ES2108969T3 - Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales. - Google Patents
Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales.Info
- Publication number
- ES2108969T3 ES2108969T3 ES94904110T ES94904110T ES2108969T3 ES 2108969 T3 ES2108969 T3 ES 2108969T3 ES 94904110 T ES94904110 T ES 94904110T ES 94904110 T ES94904110 T ES 94904110T ES 2108969 T3 ES2108969 T3 ES 2108969T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- beta
- viral infections
- didesoxinucleosid
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION SE REFIERE AL USO Y A UN METODO DE TRATAMIENTO DE (BETA)-L-5-FLUORO-2'',3''-DIDEOXICYTIDINA ((BETA)-L-5F-DDC), Y (BETA)-L-2'',3''DIDEOXICYTIDINA ((BETA)-L-DDC) Y LOS DERIVADOS FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS, PARA SU USO EN EL TRATAMIENTO DE INFECCIONES VIRALES, ESPECIFICAMENTE INFECCIONES POR HIV Y HEPATITIS B. LA INVENCION TAMBIEN INCLUYE EL USO Y EL METODO DE TRATAMIENTO DE (BETA)-D-5-FLUORO-2'',3''-DIDEOXICYTIDINA ((BETA)-D-5F-DDC) PARA EL USO EN EL TRATAMIENTO DE LAS INFECCIONES POR HEPATITIS B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929226927A GB9226927D0 (en) | 1992-12-24 | 1992-12-24 | Dideoxy nucleoside analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2108969T3 true ES2108969T3 (es) | 1998-01-01 |
Family
ID=10727197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94904110T Expired - Lifetime ES2108969T3 (es) | 1992-12-24 | 1993-12-22 | Utilizacion de analogos de didesoxinucleosidos en el tratamiento de infecciones virales. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6156737A (es) |
EP (2) | EP0765665A1 (es) |
JP (2) | JP2818299B2 (es) |
KR (1) | KR100331714B1 (es) |
AP (1) | AP450A (es) |
AT (1) | ATE157877T1 (es) |
AU (1) | AU681370B2 (es) |
CA (1) | CA2143204C (es) |
DE (1) | DE69313872T2 (es) |
DK (1) | DK0675724T3 (es) |
ES (1) | ES2108969T3 (es) |
GB (1) | GB9226927D0 (es) |
GR (1) | GR3024699T3 (es) |
HK (1) | HK1002426A1 (es) |
IL (1) | IL108063A (es) |
MY (1) | MY127808A (es) |
NZ (1) | NZ259487A (es) |
RU (1) | RU2160108C2 (es) |
SG (1) | SG48956A1 (es) |
WO (1) | WO1994014456A1 (es) |
ZA (1) | ZA939677B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
JPH09504785A (ja) * | 1993-09-10 | 1997-05-13 | エモリー、ユニバーシティー | 抗b型肝炎ウイルス活性を有するヌクレオシド |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) * | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
EP1655033A1 (en) * | 1995-06-07 | 2006-05-10 | Emory University | Nucleosides with anti-hepatitis B virus activity |
US6100301A (en) * | 1996-02-28 | 2000-08-08 | Pfizer Inc | Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
ZA984796B (en) * | 1997-06-10 | 1998-12-29 | Chong Kun Dang Corp | Novel optically active nucleoside derivative its manufacturing method and anti-HBV composition containing the derivative thereof |
US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US7115584B2 (en) * | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
HU196607B (en) * | 1985-05-15 | 1988-12-28 | Wellcome Found | Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds |
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
IL85778A0 (en) * | 1987-03-20 | 1988-09-30 | Bristol Myers Co | Production of 2',3'-dideoxynucleosides and certain such novel compounds |
US5215970A (en) * | 1987-04-16 | 1993-06-01 | Medivir Ab | Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds |
CA1327000C (en) * | 1987-08-07 | 1994-02-15 | David L.J. Tyrrell | Antiviral therapy for hepatitis b |
