WO2009044886A1 - リボフラノース誘導体の製造方法 - Google Patents

リボフラノース誘導体の製造方法 Download PDF

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Publication number
WO2009044886A1
WO2009044886A1 PCT/JP2008/068095 JP2008068095W WO2009044886A1 WO 2009044886 A1 WO2009044886 A1 WO 2009044886A1 JP 2008068095 W JP2008068095 W JP 2008068095W WO 2009044886 A1 WO2009044886 A1 WO 2009044886A1
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WO
WIPO (PCT)
Prior art keywords
acyl
production
hydrogen
aralkyl
acetyl
Prior art date
Application number
PCT/JP2008/068095
Other languages
English (en)
French (fr)
Inventor
Tomoko Maeda
Hisatoshi Uehara
Naoki Harada
Manabu Katsurada
Mitsuharu Sano
Original Assignee
Api Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Api Corporation filed Critical Api Corporation
Priority to JP2009536123A priority Critical patent/JPWO2009044886A1/ja
Priority to CN2008801191776A priority patent/CN101918422A/zh
Priority to EP08834813A priority patent/EP2210896A1/en
Priority to CA2707641A priority patent/CA2707641A1/en
Priority to US12/681,658 priority patent/US20100298550A1/en
Publication of WO2009044886A1 publication Critical patent/WO2009044886A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

　本発明の目的は、工業的に適切な方法で、１，２，３－トリ－Ｏ－アセチル－５－デオキシリボフラノースを製造する方法を提供することである。本発明によれば、式（１）又は式（２）： （式（１）中、Ｐ1及びＰ2はそれぞれ独立して水素原子又はアシル基を示し、またＯＰ1とＯＰ2が一緒になってアセタール基を形成してもよく、Ｒは水素原子、アルキル基、アリール基、アラルキル基、又はアシル基を示す。） （式（２）中、Ｘ1はＢｒ又はＩを示し、Ｐ3及びＰ4はそれぞれ独立して水素原子又はアシル基を示し、Ｒは水素原子、アルキル基、アリール基、アラルキル基、又はアシル基を示す。） で表される化合物を、金属触媒の存在下において水素添加することを含む、１，２，３－トリ－Ｏ－アセチル－５－デオキシリボフラノースを製造する方法が提供される。
PCT/JP2008/068095 2007-10-05 2008-10-03 リボフラノース誘導体の製造方法 WO2009044886A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009536123A JPWO2009044886A1 (ja) 2007-10-05 2008-10-03 リボフラノース誘導体の製造方法
CN2008801191776A CN101918422A (zh) 2007-10-05 2008-10-03 呋喃核糖衍生物的制备方法
EP08834813A EP2210896A1 (en) 2007-10-05 2008-10-03 Process for production of ribofuranose derivatives
CA2707641A CA2707641A1 (en) 2007-10-05 2008-10-03 Process for producing ribofuranose derivatives
US12/681,658 US20100298550A1 (en) 2007-10-05 2008-10-03 Process for production of ribofuranose derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007261962 2007-10-05
JP2007-261962 2007-10-05
JP2008149093 2008-06-06
JP2008-149093 2008-06-06

Publications (1)

Publication Number Publication Date
WO2009044886A1 true WO2009044886A1 (ja) 2009-04-09

Family

ID=40526306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068095 WO2009044886A1 (ja) 2007-10-05 2008-10-03 リボフラノース誘導体の製造方法

Country Status (6)

Country Link
US (1) US20100298550A1 (ja)
EP (1) EP2210896A1 (ja)
JP (1) JPWO2009044886A1 (ja)
CN (1) CN101918422A (ja)
CA (1) CA2707641A1 (ja)
WO (1) WO2009044886A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483593A (zh) * 2019-08-14 2019-11-22 贵州永诺菲特生物制药有限公司 一种卡培他滨中间体的制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847413A (en) 1953-11-23 1958-08-12 Merck & Co Inc 5'-desoxyriboflavin and processes for preparing the same
EP0021231A2 (de) 1979-06-15 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 5'-Deoxy-5-fluoruridin und Zwischenprodukte in diesem Verfahren
JPH05255368A (ja) * 1992-03-13 1993-10-05 Tokyo Yatsuka Univ 立体選択的ｄ−リボフラノシル化法
WO1994006438A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Adenosine analogues and method of increasing adenosine release
WO1997025337A1 (en) 1996-01-05 1997-07-17 Glaxo Group Limited Therapeutic compounds
JP2003306495A (ja) * 2002-02-12 2003-10-28 Mitsubishi Chemicals Corp 核酸誘導体の製造方法
JP2004217630A (ja) * 2002-12-24 2004-08-05 Sankyo Co Ltd 右糖グルコースリピドａ類縁体
CN101012252A (zh) 2007-01-30 2007-08-08 王成举 1,2,3－三－o－乙酰基－5－脱氧－d－核糖合成方法
WO2008069303A1 (ja) * 2006-12-08 2008-06-12 Api Corporation フラノース誘導体の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010011075A1 (en) * 1999-02-05 2001-08-02 Leroy B Townsend 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
US6900298B2 (en) * 2002-02-12 2005-05-31 Mitsubishi Chemical Corporation Process for producing nucleic acid derivative

Patent Citations (11)

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Publication number Priority date Publication date Assignee Title
US2847413A (en) 1953-11-23 1958-08-12 Merck & Co Inc 5'-desoxyriboflavin and processes for preparing the same
EP0021231A2 (de) 1979-06-15 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 5'-Deoxy-5-fluoruridin und Zwischenprodukte in diesem Verfahren
JPS565497A (en) 1979-06-15 1981-01-20 Hoffmann La Roche Novel manufacture of 5**deoxyy55fluorouridine
JPS59144798A (ja) * 1979-06-15 1984-08-18 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト ５−フルオロウラシル誘導体
JPH05255368A (ja) * 1992-03-13 1993-10-05 Tokyo Yatsuka Univ 立体選択的ｄ−リボフラノシル化法
WO1994006438A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Adenosine analogues and method of increasing adenosine release
WO1997025337A1 (en) 1996-01-05 1997-07-17 Glaxo Group Limited Therapeutic compounds
JP2003306495A (ja) * 2002-02-12 2003-10-28 Mitsubishi Chemicals Corp 核酸誘導体の製造方法
JP2004217630A (ja) * 2002-12-24 2004-08-05 Sankyo Co Ltd 右糖グルコースリピドａ類縁体
WO2008069303A1 (ja) * 2006-12-08 2008-06-12 Api Corporation フラノース誘導体の製造方法
CN101012252A (zh) 2007-01-30 2007-08-08 王成举 1,2,3－三－o－乙酰基－5－脱氧－d－核糖合成方法

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Also Published As

Publication number Publication date
EP2210896A1 (en) 2010-07-28
CN101918422A (zh) 2010-12-15
JPWO2009044886A1 (ja) 2011-02-10
CA2707641A1 (en) 2009-04-09
US20100298550A1 (en) 2010-11-25

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