ATE500808T1 - Onkolytische virustherapie - Google Patents
Onkolytische virustherapieInfo
- Publication number
- ATE500808T1 ATE500808T1 AT02725980T AT02725980T ATE500808T1 AT E500808 T1 ATE500808 T1 AT E500808T1 AT 02725980 T AT02725980 T AT 02725980T AT 02725980 T AT02725980 T AT 02725980T AT E500808 T1 ATE500808 T1 AT E500808T1
- Authority
- AT
- Austria
- Prior art keywords
- oncolytic virus
- pharmaceutical composition
- virus therapy
- subject
- human leukocytes
- Prior art date
Links
- 244000309459 oncolytic virus Species 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 210000000265 leukocyte Anatomy 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29005101P | 2001-05-11 | 2001-05-11 | |
| PCT/US2002/014642 WO2002091997A2 (en) | 2001-05-11 | 2002-05-09 | Oncolytic virus therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500808T1 true ATE500808T1 (de) | 2011-03-15 |
Family
ID=23114328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02725980T ATE500808T1 (de) | 2001-05-11 | 2002-05-09 | Onkolytische virustherapie |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7122182B2 (de) |
| EP (1) | EP1385466B1 (de) |
| JP (1) | JP4916641B2 (de) |
| CN (1) | CN1332712C (de) |
| AT (1) | ATE500808T1 (de) |
| AU (1) | AU2002256510B2 (de) |
| CA (1) | CA2442648C (de) |
| DE (1) | DE60239394D1 (de) |
| HU (1) | HUP0400882A3 (de) |
| IL (1) | IL157504A0 (de) |
| MX (1) | MXPA03010278A (de) |
| NZ (1) | NZ527687A (de) |
| WO (1) | WO2002091997A2 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| MXPA01010393A (es) * | 1999-04-15 | 2004-04-02 | Pro Virus Inc | Tratamiento de neoplasmas con virus. |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| MXPA03010278A (es) * | 2001-05-11 | 2004-12-06 | Wellstat Biologics Corp | Terapia con virus oncolitico. |
| US7615209B2 (en) * | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| US20050214266A1 (en) * | 2004-03-12 | 2005-09-29 | Oncolytics Biotech Inc. | Combination of transplantation and oncolytic virus treatment |
| EP1793851B1 (de) * | 2004-08-20 | 2016-10-05 | Viralytics Limited | Verfahren und zusammensetzungen zur behandlung von blutkrebs |
| EP1917351A4 (de) * | 2005-08-01 | 2009-12-16 | Univ Technologies Int | Abgeschwächtes reovirus |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| US20070077231A1 (en) * | 2005-09-30 | 2007-04-05 | Contag Christopher H | Immune effector cells pre-infected with oncolytic virus |
| WO2008009115A1 (en) * | 2006-07-18 | 2008-01-24 | Ottawa Health Research Institute | Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| WO2008144067A1 (en) * | 2007-05-21 | 2008-11-27 | Board Of Regents, University Of Texas System | Methods and compositions for treatment of cancer using oncolytic rsv activity |
| US20110044952A1 (en) * | 2007-11-27 | 2011-02-24 | Ottawa Health Research Institute | Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors |
| WO2010020247A1 (en) | 2008-08-22 | 2010-02-25 | Reapplix Aps | Multilayered blood product |
| US8481297B2 (en) * | 2009-01-08 | 2013-07-09 | Yale University | Compositions and methods of use of an oncolytic vesicular stomatitis virus |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| CA2689707A1 (en) | 2009-11-16 | 2011-05-16 | Jean-Simon Diallo | Identification of the novel small molecule viral sensitizer vse1 using high-throughput screening |
