MX337925B - Sintesis de morfina-6-glucuronido o de uno de sus derivados. - Google Patents

Sintesis de morfina-6-glucuronido o de uno de sus derivados.

Info

Publication number
MX337925B
MX337925B MX2011006264A MX2011006264A MX337925B MX 337925 B MX337925 B MX 337925B MX 2011006264 A MX2011006264 A MX 2011006264A MX 2011006264 A MX2011006264 A MX 2011006264A MX 337925 B MX337925 B MX 337925B
Authority
MX
Mexico
Prior art keywords
group
glucuronide
derivatives
morphine
reacting
Prior art date
Application number
MX2011006264A
Other languages
English (en)
Other versions
MX2011006264A (es
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2011006264A publication Critical patent/MX2011006264A/es
Publication of MX337925B publication Critical patent/MX337925B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de morfina-6-glucurónido o de uno de sus derivados, que comprende las etapas que consisten: (ii) en hacer reaccionar un compuesto que responde a la fórmula (I) siguiente : en la que: R1 representa un grupo carbonilo, COR5CO o S02R6S02 con un derivado de ácido glucurónico que responde a la fórmula (II) siguiente: en la que: PG representa un grupo acetilo, isobutirilo, benzoílo o pivaloílo, X representa un grupo trihalógenoacetamidato, y R4 representa un grupo alquilcarboxilato de 1 a 4 átomos de carbono; en presencia de un disolvente aromático y de trifluorometanosulfonilo de trimetilsilano (ii) en hacer reaccionar el producto obtenido en la etapa (i) con un agente fuertemente básico, después (iii) en recuperar el producto obtenido en la etapa (ii).
MX2011006264A 2008-12-10 2009-12-08 Sintesis de morfina-6-glucuronido o de uno de sus derivados. MX337925B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806948A FR2939436B1 (fr) 2008-12-10 2008-12-10 Synthese de morphine-6-glucuronide ou de l'un de ses derives
PCT/FR2009/052445 WO2010067007A2 (fr) 2008-12-10 2009-12-08 Synthese de morphine-6-glucuronide ou de l'un de ses derives

Publications (2)

Publication Number Publication Date
MX2011006264A MX2011006264A (es) 2011-11-04
MX337925B true MX337925B (es) 2016-03-28

Family

ID=40996840

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006264A MX337925B (es) 2008-12-10 2009-12-08 Sintesis de morfina-6-glucuronido o de uno de sus derivados.

Country Status (31)

Country Link
US (1) US8258298B2 (es)
EP (1) EP2376496B1 (es)
JP (1) JP5619768B2 (es)
KR (1) KR20110091534A (es)
CN (1) CN102307876B (es)
AR (1) AR074513A1 (es)
AU (1) AU2009326906B2 (es)
BR (1) BRPI0923238A2 (es)
CA (1) CA2746428A1 (es)
CL (1) CL2011001398A1 (es)
CO (1) CO6390060A2 (es)
CR (1) CR20110307A (es)
EA (1) EA201170790A1 (es)
EC (1) ECSP11011100A (es)
ES (1) ES2470666T3 (es)
FR (1) FR2939436B1 (es)
HK (1) HK1163096A1 (es)
HN (1) HN2011001597A (es)
IL (1) IL213379A0 (es)
MA (1) MA32950B1 (es)
MX (1) MX337925B (es)
MY (1) MY152276A (es)
NI (1) NI201100116A (es)
NZ (1) NZ593342A (es)
PE (1) PE20110836A1 (es)
SG (1) SG172069A1 (es)
TN (1) TN2011000243A1 (es)
TW (1) TW201033218A (es)
UA (1) UA103643C2 (es)
WO (1) WO2010067007A2 (es)
ZA (1) ZA201104657B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
AU723859B2 (en) 1997-04-14 2000-09-07 Ufc Limited Morphine derivatives
CA2332974C (en) * 1998-06-06 2009-03-10 Cenes Limited Morphine-6-glucuronide synthesis
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
KR20040014544A (ko) * 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
BR0308567A (pt) * 2002-03-19 2007-01-09 Michael Holick derivados de glicosìdeo e glicosìdeo de ortoéster de apomorfina, análogos, e seus usos
FR2864082B1 (fr) 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur

Also Published As

Publication number Publication date
JP2012511551A (ja) 2012-05-24
WO2010067007A2 (fr) 2010-06-17
AU2009326906A1 (en) 2011-06-30
MX2011006264A (es) 2011-11-04
NI201100116A (es) 2011-12-14
UA103643C2 (ru) 2013-11-11
SG172069A1 (en) 2011-07-28
HK1163096A1 (en) 2012-09-07
TN2011000243A1 (fr) 2012-12-17
US8258298B2 (en) 2012-09-04
CO6390060A2 (es) 2012-02-29
WO2010067007A3 (fr) 2011-07-07
PE20110836A1 (es) 2011-11-25
BRPI0923238A2 (pt) 2016-01-26
US20110275820A1 (en) 2011-11-10
MA32950B1 (fr) 2012-01-02
AU2009326906B2 (en) 2016-05-26
CN102307876B (zh) 2014-12-10
EA201170790A1 (ru) 2011-12-30
HN2011001597A (es) 2013-09-09
FR2939436B1 (fr) 2010-12-17
NZ593342A (en) 2013-07-26
TW201033218A (en) 2010-09-16
EP2376496A2 (fr) 2011-10-19
AR074513A1 (es) 2011-01-19
CR20110307A (es) 2011-09-21
CN102307876A (zh) 2012-01-04
JP5619768B2 (ja) 2014-11-05
ES2470666T3 (es) 2014-06-24
KR20110091534A (ko) 2011-08-11
ECSP11011100A (es) 2011-07-29
IL213379A0 (en) 2011-07-31
MY152276A (en) 2014-09-15
CL2011001398A1 (es) 2011-10-28
ZA201104657B (en) 2012-09-26
FR2939436A1 (fr) 2010-06-11
EP2376496B1 (fr) 2014-03-12
CA2746428A1 (fr) 2010-06-17

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