ES2108969T3 - Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales. - Google Patents

Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.

Info

Publication number
ES2108969T3
ES2108969T3 ES94904110T ES94904110T ES2108969T3 ES 2108969 T3 ES2108969 T3 ES 2108969T3 ES 94904110 T ES94904110 T ES 94904110T ES 94904110 T ES94904110 T ES 94904110T ES 2108969 T3 ES2108969 T3 ES 2108969T3
Authority
ES
Spain
Prior art keywords
treatment
beta
viral infections
didesoxinucleosid
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94904110T
Other languages
English (en)
Inventor
Tarek Des Prairies Bou Mansour
Alan H L Tse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
IAF BioChem International Inc
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IAF BioChem International Inc, Biochem Pharma Inc filed Critical IAF BioChem International Inc
Application granted granted Critical
Publication of ES2108969T3 publication Critical patent/ES2108969T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE AL USO Y A UN METODO DE TRATAMIENTO DE (BETA)-L-5-FLUORO-2'',3''-DIDEOXICYTIDINA ((BETA)-L-5F-DDC), Y (BETA)-L-2'',3''DIDEOXICYTIDINA ((BETA)-L-DDC) Y LOS DERIVADOS FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS, PARA SU USO EN EL TRATAMIENTO DE INFECCIONES VIRALES, ESPECIFICAMENTE INFECCIONES POR HIV Y HEPATITIS B. LA INVENCION TAMBIEN INCLUYE EL USO Y EL METODO DE TRATAMIENTO DE (BETA)-D-5-FLUORO-2'',3''-DIDEOXICYTIDINA ((BETA)-D-5F-DDC) PARA EL USO EN EL TRATAMIENTO DE LAS INFECCIONES POR HEPATITIS B.
ES94904110T 1992-12-24 1993-12-22 Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales. Expired - Lifetime ES2108969T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929226927A GB9226927D0 (en) 1992-12-24 1992-12-24 Dideoxy nucleoside analogues

Publications (1)

Publication Number Publication Date
ES2108969T3 true ES2108969T3 (es) 1998-01-01

Family

ID=10727197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94904110T Expired - Lifetime ES2108969T3 (es) 1992-12-24 1993-12-22 Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.

Country Status (21)

Country Link
US (1) US6156737A (es)
EP (2) EP0765665A1 (es)
JP (2) JP2818299B2 (es)
KR (1) KR100331714B1 (es)
AP (1) AP450A (es)
AT (1) ATE157877T1 (es)
AU (1) AU681370B2 (es)
CA (1) CA2143204C (es)
DE (1) DE69313872T2 (es)
DK (1) DK0675724T3 (es)
ES (1) ES2108969T3 (es)
GB (1) GB9226927D0 (es)
GR (1) GR3024699T3 (es)
HK (1) HK1002426A1 (es)
IL (1) IL108063A (es)
MY (1) MY127808A (es)
NZ (1) NZ259487A (es)
RU (1) RU2160108C2 (es)
SG (1) SG48956A1 (es)
WO (1) WO1994014456A1 (es)
ZA (1) ZA939677B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069252A (en) 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
CA2171550C (en) * 1993-09-10 2008-08-26 Raymond F. Schinazi Nucleosides with anti-hepatitis b virus activity
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) * 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
US6100301A (en) * 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ZA984796B (en) * 1997-06-10 1998-12-29 Chong Kun Dang Corp Novel optically active nucleoside derivative its manufacturing method and anti-HBV composition containing the derivative thereof
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
EP0285884A3 (en) * 1987-03-20 1990-07-04 Bristol-Myers Squibb Company process to produce 2', 3'-dideoxynucleosides
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
CA1327000C (en) * 1987-08-07 1994-02-15 David L.J. Tyrrell Antiviral therapy for hepatitis b
US5039667A (en) * 1987-08-07 1991-08-13 The Governors Of The University Of Alberta Antiviral therapy for hepatitis B with 2',3'-dideoxypurine nucleosides
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
CA2055433A1 (en) * 1989-05-15 1990-11-16 Jay H. Hoofnagle Method of treatment of hepatitis
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5179104A (en) * 1990-12-05 1993-01-12 University Of Georgia Research Foundation, Inc. Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
IL100965A (en) * 1991-02-22 1999-12-31 Univ Emory 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it
KR100270806B1 (ko) * 1991-03-06 2000-11-01 템블 존 엘 5-플루오로-2`-데옥시-3`-티아시티딘을 함유하는 b형 간염 치료를 위한 약제
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
JPH09222548A (ja) * 1996-02-19 1997-08-26 Asahi Optical Co Ltd レンズ駆動機構

Also Published As

Publication number Publication date
IL108063A (en) 1999-10-28
JPH10139668A (ja) 1998-05-26
RU2160108C2 (ru) 2000-12-10
SG48956A1 (en) 1998-05-18
EP0765665A1 (en) 1997-04-02
KR100331714B1 (ko) 2002-11-01
AU681370B2 (en) 1997-08-28
AP9300603A0 (en) 1994-01-31
NZ259487A (en) 1997-06-24
EP0675724A1 (en) 1995-10-11
DE69313872D1 (de) 1997-10-16
GR3024699T3 (en) 1997-12-31
US6156737A (en) 2000-12-05
DE69313872T2 (de) 1998-01-08
IL108063A0 (en) 1994-04-12
EP0675724B1 (en) 1997-09-10
GB9226927D0 (en) 1993-02-17
CA2143204A1 (en) 1994-07-07
DK0675724T3 (da) 1998-03-09
CA2143204C (en) 1997-06-03
WO1994014456A1 (en) 1994-07-07
ATE157877T1 (de) 1997-09-15
AP450A (en) 1996-01-19
JP2818299B2 (ja) 1998-10-30
ZA939677B (en) 1994-08-26
AU5830194A (en) 1994-07-19
HK1002426A1 (en) 1998-08-21
MY127808A (en) 2006-12-29
JPH07509730A (ja) 1995-10-26

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