ATE216366T1 - 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression - Google Patents
2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppressionInfo
- Publication number
- ATE216366T1 ATE216366T1 AT97305934T AT97305934T ATE216366T1 AT E216366 T1 ATE216366 T1 AT E216366T1 AT 97305934 T AT97305934 T AT 97305934T AT 97305934 T AT97305934 T AT 97305934T AT E216366 T1 ATE216366 T1 AT E216366T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- immunosuppression
- aminobenzazepine
- derivatives
- cancer
- Prior art date
Links
- QXUNLRUYUXSFQE-UHFFFAOYSA-N 1h-1-benzazepin-2-amine Chemical class N1C(N)=CC=CC2=CC=CC=C21 QXUNLRUYUXSFQE-UHFFFAOYSA-N 0.000 title 1
- 206010062016 Immunosuppression Diseases 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 206010065553 Bone marrow failure Diseases 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 208000024386 fungal infectious disease Diseases 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2342396P | 1996-08-16 | 1996-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE216366T1 true ATE216366T1 (de) | 2002-05-15 |
Family
ID=21815010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97305934T ATE216366T1 (de) | 1996-08-16 | 1997-08-05 | 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6043238A (de) |
| EP (1) | EP0825186B1 (de) |
| JP (1) | JP2978850B2 (de) |
| AT (1) | ATE216366T1 (de) |
| CA (1) | CA2213108C (de) |
| DE (1) | DE69711996T2 (de) |
| DK (1) | DK0825186T3 (de) |
| ES (1) | ES2173391T3 (de) |
| MX (1) | MX9706231A (de) |
| PT (1) | PT825186E (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936602B1 (en) | 1999-06-16 | 2005-08-30 | Takeda Chemical Industries, Ltd. | Benzazepine derivatives, process for the preparation of the same and uses thereof |
| SE0003795D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| TWI404537B (zh) * | 2005-08-19 | 2013-08-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
| TWI382019B (zh) * | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| PT2313111E (pt) | 2008-08-01 | 2013-12-05 | Ventirx Pharmaceuticals Inc | Formulações de agonista de receptor do tipo toll e seus usos |
| ES2545275T3 (es) | 2008-11-06 | 2015-09-09 | Ventirx Pharmaceuticals, Inc. | Métodos de síntesis de derivados de benzazepinas |
| PL2467377T3 (pl) * | 2009-08-18 | 2017-10-31 | Ventirx Pharmaceuticals Inc | Podstawione benzoazepiny jako modulatory receptora toll-podobnego |
| WO2011022509A2 (en) | 2009-08-18 | 2011-02-24 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| US20130236449A1 (en) | 2010-04-21 | 2013-09-12 | Ventirx Pharmaceuticals, Inc. | Methods of enhancing antibody-dependent cellular cytotoxicity |
| BR112013017947A2 (pt) * | 2011-01-12 | 2018-12-18 | Array Biopharma Inc | benzoazepinas substituídas como moduladores de receptor toll-like |
| US9718796B2 (en) * | 2011-01-12 | 2017-08-01 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| CN109311854B (zh) | 2016-05-23 | 2021-08-10 | 豪夫迈·罗氏有限公司 | 具有仲酰胺官能团的苯并氮杂卓二甲酰胺化合物 |
| WO2017202704A1 (en) | 2016-05-23 | 2017-11-30 | F. Hoffmann-La Roche Ag | Benzazepine dicarboxamide compounds with tertiary amide function |
| EP3468963B1 (de) | 2016-06-12 | 2021-10-27 | F. Hoffmann-La Roche AG | Dihydropyrimidinyl-benzazepincarboxamide verbindungen |
| JP2020514419A (ja) | 2017-03-15 | 2020-05-21 | シルバーバック セラピューティックス インコーポレイテッド | ベンズアゼピン化合物、そのコンジュゲート及び使用 |
| JP2021506827A (ja) | 2017-12-15 | 2021-02-22 | シルバーバック セラピューティックス インコーポレイテッド | 肝炎の治療用の抗体コンストラクト−薬物コンジュゲート |
| CN109956903B (zh) * | 2017-12-22 | 2022-08-23 | 江苏恒瑞医药股份有限公司 | 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 |
| MX2021015533A (es) | 2019-06-19 | 2022-02-10 | Silverback Therapeutics Inc | Anticuerpos anti-mesotelina e inmunoconjugados de los mismos. |
| WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| IL299508A (en) | 2020-07-01 | 2023-02-01 | Ars Pharmaceuticals Inc | Anti-asgr1 antibody conjugates and uses thereof |
| AU2022253902A1 (en) | 2021-04-10 | 2023-11-02 | Genmab A/S | Folr1 binding agents, conjugates thereof and methods of using the same |
| TW202308699A (zh) | 2021-04-23 | 2023-03-01 | 美商普方生物製藥美國公司 | Ｃｄ７０結合劑、其結合物及其使用方法 |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CA3237762A1 (en) * | 2021-11-19 | 2023-05-25 | Dun Yang | 1h-benzo[b]azepin-2(3h)-one compounds, compositions and methods of treating cancer |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| US20250296992A1 (en) | 2024-01-10 | 2025-09-25 | Genmab A/S | Slitrk6 binding agents, conjugates thereof and methods of using the same |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3509130A (en) * | 1966-12-09 | 1970-04-28 | Ciba Geigy Corp | 2-amino-1-benzazepines |
| US4968701A (en) * | 1988-04-26 | 1990-11-06 | E. I. Du Pont De Nemours And Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| US5310913A (en) * | 1989-06-09 | 1994-05-10 | Kabi Pharmacia Aktiebolag | Derivatives of quinoline-3-carboxanilide |
| US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
-
1997
- 1997-08-05 DE DE69711996T patent/DE69711996T2/de not_active Expired - Fee Related
- 1997-08-05 DK DK97305934T patent/DK0825186T3/da active
- 1997-08-05 EP EP97305934A patent/EP0825186B1/de not_active Expired - Lifetime
- 1997-08-05 PT PT97305934T patent/PT825186E/pt unknown
- 1997-08-05 AT AT97305934T patent/ATE216366T1/de not_active IP Right Cessation
- 1997-08-05 ES ES97305934T patent/ES2173391T3/es not_active Expired - Lifetime
- 1997-08-13 JP JP9218532A patent/JP2978850B2/ja not_active Expired - Fee Related
- 1997-08-14 CA CA002213108A patent/CA2213108C/en not_active Expired - Fee Related
- 1997-08-15 US US08/912,091 patent/US6043238A/en not_active Expired - Fee Related
- 1997-08-15 MX MX9706231A patent/MX9706231A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2978850B2 (ja) | 1999-11-15 |
| MX9706231A (es) | 1998-02-28 |
| EP0825186B1 (de) | 2002-04-17 |
| DE69711996D1 (de) | 2002-05-23 |
| CA2213108C (en) | 2001-12-11 |
| ES2173391T3 (es) | 2002-10-16 |
| CA2213108A1 (en) | 1998-02-16 |
| PT825186E (pt) | 2002-08-30 |
| JPH1087631A (ja) | 1998-04-07 |
| DE69711996T2 (de) | 2002-08-22 |
| US6043238A (en) | 2000-03-28 |
| EP0825186A1 (de) | 1998-02-25 |
| DK0825186T3 (da) | 2002-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |