UA103643C2 - Синтез морфин-6-глюкуронида или одного из его производных - Google Patents

Синтез морфин-6-глюкуронида или одного из его производных

Info

Publication number
UA103643C2
UA103643C2 UAA201108590A UAA201108590A UA103643C2 UA 103643 C2 UA103643 C2 UA 103643C2 UA A201108590 A UAA201108590 A UA A201108590A UA A201108590 A UAA201108590 A UA A201108590A UA 103643 C2 UA103643 C2 UA 103643C2
Authority
UA
Ukraine
Prior art keywords
group
glucuronide
derivatives
morphine
rrepresents
Prior art date
Application number
UAA201108590A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ален Длюбала
Изабелль Рипош
Клер Трекан
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of UA103643C2 publication Critical patent/UA103643C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение касается способа получения морфин-6-глюкуронида или одного из его производных, который состоит в том, что: (i) соединение, которое соответсвует формуле (I), где Rпредставляет собой карбонильную группу CORCO или SORSO, приводят во взаимодействие с производным глюкуроновой кислоты, которая соответсвует формуле (II), где: PG означает ацетил, изобутирил, бензоил или пивалоил; X означает тригалогенацетамидат; Rозначает (С-С)алкилкарбоксилат; в присутствии ароматического растворителя и трифторметансульфонилтриметилсилана; (ii) продукт, полученный на стадии (i), приводят во взаимодействие с сильнощелочным агентом и потом (iii) выделяют продукт, полученный на стадии (ii).
UAA201108590A 2008-12-10 2009-12-08 Синтез морфин-6-глюкуронида или одного из его производных UA103643C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806948A FR2939436B1 (fr) 2008-12-10 2008-12-10 Synthese de morphine-6-glucuronide ou de l'un de ses derives
PCT/FR2009/052445 WO2010067007A2 (fr) 2008-12-10 2009-12-08 Synthese de morphine-6-glucuronide ou de l'un de ses derives

Publications (1)

Publication Number Publication Date
UA103643C2 true UA103643C2 (ru) 2013-11-11

Family

ID=40996840

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108590A UA103643C2 (ru) 2008-12-10 2009-12-08 Синтез морфин-6-глюкуронида или одного из его производных

Country Status (31)

Country Link
US (1) US8258298B2 (ru)
EP (1) EP2376496B1 (ru)
JP (1) JP5619768B2 (ru)
KR (1) KR20110091534A (ru)
CN (1) CN102307876B (ru)
AR (1) AR074513A1 (ru)
AU (1) AU2009326906B2 (ru)
BR (1) BRPI0923238A2 (ru)
CA (1) CA2746428A1 (ru)
CL (1) CL2011001398A1 (ru)
CO (1) CO6390060A2 (ru)
CR (1) CR20110307A (ru)
EA (1) EA201170790A1 (ru)
EC (1) ECSP11011100A (ru)
ES (1) ES2470666T3 (ru)
FR (1) FR2939436B1 (ru)
HK (1) HK1163096A1 (ru)
HN (1) HN2011001597A (ru)
IL (1) IL213379A0 (ru)
MA (1) MA32950B1 (ru)
MX (1) MX337925B (ru)
MY (1) MY152276A (ru)
NI (1) NI201100116A (ru)
NZ (1) NZ593342A (ru)
PE (1) PE20110836A1 (ru)
SG (1) SG172069A1 (ru)
TN (1) TN2011000243A1 (ru)
TW (1) TW201033218A (ru)
UA (1) UA103643C2 (ru)
WO (1) WO2010067007A2 (ru)
ZA (1) ZA201104657B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) * 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
GB2339196B (en) 1997-04-14 2001-11-07 Salford Ultrafine Chem & Res Morphine derivatives
ES2185350T3 (es) * 1998-06-06 2003-04-16 Cenes Ltd Sintesis de morfina-6-glucuronido.
GB9914382D0 (en) * 1999-06-21 1999-08-18 Ufc Limited New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
TWI255186B (en) * 2001-06-05 2006-05-21 Control Delivery Sys Inc Sustained-release analgesic compounds
US6740641B2 (en) * 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
KR20050008658A (ko) * 2002-03-19 2005-01-21 마이클 홀릭 아포모르핀의 글리코시드 및 오르토에스테르 글리코시드유도체들, 유사체들 및 그것의 용도
FR2864082B1 (fr) 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur

Also Published As

Publication number Publication date
FR2939436B1 (fr) 2010-12-17
EP2376496A2 (fr) 2011-10-19
TW201033218A (en) 2010-09-16
MY152276A (en) 2014-09-15
WO2010067007A2 (fr) 2010-06-17
AR074513A1 (es) 2011-01-19
JP2012511551A (ja) 2012-05-24
TN2011000243A1 (fr) 2012-12-17
MA32950B1 (fr) 2012-01-02
KR20110091534A (ko) 2011-08-11
MX337925B (es) 2016-03-28
HK1163096A1 (en) 2012-09-07
EA201170790A1 (ru) 2011-12-30
US8258298B2 (en) 2012-09-04
CN102307876B (zh) 2014-12-10
CO6390060A2 (es) 2012-02-29
ZA201104657B (en) 2012-09-26
ES2470666T3 (es) 2014-06-24
IL213379A0 (en) 2011-07-31
CL2011001398A1 (es) 2011-10-28
CA2746428A1 (fr) 2010-06-17
BRPI0923238A2 (pt) 2016-01-26
JP5619768B2 (ja) 2014-11-05
AU2009326906B2 (en) 2016-05-26
MX2011006264A (es) 2011-11-04
SG172069A1 (en) 2011-07-28
PE20110836A1 (es) 2011-11-25
EP2376496B1 (fr) 2014-03-12
ECSP11011100A (es) 2011-07-29
US20110275820A1 (en) 2011-11-10
HN2011001597A (es) 2013-09-09
AU2009326906A1 (en) 2011-06-30
NZ593342A (en) 2013-07-26
FR2939436A1 (fr) 2010-06-11
CN102307876A (zh) 2012-01-04
WO2010067007A3 (fr) 2011-07-07
NI201100116A (es) 2011-12-14
CR20110307A (es) 2011-09-21

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