MX2008012950A - Anticuerpos contra el receptor del factor i de crecimiento de tipo insulina y sus usos. - Google Patents

Anticuerpos contra el receptor del factor i de crecimiento de tipo insulina y sus usos.

Info

Publication number
MX2008012950A
MX2008012950A MX2008012950A MX2008012950A MX2008012950A MX 2008012950 A MX2008012950 A MX 2008012950A MX 2008012950 A MX2008012950 A MX 2008012950A MX 2008012950 A MX2008012950 A MX 2008012950A MX 2008012950 A MX2008012950 A MX 2008012950A
Authority
MX
Mexico
Prior art keywords
receptor
growth factor
antibodies against
amount
against insulin
Prior art date
Application number
MX2008012950A
Other languages
English (en)
Inventor
Ralf Schumacher
Silke Hansen
Dietmar Reusch
Klaus Peter Kuenkele
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36940705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2008012950(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2008012950A publication Critical patent/MX2008012950A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un anticuerpo que se fija sobre el IGF-IR, es del tipo IgG1 o IgG3 humano y está glucosilado con una cadena azúcar en Asn297, el anticuerpo está caracterizado porque la cantidad de fucosa dentro de la cadena azúcar es por lo menos del 99% y además la cantidad de NGNA es del 1% o menos y/o la cantidad de alfa-1,3-galactosa del extremo N es del 1% o menos, tiene propiedades mejoradas para la terapia antineoplásica.
MX2008012950A 2006-04-11 2007-04-10 Anticuerpos contra el receptor del factor i de crecimiento de tipo insulina y sus usos. MX2008012950A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06007571 2006-04-11
PCT/EP2007/003165 WO2007115814A2 (en) 2006-04-11 2007-04-10 Antibodies against insulin-like growth factor i receptor and uses thereof

Publications (1)

Publication Number Publication Date
MX2008012950A true MX2008012950A (es) 2008-10-15

Family

ID=36940705

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012950A MX2008012950A (es) 2006-04-11 2007-04-10 Anticuerpos contra el receptor del factor i de crecimiento de tipo insulina y sus usos.

Country Status (20)

Country Link
US (1) US20080014203A1 (es)
EP (2) EP2363417A1 (es)
JP (1) JP4718634B2 (es)
KR (2) KR20120028396A (es)
CN (1) CN101421305B (es)
AR (1) AR060592A1 (es)
AU (1) AU2007236199B2 (es)
BR (1) BRPI0710185B8 (es)
CA (2) CA2647181C (es)
CR (1) CR10301A (es)
EC (1) ECSP088816A (es)
ES (1) ES2403075T3 (es)
IL (1) IL194397A (es)
MX (1) MX2008012950A (es)
NO (1) NO20084082L (es)
NZ (1) NZ571414A (es)
RU (1) RU2541765C2 (es)
UA (1) UA95284C2 (es)
WO (1) WO2007115814A2 (es)
ZA (1) ZA200808597B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
AR064464A1 (es) * 2006-12-22 2009-04-01 Genentech Inc Anticuerpos anti - receptor del factor de crecimiento insulinico
PE20090368A1 (es) 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
JP5458020B2 (ja) 2007-12-21 2014-04-02 ロシュ グリクアート アクチェンゲゼルシャフト 抗体の安定性試験
AR074726A1 (es) 2008-12-12 2011-02-09 Boehringer Ingelheim Int Anticuerpos anti-igf (factor de crecimiento insulinico)
WO2010112194A1 (en) * 2009-04-02 2010-10-07 F. Hoffmann-La Roche Ag Antigen-binding polypeptides and multispecific antibodies comprising them
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
SG177727A1 (en) 2009-07-24 2012-02-28 Hoffmann La Roche Stirrer system
WO2011044336A2 (en) * 2009-10-07 2011-04-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human domain antibodies against components of the human insulin-like growth factor (igf) system
KR20160084500A (ko) 2009-10-26 2016-07-13 에프. 호프만-라 로슈 아게 글리코실화된 면역글로불린의 제조 방법
WO2011101328A2 (en) 2010-02-18 2011-08-25 Roche Glycart Ag Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor
WO2011135040A1 (en) 2010-04-30 2011-11-03 F. Hoffmann-La Roche Ag Fluorescent antibody fusion protein, its production and use
EP2635600B1 (en) 2010-11-05 2017-06-21 F. Hoffmann-La Roche AG Optimized method for antibody capturing by mixed mode chromatography
CN103649125A (zh) 2011-06-22 2014-03-19 霍夫曼-拉罗奇有限公司 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞
RU2502798C2 (ru) * 2012-02-22 2013-12-27 Общество с ограниченной ответственностью "Фармако Биотех" КЛЕТОЧНАЯ ЛИНИЯ huFSHIK, СЕКРЕТИРУЮЩАЯ РЕКОМБИНАНТНЫЙ ЧЕЛОВЕЧЕСКИЙ ФСГ
US20150259430A1 (en) 2012-11-05 2015-09-17 Mab Discovery Gmbh Method for the production of multispecific antibodies
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
ES2700984T3 (es) 2012-12-21 2019-02-20 Hoffmann La Roche Proteínas multifuncionales que comprenden MHC de clase I multivalente unida por disulfuro
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
AR120719A1 (es) * 2019-12-10 2022-03-09 Horizon Therapeutics Ireland Designated Activity Company Anticuerpos glicosilados contra el receptor del factor de crecimiento i similar a la insulina y sus usos

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US5202238A (en) * 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) * 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
US5610297A (en) * 1991-12-27 1997-03-11 Georgia Tech Research Corp. Peptides ketoamides
JP3095175B2 (ja) 1992-11-13 2000-10-03 アイデック ファーマシューティカルズ コーポレイション Ｂ細胞リンパ腫の治療のためのヒトｂリンパ球限定分化抗原に対するキメラ抗体と放射能標識抗体の療法利用
ES2569919T3 (es) * 1999-04-09 2016-05-13 Kyowa Hakko Kirin Co., Ltd. Procedimiento para controlar la actividad de una molécula inmunofuncional
US20030165502A1 (en) * 2000-06-13 2003-09-04 City Of Hope Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth
US7553485B2 (en) * 2002-01-18 2009-06-30 Pierre Fabre Medicament Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
US7241444B2 (en) * 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
CN100422316C (zh) * 2002-05-24 2008-10-01 先灵公司 抗胰岛素样生长因子受体(igfr)的人源中和抗体
JP4473257B2 (ja) * 2003-04-02 2010-06-02 エフ．ホフマン−ラ ロシュ アーゲー インスリン様成長因子ｉ受容体に対する抗体及びその使用
AR046071A1 (es) * 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
US20070142627A1 (en) * 2003-08-01 2007-06-21 Chugai Seiyaku Kabushiki Kaisha Sugar-chain-altered anti-hm1.24 antibody
WO2005034994A1 (ja) * 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 固形腫瘍治療剤

Also Published As

Publication number Publication date
EP2007810B1 (en) 2013-02-13
CR10301A (es) 2008-10-29
BRPI0710185B1 (pt) 2020-01-14
CN101421305A (zh) 2009-04-29
IL194397A (en) 2014-04-30
NO20084082L (no) 2008-11-06
EP2007810A2 (en) 2008-12-31
BRPI0710185A8 (pt) 2019-01-22
KR101276513B1 (ko) 2013-06-21
CA2647181C (en) 2020-08-11
CA2647181A1 (en) 2007-10-18
BRPI0710185B8 (pt) 2021-05-25
ES2403075T3 (es) 2013-05-13
KR20080113233A (ko) 2008-12-29
KR20120028396A (ko) 2012-03-22
RU2541765C2 (ru) 2015-02-20
WO2007115814A3 (en) 2008-01-10
NZ571414A (en) 2011-12-22
ZA200808597B (en) 2009-11-25
AU2007236199A1 (en) 2007-10-18
AR060592A1 (es) 2008-07-02
RU2008144290A (ru) 2010-05-20
UA95284C2 (ru) 2011-07-25
ECSP088816A (es) 2008-11-27
CN101421305B (zh) 2013-05-15
CA3081707A1 (en) 2007-10-18
BRPI0710185A2 (pt) 2011-08-09
JP2009533367A (ja) 2009-09-17
WO2007115814A2 (en) 2007-10-18
JP4718634B2 (ja) 2011-07-06
AU2007236199B2 (en) 2013-07-25
US20080014203A1 (en) 2008-01-17
IL194397A0 (en) 2011-08-01
EP2363417A1 (en) 2011-09-07

Similar Documents

Publication Publication Date Title
MX2008012950A (es) Anticuerpos contra el receptor del factor i de crecimiento de tipo insulina y sus usos.
TW200833712A (en) Antibodies against insulin-like growth factor I receptor and uses thereof
CA2647288C (en) A cho-dg44 derivative cell line expressing an antibody against insulin-like growth factor receptor 1
WO2004087756A3 (en) Antibodies against insulin-like growth factor i receptor and uses thereof
EP2368913A3 (en) Glyco-engineered antibodies
UA93488C2 (uk) Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг
EP2365005A3 (en) Novel anti-IGF-IR antibodies and uses thereof
EP1847602A4 (en) STABILIZED HUMAN IGG1 AND IGG3 ANTIBODIES
MX2009005963A (es) Anticuerpos humanos contra el ligando 4 de tipo delta humano.
SG10201407388XA (en) Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
WO2008091641A3 (en) Compositions and methods for diagnosing and treating cancer
WO2005120557A3 (en) Inhibition of macrophage-stimulating protein receptor (ron)
WO2006029219A3 (en) Human monoclonal anti-ctla4 antibodies in cancer treatment
WO2009004822A1 (ja) 抗Muc17抗体
WO2005090406A3 (en) Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
WO2006106348A3 (en) Protein glycosylation
MX2009005103A (es) Conjugado anti-idiotipo y su uso como un estandar en un inmunoensayo.
WO2008100563A3 (en) Compositions and methods for diagnosing and treating cancer
EP1748075A8 (en) Recombinant chemokine-antigen vaccine
WO2008036337A3 (en) Predicted phosphorylation sites
EP1688437A4 (en) SPECIALLY BINDING ANTIBODY COMPOSITION TO IL-5 RECEPTOR
EP4252854A3 (en) Humanized antibody specific for cd22 and chimeric antigen receptor using the same
WO2009108168A3 (en) Gold nanoparticle glycoconjugates for generating igg specific for the carbohydrate
TH95354B (th) แอนตี้บอดีต่อโกรท แฟคเตอร์-1 รีเซปเตอร์คล้ายอินซูลิน และการใช้สารนั้น
TH95354A (th) แอนตี้บอดีต่อโกรท แฟคเตอร์-1 รีเซปเตอร์คล้ายอินซูลิน และการใช้สารนั้น

Legal Events

Date Code Title Description
FG Grant or registration