RU94043771A - Замещенные бензимидазольные соединения, способ лечения, фармацевтическая композиция и способ получения бензимидазольных соединений - Google Patents

Замещенные бензимидазольные соединения, способ лечения, фармацевтическая композиция и способ получения бензимидазольных соединений

Info

Publication number
RU94043771A
RU94043771A RU94043771/04A RU94043771A RU94043771A RU 94043771 A RU94043771 A RU 94043771A RU 94043771/04 A RU94043771/04 A RU 94043771/04A RU 94043771 A RU94043771 A RU 94043771A RU 94043771 A RU94043771 A RU 94043771A
Authority
RU
Russia
Prior art keywords
benzimidazole compounds
virus
synthesis
pharmaceutical composition
compounds
Prior art date
Application number
RU94043771/04A
Other languages
English (en)
Other versions
RU2141952C1 (ru
Inventor
Б. Таунсенд Лерой
Us]
Чарльз Дрэч Джон
Спенсер Гуд Стивен
Мэри Дэльюдж Сьюзн
Толар Мартин Майкл
Original Assignee
Дзе Веллкам Фаундейшн Лимитед (GB)
Дзе Веллкам Фаундейшн Лимитед
Дзе Риджентс оф дзе Юниверсити оф Мичиган (US)
Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Веллкам Фаундейшн Лимитед (GB), Дзе Веллкам Фаундейшн Лимитед, Дзе Риджентс оф дзе Юниверсити оф Мичиган (US), Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган filed Critical Дзе Веллкам Фаундейшн Лимитед (GB)
Publication of RU94043771A publication Critical patent/RU94043771A/ru
Application granted granted Critical
Publication of RU2141952C1 publication Critical patent/RU2141952C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

К особенно предпочтительным соединениям относятся такие, в которых положения 2, 5 и 6 имидазольного основания замещены галогеном. Соединения обладают активностью против вируса герпеса, особенно вируса цитомегалии, а также против инфекций вирусом гепатита В.

Claims (1)

  1. К особенно предпочтительным соединениям относятся такие, в которых положения 2, 5 и 6 имидазольного основания замещены галогеном. Соединения обладают активностью против вируса герпеса, особенно вируса цитомегалии, а также против инфекций вирусом гепатита В.
RU94043771A 1992-03-09 1993-03-08 Замещенные бензимидазольные соединения, способы получения и фармацевтическая композиция на их основе, обладающая антивирусным действием RU2141952C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9205071.5 1992-03-09
GB929205071A GB9205071D0 (en) 1992-03-09 1992-03-09 Therapeutic nucleosides
PCT/GB1993/000479 WO1993018009A1 (en) 1992-03-09 1993-03-08 Antiviral nucleoside analogues

Publications (2)

Publication Number Publication Date
RU94043771A true RU94043771A (ru) 1996-08-10
RU2141952C1 RU2141952C1 (ru) 1999-11-27

Family

ID=10711750

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94043771A RU2141952C1 (ru) 1992-03-09 1993-03-08 Замещенные бензимидазольные соединения, способы получения и фармацевтическая композиция на их основе, обладающая антивирусным действием

Country Status (20)

Country Link
US (1) US5534535A (ru)
EP (1) EP0630368B1 (ru)
JP (1) JP3450854B2 (ru)
KR (2) KR950700887A (ru)
AT (1) ATE170846T1 (ru)
AU (1) AU672597B2 (ru)
CA (1) CA2131693A1 (ru)
CZ (1) CZ209494A3 (ru)
DE (1) DE69320945T2 (ru)
DK (1) DK0630368T3 (ru)
ES (1) ES2123048T3 (ru)
FI (1) FI944134A (ru)
GB (1) GB9205071D0 (ru)
HU (1) HUT68445A (ru)
IL (1) IL104976A (ru)
NZ (1) NZ249554A (ru)
RU (1) RU2141952C1 (ru)
TW (1) TW366339B (ru)
WO (1) WO1993018009A1 (ru)
ZA (1) ZA931647B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JPH10505092A (ja) * 1994-09-09 1998-05-19 ザ・ウエルカム・ファンデーション・リミテッド 環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
EP0970100B1 (en) 1997-02-13 2003-11-12 Glaxo Group Limited Benzimidazole derivatives
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
ES2205527T3 (es) 1997-06-10 2004-05-01 Glaxo Group Limited Derivados de bencimidazol.
WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
CN100457118C (zh) 2000-04-13 2009-02-04 法玛塞特有限公司 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
ES2758027T3 (es) 2007-08-02 2020-05-04 Millennium Pharm Inc Intermedios para la síntesis de inhibidores de enzimas activadoras de actividad E1
CA2722733C (en) 2008-04-28 2016-02-23 Kyorin Pharmaceutical Co., Ltd. Cyclopentylacrylamide derivative
US11499722B2 (en) * 2020-04-30 2022-11-15 Bsh Home Appliances Corporation Household cooking appliance having an oven door with an interior camera

