|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4737462A
(en)
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
JPS63501765A
(ja)
|
1985-11-01 |
1988-07-21 |
インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド |
抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4704692A
(en)
|
1986-09-02 |
1987-11-03 |
Ladner Robert C |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP0940468A1
(en)
|
1991-06-14 |
1999-09-08 |
Genentech, Inc. |
Humanized antibody variable domain
|
|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
US5362852A
(en)
|
1991-09-27 |
1994-11-08 |
Pfizer Inc. |
Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
EP1005870B1
(en)
|
1992-11-13 |
2009-01-21 |
Biogen Idec Inc. |
Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US6080560A
(en)
|
1994-07-25 |
2000-06-27 |
Monsanto Company |
Method for producing antibodies in plant cells
|
|
KR960029336A
(ko)
|
1995-01-09 |
1996-08-17 |
김충환 |
캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
ATE234635T1
(de)
|
1995-12-22 |
2003-04-15 |
Bristol Myers Squibb Co |
Verzweigte hydrazongruppen enthaltende kuppler
|
|
ATE216366T1
(de)
|
1996-08-16 |
2002-05-15 |
Pfizer |
2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression
|
|
JP2001523958A
(ja)
|
1997-03-21 |
2001-11-27 |
ブライハム アンド ウィミンズ ホスピタル，インコーポレイテッド |
免疫療法のｃｔｌａ−４結合ペプチド
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US5985837A
(en)
|
1998-07-08 |
1999-11-16 |
Basf Aktiengesellschaft |
Dolastatin 15 derivatives
|
|
US6512162B2
(en)
|
1998-07-10 |
2003-01-28 |
Calgene Llc |
Expression of eukaryotic peptides in plant plastids
|
|
US20030167531A1
(en)
|
1998-07-10 |
2003-09-04 |
Russell Douglas A. |
Expression and purification of bioactive, authentic polypeptides from plants
|
|
US6204257B1
(en)
|
1998-08-07 |
2001-03-20 |
Universtiy Of Kansas |
Water soluble prodrugs of hindered alcohols
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
US7109003B2
(en)
|
1998-12-23 |
2006-09-19 |
Abgenix, Inc. |
Methods for expressing and recovering human monoclonal antibodies to CTLA-4
|
|
DK2112166T3
(en)
|
1998-12-23 |
2019-02-04 |
Pfizer |
Human monoclonal antibodies to CTLA-4
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
EP1224309A2
(en)
|
1999-10-21 |
2002-07-24 |
Monsanto Company |
Post-translational modification of recombinant proteins produced in plants
|
|
EP1261376A1
(en)
|
2000-01-27 |
2002-12-04 |
Genetics Institute, LLC |
Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof
|
|
ES2637801T3
(es)
|
2000-04-11 |
2017-10-17 |
Genentech, Inc. |
Anticuerpos multivalentes y usos de los mismos
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
EP1467957B1
(en)
|
2002-01-23 |
2009-11-25 |
Johnson Matthey PLC |
Method for making sulphided ion exchange resins and their use
|
|
US7591994B2
(en)
|
2002-12-13 |
2009-09-22 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
PL216630B1
(pl)
|
2002-10-17 |
2014-04-30 |
Genmab As |
Izolowane ludzkie przeciwciało monoklonalne wiążące ludzki CD20, związane z tym przeciwciałem transfektoma, komórka gospodarza, transgeniczne zwierzę lub roślina, kompozycja, immunokoniugat, cząsteczka bispecyficzna, wektor ekspresyjny, kompozycja farmaceutyczna, zastosowanie medyczne, zestaw oraz przeciwciało antyidiotypowe i jego zastosowanie
|
|
CA2508831C
(en)
|
2002-12-13 |
2012-05-01 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
ES2347241T3
(es)
|
2002-12-16 |
2010-10-27 |
Genentech, Inc. |
Variantes de inmunoglobulina y sus utilizaciones.
