RU2541765C2 - Антитела к рецептору инсулинподобного фактора роста i и их применение - Google Patents

Антитела к рецептору инсулинподобного фактора роста i и их применение Download PDF

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Publication number
RU2541765C2
RU2541765C2 RU2008144290/10A RU2008144290A RU2541765C2 RU 2541765 C2 RU2541765 C2 RU 2541765C2 RU 2008144290/10 A RU2008144290/10 A RU 2008144290/10A RU 2008144290 A RU2008144290 A RU 2008144290A RU 2541765 C2 RU2541765 C2 RU 2541765C2
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RU
Russia
Prior art keywords
igf
antibody
antibodies
cells
cell
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RU2008144290/10A
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English (en)
Russian (ru)
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RU2008144290A (ru
Inventor
ХАНЗЕН Зильке
КЮНКЕЛЕ Клаус-Петер
РОЙШ Дитмар
ШУМАХЕР Ральф
Original Assignee
Ривер Вижн Девелопмент Корп.,
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36940705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2541765(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ривер Вижн Девелопмент Корп., filed Critical Ривер Вижн Девелопмент Корп.,
Publication of RU2008144290A publication Critical patent/RU2008144290A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2008144290/10A 2006-04-11 2007-04-10 Антитела к рецептору инсулинподобного фактора роста i и их применение RU2541765C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06007571 2006-04-11
EP06007571.0 2006-04-11
PCT/EP2007/003165 WO2007115814A2 (en) 2006-04-11 2007-04-10 Antibodies against insulin-like growth factor i receptor and uses thereof

Publications (2)

Publication Number Publication Date
RU2008144290A RU2008144290A (ru) 2010-05-20
RU2541765C2 true RU2541765C2 (ru) 2015-02-20

Family

ID=36940705

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008144290/10A RU2541765C2 (ru) 2006-04-11 2007-04-10 Антитела к рецептору инсулинподобного фактора роста i и их применение

Country Status (20)

Country Link
US (1) US20080014203A1 (enExample)
EP (2) EP2007810B1 (enExample)
JP (1) JP4718634B2 (enExample)
KR (2) KR101276513B1 (enExample)
CN (1) CN101421305B (enExample)
AR (1) AR060592A1 (enExample)
AU (1) AU2007236199B2 (enExample)
BR (1) BRPI0710185B8 (enExample)
CA (2) CA3081707A1 (enExample)
CR (1) CR10301A (enExample)
EC (1) ECSP088816A (enExample)
ES (1) ES2403075T3 (enExample)
IL (1) IL194397A (enExample)
MX (1) MX2008012950A (enExample)
NO (1) NO20084082L (enExample)
NZ (1) NZ571414A (enExample)
RU (1) RU2541765C2 (enExample)
UA (1) UA95284C2 (enExample)
WO (1) WO2007115814A2 (enExample)
ZA (1) ZA200808597B (enExample)

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US7846724B2 (en) * 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
US20090068110A1 (en) * 2006-12-22 2009-03-12 Genentech, Inc. Antibodies to insulin-like growth factor receptor
PE20090368A1 (es) 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
CA2709029A1 (en) 2007-12-21 2009-07-02 Bianca Eser Stability testing of antibodies
PE20120415A1 (es) 2008-12-12 2012-05-09 Boehringer Ingelheim Int Anticuerpos anti-igf
WO2010112194A1 (en) * 2009-04-02 2010-10-07 F. Hoffmann-La Roche Ag Antigen-binding polypeptides and multispecific antibodies comprising them
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
JP5921433B2 (ja) 2009-07-24 2016-05-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 攪拌システム
CA2774953A1 (en) 2009-10-07 2011-04-14 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Human domain antibodies against components of the human insulin-like growth factor (igf) system
KR102071834B1 (ko) 2009-10-26 2020-01-30 에프. 호프만-라 로슈 아게 글리코실화된 면역글로불린의 제조 방법
WO2011101328A2 (en) 2010-02-18 2011-08-25 Roche Glycart Ag Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor
WO2011135040A1 (en) 2010-04-30 2011-11-03 F. Hoffmann-La Roche Ag Fluorescent antibody fusion protein, its production and use
KR101593766B1 (ko) 2010-11-05 2016-02-15 에프. 호프만-라 로슈 아게 혼합식 크로마토그래피에 의한 최적화된 항체 포획 방법
CN110229235A (zh) 2011-06-22 2019-09-13 霍夫曼-拉罗奇有限公司 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞
RU2502798C2 (ru) * 2012-02-22 2013-12-27 Общество с ограниченной ответственностью "Фармако Биотех" КЛЕТОЧНАЯ ЛИНИЯ huFSHIK, СЕКРЕТИРУЮЩАЯ РЕКОМБИНАНТНЫЙ ЧЕЛОВЕЧЕСКИЙ ФСГ
EP2914629A1 (en) 2012-11-05 2015-09-09 MAB Discovery GmbH Method for the production of multispecific antibodies
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
CA2889788A1 (en) 2012-12-21 2014-06-26 F. Hoffmann-La Roche Ag Disulfide-linked multivalent mhc class i comprising multi-function proteins
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
WO2021119234A1 (en) * 2019-12-10 2021-06-17 Horizon Pharma Ireland Ltd. Glycosylated antibodies against insulin-like growth factor i receptor and uses thereof
TW202228775A (zh) 2020-10-14 2022-08-01 美商維里迪恩醫療股份有限公司 用於治療甲狀腺眼病之組合物及方法
EP4384219A4 (en) 2021-08-10 2025-06-18 Viridian Therapeutics, Inc. COMPOSITIONS, DOSAGES AND METHODS FOR THE TREATMENT OF THYROID EYE DISEASE

