ES2191292T3 - Compuestos antivirales poliaromaticos. - Google Patents
Compuestos antivirales poliaromaticos.Info
- Publication number
- ES2191292T3 ES2191292T3 ES98913241T ES98913241T ES2191292T3 ES 2191292 T3 ES2191292 T3 ES 2191292T3 ES 98913241 T ES98913241 T ES 98913241T ES 98913241 T ES98913241 T ES 98913241T ES 2191292 T3 ES2191292 T3 ES 2191292T3
- Authority
- ES
- Spain
- Prior art keywords
- polyaromatic
- antiviral compounds
- herpes
- viruses
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
La presente invención se refiere a compuestos poliaromáticos que poseen actividad antivírica útil frente a virus de la familia de los herpes, a una composición que contiene dichos compuestos, y a un procedimiento para su utilización para el tratamiento de las infecciones por virus tipo herpes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4323297P | 1997-04-10 | 1997-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191292T3 true ES2191292T3 (es) | 2003-09-01 |
Family
ID=21926169
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01117751T Expired - Lifetime ES2243370T3 (es) | 1997-04-10 | 1998-04-01 | Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes. |
ES98913241T Expired - Lifetime ES2191292T3 (es) | 1997-04-10 | 1998-04-01 | Compuestos antivirales poliaromaticos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01117751T Expired - Lifetime ES2243370T3 (es) | 1997-04-10 | 1998-04-01 | Composiciones poliaromaticas para el tratamiento de infecciones por virus herpes. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5958983A (es) |
EP (1) | EP0973735B1 (es) |
JP (1) | JP2001519808A (es) |
AT (2) | ATE231839T1 (es) |
AU (1) | AU6783698A (es) |
DE (2) | DE69830751T2 (es) |
DK (1) | DK0973735T3 (es) |
ES (2) | ES2243370T3 (es) |
WO (1) | WO1998045259A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
SK7682001A3 (en) * | 1998-12-09 | 2002-07-02 | Wyeth Corp | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
HUP0203405A2 (hu) * | 1998-12-09 | 2003-02-28 | Wyeth | Szubsztituált fenilén-diamin-csoportot és heterociklikus karboxamidcsoportot hordozó herpeszvírus inhibitor hatású tiokarbamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
US6197803B1 (en) | 1998-12-09 | 2001-03-06 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
US6335350B1 (en) | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
CN1333769A (zh) * | 1998-12-09 | 2002-01-30 | 美国家庭用品有限公司 | 疱疹病毒的硫脲抑制剂 |
US6262090B1 (en) | 1998-12-09 | 2001-07-17 | American Home Products Corporation | Aminopyridine-containing thiourea inhibitors of herpes viruses |
US6201013B1 (en) | 1998-12-09 | 2001-03-13 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
PL349131A1 (en) * | 1998-12-09 | 2002-07-01 | American Home Prod | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
WO2000034269A1 (en) * | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
WO2000041698A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
MXPA02002578A (es) * | 1999-09-08 | 2002-10-23 | Guilford Pharm Inc | Compuestos de union a ciclofilina no peptidicos, y su uso. |
PT1478358E (pt) | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
CN1318404C (zh) | 2002-02-11 | 2007-05-30 | 拜耳制药公司 | 作为激酶抑制剂的芳基脲类化合物 |
DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
EP1622860B1 (en) | 2003-04-30 | 2012-02-29 | Novartis AG | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORs |
PL1626714T3 (pl) | 2003-05-20 | 2007-12-31 | Bayer Healthcare Llc | Diarylowe pochodne mocznika do schorzeń, w których pośredniczy PDGFR |
US7915293B2 (en) | 2003-05-30 | 2011-03-29 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