|
|
ATE472338T1
(de)
|
2003-02-20 |
2010-07-15 |
Seattle Genetics Inc |
Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
JP2008501621A
(ja)
|
2003-05-31 |
2008-01-24 |
マイクロメット アクツィエン ゲゼルシャフト |
Ｂ細胞関連疾患を処置するための二重特異性抗ｃｄ３、抗ｃｄ１９抗体構築物を含む薬学的組成物
|
|
CN101979650B
(zh)
|
2003-10-22 |
2015-09-16 |
凯克研究生院 |
使用单倍体交配策略在酵母中合成异聚多亚基多肽的方法
|
|
CN107213469A
(zh)
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
PL1691833T3
(pl)
|
2003-11-28 |
2010-08-31 |
Amgen Res Munich Gmbh |
Kompozycje zawierające polipeptydy
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
JP4942643B2
(ja)
|
2004-03-02 |
2012-05-30 |
シアトル ジェネティックス， インコーポレイテッド |
部分的に付加された抗体およびそれらの結合体化方法
|
|
CN1942483B
(zh)
|
2004-04-13 |
2012-09-26 |
弗·哈夫曼-拉罗切有限公司 |
抗p型选凝素抗体
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
WO2006044643A2
(en)
|
2004-10-15 |
2006-04-27 |
Seattle Genetics, Inc. |
Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
WO2007008603A1
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
EP2500352A1
(en)
|
2005-08-19 |
2012-09-19 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
|
|
TW201402124A
(zh)
|
2005-08-19 |
2014-01-16 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
|
|
KR20080056167A
(ko)
|
2005-09-26 |
2008-06-20 |
메다렉스, 인코포레이티드 |
씨디70에 대한 인간 모노크로날 항체
|
|
EP1940881B1
(en)
|
2005-10-11 |
2016-11-30 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
EP2059533B1
(en)
|
2006-08-30 |
2012-11-14 |
Genentech, Inc. |
Multispecific antibodies
|
|
DK2099823T4
(da)
|
2006-12-01 |
2022-05-09 |
Seagen Inc |
Målbindingsmiddelvarianter og anvendelser deraf
|
|
JP2010513306A
(ja)
*
|
2006-12-14 |
2010-04-30 |
メダレックス インコーポレーティッド |
Ｃｄ７０に結合するヒト抗体およびその使用
|
|
WO2008119567A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific cd3-epsilon binding domain
|
|
JP5395068B2
(ja)
|
2007-06-29 |
2014-01-22 |
ギリアード サイエンシーズ， インコーポレイテッド |
トール様受容体７の調節物質としてのプリン誘導体およびその使用
|
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
SI2235064T1
(sl)
|
2008-01-07 |
2016-04-29 |
Amgen Inc. |
Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
|
|
DK2265283T3
(da)
|
2008-03-18 |
2014-10-20 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
JP5600104B2
(ja)
|
2008-08-01 |
2014-10-01 |
ベンティアールエックス ファーマシューティカルズ， インコーポレイテッド |
Ｔｏｌｌ様受容体アゴニスト処方物およびその使用
|
|
WO2010077613A1
(en)
|
2008-12-09 |
2010-07-08 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors
|
|
CA2749115C
(en)
|
2009-01-09 |
2022-06-21 |
Seattle Genetics, Inc. |
Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates
|
|
ES2738700T3
(es)
|
2009-02-13 |
2020-01-24 |
Immunomedics Inc |
Inmunoconjugados con un enlace escindible intracelularmente
|
|
MX2011012794A
(es)
|
2009-06-03 |
2012-05-08 |
Immunogen Inc |
Metodos de conjugacion.
|
|
JP5756804B2
(ja)
|
2009-08-18 |
2015-07-29 |
ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
Ｔｏｌｌ様レセプターモジュレーターとしての置換ベンゾアゼピン
|
|
RU2580320C2
(ru)
|
2009-08-18 |
2016-04-10 |
Вентиркс Фармасьютикалз, Инк. |
Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
|
|
CN102666541B
(zh)
|
2009-10-22 |
2015-11-25 |
吉里德科学公司 |
用于治疗特别是病毒感染的嘌呤或脱氮嘌呤的衍生物
|
|
MX336540B
(es)
|
2010-06-08 |
2016-01-22 |
Genentech Inc |
Conjugados y anticuerpos manipulados geneticamente con cisteina.