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0822255A2 (en) * 1990-10-17 1998-02-04 The Wellcome Foundation Limited CHO (Chinese Hamster Ovary) glycosylated antibodies and their use in therapy

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US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) * 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5650508A (en) * 1991-12-27 1997-07-22 Georgia Tech Research Corporation Peptide ketoamides
MD1367C2 (ro) 1992-11-13 2000-11-30 Idec Pharmaceuticals Corporation Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
EP2275540B1 (en) * 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US20030165502A1 (en) * 2000-06-13 2003-09-04 City Of Hope Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth
US7241444B2 (en) * 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
US7553485B2 (en) * 2002-01-18 2009-06-30 Pierre Fabre Medicament Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
WO2003100008A2 (en) * 2002-05-24 2003-12-04 Schering Corporation Neutralizing human anti-igfr antibody
EP1613658B1 (en) * 2003-04-02 2012-03-14 F. Hoffmann-La Roche AG Antibodies against insulin-like growth factor i receptor and uses thereof
AR046071A1 (es) * 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
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SHIELDS R.L. et al., "Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human Fc[gamma]RIII and Antibody-dependent Cellular Toxicity", The Journal of Biological Chemistry (2002), 277(30):26733-26740. DAVIES J. et al., "Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for Fc[gamma]RIII" Biotechnology and Bioengineering (2001), 74(4): 288-294. PRATI E.G.P. et al., "Antisense Strategies for Glycosylation Engineering of Chinese Hamster Ovary (CHO) Cells", Biotechnology and Bioengineering (1998), 59(4): 445-450. STANLEY P. et al., "CHO cells provide access to novel N-glycans and developmentally regulated glycosyltransferases", Glycobiolology (1996), 6(7): 695-699. JEFFERIS R., "Glycosylation of Recombinant Antibody Therapeutics", Biotechnol. Prog. (2005), 21:11-16. RAJU T.S., "Glycosylation Variations with Expression Systems and Their Impact *
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Also Published As

Publication number Publication date
EP2007810B1 (en) 2013-02-13
AU2007236199B2 (en) 2013-07-25
ZA200808597B (en) 2009-11-25
UA95284C2 (ru) 2011-07-25
NO20084082L (no) 2008-11-06
BRPI0710185B8 (pt) 2021-05-25
KR20080113233A (ko) 2008-12-29
WO2007115814A2 (en) 2007-10-18
CN101421305B (zh) 2013-05-15
CR10301A (es) 2008-10-29
RU2008144290A (ru) 2010-05-20
ECSP088816A (es) 2008-11-27
AU2007236199A1 (en) 2007-10-18
CN101421305A (zh) 2009-04-29
CA2647181A1 (en) 2007-10-18
WO2007115814A3 (en) 2008-01-10
EP2363417A1 (en) 2011-09-07
IL194397A (en) 2014-04-30
BRPI0710185B1 (pt) 2020-01-14
MX2008012950A (es) 2008-10-15
ES2403075T3 (es) 2013-05-13
EP2007810A2 (en) 2008-12-31
JP4718634B2 (ja) 2011-07-06
US20080014203A1 (en) 2008-01-17
CA2647181C (en) 2020-08-11
IL194397A0 (en) 2011-08-01
AR060592A1 (es) 2008-07-02
BRPI0710185A8 (pt) 2019-01-22
BRPI0710185A2 (pt) 2011-08-09
KR101276513B1 (ko) 2013-06-21
NZ571414A (en) 2011-12-22
KR20120028396A (ko) 2012-03-22
JP2009533367A (ja) 2009-09-17
CA3081707A1 (en) 2007-10-18

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