JP2007523868A (ja) * | 2003-07-10 | 2007-08-23 | アキリオン ファーマシューティカルズ,インコーポレーテッド | ウイルス複製の阻害薬として有用な置換アリールチオウレア誘導体類 |
CN1856469B (zh) | 2003-07-23 | 2013-03-06 | 拜耳医药保健有限责任公司 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
BRPI0414199A (pt) * | 2003-09-11 | 2006-10-31 | Tibotec Pharm Ltd | inibidores de entrada do vìrus hiv |
JP5327744B2 (ja) * | 2009-03-13 | 2013-10-30 | 国立大学法人 鹿児島大学 | ジフェニルメタン誘導体を有効成分とする抗ウイルス剤 |
CA3112326A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
JP7417715B2 (ja) | 2019-09-26 | 2024-01-18 | ノバルティス アーゲー | 抗ウイルスピラゾロピリジノン化合物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56108759A (en) * | 1980-01-29 | 1981-08-28 | Mitsui Toatsu Chem Inc | Novel bisphenol compound and its preparation |
NL8120075A (nl) * | 1981-03-30 | 1983-02-01 | Ciba Geigy | Fenoxyfenylisothiourea, fenoxyfenylthiourea als tussenprodukten, de bereiding en toepassing ervan bij de bestrijding van schadelijke organismen. |
DE3626309A1 (de) * | 1986-08-02 | 1988-02-18 | Stockhausen Chem Fab Gmbh | Antivirusmittel |
JPH02237922A (ja) * | 1989-01-24 | 1990-09-20 | Green Cross Corp:The | 抗ウィルス剤 |
EP0554377A4 (en) * | 1990-10-22 | 1993-10-20 | Research Corporation Technologies, Inc. | Aryl and heteroaryl compounds having anti-retrovirus activity |
DK0498095T3 (da) * | 1991-02-05 | 1995-06-19 | Merrell Dow Pharma | Sulfoniske stilbenderivater til behandling af virussygdomme |
US5569643A (en) * | 1991-03-07 | 1996-10-29 | Nippon Oil Co., Ltd. | Grease composition for constant velocity joint |
NZ243180A (en) * | 1991-06-19 | 1995-08-28 | Schering Corp | Aromatic ether derivatives and antiviral compositions thereof |
EP0571083B1 (en) * | 1992-05-18 | 1997-06-18 | Kao Corporation | Developer additive, toner and developer composition |
JP3603315B2 (ja) * | 1993-02-19 | 2004-12-22 | 日本製紙株式会社 | 近赤外線吸収剤およびそれを含有した熱線遮蔽材 |
JP3509082B2 (ja) * | 1994-06-23 | 2004-03-22 | 日本製紙株式会社 | 感熱記録体 |
DE69613410T2 (de) * | 1995-01-31 | 2002-05-02 | Mitsubishi Chem Corp | Ladungssteuerungsmittel für die Entwicklung elektrostatischer Bilder, und Toner und ladungserzeugendes Material die es enthalten |
-
1998
- 1998-04-01 JP JP54282798A patent/JP2001519808A/ja not_active Withdrawn
- 1998-04-01 WO PCT/US1998/006152 patent/WO1998045259A2/en active IP Right Grant
- 1998-04-01 DE DE69830751T patent/DE69830751T2/de not_active Expired - Fee Related
- 1998-04-01 EP EP98913241A patent/EP0973735B1/en not_active Expired - Lifetime
- 1998-04-01 ES ES01117751T patent/ES2243370T3/es not_active Expired - Lifetime
- 1998-04-01 DK DK98913241T patent/DK0973735T3/da active
- 1998-04-01 AU AU67836/98A patent/AU6783698A/en not_active Abandoned
- 1998-04-01 DE DE69811062T patent/DE69811062T2/de not_active Expired - Fee Related
- 1998-04-01 ES ES98913241T patent/ES2191292T3/es not_active Expired - Lifetime
- 1998-04-01 AT AT98913241T patent/ATE231839T1/de not_active IP Right Cessation
- 1998-04-01 AT AT01117751T patent/ATE298741T1/de not_active IP Right Cessation
- 1998-04-01 US US09/053,177 patent/US5958983A/en not_active Expired - Fee Related
-
1999
- 1999-05-11 US US09/309,645 patent/US6147116A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2243370T3 (es) | 2005-12-01 |
ATE298741T1 (de) | 2005-07-15 |
WO1998045259A2 (en) | 1998-10-15 |
WO1998045259A3 (en) | 1999-02-25 |
DK0973735T3 (da) | 2003-06-23 |
DE69811062T2 (de) | 2003-07-17 |
JP2001519808A (ja) | 2001-10-23 |
AU6783698A (en) | 1998-10-30 |
EP0973735B1 (en) | 2003-01-29 |
DE69830751T2 (de) | 2006-05-18 |
US6147116A (en) | 2000-11-14 |
DE69830751D1 (de) | 2005-08-04 |
US5958983A (en) | 1999-09-28 |
ATE231839T1 (de) | 2003-02-15 |
EP0973735A2 (en) | 2000-01-26 |
DE69811062D1 (de) | 2003-03-06 |
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