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
CA2131693A1 (en) 1993-09-16
FI944134A0 (fi) 1994-09-08
JPH07506816A (ja) 1995-07-27
NZ249554A (en) 1996-05-28
AU3643293A (en) 1993-10-05
EP0630368A1 (en) 1994-12-28
GB9205071D0 (en) 1992-04-22
KR970705547A (ko) 1997-10-09
AU672597B2 (en) 1996-10-10
DE69320945T2 (de) 1999-02-04
ATE170846T1 (de) 1998-09-15
RU2141952C1 (ru) 1999-11-27
FI944134A (fi) 1994-11-07
ZA931647B (en) 1994-09-08
DK0630368T3 (da) 1999-06-07
IL104976A (en) 1998-10-30
CZ209494A3 (en) 1995-11-15
HUT68445A (en) 1995-06-28
KR950700887A (ko) 1995-02-20
US5534535A (en) 1996-07-09
DE69320945D1 (de) 1998-10-15
HU9402582D0 (en) 1994-11-28
WO1993018009A1 (en) 1993-09-16
EP0630368B1 (en) 1998-09-09
ES2123048T3 (es) 1999-01-01
IL104976A0 (en) 1993-07-08
TW366339B (en) 1999-08-11
JP3450854B2 (ja) 2003-09-29

Similar Documents

Publication Publication Date Title
RU94043771A (ru) Замещенные бензимидазольные соединения, способ лечения, фармацевтическая композиция и способ получения бензимидазольных соединений
NL300247I1 (nl) 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.
DK118286A (da) Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne
EA199800943A1 (ru) Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
RU94046306A (ru) Производные индолокарбазолимида, смесь их изомеров или отдельные изомеры и их соли и фармацевтическая композиция с активностью, ингибирующей протеинкиназу с или киназу легкой миозиновой цепи или подавляющей иммунные реакции
KR950700298A (ko) 뉴클레오시드 치료제(Therapeutic Nucleosides)
EA200200247A1 (ru) Производные арилметилкарбониламинотиазола и их применение в качестве противоопухолевых средств
EA199900494A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
RU95108243A (ru) Производные амидов вальпроновой и 2-вальпроеновой кислоты, фармацевтическая композиция, способы лечения
ATE20748T1 (de) Guaninderivate.
ATE112279T1 (de) Cc-1065 analoge.
SE8900192D0 (sv) Dideoxididehydrokarbocykliska nukleosider
KR880013937A (ko) 옥세타노신 유도체
RU94038256A (ru) Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе
DK468288D0 (da) Antivirale forbindelser
EA200000996A1 (ru) Конденсированные с арилом азаполициклические соединения
RU94035964A (ru) Производные бензопирана, фармацевтическая композиция на их основе, способ их получения, способ лечения и способ получения промежуточного продукта
RU94039545A (ru) Новые производные аденозина, способы их получения, фармацевтические композиции на их основе, способы получения фармацевтических композиций и их применение
KR900009083A (ko) 2', 3'-디데옥시푸린 뉴클레오사이드/푸린 뉴클레오 사이드 포스포릴라제 억제제 배합 치료법 및 조성물
MC1930A1 (fr) Produit antiviral
ES2105923A1 (es) Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv).
DE3273975D1 (de) Antiviral alpha, alpha-dialkyl adamantylethylamines
ES2194320T3 (es) Sustancias naturales antivirales o antitumorales y uso de las mismas.
RU94046312A (ru) Применение биологически активных уреидопроизводных для лечения индуцируемых лентивирусами заболеваний, продукты, содержащие уреидопроизводные
ATE26267T1 (de) Pyrimidin-derivate, ausgestattet mit antiviraler wirkung.