| US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| US20140087362A1 (en) | 2012-03-16 | 2014-03-27 | Aladar A. Szalay | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| CN108064282A (zh) | 2014-10-14 | 2018-05-22 | 哈洛齐梅公司 | 腺苷脱氨酶-2(ada2)、其变体的组合物及使用其的方法 |
| ES2952055T3 (es) | 2015-01-26 | 2023-10-26 | Ottawa Hospital Res Inst | Composiciones y métodos para la sensibilización viral |
| GB201504251D0 (en) | 2015-03-13 | 2015-04-29 | Virttu Biolog Ltd And University Of Sheffield The | Oncolytic herpes simplex virus infected cells |
| JP6933652B2 (ja) | 2016-01-06 | 2021-09-08 | リアプリックス エーピーエス | 後続の自己使用に適した凝固促進因子 |
| SG11201808457PA (en) | 2016-04-15 | 2018-10-30 | Alpine Immune Sciences Inc | Icos ligand variant immunomodulatory proteins and uses thereof |
| US11078282B2 (en) | 2016-04-15 | 2021-08-03 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
| US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
| CN110088127A (zh) | 2016-07-28 | 2019-08-02 | 高山免疫科学股份有限公司 | Cd155变体免疫调节蛋白及其用途 |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| SI3518948T1 (sl) | 2016-10-03 | 2023-09-29 | Ottawa Hospital Research Institute | Kompozicije in metode za povečanje rasti, širjenja ter onkolitične in imunoterapevtske učinkovitosti onkolitičnih RNA-virusov |
| EP3529361B1 (de) | 2016-10-20 | 2021-03-24 | Alpine Immune Sciences, Inc. | Sekretierbare variante immunmodulatorische proteine und manipulierte zelltherapie |
| JP2020507349A (ja) | 2017-02-09 | 2020-03-12 | インダプタ セラピューティクス インコーポレイテッド | 操作されたナチュラルキラー(nk)細胞ならびにその組成物および方法 |
| WO2018170023A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
| CN110662758A (zh) | 2017-03-16 | 2020-01-07 | 高山免疫科学股份有限公司 | Cd80变体免疫调节蛋白及其用途 |
| KR102692556B1 (ko) | 2017-03-16 | 2024-08-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l1 변이체 면역조절 단백질 및 그의 용도 |
| PT3697810T (pt) | 2017-10-18 | 2026-02-19 | Alpine Immune Sciences Inc | Proteínas imunomoduladoras de ligandos icos variantes e composições e métodos relacionados |
| CN111373032A (zh) | 2017-11-24 | 2020-07-03 | 渥太华医院研究所 | 用于增强干扰素敏感性病毒的生产、生长、扩散或溶瘤和免疫治疗功效的组合物和方法 |
| BR112020013236A2 (pt) | 2018-01-03 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras de múltiplos domínios e métodos de seu uso |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| AU2019282239B2 (en) | 2018-06-04 | 2024-06-06 | Calidi Biotherapeutics (Nevada), Inc. | Cell-based vehicles for potentiation of viral therapy |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| EP3844276A2 (de) | 2018-08-28 | 2021-07-07 | Actym Therapeutics, Inc. | Manipulierte immunstimulierende bakterienstämme und verwendungen davon |
| EP3876951A1 (de) | 2018-11-06 | 2021-09-15 | Calidi Biotherapeutics, Inc. | Verbesserte systeme für zellvermittelte onkolytische virustherapie |
| CN113891934A (zh) | 2018-11-21 | 2022-01-04 | 因达普塔治疗公司 | 扩增天然杀伤(nk)细胞子集的方法以及相关组合物和方法 |
| EP3887394A2 (de) | 2018-11-30 | 2021-10-06 | Alpine Immune Sciences, Inc. | Cd86-variante immunmodulatorische proteine und verwendungen davon |
