ATE216366T1 - 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression - Google Patents

2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression

Info

Publication number
ATE216366T1
ATE216366T1 AT97305934T AT97305934T ATE216366T1 AT E216366 T1 ATE216366 T1 AT E216366T1 AT 97305934 T AT97305934 T AT 97305934T AT 97305934 T AT97305934 T AT 97305934T AT E216366 T1 ATE216366 T1 AT E216366T1
Authority
AT
Austria
Prior art keywords
treatment
immunosuppression
aminobenzazepine
derivatives
cancer
Prior art date
Application number
AT97305934T
Other languages
English (en)
Inventor
Christopher B Cooper
Joseph P Lyssikatos
Donald W Mann
Scott J Hecker
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE216366T1 publication Critical patent/ATE216366T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97305934T 1996-08-16 1997-08-05 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression ATE216366T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2342396P 1996-08-16 1996-08-16

Publications (1)

Publication Number Publication Date
ATE216366T1 true ATE216366T1 (de) 2002-05-15

Family

ID=21815010

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97305934T ATE216366T1 (de) 1996-08-16 1997-08-05 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression

Country Status (10)

Country Link
US (1) US6043238A (de)
EP (1) EP0825186B1 (de)
JP (1) JP2978850B2 (de)
AT (1) ATE216366T1 (de)
CA (1) CA2213108C (de)
DE (1) DE69711996T2 (de)
DK (1) DK0825186T3 (de)
ES (1) ES2173391T3 (de)
MX (1) MX9706231A (de)
PT (1) PT825186E (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076993A1 (fr) * 1999-06-16 2000-12-21 Takeda Chemical Industries, Ltd. Derives de benzazepine, procede de preparation de ces derives et utilisation
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
TWI404537B (zh) * 2005-08-19 2013-08-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
TWI382019B (zh) * 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
DK2313111T3 (da) 2008-08-01 2013-12-02 Ventirx Pharmaceuticals Inc Toll-lignende receptoragonistformuleringer og anvendelse deraf
CA2742863C (en) 2008-11-06 2017-05-09 Ventirx Pharmaceuticals, Inc. Methods of synthesis of benzazepine derivatives
WO2011022509A2 (en) 2009-08-18 2011-02-24 Ventirx Pharmaceuticals, Inc. Substituted benzoazepines as toll-like receptor modulators
ES2620629T3 (es) * 2009-08-18 2017-06-29 Ventirx Pharmaceuticals, Inc. Benzoazepinas sustituidas como moduladores del receptor tipo Toll
CN105640964A (zh) 2010-04-21 2016-06-08 文蒂雷克斯药品公司 增强抗体依赖性细胞的细胞毒性的方法
PT2663555T (pt) * 2011-01-12 2017-03-23 Array Biopharma Inc Benzoazepinas substituídas como moduladores de recetores tipo-toll
MX346387B (es) * 2011-01-12 2017-03-02 Ventirx Pharmaceuticals Inc Benzoazepinas sustituidas como moduladores de receptores tipo toll.
WO2017202703A1 (en) 2016-05-23 2017-11-30 F. Hoffmann-La Roche Ag Benzazepine dicarboxamide compounds with secondary amide function
EP3464245B1 (de) 2016-05-23 2020-10-14 H. Hoffnabb-La Roche Ag Benzazepindicarboxamidverbindungen mit tertiärer amidfunktion
JP7012668B2 (ja) 2016-06-12 2022-02-14 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物
CN110612104A (zh) 2017-03-15 2019-12-24 希沃尔拜克治疗公司 苯并氮杂*化合物、缀合物及其用途
WO2019118884A1 (en) 2017-12-15 2019-06-20 Silverback Therapeutics, Inc. Antibody construct-drug conjugate for the treatment of hepatitis
CN109956903B (zh) * 2017-12-22 2022-08-23 江苏恒瑞医药股份有限公司 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用
CN114341185A (zh) 2019-06-19 2022-04-12 希沃尔拜克治疗公司 抗间皮素抗体及其免疫缀合物
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
EP4175673A1 (de) 2020-07-01 2023-05-10 ARS Pharmaceuticals Inc. Anti-asgr1-antikörperkonjugate und verwendungen davon
CA3215049A1 (en) 2021-04-10 2022-10-13 Baiteng ZHAO Folr1 binding agents, conjugates thereof and methods of using the same
EP4326768A1 (de) 2021-04-23 2024-02-28 Profoundbio Us Co. Anti-cd70-antikörper, konjugate davon und verfahren zur verwendung davon
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN118525007A (zh) * 2021-11-19 2024-08-20 成都安泰康赛生物科技有限公司 治疗癌症的1h-苯并[b]氮杂䓬-2(3h)-酮化合物、组合物和方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509130A (en) * 1966-12-09 1970-04-28 Ciba Geigy Corp 2-amino-1-benzazepines
US4968701A (en) * 1988-04-26 1990-11-06 E. I. Du Pont De Nemours And Company 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents
US5310913A (en) * 1989-06-09 1994-05-10 Kabi Pharmacia Aktiebolag Derivatives of quinoline-3-carboxanilide
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines

Also Published As

Publication number Publication date
DK0825186T3 (da) 2002-07-22
ES2173391T3 (es) 2002-10-16
CA2213108C (en) 2001-12-11
EP0825186B1 (de) 2002-04-17
EP0825186A1 (de) 1998-02-25
PT825186E (pt) 2002-08-30
JPH1087631A (ja) 1998-04-07
DE69711996T2 (de) 2002-08-22
JP2978850B2 (ja) 1999-11-15
US6043238A (en) 2000-03-28
DE69711996D1 (de) 2002-05-23
MX9706231A (es) 1998-02-28
CA2213108A1 (en) 1998-02-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee