AU785038B2 - Ultra high affinity neutralizing antibodies - Google Patents

Ultra high affinity neutralizing antibodies Download PDF

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Publication number
AU785038B2
AU785038B2 AU31180/01A AU3118001A AU785038B2 AU 785038 B2 AU785038 B2 AU 785038B2 AU 31180/01 A AU31180/01 A AU 31180/01A AU 3118001 A AU3118001 A AU 3118001A AU 785038 B2 AU785038 B2 AU 785038B2
Authority
AU
Australia
Prior art keywords
seq
amino acid
acid sequence
high affinity
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU31180/01A
Other languages
English (en)
Other versions
AU785038C (en
AU3118001A (en
Inventor
William D. Huse
Leslie S. Johnson
Scott Koenig
Jeffry D. Watkins
Herren Wu
James F. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Applied Molecular Evolution Inc
Original Assignee
MedImmune LLC
Applied Molecular Evolution Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC, Applied Molecular Evolution Inc filed Critical MedImmune LLC
Application granted granted Critical
Publication of AU785038C publication Critical patent/AU785038C/en
Publication of AU3118001A publication Critical patent/AU3118001A/en
Priority to AU2006203015A priority Critical patent/AU2006203015B2/en
Publication of AU785038B2 publication Critical patent/AU785038B2/en
Assigned to MEDIMMUNE, LLC, APPLIED MOLECULAR EVOLUTION, INC. reassignment MEDIMMUNE, LLC Request to Amend Deed and Register Assignors: APPLIED MOLECULAR EVOLUTION, INC., MED IMMUNE, INC.
Priority to AU2010201090A priority patent/AU2010201090B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Disintegrating Or Milling (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU31180/01A 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies Ceased AU785038B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2006203015A AU2006203015B2 (en) 2000-01-27 2006-07-14 Ultra high affinity neutralizing antibodies
AU2010201090A AU2010201090B2 (en) 2000-01-27 2010-03-19 Ultra high affinity neutralizing antibodies

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17842600P 2000-01-27 2000-01-27
US60/178426 2000-01-27
PCT/US2001/002618 WO2001055217A1 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2006203015A Division AU2006203015B2 (en) 2000-01-27 2006-07-14 Ultra high affinity neutralizing antibodies
AU2006203134A Division AU2006203134B2 (en) 2000-01-27 2006-07-21 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment

Publications (3)

Publication Number Publication Date
AU785038C AU785038C (en) 2001-08-07
AU3118001A AU3118001A (en) 2001-08-07
AU785038B2 true AU785038B2 (en) 2006-08-31

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU31180/01A Ceased AU785038B2 (en) 2000-01-27 2001-01-26 Ultra high affinity neutralizing antibodies
AU2010201090A Ceased AU2010201090B2 (en) 2000-01-27 2010-03-19 Ultra high affinity neutralizing antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010201090A Ceased AU2010201090B2 (en) 2000-01-27 2010-03-19 Ultra high affinity neutralizing antibodies

Country Status (12)

Country Link
US (4) US6656467B2 (enExample)
EP (2) EP2289550A3 (enExample)
JP (2) JP4992068B2 (enExample)
AT (1) ATE474854T1 (enExample)
AU (2) AU785038B2 (enExample)
CA (1) CA2398466A1 (enExample)
CY (1) CY1111542T1 (enExample)
DE (1) DE60142614D1 (enExample)
DK (1) DK1265928T3 (enExample)
ES (1) ES2349348T3 (enExample)
PT (1) PT1265928E (enExample)
WO (1) WO2001055217A1 (enExample)

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US20100266614A1 (en) 2010-10-21
JP4992068B2 (ja) 2012-08-08
AU2010201090B2 (en) 2012-05-17
US6656467B2 (en) 2003-12-02
CA2398466A1 (en) 2001-08-02
AU2010201090A1 (en) 2010-04-15
EP2289550A2 (en) 2011-03-02
JP2010180207A (ja) 2010-08-19
US20020164326A1 (en) 2002-11-07
ATE474854T1 (de) 2010-08-15
EP1265928A1 (en) 2002-12-18
WO2001055217A1 (en) 2001-08-02
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US20040131609A1 (en) 2004-07-08
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ES2349348T3 (es) 2010-12-30
DK1265928T3 (da) 2010-11-15
US7740851B2 (en) 2010-06-22
AU785038C (en) 2001-08-07
CY1111542T1 (el) 2015-08-05
AU3118001A (en) 2001-08-07

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