US5039667A (en) * | 1987-08-07 | 1991-08-13 | The Governors Of The University Of Alberta | Antiviral therapy for hepatitis B with 2',3'-dideoxypurine nucleosides |
SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
EP0472595A4 (en) * | 1989-05-15 | 1992-07-08 | Us Commerce | Method of treatment of hepatitis |
SE464168B (sv) * | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
US5179104A (en) * | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
NZ250842A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | Resolution of a racemic mixture of nucleoside enantiomers such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (ftc) |
DK0574487T3 (da) * | 1991-03-06 | 2002-10-14 | Univ Emory | Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B |
WO1992018517A1 (en) * | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
JPH09222548A (ja) * | 1996-02-19 | 1997-08-26 | Asahi Optical Co Ltd | レンズ駆動機構 |
-
1992
- 1992-12-24 GB GB929226927A patent/GB9226927D0/en active Pending
-
1993
- 1993-12-17 IL IL10806393A patent/IL108063A/en not_active IP Right Cessation
- 1993-12-22 MY MYPI93002810A patent/MY127808A/en unknown
- 1993-12-22 AU AU58301/94A patent/AU681370B2/en not_active Ceased
- 1993-12-22 KR KR1019950701603A patent/KR100331714B1/ko not_active IP Right Cessation
- 1993-12-22 EP EP96116738A patent/EP0765665A1/en not_active Withdrawn
- 1993-12-22 DK DK94904110.7T patent/DK0675724T3/da active
- 1993-12-22 JP JP6514645A patent/JP2818299B2/ja not_active Expired - Lifetime
- 1993-12-22 US US08/416,746 patent/US6156737A/en not_active Expired - Fee Related
- 1993-12-22 EP EP94904110A patent/EP0675724B1/en not_active Expired - Lifetime
- 1993-12-22 CA CA002143204A patent/CA2143204C/en not_active Expired - Fee Related
- 1993-12-22 DE DE69313872T patent/DE69313872T2/de not_active Expired - Fee Related
- 1993-12-22 SG SG1996004109A patent/SG48956A1/en unknown
- 1993-12-22 NZ NZ259487A patent/NZ259487A/en not_active IP Right Cessation
- 1993-12-22 RU RU95117097/14A patent/RU2160108C2/ru not_active IP Right Cessation
- 1993-12-22 WO PCT/CA1993/000563 patent/WO1994014456A1/en active IP Right Grant
- 1993-12-22 AT AT94904110T patent/ATE157877T1/de not_active IP Right Cessation
- 1993-12-22 ES ES94904110T patent/ES2108969T3/es not_active Expired - Lifetime
- 1993-12-23 ZA ZA939677A patent/ZA939677B/xx unknown
- 1993-12-23 AP APAP/P/1993/000603A patent/AP450A/en active
-
1997
- 1997-09-11 GR GR970401364T patent/GR3024699T3/el unknown
- 1997-11-06 JP JP9304516A patent/JPH10139668A/ja active Pending
-
1998
- 1998-02-24 HK HK98101411A patent/HK1002426A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6156737A (en) | 2000-12-05 |
DE69313872T2 (de) | 1998-01-08 |
AP9300603A0 (en) | 1994-01-31 |
SG48956A1 (en) | 1998-05-18 |
RU2160108C2 (ru) | 2000-12-10 |
WO1994014456A1 (en) | 1994-07-07 |
DE69313872D1 (de) | 1997-10-16 |
CA2143204C (en) | 1997-06-03 |
GR3024699T3 (en) | 1997-12-31 |
HK1002426A1 (en) | 1998-08-21 |
IL108063A0 (en) | 1994-04-12 |
CA2143204A1 (en) | 1994-07-07 |
MY127808A (en) | 2006-12-29 |
JPH10139668A (ja) | 1998-05-26 |
JP2818299B2 (ja) | 1998-10-30 |
NZ259487A (en) | 1997-06-24 |
AP450A (en) | 1996-01-19 |
AU5830194A (en) | 1994-07-19 |
EP0765665A1 (en) | 1997-04-02 |
EP0675724B1 (en) | 1997-09-10 |
DK0675724T3 (da) | 1998-03-09 |
AU681370B2 (en) | 1997-08-28 |
EP0675724A1 (en) | 1995-10-11 |
ATE157877T1 (de) | 1997-09-15 |
JPH07509730A (ja) | 1995-10-26 |
ZA939677B (en) | 1994-08-26 |
IL108063A (en) | 1999-10-28 |
KR100331714B1 (ko) | 2002-11-01 |
GB9226927D0 (en) | 1993-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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