
| MX2014006770A (es) | 2014-10-17 |
| US20140010828A1 (en) | 2014-01-09 |
| RU2014127298A (ru) | 2016-01-27 |
| MX358680B (es) | 2018-08-31 |
| WO2013083817A1 (en) | 2013-06-13 |
| EP2788030A1 (en) | 2014-10-15 |
| NZ626680A (en) | 2016-05-27 |
| AU2012372140A1 (en) | 2013-09-26 |
| JP2015500822A (ja) | 2015-01-08 |
| HK1203053A1 (en) | 2015-10-16 |
| IL232991A0 (en) | 2014-07-31 |
| US10117932B2 (en) | 2018-11-06 |
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