HK1163096A1 - Synthesis of morphine-6-glucuronide or of a derivative thereof -6- - Google Patents

Synthesis of morphine-6-glucuronide or of a derivative thereof -6-

Info

Publication number
HK1163096A1
HK1163096A1 HK12103827.9A HK12103827A HK1163096A1 HK 1163096 A1 HK1163096 A1 HK 1163096A1 HK 12103827 A HK12103827 A HK 12103827A HK 1163096 A1 HK1163096 A1 HK 1163096A1
Authority
HK
Hong Kong
Prior art keywords
glucuronide
morphine
derivative
synthesis
Prior art date
Application number
HK12103827.9A
Other languages
English (en)
Chinese (zh)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HK1163096A1 publication Critical patent/HK1163096A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK12103827.9A 2008-12-10 2012-04-18 Synthesis of morphine-6-glucuronide or of a derivative thereof -6- HK1163096A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806948A FR2939436B1 (fr) 2008-12-10 2008-12-10 Synthese de morphine-6-glucuronide ou de l'un de ses derives
PCT/FR2009/052445 WO2010067007A2 (fr) 2008-12-10 2009-12-08 Synthese de morphine-6-glucuronide ou de l'un de ses derives

Publications (1)

Publication Number Publication Date
HK1163096A1 true HK1163096A1 (en) 2012-09-07

Family

ID=40996840

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12103827.9A HK1163096A1 (en) 2008-12-10 2012-04-18 Synthesis of morphine-6-glucuronide or of a derivative thereof -6-

Country Status (31)

Country Link
US (1) US8258298B2 (xx)
EP (1) EP2376496B1 (xx)
JP (1) JP5619768B2 (xx)
KR (1) KR20110091534A (xx)
CN (1) CN102307876B (xx)
AR (1) AR074513A1 (xx)
AU (1) AU2009326906B2 (xx)
BR (1) BRPI0923238A2 (xx)
CA (1) CA2746428A1 (xx)
CL (1) CL2011001398A1 (xx)
CO (1) CO6390060A2 (xx)
CR (1) CR20110307A (xx)
EA (1) EA201170790A1 (xx)
EC (1) ECSP11011100A (xx)
ES (1) ES2470666T3 (xx)
FR (1) FR2939436B1 (xx)
HK (1) HK1163096A1 (xx)
HN (1) HN2011001597A (xx)
IL (1) IL213379A0 (xx)
MA (1) MA32950B1 (xx)
MX (1) MX337925B (xx)
MY (1) MY152276A (xx)
NI (1) NI201100116A (xx)
NZ (1) NZ593342A (xx)
PE (1) PE20110836A1 (xx)
SG (1) SG172069A1 (xx)
TN (1) TN2011000243A1 (xx)
TW (1) TW201033218A (xx)
UA (1) UA103643C2 (xx)
WO (1) WO2010067007A2 (xx)
ZA (1) ZA201104657B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
AU723859B2 (en) 1997-04-14 2000-09-07 Ufc Limited Morphine derivatives
CA2332974C (en) * 1998-06-06 2009-03-10 Cenes Limited Morphine-6-glucuronide synthesis
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
KR20040014544A (ko) * 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
BR0308567A (pt) * 2002-03-19 2007-01-09 Michael Holick derivados de glicosìdeo e glicosìdeo de ortoéster de apomorfina, análogos, e seus usos
FR2864082B1 (fr) 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur

Also Published As

Publication number Publication date
JP2012511551A (ja) 2012-05-24
WO2010067007A2 (fr) 2010-06-17
AU2009326906A1 (en) 2011-06-30
MX2011006264A (es) 2011-11-04
NI201100116A (es) 2011-12-14
UA103643C2 (ru) 2013-11-11
SG172069A1 (en) 2011-07-28
TN2011000243A1 (fr) 2012-12-17
US8258298B2 (en) 2012-09-04
CO6390060A2 (es) 2012-02-29
WO2010067007A3 (fr) 2011-07-07
PE20110836A1 (es) 2011-11-25
BRPI0923238A2 (pt) 2016-01-26
US20110275820A1 (en) 2011-11-10
MA32950B1 (fr) 2012-01-02
AU2009326906B2 (en) 2016-05-26
CN102307876B (zh) 2014-12-10
EA201170790A1 (ru) 2011-12-30
HN2011001597A (es) 2013-09-09
FR2939436B1 (fr) 2010-12-17
NZ593342A (en) 2013-07-26
TW201033218A (en) 2010-09-16
EP2376496A2 (fr) 2011-10-19
AR074513A1 (es) 2011-01-19
MX337925B (es) 2016-03-28
CR20110307A (es) 2011-09-21
CN102307876A (zh) 2012-01-04
JP5619768B2 (ja) 2014-11-05
ES2470666T3 (es) 2014-06-24
KR20110091534A (ko) 2011-08-11
ECSP11011100A (es) 2011-07-29
IL213379A0 (en) 2011-07-31
MY152276A (en) 2014-09-15
CL2011001398A1 (es) 2011-10-28
ZA201104657B (en) 2012-09-26
FR2939436A1 (fr) 2010-06-11
EP2376496B1 (fr) 2014-03-12
CA2746428A1 (fr) 2010-06-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171208