EA199800526A1 - Производные бензимидазола и их применение для лечения вирусных инфекций - Google Patents

Производные бензимидазола и их применение для лечения вирусных инфекций

Info

Publication number
EA199800526A1
EA199800526A1 EA199800526A EA199800526A EA199800526A1 EA 199800526 A1 EA199800526 A1 EA 199800526A1 EA 199800526 A EA199800526 A EA 199800526A EA 199800526 A EA199800526 A EA 199800526A EA 199800526 A1 EA199800526 A1 EA 199800526A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
viral infections
benzimidazole
derivatives
application
Prior art date
Application number
EA199800526A
Other languages
English (en)
Other versions
EA001770B1 (ru
Inventor
Стенли Доз Чеймберлейн
Джордж Уолтер Козалка
Джеффри Х. Тидвелл
Нэнин Агнета Ван Драанен
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA199800526A1 publication Critical patent/EA199800526A1/ru
Publication of EA001770B1 publication Critical patent/EA001770B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к производным бензимидазола и их применению в медицинской терапии, особенно для лечения или профилактики вирусных инфекций, таких как инфекции, вызываемые вирусами герпеса. Изобретение также относится к получению производных бензимидазола и фармацевтическим препаратам, их содержащим.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800526A 1996-01-05 1996-12-19 Производные бензимидазола и их применение для лечения вирусных инфекций EA001770B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9600143.3A GB9600143D0 (en) 1996-01-05 1996-01-05 Therapeutic compounds
PCT/GB1996/003151 WO1997025337A1 (en) 1996-01-05 1996-12-19 Therapeutic compounds

Publications (2)

Publication Number Publication Date
EA199800526A1 true EA199800526A1 (ru) 1999-04-29
EA001770B1 EA001770B1 (ru) 2001-08-27

Family

ID=10786611

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800526A EA001770B1 (ru) 1996-01-05 1996-12-19 Производные бензимидазола и их применение для лечения вирусных инфекций

Country Status (21)

Country Link
US (2) US6204249B1 (ru)
EP (1) EP0876389A1 (ru)
JP (1) JP2000515119A (ru)
KR (1) KR19990077041A (ru)
CN (1) CN1214049A (ru)
AP (1) AP9801286A0 (ru)
AU (1) AU729541B2 (ru)
BR (1) BR9612413A (ru)
CA (1) CA2241993A1 (ru)
CZ (1) CZ212698A3 (ru)
EA (1) EA001770B1 (ru)
GB (1) GB9600143D0 (ru)
HU (1) HUP9904301A3 (ru)
IS (1) IS4789A (ru)
MX (1) MX9805441A (ru)
NO (1) NO983090L (ru)
NZ (1) NZ324380A (ru)
OA (1) OA10707A (ru)
PL (1) PL327732A1 (ru)
TR (1) TR199801289T2 (ru)
WO (1) WO1997025337A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2223814A1 (en) * 1995-08-18 1997-02-27 John C. Drach 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
WO1998035977A1 (en) * 1997-02-13 1998-08-20 Glaxo Group Limited Benzimidazole derivatives
JP2001513084A (ja) 1997-02-25 2001-08-28 ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ，レプリゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール
JP2001512132A (ja) 1997-07-30 2001-08-21 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン 抗ウイルス薬としてのリクソフラノシルベンズイミダゾール
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP1698635B1 (en) 2003-12-26 2011-12-14 Kissei Pharmaceutical Co., Ltd. Benzimidazole derivatives and medical uses thereof
WO2009044886A1 (ja) 2007-10-05 2009-04-09 Api Corporation リボフラノース誘導体の製造方法
JP7376108B2 (ja) * 2020-06-23 2023-11-08 バイオメトリックス テクノロジーズ インコーポレイテッド 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE130030C (ru)
US3399987A (en) 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
US4002623A (en) 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2551442B1 (fr) 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
DK405988A (da) 1987-07-29 1989-01-30 Hoffmann La Roche Benzimidazolderivater
IT1226100B (it) 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1992018517A1 (en) 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9205071D0 (en) 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AU5447094A (en) * 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
GB9226879D0 (en) 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US5399580A (en) 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
CA2223814A1 (en) 1995-08-18 1997-02-27 John C. Drach 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US5995610A (en) * 1997-05-06 1999-11-30 Telefonaktiebolaget Lm Ericsson Cooperative call processing across public and private intelligent networks

Also Published As

Publication number Publication date
EA001770B1 (ru) 2001-08-27
PL327732A1 (en) 1998-12-21
HUP9904301A2 (hu) 2000-05-28
NO983090L (no) 1998-09-01
WO1997025337A1 (en) 1997-07-17
TR199801289T2 (en) 1998-10-21
NO983090D0 (no) 1998-07-03
US6204249B1 (en) 2001-03-20
IS4789A (is) 1998-06-30
OA10707A (en) 2001-05-09
JP2000515119A (ja) 2000-11-14
US6617315B1 (en) 2003-09-09
KR19990077041A (ko) 1999-10-25
NZ324380A (en) 2000-01-28
AU1164097A (en) 1997-08-01
AP9801286A0 (en) 1998-09-30
CZ212698A3 (cs) 1998-12-16
CN1214049A (zh) 1999-04-14
CA2241993A1 (en) 1997-07-17
MX9805441A (es) 1998-11-30
EP0876389A1 (en) 1998-11-11
BR9612413A (pt) 1999-07-13
GB9600143D0 (en) 1996-03-06
HUP9904301A3 (en) 2001-07-30
AU729541B2 (en) 2001-02-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU