AR074513A1 - Sintesis de morfina-6-glucuronido o de uno de sus derivados - Google Patents
Sintesis de morfina-6-glucuronido o de uno de sus derivadosInfo
- Publication number
- AR074513A1 AR074513A1 ARP090104751A ARP090104751A AR074513A1 AR 074513 A1 AR074513 A1 AR 074513A1 AR P090104751 A ARP090104751 A AR P090104751A AR P090104751 A ARP090104751 A AR P090104751A AR 074513 A1 AR074513 A1 AR 074513A1
- Authority
- AR
- Argentina
- Prior art keywords
- diyl
- group
- biarene
- heterocycloalkane
- heteroarene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Procedimiento de preparación de morfina-6-glucurónido o uno de sus derivados, que comprende las etapas consistentes: (i) en hacer reaccionar un compuesto que responde a la fórmula (1) en la que R1 representa un grupo carbonilo, COR5CO en donde R5 representa un grupo alcano C1-4-diilo, alqueno C2-4-diilo, alquino C2-4-diilo, heteroalcano C1-4-diilo, heterocicloalcano C3-6-diilo, areno C5-14-diilo, biaren-óxido C10-16-diilo, biareno C10-16-diilo o heteroareno C4-10-diilo, SO2R6SO2 en donde R6 representa un grupo alcano C1-4-diilo, alqueno C2-4-diilo, alquino C2-4-diilo, heteroalcano C1-4-diilo, heterocicloalcano C3-6-diilo, areno C5-14-diilo, heteroareno C4-10-diilo, biarenóxido C10-16-diilo, o biareno C10-16-diilo, con un derivado de ácido glucurónico que responde a la fórmula (2) en la que: PG representa un grupo acetilo, isobutirilo, benzoílo o pivaloílo, X representa un grupo trihalógenoacetamidato, y R4 representa un grupo alquil C1-4carboxilato; en presencia: de un disolvente aromático no sustituido o sustituido con uno o varios sustituyentes seleccionados del grupo constituido por un átomo de halógeno, un grupo alquilo C1-4 y un grupo alquiloxi C1-4, presentando dicho disolvente un punto de fusión inferior o igual a - 20sC, y de trifluorometanosulfonilo de trimetilsilano; (ii) en hacer reaccionar el producto obtenido en la etapa (i) con un agente fuertemente básico, después (iii) en recuperar el producto obtenido en la etapa (ii).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806948A FR2939436B1 (fr) | 2008-12-10 | 2008-12-10 | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074513A1 true AR074513A1 (es) | 2011-01-19 |
Family
ID=40996840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104751A AR074513A1 (es) | 2008-12-10 | 2009-12-09 | Sintesis de morfina-6-glucuronido o de uno de sus derivados |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8258298B2 (es) |
| EP (1) | EP2376496B1 (es) |
| JP (1) | JP5619768B2 (es) |
| KR (1) | KR20110091534A (es) |
| CN (1) | CN102307876B (es) |
| AR (1) | AR074513A1 (es) |
| AU (1) | AU2009326906B2 (es) |
| BR (1) | BRPI0923238A2 (es) |
| CA (1) | CA2746428A1 (es) |
| CL (1) | CL2011001398A1 (es) |
| CO (1) | CO6390060A2 (es) |
| CR (1) | CR20110307A (es) |
| EA (1) | EA201170790A1 (es) |
| EC (1) | ECSP11011100A (es) |
| ES (1) | ES2470666T3 (es) |
| FR (1) | FR2939436B1 (es) |
| HK (1) | HK1163096A1 (es) |
| HN (1) | HN2011001597A (es) |
| IL (1) | IL213379A0 (es) |
| MA (1) | MA32950B1 (es) |
| MX (1) | MX337925B (es) |
| MY (1) | MY152276A (es) |
| NI (1) | NI201100116A (es) |
| NZ (1) | NZ593342A (es) |
| PE (1) | PE20110836A1 (es) |
| SG (1) | SG172069A1 (es) |
| TN (1) | TN2011000243A1 (es) |
| TW (1) | TW201033218A (es) |
| UA (1) | UA103643C2 (es) |
| WO (1) | WO2010067007A2 (es) |
