ES2123048T3 - Analogos de nucleosidos antiviricos. - Google Patents

Analogos de nucleosidos antiviricos.

Info

Publication number
ES2123048T3
ES2123048T3 ES93905536T ES93905536T ES2123048T3 ES 2123048 T3 ES2123048 T3 ES 2123048T3 ES 93905536 T ES93905536 T ES 93905536T ES 93905536 T ES93905536 T ES 93905536T ES 2123048 T3 ES2123048 T3 ES 2123048T3
Authority
ES
Spain
Prior art keywords
antiviric
nucleosid
analogs
nucleosid analogs
carbociclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905536T
Other languages
English (en)
Inventor
Leroy B Townsend
John Charles Drach
Steven Spencer Good
Susan Mary Daluge
Michael Tolar Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
University of Michigan
Original Assignee
Wellcome Foundation Ltd
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd, University of Michigan filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2123048T3 publication Critical patent/ES2123048T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS ANALOGOS DE NUCLEOSIDOS ANTIVIRICOS CONTIENEN UNA BASE DE BENCIMIDAZOL SUSTITUIDO ADHERIDA A UN ANILLO CARBOCICLICO EN UN LUGAR DEL RESIDUO DE AZUCAR CONVENCIONAL. PARTICULARMENTE, LOS COMPUESTOS PREFERENTES INCLUYEN AQUELLOS EN LOS QUE LAS POSICIONES 2-, 2POR HALOGENOS. LOS COMPUESTOS TIENEN UNA ACTIVIDAD CONTRA LOS VIRUS DE HERPES, ESPECIALMENTE INFECCIONES DEL CITOMEGALOVIRUS Y TAMBIEN DEL VIRUS DE LA HEPATITIS B.
ES93905536T 1992-03-09 1993-03-08 Analogos de nucleosidos antiviricos. Expired - Lifetime ES2123048T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205071A GB9205071D0 (en) 1992-03-09 1992-03-09 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
ES2123048T3 true ES2123048T3 (es) 1999-01-01

Family

ID=10711750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905536T Expired - Lifetime ES2123048T3 (es) 1992-03-09 1993-03-08 Analogos de nucleosidos antiviricos.

Country Status (20)

Country Link
US (1) US5534535A (es)
EP (1) EP0630368B1 (es)
JP (1) JP3450854B2 (es)
KR (2) KR950700887A (es)
AT (1) ATE170846T1 (es)
AU (1) AU672597B2 (es)
CA (1) CA2131693A1 (es)
CZ (1) CZ209494A3 (es)
DE (1) DE69320945T2 (es)
DK (1) DK0630368T3 (es)
ES (1) ES2123048T3 (es)
FI (1) FI944134A (es)
GB (1) GB9205071D0 (es)
HU (1) HUT68445A (es)
IL (1) IL104976A (es)
NZ (1) NZ249554A (es)
RU (1) RU2141952C1 (es)
TW (1) TW366339B (es)
WO (1) WO1993018009A1 (es)
ZA (1) ZA931647B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
BR9508826A (pt) * 1994-09-09 1997-09-30 Wellcome Found Análogos de nucleosídeo antivirais contendo uma base de benzimidazol substituída ligada a um anel carboxílico
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
JP2001512453A (ja) 1997-02-13 2001-08-21 グラックス グループ リミテッド ベンゾイミダゾール誘導体
SK284810B6 (sk) * 1997-05-13 2005-12-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu
BR9810745A (pt) 1997-06-10 2001-03-13 Glaxo Group Ltd Derivados de benzimidazol
PL338454A1 (en) 1997-07-30 2000-11-06 Univ Michigan Lixofuranosilbenzimidazoles as antiviral agents
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
BR0110023A (pt) 2000-04-13 2003-12-30 Pharmasset Ltd Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
CN106243111B (zh) 2007-08-02 2019-07-23 米伦纽姆医药公司 合成e1活化酶抑制剂的方法
SI2275414T1 (sl) 2008-04-28 2015-10-30 Kyorin Pharmaceutical Co., Ltd., Ciklopentilakrilamidni derivat
US11499722B2 (en) * 2020-04-30 2022-11-15 Bsh Home Appliances Corporation Household cooking appliance having an oven door with an interior camera

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides

Also Published As

Publication number Publication date
AU3643293A (en) 1993-10-05
CA2131693A1 (en) 1993-09-16
FI944134A (fi) 1994-11-07
ATE170846T1 (de) 1998-09-15
KR950700887A (ko) 1995-02-20
IL104976A0 (en) 1993-07-08
AU672597B2 (en) 1996-10-10
TW366339B (en) 1999-08-11
FI944134A0 (fi) 1994-09-08
NZ249554A (en) 1996-05-28
IL104976A (en) 1998-10-30
EP0630368A1 (en) 1994-12-28
DE69320945D1 (de) 1998-10-15
DE69320945T2 (de) 1999-02-04
DK0630368T3 (da) 1999-06-07
GB9205071D0 (en) 1992-04-22
HUT68445A (en) 1995-06-28
EP0630368B1 (en) 1998-09-09
JP3450854B2 (ja) 2003-09-29
RU94043771A (ru) 1996-08-10
CZ209494A3 (en) 1995-11-15
WO1993018009A1 (en) 1993-09-16
KR970705547A (ko) 1997-10-09
HU9402582D0 (en) 1994-11-28
US5534535A (en) 1996-07-09
JPH07506816A (ja) 1995-07-27
ZA931647B (en) 1994-09-08
RU2141952C1 (ru) 1999-11-27

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