JP2021527640A5 - - Google Patents

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Publication number
JP2021527640A5
JP2021527640A5 JP2020568439A JP2020568439A JP2021527640A5 JP 2021527640 A5 JP2021527640 A5 JP 2021527640A5 JP 2020568439 A JP2020568439 A JP 2020568439A JP 2020568439 A JP2020568439 A JP 2020568439A JP 2021527640 A5 JP2021527640 A5 JP 2021527640A5
Authority
JP
Japan
Prior art keywords
seq
solvate
salt
indicated
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020568439A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021527640A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2019/065517 external-priority patent/WO2019243159A1/de
Publication of JP2021527640A publication Critical patent/JP2021527640A/ja
Publication of JP2021527640A5 publication Critical patent/JP2021527640A5/ja
Pending legal-status Critical Current

Links

JP2020568439A 2018-06-18 2019-06-13 酵素的に切断可能なリンカーおよび改善された活性プロファイルを有する、cxcr5に対して向けられるバインダー/活性薬剤複合体 Pending JP2021527640A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18178299.6 2018-06-18
EP18178299 2018-06-18
PCT/EP2019/065517 WO2019243159A1 (de) 2018-06-18 2019-06-13 Gegen cxcr5 gerichtete binder-wirkstoff-konjugate mit enzymatisch spaltbaren linkern und verbessertem wirkungsprofil

Publications (2)

Publication Number Publication Date
JP2021527640A JP2021527640A (ja) 2021-10-14
JP2021527640A5 true JP2021527640A5 (enExample) 2022-06-21

Family

ID=62705502

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020568439A Pending JP2021527640A (ja) 2018-06-18 2019-06-13 酵素的に切断可能なリンカーおよび改善された活性プロファイルを有する、cxcr5に対して向けられるバインダー/活性薬剤複合体

Country Status (14)

Country Link
US (1) US20210275686A1 (enExample)
EP (1) EP3806908A1 (enExample)
JP (1) JP2021527640A (enExample)
KR (1) KR20210033470A (enExample)
CN (1) CN112601553A (enExample)
AU (1) AU2019289506A1 (enExample)
BR (1) BR112020025718A2 (enExample)
CA (1) CA3103327A1 (enExample)
EA (1) EA202190059A1 (enExample)
IL (1) IL279400A (enExample)
MA (1) MA71421A (enExample)
MX (1) MX2020013832A (enExample)
SG (1) SG11202012608VA (enExample)
WO (1) WO2019243159A1 (enExample)

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MX2017017138A (es) 2015-06-23 2018-04-30 Bayer Pharma AG Conjugados homogeneos especificos de sitio con inhibidores de ksp.
SG10202008909VA (en) 2016-03-24 2020-10-29 Bayer Pharma AG Prodrugs of cytotoxic active agents having enzymatically cleavable groups
WO2017216028A1 (en) 2016-06-15 2017-12-21 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies
US12059472B2 (en) 2016-12-21 2024-08-13 Bayer Aktiengesellschaft Prodrugs of cytotoxic active agents having enzymatically cleavable groups
AU2017380871C1 (en) 2016-12-21 2025-05-15 Bayer Aktiengesellschaft Antibody drug conjugates (ADCs) having enzymatically cleavable groups
US11433140B2 (en) 2016-12-21 2022-09-06 Bayer Pharma Aktiengesellschaft Specific antibody drug conjugates (ADCs) having KSP inhibitors
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
CN116745323A (zh) 2021-01-22 2023-09-12 拜耳股份有限公司 Lrrc15抗体及其缀合物
CN115400223B (zh) * 2022-09-29 2024-11-22 山东大学 一种二茂铁和tlr7/8激动剂共连接纳米粒及其制备方法和应用
TW202540200A (zh) 2023-12-01 2025-10-16 美商基利科學股份有限公司 抗fap-light融合蛋白及其用途
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025259871A1 (en) 2024-06-14 2025-12-18 Gilead Sciences, Inc. Anti-ccr8 antibodies and uses thereof

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SG11201710639YA (en) * 2015-06-22 2018-01-30 Bayer Pharma AG Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups
SG10202008909VA (en) * 2016-03-24 2020-10-29 Bayer Pharma AG Prodrugs of cytotoxic active agents having enzymatically cleavable groups
AU2017380871C1 (en) * 2016-12-21 2025-05-15 Bayer Aktiengesellschaft Antibody drug conjugates (ADCs) having enzymatically cleavable groups

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