| ZA (1) | ZA201104657B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020012245A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Thienothiophene-naltrexone prodrugs for long-acting injectable compositions |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766188A (en) * | 1971-06-28 | 1973-10-16 | Yamanouchi Pharma Co Ltd | Carbonyldioxymorphinan derivatives |
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| GB2282758A (en) | 1993-08-23 | 1995-04-19 | Euro Celtique Sa | Oral morphine-6-glucuronide compositions |
| GB2339196B (en) | 1997-04-14 | 2001-11-07 | Salford Ultrafine Chem & Res | Morphine derivatives |
| ES2185350T3 (es) * | 1998-06-06 | 2003-04-16 | Cenes Ltd | Sintesis de morfina-6-glucuronido. |
| GB9914382D0 (en) * | 1999-06-21 | 1999-08-18 | Ufc Limited | New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries |
| TWI255186B (en) * | 2001-06-05 | 2006-05-21 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
| US6740641B2 (en) * | 2001-07-27 | 2004-05-25 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain |
| KR20050008658A (ko) * | 2002-03-19 | 2005-01-21 | 마이클 홀릭 | 아포모르핀의 글리코시드 및 오르토에스테르 글리코시드유도체들, 유사체들 및 그것의 용도 |
| FR2864082B1 (fr) | 2003-12-22 | 2006-03-10 | Synt Em | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
-
2008
- 2008-12-10 FR FR0806948A patent/FR2939436B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-08 EA EA201170790A patent/EA201170790A1/ru unknown
- 2009-12-08 CA CA2746428A patent/CA2746428A1/fr not_active Abandoned
- 2009-12-08 JP JP2011540161A patent/JP5619768B2/ja not_active Expired - Fee Related
- 2009-12-08 WO PCT/FR2009/052445 patent/WO2010067007A2/fr active Application Filing
- 2009-12-08 MA MA33997A patent/MA32950B1/fr unknown
- 2009-12-08 EP EP09803824.3A patent/EP2376496B1/fr active Active
- 2009-12-08 BR BRPI0923238A patent/BRPI0923238A2/pt not_active IP Right Cessation
- 2009-12-08 NZ NZ593342A patent/NZ593342A/xx not_active IP Right Cessation
- 2009-12-08 MY MYPI20112601 patent/MY152276A/en unknown
- 2009-12-08 CN CN200980156211.1A patent/CN102307876B/zh not_active Expired - Fee Related
- 2009-12-08 SG SG2011042322A patent/SG172069A1/en unknown
- 2009-12-08 MX MX2011006264A patent/MX337925B/es active IP Right Grant
- 2009-12-08 PE PE2011001187A patent/PE20110836A1/es not_active Application Discontinuation
- 2009-12-08 UA UAA201108590A patent/UA103643C2/ru unknown
- 2009-12-08 ES ES09803824.3T patent/ES2470666T3/es active Active
- 2009-12-08 KR KR1020117013141A patent/KR20110091534A/ko active IP Right Grant
- 2009-12-08 AU AU2009326906A patent/AU2009326906B2/en not_active Ceased
- 2009-12-09 AR ARP090104751A patent/AR074513A1/es unknown
- 2009-12-09 TW TW098142093A patent/TW201033218A/zh unknown
-
2011
- 2011-05-17 TN TN2011000243A patent/TN2011000243A1/fr unknown
- 2011-06-03 EC EC2011011100A patent/ECSP11011100A/es unknown
- 2011-06-05 IL IL213379A patent/IL213379A0/en unknown
- 2011-06-06 CR CR20110307A patent/CR20110307A/es unknown
- 2011-06-08 US US13/155,646 patent/US8258298B2/en not_active Expired - Fee Related
- 2011-06-08 NI NI201100116A patent/NI201100116A/es unknown
- 2011-06-09 HN HN2011001597A patent/HN2011001597A/es unknown
- 2011-06-09 CL CL2011001398A patent/CL2011001398A1/es unknown
- 2011-06-10 CO CO11072135A patent/CO6390060A2/es active IP Right Grant
- 2011-06-23 ZA ZA2011/04657A patent/ZA201104657B/en unknown
-
2012
- 2012-04-18 HK HK12103827.9A patent/HK1163096A1/xx not_active IP Right Cessation
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| FB | Suspension of granting procedure |