|
|
CN103200950B
(zh)
|
2010-06-10 |
2016-03-16 |
西雅图基因公司 |
新颖的耳他汀衍生物及其用途
|
|
MX347954B
(es)
|
2010-09-29 |
2017-05-19 |
Agensys Inc |
Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
|
|
CN107970451A
(zh)
|
2010-10-01 |
2018-05-01 |
帆德制药股份有限公司 |
Tlr激动剂和联合治疗的治疗应用
|
|
WO2012045089A2
(en)
|
2010-10-01 |
2012-04-05 |
Ventirx Pharmaceuticals, Inc. |
Methods for the treatment of allergic diseases
|
|
WO2012097177A2
(en)
|
2011-01-12 |
2012-07-19 |
Ventirx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
BR112013017943A2
(pt)
|
2011-01-12 |
2018-12-18 |
Array Biopharma Inc |
benzoazepinas substituídas como moduladores receptores do tipo toll
|
|
BR112013024574B1
(pt)
|
2011-03-29 |
2022-08-09 |
Roche Glycart Ag |
Anticorpo e uso do anticorpo
|
|
KR101946499B1
(ko)
|
2011-04-08 |
2019-02-11 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
바이러스 감염 치료를 위한 피리미딘 유도체
|
|
HUE036220T2
(hu)
|
2011-05-18 |
2018-06-28 |
Janssen Sciences Ireland Uc |
Kinazolin származékok vírusfertõzések és további betegségek kezelésére
|
|
EP3228325A1
(en)
|
2011-06-10 |
2017-10-11 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
JP6240599B2
(ja)
|
2011-07-19 |
2017-11-29 |
セルモザイク， インコーポレイテッド |
新規の架橋試薬、高分子、治療用コンジュゲートおよびその合成法
|
|
PH12013502531A1
(en)
|
2011-08-23 |
2014-01-20 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
CN104136461B
(zh)
|
2011-09-22 |
2021-06-08 |
安姆根有限公司 |
Cd27l抗原结合蛋白
|
|
EA037918B1
(ru)
|
2011-12-21 |
2021-06-07 |
Новира Терапьютикс, Инк. |
Противовирусные агенты против гепатита в
|
|
EA039373B1
(ru)
|
2012-02-08 |
2022-01-19 |
Янссен Сайенсиз Айрлэнд Юси |
Производные пиперидино-пиримидина для лечения вирусных инфекций
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
BR112015002524B1
(pt)
|
2012-08-10 |
2021-11-03 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina, composição farmacêutica que os compreende e uso dos mesmos
|
|
NZ705589A
(en)
|
2012-10-10 |
2019-05-31 |
Janssen Sciences Ireland Uc |
Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
|
|
IL294622B2
(en)
|
2012-10-11 |
2023-10-01 |
Daiichi Sankyo Co Ltd |
Antibody-drug conjugates and methods for their preparation
|
|
SI2911699T2
(sl)
|
2012-10-23 |
2026-01-30 |
Synaffix B.V. |
Modificirano protitelo, protitelo-konjugat in proces za njihovo pripravo
|
|
US10036010B2
(en)
|
2012-11-09 |
2018-07-31 |
Innate Pharma |
Recognition tags for TGase-mediated conjugation
|
|
AU2013346793B2
(en)
|
2012-11-16 |
2018-03-08 |
Janssen Sciences Ireland Uc |
Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
|
|
KR102225233B1
(ko)
|
2013-02-21 |
2021-03-09 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
EP3027624B1
(en)
|
2013-07-30 |
2018-09-12 |
Janssen Sciences Ireland UC |
Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
|
|
TWI526446B
(zh)
|
2013-09-27 |
2016-03-21 |
中國醫藥大學附設醫院 |
喜樹鹼的新穎２０（ｓ）－磺基脒衍生物及其抗腫瘤劑的用途
|
|
EP2935611B1
(en)
|
2013-10-14 |
2021-07-07 |
SynAffix B.V. |
Glycoengineered antibody, antibody-conjugate and methods for their preparation
|
|
US20160287623A1
(en)
|
2013-11-19 |
2016-10-06 |
The University Of Chicago |
Use of sting agonist as cancer treatment
|
|
TWI727919B
(zh)
|
2013-12-19 |
2021-05-21 |
美商西雅圖遺傳學公司 |
與標的-藥物結合物併用之亞甲基胺基甲酸酯連接物
|
|
JP6716461B2
(ja)
|
2014-02-17 |
2020-07-01 |
シアトル ジェネティックス， インコーポレイテッド |
親水性抗体−薬物コンジュゲート
|
|
PL3134402T3
(pl)
|
2014-04-22 |
2020-11-02 |
F.Hoffmann-La Roche Ag |
Związki 4-amino-imidazochinolinowe
|
|
SG11201609462RA
(en)
|
2014-06-13 |
2016-12-29 |
Novartis Ag |
Auristatin derivatives and conjugates thereof
|
|
EP4140485A1
(en)
|
2014-07-11 |
2023-03-01 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors for the treatment of hiv
|
|
KR20170030648A
(ko)
|
2014-08-04 |
2017-03-17 |
시나픽스 비.브이. |
베타-(1,4)-n-아세틸갈락토오스아미닐트랜스퍼라아제, 또는 이의 돌연변이체를 이용한 당 단백질의 변형 방법
|
|
DK3191502T3
(da)
|
2014-09-11 |
2021-07-19 |
Seagen Inc |
Målrettet indgivelse af tertiært aminholdige lægemiddelstoffer
|
|
US10077318B2
(en)
|
2014-09-12 |
2018-09-18 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
KR102557560B1
(ko)
|
2014-12-08 |
2023-07-20 |
에프. 호프만-라 로슈 아게 |
바이러스 감염의 치료 또는 예방을 위한 3-치환된 5-아미노-6H-티아졸로[4,5-d]피리미딘-2,7-다이온 화합물
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
PL3097102T3
(pl)
|
2015-03-04 |
2018-04-30 |
Gilead Sciences Inc |
Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego
|
|
PE20171456A1
(es)
|
2015-03-06 |
2017-10-06 |
Hoffmann La Roche |
Compuestos de dicarboxamida de benzazepinas
|
|
AU2016232705C1
(en)
|
2015-03-18 |
2021-06-17 |
Arvinas, Inc. |
Compounds and methods for the enhanced degradation of targeted proteins
|
|
JP6893501B2
(ja)
|
2015-09-17 |
2021-06-23 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
スルフィニルフェニル又はスルホンイミドイルフェニルベンザゼピン
|
|
EP3368229B1
(en)
|
2015-10-27 |
2021-12-08 |
Koninklijke Philips N.V. |
Anti-fouling system , controller and method of controlling the anti-fouling system
|
|
EP3370726A4
(en)
|
2015-11-02 |
2019-06-12 |
VentiRx Pharmaceuticals, Inc. |
USE OF TLR8 AGONISTS FOR CANCER TREATMENT
|
|
US10393904B2
(en)
|
2015-11-06 |
2019-08-27 |
Weatherford Technology Holdings, Llc |
Predicting stress-induced anisotropy effect on acoustic tool response
|
|
US11229708B2
(en)
|
2015-12-04 |
2022-01-25 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
EP3419670A2
(en)
|
2016-02-26 |
2019-01-02 |
Regeneron Pharmaceuticals, Inc. |
Optimized transglutaminase site-specific antibody conjugation
|
|
EP4063858A1
(en)
|
2016-03-14 |
2022-09-28 |
Biogen International Neuroscience GmbH |
Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins
|
|
LT3453707T
(lt)
|
2016-05-06 |
2022-03-10 |
Shanghai De Novo Pharmatech Co., Ltd. |
Benzazepino darinys, gamybos būdas, farmacinė kompozicija ir jos naudojimas
|
|
CN118436801A
(zh)
|
2016-05-20 |
2024-08-06 |
豪夫迈·罗氏有限公司 |
Protac抗体缀合物及其使用方法
|
|
JP6918838B2
(ja)
|
2016-05-23 |
2021-08-11 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
第三級アミド基を有するベンズアゼピンジカルボキサミド化合物
|
|
JP7022702B2
(ja)
|
2016-05-23 |
2022-02-18 |
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト |
第二級アミド基を有するベンズアゼピンジカルボキサミド化合物
|
|
EP3468963B1
(en)
|
2016-06-12 |
2021-10-27 |
F. Hoffmann-La Roche AG |
Dihydropyrimidinyl benzazepine carboxamide compounds
|
|
KR20240010534A
(ko)
|
2016-08-09 |
2024-01-23 |
씨젠 인크. |
개선된 물리화학적 특성을 갖는 자기 안정화 링커를 구비한 약물 접합체
|
|
ES2826748T3
(es)
|
2016-09-02 |
2021-05-19 |
Gilead Sciences Inc |
Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
|
|
MX2019010804A
(es)
|
2017-03-15 |
2020-01-23 |
Silverback Therapeutics Inc |
Compuestos de benzazepina, conjugados y usos de los mismos.
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
CN110891605A
(zh)
|
2017-06-07 |
2020-03-17 |
希沃尔拜克治疗公司 |
免疫调节化合物的抗体缀合物及其用途
|
|
KR102867311B1
(ko)
|
2017-08-11 |
2025-10-01 |
리서치 디벨럽먼트 파운데이션 |
증강된 혈청 반감기를 위한 조작된 항체 fc 변이체
|
|
EP4667495A3
(en)
|
2017-12-15 |
2026-03-11 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Bioactive molecule conjugate, preparation method and use thereof
|
|
CA3088059A1
(en)
|
2018-01-10 |
2019-07-18 |
Development Center For Biotechnology |
Antibody protac conjugates
|
|
IL276546B2
(en)
|
2018-02-20 |
2024-08-01 |
Seagen Inc |
Hydrophobic auristatin F compounds and their conjugates
|
|
WO2019213046A1
(en)
|
2018-05-01 |
2019-11-07 |
Cellmosaic Inc. |
Branched sugar alcohol-based compounds, and compositions and methods thereof
|
|
WO2020056194A1
(en)
|
2018-09-12 |
2020-03-19 |
Silverback Therapeutics, Inc. |
Benzazepine compounds, conjugates, and uses thereof
|
|
US20220048895A1
(en)
|
2018-09-12 |
2022-02-17 |
Silverback Therapeutics, Inc. |
Substituted benzazepine compounds, conjugates, and uses thereof
|
|
CN112770771A
(zh)
|
2018-09-17 |
2021-05-07 |
丘拉提斯股份有限公司 |
包含干扰素基因刺激蛋白激动剂的免疫佐剂及疫苗组合物
|
|
TWI855000B
(zh)
|
2018-10-11 |
2024-09-11 |
日商小野藥品工業股份有限公司 |
Ｓｔｉｎｇ促效化合物
|
|
WO2020074004A1
(zh)
|
2018-10-12 |
2020-04-16 |
上海济煜医药科技有限公司 |
环二核苷酸类化合物及其应用
|
|
WO2020123425A2
(en)
|
2018-12-12 |
2020-06-18 |
Bristol-Myers Squibb Company |
Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses
|
|
US10781239B2
(en)
|
2018-12-28 |
2020-09-22 |
Vividion Therapeutics, Inc. |
In vivo engineered cereblon protein
|
|
CN113286796B
(zh)
|
2019-01-30 |
2024-07-05 |
四川科伦博泰生物医药股份有限公司 |
喜树碱衍生物及其水溶性前药、包含其的药物组合物及其制备方法和用途
|
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
|
EP3976112A1
(en)
|
2019-06-03 |
2022-04-06 |
Synaffix B.V. |
Acetal-based cleavable linkers
|
|
CN113444178B
(zh)
*
|
2021-06-17 |
2022-12-02 |
南京蓝盾生物科技有限公司 |
抗cd70内化的抗体、抗体偶联物及其应用
|