| SG11202108459QA (en) | 2019-02-27 | 2021-09-29 | Actym Therapeutics Inc | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| KR20230088306A (ko) | 2020-04-22 | 2023-06-19 | 인답타 세라뷰틱스 인코포레이티드 | 자연 살해(nk) 세포 조성물 및 이를 생성하는 방법 |
| WO2022147480A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma, Inc. | Oncolytic virus encoding sialidase and multispecific immune cell engager |
| CN117379389B (zh) * | 2022-07-12 | 2026-03-06 | 四川大学 | 血小板-溶瘤病毒复合物、其制备方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| EP1314431B1 (de) * | 1993-04-30 | 2008-07-16 | Wellstat Biologics Corporation | Gereinigte Zusammensetzungen von Newcastle-Krankheitvirus |
| US5595739A (en) * | 1993-05-07 | 1997-01-21 | Abbott Laboratories | Hepatitis B virus mutants, reagents and methods for detection |
| US5910434A (en) * | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| CA2267157C (en) * | 1996-10-11 | 2005-05-31 | The Regents Of The University Of California | Cancer immunotherapy using tumor cells combined with mixed lymphocytes |
| JP2001519175A (ja) * | 1997-10-09 | 2001-10-23 | プロ − バイラス,インコーポレイテッド | ウイルスを用いた新生物の処置 |
| US6177076B1 (en) * | 1997-12-09 | 2001-01-23 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
| EP1061806A4 (de) * | 1998-03-12 | 2001-09-12 | Univ Pennsylvania | Produktive zellen für replikationsselektive viren zur behandlung bösartiger erkrankungen |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| MXPA01010393A (es) * | 1999-04-15 | 2004-04-02 | Pro Virus Inc | Tratamiento de neoplasmas con virus. |
| JP3639772B2 (ja) * | 1999-06-30 | 2005-04-20 | キヤノン株式会社 | 情報処理装置および印刷システムおよび印刷制御方法およびコンピュータが読み出し可能なプログラムを格納した記憶媒体 |
| ES2320239T3 (es) | 1999-09-17 | 2009-05-20 | Wellstat Biologics Corporation | Virus oncolitico. |
| US6270147B1 (en) * | 2000-01-07 | 2001-08-07 | Daimlerchrysler Corporation | Drive arrangement for a power liftgate including clutching mechanism |
| AU2001279264B2 (en) * | 2000-06-26 | 2005-04-28 | University Of Ottawa | Purging of cells using viruses |
| MXPA03010278A (es) | 2001-05-11 | 2004-12-06 | Wellstat Biologics Corp | Terapia con virus oncolitico. |
-
2002
- 2002-05-09 MX MXPA03010278A patent/MXPA03010278A/es active IP Right Grant
- 2002-05-09 CA CA2442648A patent/CA2442648C/en not_active Expired - Fee Related
- 2002-05-09 IL IL15750402A patent/IL157504A0/xx not_active IP Right Cessation
- 2002-05-09 CN CNB028097009A patent/CN1332712C/zh not_active Expired - Fee Related
- 2002-05-09 US US10/142,405 patent/US7122182B2/en not_active Expired - Fee Related
- 2002-05-09 DE DE60239394T patent/DE60239394D1/de not_active Expired - Lifetime
- 2002-05-09 JP JP2002588916A patent/JP4916641B2/ja not_active Expired - Fee Related
- 2002-05-09 HU HU0400882A patent/HUP0400882A3/hu unknown
- 2002-05-09 AU AU2002256510A patent/AU2002256510B2/en not_active Ceased
- 2002-05-09 WO PCT/US2002/014642 patent/WO2002091997A2/en not_active Ceased
- 2002-05-09 AT AT02725980T patent/ATE500808T1/de not_active IP Right Cessation
- 2002-05-09 EP EP02725980A patent/EP1385466B1/de not_active Expired - Lifetime
- 2002-05-09 NZ NZ527687A patent/NZ527687A/en not_active IP Right Cessation
-
2005
- 2005-05-05 US US11/122,690 patent/US7595042B2/en not_active Expired - Fee Related
-
2009
- 2009-03-26 US US12/412,035 patent/US8137663B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1385466B1 (de) | 2011-03-09 |
| CN1332712C (zh) | 2007-08-22 |
| US20050208024A1 (en) | 2005-09-22 |
| WO2002091997A3 (en) | 2003-03-13 |
| US20090180994A1 (en) | 2009-07-16 |
| JP4916641B2 (ja) | 2012-04-18 |
| AU2002256510B2 (en) | 2007-08-30 |
| EP1385466A4 (de) | 2005-10-12 |
| JP2004521938A (ja) | 2004-07-22 |
| US7122182B2 (en) | 2006-10-17 |
| IL157504A0 (en) | 2004-03-28 |
| CN1514688A (zh) | 2004-07-21 |
| CA2442648C (en) | 2012-10-16 |
| HUP0400882A3 (en) | 2011-01-28 |
| US20030077819A1 (en) | 2003-04-24 |
| DE60239394D1 (de) | 2011-04-21 |
| US7595042B2 (en) | 2009-09-29 |
| MXPA03010278A (es) | 2004-12-06 |
| CA2442648A1 (en) | 2002-11-21 |
| US8137663B2 (en) | 2012-03-20 |
| HUP0400882A2 (hu) | 2004-07-28 |
| EP1385466A2 (de) | 2004-02-04 |
| NZ527687A (en) | 2005-10-28 |
| WO2002091997A2 (en) | 2002-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE500808T1 (de) | Onkolytische virustherapie | |
| NO20026044D0 (no) | Behandling av human papillomavirus | |
| ES2187798T3 (es) | Procedimiento de conservacion de virus recombinantes infecciosos, suspension acuosa viral y su utilizacion como medicamento. | |
| BR9912653A (pt) | Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animal | |
| ATE319460T1 (de) | Onkolytisches vesicular stomatitis virus | |
| DK184186A (da) | Terapeutisk praeparat til behandling af virussygdomme | |
| MY117892A (en) | Therapeutic compounds | |
| TR200001891T2 (tr) | ASPB28- İnsan ensülini ve kullanımı. | |
| CY1106152T1 (el) | Νεα ανοσογονα αντι-hiv (ανατοξινες), μεθοδοι παρασκευης και εφαρμογη στην προληψη και στην αγωγη του aids | |
| CY1105818T1 (el) | Χρησεις του et743 στην θepαπευτικη αγωγη του καρκινου | |
| FI935693A7 (fi) | Bifenyylin johdannaiset, niiden valmistus ja käyttö korkean verenpaineen ja sydäntautien hoitoon | |
| AP9801286A0 (en) | Therapeutic compounds. | |
| BR0109928A (pt) | Uso de um herpes vìrus atenuado, e, método para estimular uma resposta imune em um indivìduo humano ou animal, ou para tratar ou prevenir uma infecção patogênica ou câncer em um indivìduo humano ou animal | |
| PL368686A1 (en) | Novel aminobenzoephenones | |
| ATE185274T1 (de) | Therapeutisches mittel gegen drohenden abortus | |
| ATE345805T1 (de) | Calciumtrifluoracetat mit zytotoxischer wirkung | |
| EA199800770A1 (ru) | Лекарственный препарат для терапевтического лечения вирусного гепатита | |
| ATE295159T1 (de) | Bupropion zur behandlung von viralen erkrankungen | |
| DK1150981T3 (da) | Terapeutisk necleosidforbindelse | |
| SG165996A1 (en) | Combination therapies with l-fmau for the treatment of hepatitis b virus infection | |
| DE69803052D1 (de) | Therapeutischer viraler wirkstoff, welcher das fortschreiten von tumoren stoppt | |
| TW200513258A (en) | Auxiliary agent for hepatitis C | |
| SU1565027A1 (ru) | Инактиватор вируса западного нила | |
| ITAG940002A0 (it) | Apparecchio ossigenatore e purificatore del sangue infetto da virus | |
| DK0788355T3 (da) | Anvendelse af intravenøst indgiveligt jern til behandling af tumorsygdomme og/eller infektionssygdomme |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |