NI201100116A - Síntesis de morfina - 6 - glucurónido o de uno de sus derivados. - Google Patents

Síntesis de morfina - 6 - glucurónido o de uno de sus derivados.

Info

Publication number
NI201100116A
NI201100116A NI201100116A NI201100116A NI201100116A NI 201100116 A NI201100116 A NI 201100116A NI 201100116 A NI201100116 A NI 201100116A NI 201100116 A NI201100116 A NI 201100116A NI 201100116 A NI201100116 A NI 201100116A
Authority
NI
Nicaragua
Prior art keywords
group
glucuronide
morphine
derivatives
responds
Prior art date
Application number
NI201100116A
Other languages
English (en)
Inventor
Dlubala Alain
Ripoche Isabelle
Trecant Claire
Original Assignee
Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados filed Critical Aplicaciones Terapeuticas En El Dominio Cardiovascular De Derivados
Publication of NI201100116A publication Critical patent/NI201100116A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de morfina-6-glucurónido o de uno de sus derivados, que comprende las etapas que consisten: (ii) en hacer reaccionar un compuesto que responde a la fórmula (I) siguiente: en la que: R1 representa un grupo carbonilo, COR5C0 o S02R6S02 con un derivado de ácido glucurónico que responde a la fórmula (II) siguiente: en la que: PG representa un grupo acetilo, isobutirilo, benzollo o pivaloílo, X representa un grupo trihalógenoacetamidato, y R4 representa un grupo alquil(C1-C4)carboxilato; en presencia de un disolvente aromático y de trifluorometanosulfonilo de trimetilsilano (ii) en hacer reaccionar el producto obtenido en la etapa (i) con un agente fuertemente básico, después (iii) en recuperar el producto obtenido en la etapa (ii).
NI201100116A 2008-12-10 2011-06-08 Síntesis de morfina - 6 - glucurónido o de uno de sus derivados. NI201100116A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806948A FR2939436B1 (fr) 2008-12-10 2008-12-10 Synthese de morphine-6-glucuronide ou de l'un de ses derives

Publications (1)

Publication Number Publication Date
NI201100116A true NI201100116A (es) 2011-12-14

Family

ID=40996840

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100116A NI201100116A (es) 2008-12-10 2011-06-08 Síntesis de morfina - 6 - glucurónido o de uno de sus derivados.

Country Status (31)

Country Link
US (1) US8258298B2 (es)
EP (1) EP2376496B1 (es)
JP (1) JP5619768B2 (es)
KR (1) KR20110091534A (es)
CN (1) CN102307876B (es)
AR (1) AR074513A1 (es)
AU (1) AU2009326906B2 (es)
BR (1) BRPI0923238A2 (es)
CA (1) CA2746428A1 (es)
CL (1) CL2011001398A1 (es)
CO (1) CO6390060A2 (es)
CR (1) CR20110307A (es)
EA (1) EA201170790A1 (es)
EC (1) ECSP11011100A (es)
ES (1) ES2470666T3 (es)
FR (1) FR2939436B1 (es)
HK (1) HK1163096A1 (es)
HN (1) HN2011001597A (es)
IL (1) IL213379A0 (es)
MA (1) MA32950B1 (es)
MX (1) MX337925B (es)
MY (1) MY152276A (es)
NI (1) NI201100116A (es)
NZ (1) NZ593342A (es)
PE (1) PE20110836A1 (es)
SG (1) SG172069A1 (es)
TN (1) TN2011000243A1 (es)
TW (1) TW201033218A (es)
UA (1) UA103643C2 (es)
WO (1) WO2010067007A2 (es)
ZA (1) ZA201104657B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
GB2339196B (en) 1997-04-14 2001-11-07 Salford Ultrafine Chem & Res Morphine derivatives
WO1999064430A2 (en) * 1998-06-06 1999-12-16 Cenes Limited Morphine-6-glucuronide synthesis
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
EP1709957A3 (en) * 2001-06-05 2007-02-14 Control Delivery Systems Sustained-release analgesic compounds
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
AU2003223304A1 (en) * 2002-03-19 2003-10-08 Michael Holick Glycoside and orthoester glycoside derivatives of apomorphine, analogs, and uses thereof
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur

Also Published As

Publication number Publication date
US8258298B2 (en) 2012-09-04
ECSP11011100A (es) 2011-07-29
ES2470666T3 (es) 2014-06-24
AU2009326906A1 (en) 2011-06-30
CN102307876B (zh) 2014-12-10
PE20110836A1 (es) 2011-11-25
TW201033218A (en) 2010-09-16
MA32950B1 (fr) 2012-01-02
WO2010067007A2 (fr) 2010-06-17
CR20110307A (es) 2011-09-21
EP2376496B1 (fr) 2014-03-12
NZ593342A (en) 2013-07-26
HK1163096A1 (en) 2012-09-07
MX2011006264A (es) 2011-11-04
CO6390060A2 (es) 2012-02-29
EA201170790A1 (ru) 2011-12-30
UA103643C2 (ru) 2013-11-11
FR2939436A1 (fr) 2010-06-11
WO2010067007A3 (fr) 2011-07-07
CN102307876A (zh) 2012-01-04
AU2009326906B2 (en) 2016-05-26
EP2376496A2 (fr) 2011-10-19
HN2011001597A (es) 2013-09-09
KR20110091534A (ko) 2011-08-11
JP5619768B2 (ja) 2014-11-05
MX337925B (es) 2016-03-28
US20110275820A1 (en) 2011-11-10
TN2011000243A1 (fr) 2012-12-17
CL2011001398A1 (es) 2011-10-28
IL213379A0 (en) 2011-07-31
MY152276A (en) 2014-09-15
SG172069A1 (en) 2011-07-28
JP2012511551A (ja) 2012-05-24
AR074513A1 (es) 2011-01-19
BRPI0923238A2 (pt) 2016-01-26
FR2939436B1 (fr) 2010-12-17
CA2746428A1 (fr) 2010-06-17
ZA201104657B (en) 2012-09-26

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